pik3r2
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 2 (beta)
  • Background
  • The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin r
  • Synonyms
  • PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphatidylinositol 3-kinase regulatory subunit beta; p85; P85B; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory sub
Cat.#:PIK3R2-51HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-kinase, Regulatory Subunit 2 (Beta)
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Cat.#:PIK3R2-180BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine PIK3R2 (Beta)
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Cat.#:PIK3R2-1718HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2, His-tagged
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Cat.#:PIK3R2-316HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2 protein, His/MBP-tagged
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Cat.#:PIK3R2-12807MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIK3R2 Protein
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Cat.#:PIK3R2-3435RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R2 Protein, His-tagged
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Cat.#:PIK3R2-12088ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3R2
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Involved Pathway

PIK3R2 involved in several pathways and played different roles in them. We selected most pathways PIK3R2 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
CAMK2D; NCK2; GSK3B; PAK2B; HBEGFA; MAP2K2; PIK3R2; NCK2A; NCK2B; CBLB
Ras signaling pathway
NGFR; MRAS; ABL1; GNB3; PLA2G2E; FGF17; PIK3R1; PGF; BRAP; INSR
Rap signaling pathway
F2RL3; MAP2K3; Itgam&Itgb2; MAPK1; PDGFD; BCAR1; PARD3; FGF13; LPAR4; NGF
cGMP-PKG signaling pathway
PDE3B; IRS1; ATP1B1; NFATC4; PIK3R1; PPP3CB; ATP1A1; CALM2; ROCK1; BDKRB2
cAMP signaling pathway
RELA; GRIA2; CAMK2A; ATP1B3; Adcy4; HTR1E; GRIA4; NPR1; RAP1A; GRIN2B
Chemokine signaling pathway
STAT1; CCL19; CXCL9; CXCR5; CCL16; Ccl21c; GM10591; Ccl12; CCL18; GNGT2
HIF- signaling pathway
NOX3; RBX1; TCEB2; MAPK3; PIK3R1; INSR; ALDOA; CAMK2G; INS2; PDHA2
FoxO signaling pathway
SMAD2; GADD45G; RBL2; CCNB2; INS; PIK3R3B; FOXO3; PRKAG2A; CCND2; HOMER1B
Phosphatidylinositol signaling system
INPP4B; PLCD3A; PIK3R2; CALM2A; PLCG1; IPMKB; MTMR1B; IMPA2; PIKFYVE; DGKAA
Sphingolipid signaling pathway
MAP3K5; AKT2; MAP2K2; PLD2; BDKRB2; PPP2R5C; S1PR5; MAPK11; PTEN; RAC1
Phospholipase D signaling pathway
Kitl; PLA2G4A; SPHK1; GRM6; RRAS2; AGPAT3; IL-8; LPAR6; SYK; GRM1
mTOR signaling pathway
RRN3; CAB39; TSC1; RPS6KB1; RPS6KA3A; INS1; EIF4E1C; RRAGC; RPS6; PDPK1
PIK-Akt signaling pathway
GNG4; ITGB1; NRAS; KITLG; FGFR1; IKBKB; PRKCA; PPP2R5A; ITGB5; NGF
AMPK signaling pathway
G6PC3; CAB39; STRADB; LEP; PFKL; CAMKK1; PFKFB3; PIK3CG; PPP2CA; SCD
Apoptosis
CASP6; DFFA; CLSPN; PIK3R3B; PIK3R3A; TRADD; PIK3R1; STK24; TNF; TNFRSF10D
Adrenergic signaling in cardiomyocytes
TNNC1; ATP1A3; SCN1BB; MYL3; CAMK2B1; CACNA2D1A; SCN5A; ATP1A1A.1; CACNG1A; KCNQ1
VEGF signaling pathway
RAF1; RAC3B; MAPK1; PRKCG; HRASA; AKT1; MAPK12A; MAPKAPK2; PLA2G4AA; BAD
Osteoclast differentiation
