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Official Full Name phosphoinositide-3-kinase, regulatory subunit 2 (beta)
Background The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin r
Synonyms PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphatidylinositol 3-kinase regulatory subunit beta; p85; P85B; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory sub
    • Species :
    • Bovine
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • His
    • MBP
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PIK3R2-1718H Recombinant Human PIK3R2, His-tagged E.coli His
    Human PIK3R2-316H Recombinant Human PIK3R2 protein, His/MBP-tagged E.coli His/MBP
    Human PIK3R2-51H Recombinant Human Phosphoinositide-3-kinase, Regulatory Subunit 2 (Beta) Sf9 Insect Cell N/A
    Mouse PIK3R2-12807M Recombinant Mouse PIK3R2 Protein Mammalian Cell His
    Rhesus Macaque PIK3R2-3435R Recombinant Rhesus monkey PIK3R2 Protein, His-tagged Mammalian Cell His
    Bovine PIK3R2-180B Recombinant Bovine PIK3R2 (Beta) Sf9 Insect Cell N/A
    Zebrafish PIK3R2-12088Z Recombinant Zebrafish PIK3R2 Mammalian Cell His

    PIK3R2 involved in several pathways and played different roles in them. We selected most pathways PIK3R2 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway CAMK2D2; MAPK1; CDKN1BA; CAMK2A; PIK3R3; SHC1; SHC3; AKT2L; ERBB3A; SRC
    Ras signaling pathway PAK3; MAPK8; HGF; HRAS; PIK3CG; PAK1; RRAS2; FLT1; PLA2G4C; FGF16
    Rap signaling pathway FGF20; GNAO1; PDGFC; CALM1; SIPA1L2; VEGFC; THBS1; FGF17; RAC1; FGF16
    cGMP-PKG signaling pathway PLCB1; BDKRB2; GNAQ; PIK3R2; KCNMB4; PPP3CA; AKT2; KCNJ8; RHOA; VDAC1
    cAMP signaling pathway ATP1B4; PDE4A; ATP1B1; CALM4; ATP2B4; PLD2; CREB3L1; NFKBIA; GRIN2C; PIK3CA
    Chemokine signaling pathway ARRB2; JAK2; FGR; CCL13; AKT2; CCR7; CCL2; CXCL8; GNG2; CXCL13
    HIF- signaling pathway TFRC; IGF1; INS1; MAPK1; HIF1A; INS; TLR4; NOX3; Trf; NFKB1
    FoxO signaling pathway PIK3R5; MAPK14A; SKP2; PIK3CA; KLF2A; FOXO1; G6PC; PIK3R3B; INS1; CCNB1
    Phosphatidylinositol signaling system PIP5K1AB; MTMR7A; CDS1; PI4K2A; CDS2; DGKD; PIP4K2AA; MTMR1; PLCD1B; PIK3C2G
    Sphingolipid signaling pathway RELA; NOS3; SMPD1; PLCB2; MAPK9; MS4A2; PPP2R3A; PTEN; PPP2R5D; SGMS2
    Phospholipase D signaling pathway PLD1; PPAP2A; PIK3R5; PLA2G4A; FYN; TSC1; CXCR1; NRAS; AGPAT4; LPAR5
    mTOR signaling pathway STK11; AKT1S1; TSC1B; PIK3R5; RPS6; PIK3CB; RICTOR; VEGFA; EIF4E1C; PRKCB
    PIK-Akt signaling pathway RXRA; BRCA1; IGF1; SPP1; ITGA7; IL2RG; PDGFRA; INS; SYK; FGF21
    AMPK signaling pathway CREB1; RPTOR; IGF1; CREB3L1; TSC1; ADIPOR2; RAB14; FBP1; TBC1D1; PFKFB2
    Adrenergic signaling in cardiomyocytes ATP1B3; ADRB2; GNA11A; ACTC1; CREM; GNAI2B; SCN1B; ATP1A2; PIK3CD; KCNQ1
    VEGF signaling pathway VEGFAA; PLA2G4AA; PTK2; PRKCBA; MAPK3; PLCG1; MAPK14A; RAC1A; MAP2K2; AKT3A
    Osteoclast differentiation TYROBP; MAP2K7; PIK3CD; CALCR; LCP2; PIK3R3; MAPK12; FCGR4; TNFRSF1A; LILRB1
    Focal adhesion PPP1R12A; COL27A1B; SRC; FYN; LAMB2; LAMA4; AASS; BAD; ACTB1; PTK2AA
