NOS1
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Official Full Name
Nos1 nitric oxide synthase 1, neuronal -
Overview
The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from;L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including;neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric;oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke;and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This;protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that;differ in the 5 UTR have been described for this gene but the full-length nature of these transcripts is not known.Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been;found for this gene. -
Synonyms
NOS1;nitric oxide synthase 1, neuronal;nitric oxide synthase, brain;N-NOS;NC-NOS;NOS type I;neuronal NOS;constitutive NOS;neuronal nitric oxide synthase;peptidyl-cysteine S-nitrosylase NOS1;NO;bNOS;nNOS;NOS-I;Nos-1;2310005C01Rik
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- Non
- His
- Avi
- Fc
- Flag
- DDK
- Myc
- GST
Involved Pathway
NOS1 involved in several pathways and played different roles in them. We selected most pathways NOS1 participated on our site, such as Arginine biosynthesis,Arginine and proline metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Circadian entrainment | PLCB4,ITPR3,GRIA1,GUCY1B3,GNB3,GRIA4,GUCY1A3,PER3,GNG4,GNG5 |
| Metabolic pathways | AK4,UPB1,MTHFR,PTS,ALG2,MBOAT1,UQCRC2,GALNTL1,CECR1A,BHMT |
| Amyotrophic lateral sclerosis (ALS) | CASP1,GRIN2B,GRIN1,GPX1,APAF1,GRIN2A,CCS,BID,PPP3CA,DAXX |
| Calcium signaling pathway | PTGER1,CACNA1D,ATP2A1,CALM1B,EDNRB2,ERBB4,P2RX2,GRIN1A,GRM5,PRKCA |
| Phagosome | TUBB2A,TUBA1L,THBS4A,SEC61AL2,MHC2DCB,NCF2,THBS3,MSR1,MPO,FCGR1 |
| Arginine biosynthesis | GOT2B,ARG1,NOS2B,NOS2A,ASL2,CPS1,GLUD1B,GLS,GLSA,GLUD1A |
| Arginine and proline metabolism | L3HYPDH,ALDH9A1A.1,LAP3,CNDP2,ALDH2.1,AGMAT,P4HA1A,PYCR1B,ALDH3A2A,CKBB |
| Salivary secretion | PRKCA,PRKG2,ATP1B1,PRKCG,BEST2,ATP1A1,PRKACA,CST3,LYZ,ATP1A2 |
| Alzheimers disease | COX6A1,COX7C,PSENEN,ERN1,NDUFB5,APAF1,UQCR10,BID,MME,IL1B2 |
Protein Function
NOS1 has several biochemical functions, for example, FMN binding,NADP binding,NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOS1 itself. We selected most functions NOS1 had, and list some proteins which have the same functions with NOS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| iron ion binding | AOX3,CYP2K19,CYP24A1,ISCU,Agmo,CYP2D9,AOX3L1,FTL,CYP4F18,CYP2P7 |
| scaffold protein binding | DLG4,HOMER1,P2RY1,DSP,ADCY6,KRT8,CACNA1H,CRIPT,PDE4D,NCK2 |
| arginine binding | RARS,NOS2,NAGS,NOS3 |
| tetrahydrobiopterin binding | NOS3,NOS2,TH |
| flavin adenine dinucleotide binding | GSR,CYBB,SDHA,DLDH,MAOA,ACADS,KMO,ETFDH,DPYD,GCDHB |
| ion channel binding | CALM1,VDAC1,HTT,HERPUD1,SRI,PRNP,YWHAH,FHL1,PANX1,PACS1 |
| FMN binding | HAO1,TYW1,NOS3,CREG1,CREG2,NOS2A,NDOR1,NOS2,POR,DHODH |
| enzyme binding | PRMT1,RCOR3,SUPT5H,RCOR1,RPS3,ERN1,GSTM3,STUB1,JUND,BRCA1 |
| calmodulin binding | CNN3B,MYH3,PATE4,MYO5B,NDUFAF4,MYO1C,SLC8A2,ADCY3,MYO5A,CAMK2G1 |
Interacting Protein
NOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOS1.
VAC14;Scn7a;Htr2b
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References
- Bergner, AJ; Stamp, LA; et al. Birthdating of Myenteric Neuron Subtypes in the Small Intestine of the Mouse. JOURNAL OF COMPARATIVE NEUROLOGY 522:514-527(2014).
- Yoshimura, T; Moon, TC; et al. Expression of nitric oxide synthases in leukocytes in nasal polyps. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 108:172-U133(2012).