RELA; MAPK3; PIK3R5; PPP3CA; LILRB4; MAP3K7; AKT1; FCGR2A; CALCR; PIK3CG
Focal adhesion
HGF; PAK6; MYL12.2; COL2A1B; SEPP1; COL6A1; PIP5K1C; LAMB2; BCL2A; COL2A1A
Signaling pathways regulating pluripotency of stem cells
SMAD5; NRAS; WNT2; WNT8A; ACVR2B; SMAD1; SMAD9; STAT3; ZIC3; PIK3R1
Platelet activation
AKT2; FGB; ITGB3; PIK3R2; PLCB1; P2RY1; MYLK3; PLA2G4C; MAPK3; PPP1CB
Toll-like receptor signaling pathway
AKT2; TLR1; RIPK1; IRAK4; TLR9; MYD88; RELA; PIK3R3; IFNA17; PIK3R5
Jak-STAT signaling pathway
IFNA7; CISH; PIAS1; EP300; IL6R; Ifna15; IL12B; AOX4; CCND1; Il23a
Natural killer cell mediated cytotoxicity
IFNA4; IFNA10; FCGR4; KIR2DL3; KRAS; PIK3CA; PIK3CD; MAPK1; ULBP1; RAET1E
T cell receptor signaling pathway
NFKB1; CBL; PAK3; BCL10; RHOA; GRAPA; CD247; MAP2K1; TNF; PIK3R5
B cell receptor signaling pathway
RASGRP3; NFATC3; CRKL; INPP5D; CD79B; IGHM; NEDD9; DOK1B; Cd79a, Cd79b; PTPN6
Fc epsilon RI signaling pathway
MAP2K1; PLCG2; PIK3CG; PLA2G4B; FYN; MAPK11; MAPK12; AKT1; KRAS; IL5
Fc gamma R-mediated phagocytosis
VASP; PPAP2A; RAC2; PIP5K1A; LIMK2; RPS6KB1; PLA2G4D; PLCG2; WASF1; HCK
TNF signaling pathway
SOCS3; PIK3CG; TNFAIP3; MAPK9; IL18R1; TRADD; ATF4; FOS; VCAM1; FAS
Leukocyte transendothelial migration
RAP1A; CLDN20; PRKCB; ESAM; CXCR4; CD99; ITGA4; MSN; PIK3R5; VCL
Neurotrophin signaling pathway
PRDM4; MAPK8; NGF; MAGED1; MAPK3; MAPK9; GSK3B; SOS1; RAP1B; NFKB1
Cholinergic synapse
GNG12; PIK3CA; CAMK2A; GNG2; AKT1; CHRNA6; CHRM2; SLC5A7; PIK3CD; ITPR3
Inflammatory mediator regulation of TRP channels
PLA2G4D; PPP1CA; CALM3; CYP2C54; PRKCQ; PRKCD; CYP4A14; TRPM8; MAPK8; HTR2B
Regulation of actin cytoskeleton
RRAS; FGF6; PAK6; RRAS2; VCL; ITGAE; Pdgfa&Pdgfb; ACTN4; ACTN3; PIK3R3
Insulin signaling pathway
INS1; MKNK2; INPP5K; PPP1CAA; PKLR; CALM2; PIK3CG; NRAS; ELK1; PRKAB1
Progesterone-mediated oocyte maturation
MAD2L1; CDK1; INS; MAPK3; RAF1B; MAPK8B; RPS6KA3; RPS6KA1; IGF1RB; PIK3CB
Estrogen signaling pathway
GRM1; SRC; PIK3R2; ATF6B; PIK3R5; GNAO1; HSPA2; CREB3L1; HSPA1B; GPR30
Prolactin signaling pathway
TH; MAPK10; SLC2A2; PIK3R1; MAPK9; AKT2; SOCS4; SHC2; ELF5; SHC1
Thyroid hormone signaling pathway
NOTCH4; MED12; ATP1B3; ATP1A3; BAD; ITGAV; NCOA1; PLCZ1; PRKACG; HIF1A
Oxytocin signaling pathway
GNAI3; PIK3CD; PRKCA; CACNA2D1; PPP1CC; ITPR3; MYL6; ROCK2; PRKACA; CACNG4
Regulation of lipolysis in adipocytes
PTGS2; PRKG1; PRKACG; GNAS; AKT2; PRKACB; TSHB; PTGER3; PDE3B; TSHR
Type II diabetes mellitus
MAPK1; HKDC1; SLC2A2; MAPK8; INS2; PIK3R1; IKBKB; MAPK3; PIK3CG; PIK3R2
Insulin resistance
SLC27A1A; RPS6KA6; CREB5; RPS6KA1; G6PC; PPP1R3CA; PRKAA2; PRKCBB; PIK3R3; PIK3CA
Non-alcoholic fatty liver disease (NAFLD)
GSK3A; MAPK9; Casp3; COX6B2; PRKAG1; Fasl; NDUFA13; BID; IL6R; INSR
Aldosterone-regulated sodium reabsorption
PIK3R2; INS1; INSR; SLC9A3R2; ALPHA-ENAC; PDPK1; PIK3CB; SGK1; ATP1A1; SFN
Carbohydrate digestion and absorption
AMY2A3; SLC37A4; PIK3R1; HKDC1; GNAT3; TAS1R2; AMY2A; SI; AMY1A; SLC5A1
Bacterial invasion of epithelial cells
CRK; SHC1; PIK3R1; RAC1; DNM1; MET; DNM3; PTK2; SEPT9; MAD2L2
Chagas disease (American trypanosomiasis)
GNA15; IKBKG; IL6; GNAI3; TLR2; TNFRSF1A; PIK3CB; CFLAR; IFNGR1; PPP2R2D
Toxoplasmosis
