| Official Full Name | Nos1 nitric oxide synthase 1, neuronal |
| Background | The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from;L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including;neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric;oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke;and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This;protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that;differ in the 5 UTR have been described for this gene but the full-length nature of these transcripts is not known.Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been;found for this gene. |
| Synonyms | NOS1; nitric oxide synthase 1, neuronal; nitric oxide synthase, brain; N-NOS; NC-NOS; NOS type I; neuronal NOS; constitutive NOS; neuronal nitric oxide synthase; peptidyl-cysteine S-nitrosylase NOS1; NO; bNOS; nNOS; NOS-I; Nos-1; 2310005C01Rik; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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NOS1 involved in several pathways and played different roles in them. We selected most pathways NOS1 participated on our site, such as Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arginine biosynthesis | NOS2A; CPS1; GLULB; GLUD1A; NOS2; GPT; GLULC; ASS1; ASL2; GPT2 |
| Arginine and proline metabolism | ARG1; ALDH3A2A; DAO; ALDH3A2; AGMAT; P4HA3; P4HA1A; ALDH9A1; ALDH4A1; DHDPSL |
| Metabolic pathways | COX6B1; GRHPRA; LDHAL6A; INPP5B; PFKL; CBR3; NANS; CKMT1A; HIBCH; PIGV |
| Calcium signaling pathway | CALM2B; CAMK4; DRD1A; P2RX3B; TACR3L; ORAI1B; PTGER3; GNAS; GNA11B; GRIN1B |
| Phagosome | TUBB; NCF1; H2-AB1; COLEC12; MARCO; LAMP2; TUBA8L; RAB5B; CD209A; HLA-DQA1 |
| Circadian entrainment | ITPR3; Adcy4; PLCB1; KCNJ6; GNG8; GRIN2B; KCNJ5; RYR1; GRIN1; GNG11 |
| Long-term depression | KRAS; GNA11; PLA2G4D; GNA13; MAP2K1; GNAI1; MAPK3; LYN; GRID2; GNAI3 |
| Salivary secretion | CD38; CST2; CST1; ITPR1; GNAQ; ATP1B2; BEST2; ATP1A3; PRH1; CST4 |
| Alzheimers disease | ATF6; CALM4; UQCRQ; IL1B2; COX7A1; APH1B; NDUFB3; HSD17B10; ATP2A3; NAE1 |
| Amyotrophic lateral sclerosis (ALS) | GRIN2A; Casp3; CASP12; CCS; GPX1; TNFRSF1A; TRP53; PPP3R2; TNFRSF1B; MAPK12 |
NOS1 has several biochemical functions, for example, FMN binding, NADP binding, NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOS1 itself. We selected most functions NOS1 had, and list some proteins which have the same functions with NOS1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| FMN binding | HAO2; NOS2A; MTRR; PNPO; NOS2B; NDOR1; CREG2; TYW1B; POR; HAO1 |
| NADP binding | DPYD; MTHFR; CRYM; G6PDX; MTRR; NOS3; MIOX; NDOR1; POR; FMO3 |
| NADPH-hemoprotein reductase activity | NOS2B; NOS2A; MTRR; NDOR1; POR; NOS2; NOS3; NOS1; CYP2J6 |
| arginine binding | RARS; NOS1; NOS3; NAGS; NOS2 |
| cadmium ion binding | SLC11A2; NOS3; P2RX2; NOS1; MT3 |
| calmodulin binding | RYR2; SLC8A2; CNN3; CAMK4; ITPKC; TJP1; NOS3; VAMP2; MAPKAPK2A; PHKA2 |
| enzyme binding | POR; LDB1; LYN; TRP53; PDE4DIP; PRTN3; STC2; SLC18A1; CCND1; MSH3 |
| flavin adenine dinucleotide binding | DUS1L; SQLEA; TXNRD2; AOX1; MAOB; TXNRD1; ETFDH; MAOA; CHDH; MTHFR |
| heme binding | CYP2E1; CYP17A1; PGRMC1; NOS3; CYP4A12A; CYP11A1; FECH; CYP46A1.2; CYP4F2; CYP2C37 |
| ion channel binding | LRRK2; CAV1; YWHAQ; GRINA; TCAP; ACTN4; FKBP1B; RIMS1; SRC; KCNB2 |
| iron ion binding | CYP2X7; KDM3A; PLOD1A; NDOR1; CYP4F22; AOX3; CYP2C9; CYP2V1; CYP24A1; CYP2B6 |
| nitric-oxide synthase activity | NOS2; NOS1; NOS2B; NOS2A; NOS3 |
| protein binding | TFG; TTLL10; ZNF69; NPPB; PNOC; DOK3; ZC3H11A; TNNI2; PDZK1; SGTA |
| protein homodimerization activity | DAPK3; TRIM37; GRHPR; RAB11FIP4A; DMRTA2; GPD1C; MECOM; RASGRP1; ENPP1; IL6R |
| scaffold protein binding | ADCY6; SHANK3; MAP2K2; SRC; NLGN4Y; CHUK; GRIN2A; TREM2; MAPK3; P2RY1 |
| sodium channel regulator activity | GPLD1; RANGRF; SGK2; FXYD7; FXYD1; FGF12; FXYD2; AGT; CAV3; SGK2B |
| tetrahydrobiopterin binding | NOS3; NOS2; TH; NOS1 |
NOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOS1.
VAC14; Scn7a; Htr2b
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