pik3r2
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 2 (beta)
  • Background
  • The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin r
  • Synonyms
  • PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphatidylinositol 3-kinase regulatory subunit beta; p85; P85B; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory sub
Cat.#:PIK3R2-51HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-kinase, Regulatory Subunit 2 (Beta)
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Cat.#:PIK3R2-180BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine PIK3R2 (Beta)
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Cat.#:PIK3R2-1718HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2, His-tagged
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Cat.#:PIK3R2-316HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2 protein, His/MBP-tagged
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Cat.#:PIK3R2-12807MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIK3R2 Protein
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Cat.#:PIK3R2-3435RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R2 Protein, His-tagged
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Cat.#:PIK3R2-12088ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3R2
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Involved Pathway

PIK3R2 involved in several pathways and played different roles in them. We selected most pathways PIK3R2 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PTK2AA; ABL2; SHC3; CBLC; PLCG1; GRB2A; PRKCB; MAPK1; MAPK8B; CAMK2B1
Ras signaling pathway
FGF14; PIK3R5; Fgf15; HTR7; RELA; IGF1; PIK3CG; FGF17; SHC2; PRKCA
Rap signaling pathway
CALM4; PFN3; LAT; BCAR1; FGFR1; PGF; PDGFA; PFN1; IGF1; FGF11
cGMP-PKG signaling pathway
NPR1; MAPK1; PDE2A; MEF2D; ROCK2; MAP2K2; PIK3R1; KCNMB4; CALML5; CREB3L1
cAMP signaling pathway
GRIN1; MAPK10; GNAS; HTR6; RAP1A; AKT2; GIPR; PDE3B; GNAI3; FXYD1
Chemokine signaling pathway
CCL3L3; PIK3CD; GRK1; GNAI1; CCL1; XCL1; CCL15; PREX1; VAV3; RHOA
HIF- signaling pathway
LDHA; PIK3CB; PLCG1; AKT2; SLC2A1; MKNK2; EIF4E1B; IGF1; MAPK1; HMOX1
FoxO signaling pathway
PRKAG3B; PDPK1B; FASLG; PTENA; CCNB3; GRB2; SETD7; MAPK12A; RAF1; ATG12
Phosphatidylinositol signaling system
PIK3C2B; PRKCBA; ITPR3; PTEN; PIKFYVE; PIP5K1AB; PLCB3; SYNJ1; SYNJ2; ITPKB
Sphingolipid signaling pathway
GNA12; RELA; PLCB3; PPP2R2C; SGPP1; MAPK11; RAC3; GNAI2; S1PR4; PPP2CA
Phospholipase D signaling pathway
LPAR4; GRM6; CYTH4; GRM7; RRAS; TSC2; SHC2; PIP5K1A; AVPR1B; MAP2K1
mTOR signaling pathway
TSC1A; TNF; PIK3CA; PRKAA2; RPS6KB2; PIK3R1; PIK3CB; AKT3A; INS; PRKAA1
PIK-Akt signaling pathway
FGF18; COL6A6; LPAR2; PIK3CD; TLR2; KIT; PPP2R2B; ITGA6; G6PC3; PRLR
AMPK signaling pathway
PIK3CD; ADRa1A; FOXO3; EEF2; IRS4; RPS6KB2; PRKAG2; PRKAB2; MAP3K7; PDPK1
Apoptosis
IRF2A; BIRC8; NMT1; CAPN2; HDR; SATB1; HIST1H1D; TRP53; STK24; BCL2A
Adrenergic signaling in cardiomyocytes
ATP1A1; ADCY1B; PPP2R5A; SLC14A2; GNA15.4; PPP1CC; ATP2B1; ATP1B1A; CACNB4A; PPP2R5CB
VEGF signaling pathway
SRC; PPP3CC; PRKCB; NFATC2; HRAS; MAP2K2A; VEGFAA; RAF1A; PLA2G4C; MAPK13
Osteoclast differentiation
SOCS3; MAPK13; TGFB1; LCP2; NCF2; RELA; FCGR3A; PIK3CD; FYN; LILRA5
