nos1
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  • Official Full Name
  • Nos1 nitric oxide synthase 1, neuronal
  • Background
  • The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from;L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including;neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric;oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke;and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This;protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that;differ in the 5 UTR have been described for this gene but the full-length nature of these transcripts is not known.Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been;found for this gene.
  • Synonyms
  • NOS1; nitric oxide synthase 1, neuronal; nitric oxide synthase, brain; N-NOS; NC-NOS; NOS type I; neuronal NOS; constitutive NOS; neuronal nitric oxide synthase; peptidyl-cysteine S-nitrosylase NOS1; NO; bNOS; nNOS; NOS-I; Nos-1; 2310005C01Rik;
Cat.#:NOS1-5989HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human NOS1 Protein, GST-tagged
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Cat.#:NOS1-16HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NOS1 protein
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Cat.#:NOS1-299HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human NOS1
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Cat.#:NOS1-7736HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human NOS1 protein, His-tagged
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Cat.#:NOS1-10784MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse NOS1 Protein
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Cat.#:Nos1-7737MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nos1 protein, His-tagged
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Cat.#:Nos1-7738MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nos1 protein, His-tagged
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Cat.#:Nos1-7739MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nos1 protein, His-tagged
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Cat.#:Nos1-7740MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Nos1 protein, His-tagged
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Cat.#:NOS1-4022RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat NOS1 Protein
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Cat.#:Nos1-7741RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nos1 protein, His-tagged
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Cat.#:Nos1-7742RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nos1 protein, His-tagged
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Cat.#:Nos1-7743RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Nos1 protein, His-tagged
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Cat.#:NOS1-9191ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish NOS1
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Cat.#:NOS1-612HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Nitric Oxide Synthase 1 (Neuronal)
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Cat.#:NOS1-3761HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human NOS1 293 Cell Lysate
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Involved Pathway

NOS1 involved in several pathways and played different roles in them. We selected most pathways NOS1 participated on our site, such as Arginine biosynthesis, Arginine and proline metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arginine biosynthesis
NOS2B; GLULA; ASS1; GPT; ASL2; ARG1; GOT1; ASL; GLUL; CPS1
Arginine and proline metabolism
P4HA3; PYCR1B; SAT1A.1; ALDH9A1; CKMT1B; GATM; SAT1; GOT1; LAP3; SMOX
Metabolic pathways
NADKD1; DCT; PI4K2B; PTDSS2; ATP6V0E1; B4GALT3; DGAT1; BCO1L; AHCY; DNMT3AA
Calcium signaling pathway
TBXA2R; P2RX4; TACR3L; CHRM3; HRH1; RYR1; ITPKC; MLCK2; TRHR2; NOS1
Phagosome
TUBAL3; EEA1; HLA-G; C3A.2; HLA-A; FAM49BA; HLA-DOA; HLA-DQA2; MBL1; VAMP3
Circadian entrainment
GRIN2C; GNB4; RPS6KA5; GNAO1; PRKACA; GRIA2; MAPK1; ITPR1; GNAS; RYR1
Long-term depression
HRAS; GNAI1; PRKG1; PLA2G4C; PLCB1; GNA11; ITPR3; GNAS; MAP2K1; PLA2G4A
Salivary secretion
GUCY1A3; HTN1; ATP1B1; AMY1B; ATP1A3; PRB1; PLCB3; PRKCA; LYZ1; LYZ2
Alzheimers disease
CALML3; IL1B; NCSTN; NDUFS6; UQCRH; MME; NDUFV3; PSEN2; COX8A; NAE1
Amyotrophic lateral sclerosis (ALS)
Casp3; CAT; MAP2K6; PRPH; PPP3R1; TOMM40; GRIN1; NEFH; PPP3R2; CASP9

Protein Function

NOS1 has several biochemical functions, for example, FMN binding, NADP binding, NADPH-hemoprotein reductase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NOS1 itself. We selected most functions NOS1 had, and list some proteins which have the same functions with NOS1. You can find most of the proteins on our site.
Function
Related Protein
Function FMN binding
Related Protein NOS1; MTRR; TYW1; NDOR1; NOS3; CREG2; POR; HAO1; PNPO; NOS2
Function NADP binding
Related Protein NOS1; H6PD; GAPDHS; IDH1; NOS3; MTRR; NOS2; POR; HMGCRA; DHFRL1
Function NADPH-hemoprotein reductase activity
Related Protein NDOR1; MTRR; CYP2J6; NOS1; NOS2A; POR; NOS2; NOS3; NOS2B
Function arginine binding
Related Protein RARS; NOS3; NAGS; NOS1; NOS2
Function cadmium ion binding
Related Protein NOS3; SLC11A2; MT3; P2RX2; NOS1
Function calmodulin binding
Related Protein MYH11; CTH; PCDP1; NETO2; IQCB1; SLC9A1; MARCKS; KCNN1A; TRPV5; STRN4
Function enzyme binding
Related Protein HIST1H2AL; CYB5A; PIAS1; MAT2B; HSPA8; PHKG1; CALU; LAMP2; CSF3; UGT1A1
Function flavin adenine dinucleotide binding
Related Protein ACADL; DUS4L; ACADVL; DMGDH; KMO; MTRR; NOS1; ETFDH; GCDHA; MTHFR
Function heme binding
Related Protein CYP2A7; CYP2F2; CYBB; NR1D1; NENF; CYP3A7; CYP2W1; CYP2AA8; CYP4A11; CYP2R1
Function ion channel binding
Related Protein KCNH1; HERPUD1; ARRB1; CTNNB1; EPN1; CDH5; ASPH; ID2; KCNH5; PPP1R9B
Function iron ion binding
Related Protein CYP17A1; CYP11C1; OGFOD2; HBAA; CH25H; CYP4Z1; CYP4F18; ALOX5; CYP2D26; CYP4V2
Function nitric-oxide synthase activity
Related Protein NOS2A; NOS3; NOS2B; NOS1; NOS2
Function protein binding
Related Protein PDHB; LETMD1; SIKE1; EIF2B4; CARD10; ACTL7A; HLCS; ADM; RAB3A; NADK
Function protein homodimerization activity
Related Protein CHKA; PEX11A; ROPN1B; ANO6; SLK; CCL5; MSH2; ABCB9; TBX15; GTF2A2
Function scaffold protein binding
Related Protein NLGN1; NLGN4X; SRC; CACNA1H; PDE4D; DLG4; MAPK3; NLGN3; CRIPT; NOS1
Function sodium channel regulator activity
Related Protein FXYD6; FXYD5; TMPRSS3; SCLT1; PTPN3; SCN3B; SGK2B; GPLD1; FXYD7; SCN1BA
Function tetrahydrobiopterin binding
Related Protein NOS2; TH; NOS3; NOS1

Interacting Protein

NOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOS1.
VAC14; Scn7a; Htr2b

NOS1 Related Articles

Bergner, AJ; Stamp, LA; et al. Birthdating of Myenteric Neuron Subtypes in the Small Intestine of the Mouse. JOURNAL OF COMPARATIVE NEUROLOGY 522:514-527(2014).
Yoshimura, T; Moon, TC; et al. Expression of nitric oxide synthases in leukocytes in nasal polyps. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY 108:172-U133(2012).