PIK3R2
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Official Full Name
phosphoinositide-3-kinase, regulatory subunit 2 (beta) -
Overview
The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin r -
Synonyms
PIK3R2;phosphoinositide-3-kinase, regulatory subunit 2 (beta);phosphatidylinositol 3-kinase regulatory subunit beta;p85;P85B;PI3-kinase subunit p85-beta;PI3K regulatory subunit beta;PI3-kinase regulatory subunit beta;ptdIns-3-kinase regulatory sub
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Bovine
- Rhesus macaque
- E.coli
- Mammalian Cells
- Sf9 Cells
- Insect cells
- HEK293
- His
- Non
- GST
- Avi
- Fc
Involved Pathway
PIK3R2 involved in several pathways and played different roles in them. We selected most pathways PIK3R2 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF signaling pathway | TNFAIP3,MAP3K7,ICAM1,FOS,VCAM1,MAPK12,ITCH,MAP3K7IP3,DNM1L,SELE |
| Glioma | MTOR,RAF1,PDGFRB,PTEN,PIK3CD,MDM2,SOS1,PRKCA,TRP53,AKT1 |
| Pathways in cancer | VHL,FGF5,GNG12,AGTR1A,Adcy4,FGF2,PML,FGFR2,VEGFA,BRAF |
| Melanoma | PDGFC,HRAS,FGF9,HGF,FGF21,IGF1,FGF6,AKT2,FGF22,FGF17 |
| Ras signaling pathway | ETS2,EFNA4,GNG13,CALM3,GNB3,SHOC2,GNGT1,PRKACB,PTPN11,PLA2G2F |
| Endometrial cancer | TCF7,CTNNA2,APC2,CCND1,PIK3R3,MLH1,ILK,TRP53,PIK3CD,GRB2 |
| Viral carcinogenesis | REL,CCNE2,NFKBIA,MAPKAPK2,GTF2H2,CREB3L3,RBPJL,HIST2H4,CREB3L1,PIK3CA |
| Amoebiasis | PRKACB,ARG1,SERPINB3,TLR4,IL6,LAMA2,COL3A1,PIK3R5,SERPINB6,TLR2 |
| Leukocyte transendothelial migration | MAPK12,JAM3,MYL2,ITGB2,CLDN20,PXN,CLDN3,ICAM1,CD99,MYL7 |
Protein Function
PIK3R2 has several biochemical functions, for example, contributes_to 1-phosphatidylinositol-3-kinase activity,1-phosphatidylinositol-3-kinase regulator activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R2 itself. We selected most functions PIK3R2 had, and list some proteins which have the same functions with PIK3R2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol-3-kinase regulator activity | PIK3R1,PIK3R5,PIK3R6,PIK3R3A,CCKBR,PIK3R3B,PIK3R3 |
| protein heterodimerization activity | HIST1H4L,BOKA,KCNK3,Defa-rs7,PPP3CB,SOX6,HOMER2,HIST2H2L,BIK,GABRR1 |
| protein binding | MUC5B,ALX1,RNF14,TIMP3,ABT1,NAT8B,TRPC5,CD99L2,CCER1,KCNE3 |
| protein phosphatase binding | TRP53,HSP90B1,HSF4,ROS1,MAP3K5,VCP,CTNNB1,PPP6R3,EGFR,PPARG |
| receptor tyrosine kinase binding | SHC4,PCNA,FIZ1,ANGPT2A,GAS6,NRG1,SHC3,ZFP259,PITPNM3,Flt3l |
Interacting Protein
PIK3R2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R2.
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