Focal adhesion
RAP1A; GRB2; ITGB1; LAMA2; SEPP1; PIK3CA; TNC; MAP2K1; BAD; THBS1
Signaling pathways regulating pluripotency of stem cells
ISL1; WNT7B; MAP2K2; OTX1; ACVR2A; BMP4; FZD1; AKT2; LHX5; WNT16
Platelet activation
PLCB4; RAP1A; MYLK3; PLCG2; GNAI2; SRC; PIK3R5; AKT2; MAPK12; GNAI3
Toll-like receptor signaling pathway
RAC1A; MAP2K4B; TNF; PIK3CB; MAP2K2A; RAC1B; IFNA6; FOS; IFNA1; MAP2K3
Jak-STAT signaling pathway
SOCS1A; CCND2A; SOCS5; LEPA; MCL1; IFNA5; IFNA12; FHL1A; IL12BA; CNTFR
Natural killer cell mediated cytotoxicity
PIK3R1; FCGR4; H60a; HLA-B; CD247; HLA-G; ULBP2; SHC3; LCP2; KIR2DS3
T cell receptor signaling pathway
CD247; NFATC1; NFKBIA; SLA1; CDC42; NFATC3; PPP3CA; EVLB; RHOA; TNF
B cell receptor signaling pathway
AKT2; BCL10; IFITM1; ARPC5; RAP2A; TTC6; ACTR2; LILRB3; CD79A; IKBKB
Fc epsilon RI signaling pathway
PIK3R5; MAP2K3; BTK; PLA2G4C; PRKCA; TNF; GAB2; MAPK12; MS4A2; INPP5D
Fc gamma R-mediated phagocytosis
INPP5D; PIK3R1; LIMK1; PAK1; SYK; VASP; PRKCE; LIMK2; RPS6KB2; GAB2
TNF signaling pathway
MAP2K1; BIRC3; SELE; CREB3L2; PIK3R5; RPS6KA5; ICAM1; TRAF3; NFKB1; MAPK13
Leukocyte transendothelial migration
ICAM1; NOX3; MLLT4; GNAI1; ITGB2L; ITGB2; MSN; AASS; GNAI2; CDC42
Neurotrophin signaling pathway
AKT2; MAP2K1; GSK3B; SOS1; NTF3; MAP3K1; RPS6KA1; ZFP110; PDPK1; BDNF
Cholinergic synapse
PIK3CD; GNG7; PIK3CG; CAMK2D; KCNJ3; GNG13; ITPR3; PIK3R1; PIK3R2; GNGT2
Inflammatory mediator regulation of TRP channels
PLCB2; ASIC1; CYP4A10; CYP2C70; TRPV4; ASIC5; CYP2C54; PRKCQ; CALML5; IL1RAP
Regulation of actin cytoskeleton
FGF11; ITGA10; RRAS2; VCLA; PFN2; RAC1; PAK3; IQGAP3; ACTG1; PDGFRA
Insulin signaling pathway
PRKAG1; PRKAR1AB; MKNK2A; PHKA1; PRKACBA; FLOT2A; PPP1R3C; SOCS1; AKT1; EIF4E1C
Progesterone-mediated oocyte maturation
GNAI2A; FZR1; PIK3CA; HSP90AA1.2; RPS6KA3B; CDC26; IGF1RB; AKT2L; MAD1L1; AKT3A
Estrogen signaling pathway
KCNJ5; SRC; KCNJ9; PRKACG; HSPA8; GNAI2; HSP90AA1; PIK3R5; CALM1; CREB3L1
Prolactin signaling pathway
PIK3CB; MAPK11; IRF1; SHC1; SHC3; PIK3R1; LHB; SOCS1; FOS; SHC4
Thyroid hormone signaling pathway
PRKCG; MAPK1; MED12L; PLCE1; BMP4; MED24; ITGB3; KRAS; TRP53; STAT1
Oxytocin signaling pathway
MAP2K1; CAMK1G; RCAN1; NPR1; PPP1CC; SRC; PPP3R2; PRKCG; ITPR1; PPP1R12A
Regulation of lipolysis in adipocytes
PIK3R5; AKT1; PRKG2; GNAI3; NPY; IRS4; PRKACA; NPR1; PIK3CD; PDE3B
Type II diabetes mellitus
HKDC1; TNF; HK3; MAPK1; CACNA1G; PKLR; PIK3R1; PKM; INS2; MAPK8
Insulin resistance
INS2; RELA; PDPK1; FOXO1; NOS3; INSR; PPARGC1B; SLC27A3; NFKBIA; PPP2R4
Non-alcoholic fatty liver disease (NAFLD)
IL-8; PRKAA1; COX6B2; ADIPOQ; UQCRC1; SREBF1; COX7A2L; PRKAG1; NDUFA13; PIK3CA
Aldosterone-regulated sodium reabsorption
IRS1; IGF1; FXYD2; ALPHA-ENAC; PRKCB; INS1; PIK3CA; MAPK3; PRKCG; SGK1
Carbohydrate digestion and absorption
AMY2A3; AKT2; TAS1R3; ATP1B2; G6PC; PRKCB; PIK3CA; HK2; AMY2A2; HK3
Bacterial invasion of epithelial cells
ARPC3; PIK3CG; DNM1; SEPT12; CTNNA2; PIK3R5; ACTG1; ARPC1B; SHC4; PTK2
Chagas disease (American trypanosomiasis)
C1QC; TLR9; TNFRSF1A; IKBKB; IL-8; CCL5; PPP2R2B; TGFB2; CCL3L3; CCL3L1
Toxoplasmosis
HLA-DMB; CD40LG; LAMB4; GNAI2; AKT2; Toxoplasma Gondii Major Surface Antigen P30; XIAP; MAP3K7; IFNGR2; CD40