    Signaling pathways regulating pluripotency of stem cells GSK3B; FZD3; MAP2K2; HNF1A; WNT5B; WNT10B; PCGF5; WNT2; APC; BMPR2
    Platelet activation VAMP8; RAP1B; P2RX1; VWF; PRKACB; PLA2G4C; FGA; FCER1G; PLA2G4F; ACTG1
    Toll-like receptor signaling pathway LBP; STAT1; MAP3K7; NFKB1; CCL5; MAPK8B; IFNAR1; IFNA5; PIK3CA; IFNB1
    Jak-STAT signaling pathway IFNG; IL3; BCL2A; IFNA3; IL12RB2; CRFB16; IFNL3; GRB2; IL7; AOX3
    Natural killer cell mediated cytotoxicity Ifna11; BID; IFNA1; KIR2DS3; NCR2; IFNAR2; SHC2; HLA-C; IFNGR2; ITGB2
    T cell receptor signaling pathway PIK3CD; ZAP70; MAPK3; PPP3CB; VAV2; GRAPA; PTPRC; ICOS; CD3G; CD3E
    B cell receptor signaling pathway PDK2; ITK; NFKBIE; BLK; DAPP1; MAP2K1; NFKB1; MAPK1; FOS; GSK3B
    Fc epsilon RI signaling pathway LCP2; HRAS; GM-CSF; FYN; FCER1A; AKT2; KRAS; MAPK1; PRKCA; NRAS
    Fc gamma R-mediated phagocytosis PIK3R5; AMPH; FCGR1A; LYN; cgr2b; PTPRC; WASF3; LIMK2; PPAP2B; BIN1
    TNF signaling pathway CCL2; CXCL2; TRAF2; IL18R1; Casp3; MAP2K7; CREB3L2; MAPK1; MAPK8; IL6
    Leukocyte transendothelial migration MAPK11; CLDN1; VASP; CLDN2; CLDN18; ACTN4; MMP2; CLDN4; MYL5; CLDN22
    Neurotrophin signaling pathway MAGED1; SH2B1; SOS1; MAPK7; SH2B2; MAPK9; MAP2K5; ZFP110; PSEN1; RPS6KA2
    Cholinergic synapse GNG4; PIK3CG; KCNQ5; PIK3R5; PIK3R3; ATF4; AKT2; CHRNB2; CHRNA3; PIK3CB
    Inflammatory mediator regulation of TRP channels TRPM8; CAMK2A; IL1R1; P2RY2; PRKCE; SRC; PLA2G4C; PIK3CD; NGF; PLCB3
    Regulation of actin cytoskeleton PIK3R2; ABI2B; ITGB7; ITGAE; ITGB1B.2; PDGFRB; MYLK3; RDX; FGF18; MYH9
    Insulin signaling pathway INPPL1; TSC1; INSRA; PRKAR2AB; CALM2B; FOXO1A; PRKAB1; PRKAB1B; RAF1B; PPP1R3CB
    Progesterone-mediated oocyte maturation PIK3R3; CPEB1B; PRKACB; RAF1A; RPS6KA3; MAPK14A; CDC25C; PGR; PDE3B; PRKACA
    Estrogen signaling pathway AKT1; CALML5; GRM1; GNAO1; FKBP4; SHC4; CREB3L3; SHC1; HRAS; GNAI1
    Prolactin signaling pathway TH; TNFRSF11A; PPIB; SOCS7; MAPK1; SOCS1; MAPK8; SHC3; MAPK10; FOS
    Thyroid hormone signaling pathway ATP1A1; SLC9A1; MED14; SIN3A; KAT2B; ATP1B4; STAT1; AKT2; PLCG1; MED12L
    Oxytocin signaling pathway MAPK3; RYR3; PIK3CD; ITPR3; MAP2K2; PLA2G4F; NPR2; PIK3CG; CALM2; CACNB2
    Regulation of lipolysis in adipocytes IRS4; AQP7; FABP4; PRKACG; PIK3CG; PTGS2; PRKACA; AKT1; PTGS1; ABHD5
    Type II diabetes mellitus MTOR; PKLR; ADIPOQ; IRS1; PIK3CB; PIK3R2; PIK3CD; INSR; PKM2; IRS2
    Insulin resistance SLC27A5; TBC1D4; RELA; PRKAB1; SLC2A4; PRKCB; PRKAG3; PPARAB; PPARA; PTEN
    Non-alcoholic fatty liver disease (NAFLD) PIK3R3; PIK3CA; INS1; PPARA; UQCRFS1; MAP3K11; NDUFB4; TNFRSF1A; SDHC; TRAF2
    Aldosterone-regulated sodium reabsorption INS2; ATP1B3; SCNN1G; PIK3CD; FXYD2; IGF1; SFN; SLC9A3R2; ATP1B4; PRKCG
    Carbohydrate digestion and absorption PIK3R2; TAS1R3; HKDC1; PIK3R5; AMY2A3; AMY1B; ATP1B1; HK1; AMY2A2; AMY2B
    Bacterial invasion of epithelial cells CRKL; ARPC2; DNM3; DNM2; CLTA; ACTG1; HCLS1; ARPC1A; ARPC1B; WASF1