LAMA2; MAPK11; TGFB2; TLR2; PIK3CB; XIAP; BCL2L1; CD40LG; SOCS1; TRAF6
Amoebiasis
IL12A; PRKCB; PLCB2; RAB7B; PLCB4; IL10; IL-8; RAB5C; GNAS; SERPINB1A
Hepatitis C
CLDN17; OAS1A; PPP2CB; IFNAR1; TLR3; TNF; PIK3CG; RNASEL; EIF2AK3; IL-8
Hepatitis B
PIK3CD; PRKCA; CYCS; CREB5; NRAS; STAT6; STAT1; ATP6AP1; CASP10; FADD
Measles
TP73; CCND1; IFNGR2; IL12A; RCHY1; IFNGR1; MSN; IFNAR2; TLR4; IFNA21
Influenza A
EIF2AK2; IFNA2; TNFRSF10C; TLR7; IL-8; PYCARD; IFNA13; OAS3; Ifna11; CXCL10
HTLV-I infection
RRAS2; CRTC3; TGFBR2; HLA-DQA1; KAT2A; PIK3R2; WNT8B; CANX; TP53; CCNB2
Epstein-Barr virus infection
HLA-F; PSMD12; STAT3; POLR3E; PTMA; POLR2I; RBPJL; POLR1D; POLR2J3; TBP
Pathways in cancer
FGF6; FGF9; GNAI3; TGFA; RELA; PRKCG; GNB4; FOS; LPAR6; FH
Viral carcinogenesis
HIST1H4A; GTF2H2C_2; HDAC4; STAT3; MRPS18B; RBL1; HIST1H2BO; MDM2; SND1; YWHAB
Proteoglycans in cancer
ERBB3; ANK1; AKT2; EZR; ITGB5; MAPK12; ITGB3; CAMK2D; ITGA2; PIK3R1
MicroRNAs in cancer
ZEB1; ERBB2; HMOX1; TRP63; Pdgfa&Pdgfb; IRS1; TRIM71; GLS; DNMT3B; TGFB2
Colorectal cancer
MAPK3; MAPK10; APPL1; PIK3CD; GSK3B; BRAF; PIK3CB; MSH3; CYCS; BAX
Renal cell carcinoma
ETS1; PIK3CD; RAC1; TGFA; PIK3R3; MAPK3; TGFB2; GAB1; PAK7; PIK3CG
Pancreatic cancer
RAC2; PIK3CD; MAPK9; MAPK8; KRAS; TRP53; PIK3R1; RALGDS; PLD1; PIK3CG
Endometrial cancer
BAD; MAP2K1; LEF1; PIK3R3; PDPK1; APC; AXIN1; AXIN2; TRP53; ILK
Glioma
MDM2; MTOR; SHC1; TP53; PIK3CG; PLCG1; CAMK2D; PRKCB; PIK3R2; PTEN
Prostate cancer
PIK3R3; NFKB1; CREB5; GSTP1; SPINK1; MAPK1; FGFR2; RELA; NKX3; CCNE1
Melanoma
PIK3CA; AKT1; PIK3R3; FGF11; NRAS; MAP2K1; MITF; AKT2; MAP2K2; PDGFRB
Chronic myeloid leukemia
MDM2; NFKBIA; GRB2; PIK3CG; MAP2K2; TP53; BAD; SHC1; PIK3CD; RAF1
Acute myeloid leukemia
MAP2K1; MAPK3; PIK3R3; RELA; LEF1; MAPK1; GRB2; PIM1; AKT1; BRAF
Small cell lung cancer
PIK3CA; IKBKG; RARB; TRAF4; CASP9; LAMA1; BIRC2; AKT1; FHIT; NFKBIA
Non-small cell lung cancer
MAP2K1; PDPK1; MAP2K2; MAPK1; HRAS; ARAF; PIK3CD; RAF1; ERBB2; PIK3R5
Central carbon metabolism in cancer
FLT3; SIRT3; FGFR1; PTEN; LDHA; PKM; MAP2K2; HK3; HKDC1; MET
Choline metabolism in cancer
MAPK8; DGKB; PIK3R2; PRKCB; PDPK1; SOS1; MTOR; PLCG1; PCYT1A; PIK3CD

Protein Function

PIK3R2 has several biochemical functions, for example, contributes_to 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R2 itself. We selected most functions PIK3R2 had, and list some proteins which have the same functions with PIK3R2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3R2
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein PIK3R3; PIK3R3A; PIK3R3B; PIK3R1; PIK3R5; PIK3R2; PIK3R6; CCKBR
Function protein binding
Related Protein SYT11; ADAM10; DARS2; SPRED2; DSCAM; TSC22D1; ISY1; DTNB; CSPG5; CSNK2A2
Function protein heterodimerization activity
Related Protein SCGB2A1; HIST3H3; SMAD2; UGT1A1; TPD52; LTC4S; ITGB1A; NFYBA; VAPA; ABCG8
Function protein phosphatase binding
Related Protein CSF1R; VRK3; TRAF3; DRD1A; CDH5; KAT2A; MVP; ANAPC7; VCAN; DRD1
Function receptor tyrosine kinase binding
Related Protein ANGPT2A; ELMO2; Flt3l; SHC3; PCNA; ANXA5; NRG3; GNB2L1; ZNF259; TRP53

Interacting Protein

PIK3R2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R2.
ERBB3