Amoebiasis
RAB5B; CD14; GNA15; CXCL8; NOS2; ADCY1; ITGAM; PRKACA; IL6; COL4A6
Hepatitis C
CLDN1; PDPK1; PPP2R1A; EIF2AK4; MAPK13; CLDN10; OAS1; PIK3R5; EIF2AK1; NR1H3
Hepatitis B
ATP6AP1; TIRAP; TGFB2; CCND1; IRF7; NRAS; IFNAR1; CCNE2; NFATC3; Ifna11
Measles
FASLG; SLAMF1; CD28; CD3D; TACR1; IFNA8; FCGR2B; MX1; EIF2AK1; IFNB1
Influenza A
HLA-DQA1; TMPRSS4; PIK3R3; NLRP3; IFNA3; HSPA1B; HLA-DRB3; TMPRSS2; IFNA10; BCL2L2-PABPN1
HTLV-I infection
SPI1; ELK1; XBP1; CCND2; SFPI1; HLA-G; PIK3R5; TGFB2; WNT6; MAP2K4
Epstein-Barr virus infection
HLA-F; HLA-E; DDX58; BCL2; SPN; TRADD; POLR2J2; PSMC3; PSMD7; TRP53
Pathways in cancer
GNAI2; MAPK3; BCR; NFKB2; PPARD; WNT8B; MAP2K2; PLCB1; CBLB; PIK3R2
Viral carcinogenesis
LTBR; HDAC7; H2-Q10; GTF2B; GTF2A2; KAT2A; CCNA1; GTF2H2C_2; CDK1; HIST1H2BL
Proteoglycans in cancer
WNT11; WNT16; PLCG1; HSPG2; FZD5; SDC4; CBLB; FZD8; DROSHA; BRAF
MicroRNAs in cancer
SIRT1; TGFB2; HRAS; PLCG1; DNMT1; IGF2BP1; EP300; TP63; BAK1; SOS1
Colorectal cancer
PIK3R5; FOS; TGFBR2; TCF7; APPL1; BRAF; SMAD2; MAPK3; APC; BIRC5
Renal cell carcinoma
TGFB2; PAK1; RAF1; EGLN2; PAK7; AKT1; PIK3R3; RBX1; GRB2; PIK3R1
Pancreatic cancer
KRAS; RAC1; TGFB2; MAPK3; STAT3; TGFB1; PIK3R5; ARHGEF6; BAD; MAPK1
Endometrial cancer
MAP2K2; PIK3R3; TCF7; APC2; PIK3CA; CTNNA2; GSK3B; HRAS; FOXO3; AXIN2
Glioma
PDGFB; PIK3CG; SHC4; PIK3R1; PLCG2; PDGFRB; ARAF; SOS1; PLCG1; TGFA
Prostate cancer
CREB5; PIK3R1; NKX3; PDGFB; CPN1; SRD5A2; Pdgfa&Pdgfb; PIK3CG; FOXO1; INS1
Melanoma
MDM2; NRAS; FGF16; TRP53; PIK3CG; FGF1; PTEN; PIK3R5; FGF21; MAP2K2
Chronic myeloid leukemia
STAT5B; SMAD3; KRAS; PIK3R2; CBL; CCND1; CTBP1; BAD; MAPK1; BCR
Acute myeloid leukemia
PIM2; KIT; STAT5B; RUNX1; RARA; ZBTB16; MTOR; PIM1; PIK3R1; SOS1
Small cell lung cancer
NFKBIA; APAF1; IKBKG; SKP2; CYCS; ITGB1; LAMB2; MAX; CCNE2; COL4A1
Non-small cell lung cancer
BAD; TGFA; CASP9; PIK3CG; FHIT; RXRA; BRAF; TP53; RB1; PIK3CD
Central carbon metabolism in cancer
HRAS; PIK3R2; LDHA; RET; SIRT6; PIK3R3; PIK3R1; FGFR1; IDH1; PFKM
Choline metabolism in cancer
DGKQ; MAPK8; PRKCG; HIF1A; PCYT1A; PDGFRB; AKT2; DGKB; FOS; PLA2G4C

Protein Function

PIK3R2 has several biochemical functions, for example, contributes_to 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R2 itself. We selected most functions PIK3R2 had, and list some proteins which have the same functions with PIK3R2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3R2
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein CCKBR; PIK3R3A; PIK3R3B; PIK3R1; PIK3R6; PIK3R3; PIK3R5; PIK3R2
Function protein binding
Related Protein CLUAP1; ATP6V0A2; CADPS; FAM117B; CD276; GPA33; DIXDC1; POLR3GL; CFL1; ANGPTL4
Function protein heterodimerization activity
Related Protein CLNS1A; SDCBP; TYRP1; HIST1H2A9; TCF12; H2-AB1; HIST1H2AG; SUPT4H1; TFAP2E; RRAGA
Function protein phosphatase binding
Related Protein KAT2A; PPP6R1; FGF19; KCNN4; DRD1A; AP3B1; HSP90B1; NEK2; ITPR1; PPP6R3
Function receptor tyrosine kinase binding
Related Protein NRG3; PITPNM3; ANGPT2A; MYOC; ANGPT2; LRP4; PIK3R2; DOCK4; Flt3l; SHC3

Interacting Protein

PIK3R2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R2.
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