    Chagas disease (American trypanosomiasis) TNF; IFNB1; CCL3L1; CD3E; CD3D; IFNGR1; PIK3CG; PPP2CA; MAPK10; Fasl; PLCB3
    Toxoplasmosis HSPA1B; TGFB3; BIRC8; LAMA3; RELA; Casp3; BIRC3; MAPK11; MAPK3; ALOX5
    Amoebiasis CD1D; FN1; HSPB1; VCL; TGFB2; IL12B; ACTN3; COL1A1; NOS2; COL5A2
    Hepatitis B STAT5A; HRAS; Ifna11; TGFBR1; PIK3CD; NFATC4; IL6; MAVS; SRC; IFNA21
    Influenza A MAPK12; IL12B; H2-AA; IFNG; HLA-DMB; NUP98; ADAR; PRSS1; PIK3R5; SLC25A6
    Epstein-Barr virus infection PIK3CA; POLR2C; GTF2E1; STAT3; TBPL2; HSPA1L; PSMC4; PRKACA; TBP; PIK3CG
    Pathways in cancer RET; PPARD; BIRC5; FZD1; FGF4; GNB3; ARHGEF1; FZD9; MSH2; IGF1R
    Viral carcinogenesis HDAC11; HIST1H2BM; TRAF2; IL6ST; HIST1H2BJ; CREB5; HIST1H2BI; GTF2H1; TRAF1; CCND2
    Proteoglycans in cancer SDC2; WNT3A; FZD7; TGFB2; FZD1; NANOG; ITGB5; DROSHA; WNT10B; FGFR1
    MicroRNAs in cancer TRIM71; NRAS; BMI1; MET; PIK3R2; HDAC1; PLCG1; MARCKS; GRB2; SHC4
    Colorectal cancer TGFB3; AXIN2; MAPK10; DCC; MAPK9; PIK3R3; LEF1; BRAF; PIK3CD; RHOA
    Renal cell carcinoma ARAF; NRAS; MAP2K2; FH1; MAPK1; ETS1; RAP1A; KRAS; PIK3R1; PIK3R2
    Pancreatic cancer IKBKB; RAC1; SMAD4; CASP9; MAP2K1; KRAS; BAD; RALGDS; PIK3R3; NFKB1
    Endometrial cancer CCND1; ELK1; HRAS; AXIN1; KRAS; PTEN; PIK3R5; BRAF; AKT1; CTNNA2
    Glioma MAP2K2; TP53; AKT1; PLCG2; PRKCB; CALM3; MAP2K1; Pdgfa&Pdgfb; PLCG1; PIK3R1
    Prostate cancer PDGFRB; TP53; PDGFA; IKBKB; GSK3B; RB1; PDGFD; NFKBIA; Ar; SMARCD1
    Melanoma PIK3CA; MAP2K1; FGF17; FGF3; FGF20; FGF1; FGFR1; PDGFC; HRAS; FGF14
    Chronic myeloid leukemia HDAC2; IKBKB; PIK3R3; RUNX1; MAP2K1; HRAS; SHC3; RB1; MECOM; KRAS
    Acute myeloid leukemia MAPK1; MYC; EIF4EBP1; AKT2; RARA; PIK3R5; RUNX1T1; STAT5A; IKBKG; MAP2K2
    Small cell lung cancer IKBKB; LAMA1; TRAF6; PTGS2; COL4A1; CASP9; PIK3CA; ITGA3; TRAF3; PIK3R5
    Non-small cell lung cancer RXRG; HRAS; ARAF; PIK3R3; TP53; PIK3R2; RASSF1; BRAF; MAP2K2; FOXO3
    Central carbon metabolism in cancer PIK3CB; HRAS; PKM2; PIK3R3; HIF1A; MAPK3; RAF1; TRP53; NTRK3; SLC2A2
    Choline metabolism in cancer PLCG1; HRAS; CHKA; RAC2; WASL; MAPK9; PIK3R3; PDPK1; SLC22A3; MAP2K2

    PIK3R2 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R2 itself. We selected most functions PIK3R2 had, and list some proteins which have the same functions with PIK3R2. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to 1-phosphatidylinositol-3-kinase activity PIK3R2
    1-phosphatidylinositol-3-kinase regulator activity PIK3R3; PIK3R5; PIK3R3B; PIK3R1; PIK3R3A; PIK3R2; PIK3R6; CCKBR
    protein binding DUSP1; NKX3-1; KRT2; RPGRIP1L; CSRP2; C12orf68; PLEKHB2; FH; ASAP3; TEX14
    protein heterodimerization activity POLA1; TRP53; Fzd4; SPNA1; RXRA; SRY; DRD1A; IKZF4; HIST1H2BE; DRD2
    protein phosphatase binding SKAP1; FGF19; TP53; CTNNB1; ROS1; CDKN1B; Itga10&Itgb1; PARD3; DRD1; PPP1R3G
    receptor tyrosine kinase binding PIK3R2; PTPN11; SHC3; NRG1; ELMO2; PITPNM3; NRG3; TOB1; GAS6; PTPN2

    PIK3R2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R2.


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