MRC1
-
Official Full Name
mannose receptor, C type 1
-
Overview
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Apr 2011] -
Synonyms
MRC1; mannose receptor, C type 1; MMR; CD206; MRC1L1; CLEC13D; CLEC13DL; bA541I19.1; macrophage mannose receptor 1; mannose receptor, C type 1-like 1; C-type lectin domain family 13 member D; macrophage mannose receptor 1-like protein 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian cells
- Wheat Germ
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- His|SUMO
- His|T7
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- MRC1 Related Articles
- MRC1 Related Research Area
MRC1 involved in several pathways and played different roles in them. We selected most pathways MRC1 participated on our site, such as Phagosome, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phagosome | SEC61G;TLR4;CCDC102A;TUBA8;CTSSB.1;TUBA4A;ACTB1;TUBA1C;ITGB2 |
| Tuberculosis | PLK3;IFNA10;MAPK3;IL12A;FADD;IL10RA;TLR1;H2-AA;IFNA7 |
MRC1 has several biochemical functions, for example, mannose binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MRC1 itself. We selected most functions MRC1 had, and list some proteins which have the same functions with MRC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mannose binding | Acr;CLN5;MAN2B1;CD209A;LMAN2;MANBA;CD209B;CD209;IGF2R |
| protein binding | PCMT1;RAB39B;CBX5;HRAS;SOX9A;RXFP4;ADCK5;ZFP36;CCDC43 |
| receptor activity | JMJD6;CD4;ADCYAP1R1;DERL1;SEC63;IL10RA;NCR3;PLXNA1;SMAGP |
| transmembrane signaling receptor activity | FZD1;TLR5;CALCRLA;OR12D3;NRXN3;LGR4;GPR98;TLR4;FZD8B |
| virus receptor activity | TFRC;TYRO3;PVRL2;PVR;PVRL4;CD209A;SCARB2;HYAL2;HSPA1B |
MRC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRC1.
rpoB; flhA
- Q&As
- Reviews
Q&As (6)
Ask a questionThe primary function of MRC1 in the immune system is to recognize and bind mannose on the cell walls of bacteria and fungi, thereby limiting the growth and spread of these pathogens. It is also involved in regulating the activation and phagocytosis of macrophages.
Studies have shown that the expression level of MRC1 is associated with certain infectious diseases, inflammatory diseases, and autoimmune diseases. The high expression of MRC1 may enhance the phagocytosis and killing ability of macrophages and help control infection. However, low expression of MRC1 may affect the activation and function of macrophages, leading to disease progression.
The structure of MRC1 determines its ability to recognize and bind mannose, and where and how it interacts with proteins such as TLR2 and TLR4. The study of its structure can help us understand its function and mechanism of action.
In lung infections, MRC1 may control the progression of lung infections by recognizing and binding to inhaled mannose, triggering an inflammatory response and activation of macrophages. It could be a potential target for the treatment of lung infections.
MRC1 can interact with a variety of other proteins, including TLR2, TLR4, etc. These interactions allow it to recognize and bind to mannose and trigger an inflammatory response and activation of macrophages.
Therapeutic strategies for MRC1 can include regulating its expression level, enhancing its ability to recognize and bind mannose, and promoting macrophage activation and phagocytosis. These methods may have potential applications in the treatment of infectious diseases, inflammatory diseases and autoimmune diseases.
Customer Reviews (3)
Write a reviewWith MRC1, the reproducibility of Western blot was significantly improved.
It can enhance the effectiveness of the body's immune response.
It has high biological activity and stability.
Ask a Question for All MRC1 Products
Required fields are marked with *
My Review for All MRC1 Products
Required fields are marked with *
