pik3r2
Share
  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 2 (beta)
  • Background
  • The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin r
  • Synonyms
  • PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphatidylinositol 3-kinase regulatory subunit beta; p85; P85B; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory sub
Cat.#:PIK3R2-51HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-kinase, Regulatory Subunit 2 (Beta)
+Inquiry
Cat.#:PIK3R2-180BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine PIK3R2 (Beta)
+Inquiry
Cat.#:PIK3R2-1718HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2, His-tagged
+Inquiry
Cat.#:PIK3R2-316HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2 protein, His/MBP-tagged
+Inquiry
Cat.#:PIK3R2-12807MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIK3R2 Protein
+Inquiry
Cat.#:PIK3R2-3435RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R2 Protein, His-tagged
+Inquiry
Cat.#:PIK3R2-12088ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3R2
+Inquiry

Involved Pathway

PIK3R2 involved in several pathways and played different roles in them. We selected most pathways PIK3R2 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
CAMK2D2; RAF1A; PLCG1; PAK7; PAK1; PIK3R3; EGFRA; PRKCBB; NCK2; MAPK8A
Ras signaling pathway
PLCG2; RRAS; MRAS; MAPK1; GNG13; ABL1; CALM3; GNGT2; BAD; VEGFC
Rap signaling pathway
PRKD1; SIPA1L2; NGFR; RAC2; FGF11; F2RL3; FARP2; MAPK13; CALML3; CALM4
cGMP-PKG signaling pathway
MYH7; SLC25A31; OPRD1; MAP2K2; ATP2B4; MEF2D; PDE2A; PIK3CB; BNP; NPR1
cAMP signaling pathway
GIPR; NPR1; BDNF; NPY; Adcy4; ATP2A2; GRIN2D; GPR81; RAC3; GRIN3A
Chemokine signaling pathway
CCL5; CXCL8; MAPK3; PARD3; CCL8; CCL28; SHC2; NFKBIA; FOXO3; GNG12
HIF- signaling pathway
EPO; IFNGR1; TEK; ENO1; NOX1; Trf; NFKB1; TF; CAMK2A; SERPINE1
FoxO signaling pathway
PLK2B; MAPK12; SOS1; CCND2; HRAS; CCND1; MAPK13; PRKAG2; PRKAB2; RAG1
Phosphatidylinositol signaling system
PRKCG; CALM4; CALM3B; MTMR8; PLCD3; CDS1; PI4K2B; IMPAD1; IMPA1; PLCE1
Sphingolipid signaling pathway
PPP2R5A; PPP2CA; TRADD; PPP2R3A; PPP2CB; AKT1; SGMS1; PPP2R1B; GNA12; ABCC1
Phospholipase D signaling pathway
LPAR3; LPAR5; ARF6; LPAR4; PIP5K1C; RHEB; PIP5K1A; AVP; Adcy4; GRM3
mTOR signaling pathway
INS1; RPS6KB1B; PDPK1; AKT1S1; ULK3; RPS6KA3B; PRKAA1; PRKCBA; MTOR; HIF1A
PIK-Akt signaling pathway
TCL1B; CCNE2; CCNE1; FGF4; PDGFD; ITGA9; ITGB7; IFNA4; EPO; ITGA2B
AMPK signaling pathway
FASN; PFKFB2; G6PC; FBP1; GYS2; PPP2CB; AKT1; RHEB; PDPK1; HNF4A
Apoptosis
PTBP3; IRF2; TNFRSF10C; PLECA; IRAK2; BNIP3L; BIRC5A; PRKAR1B; FADD; IRAK4
Adrenergic signaling in cardiomyocytes
MAPK1; PPP2R3C; MYL2; CAMK2G; CACNA1C; PRKACAB; ATP1A3; KCNE1; AKT2; CACNG7A
VEGF signaling pathway
RAC3A; AKT3A; PPP3R2; PLCG2; RAF1; AKT2L; CDC42; MAPK14A; PLA2G4A; AKT1
Osteoclast differentiation
NFATC2; PPARG; NFKB1; TRAF6; SOCS3; TGFBR2; CSF1R; IFNGR2; MAP2K1; LCK
Focal adhesion
CHAD; VAV1; GRB2A; RAP1B; COL6A4; BADB; THBS4; TESK2; STYK1; PRKCG
Signaling pathways regulating pluripotency of stem cells
APC; HESX1; PCGF2; PIK3CD; MAPK3; NRAS; IGF1R; WNT9A; ACVR1; ZFHX3
Platelet activation
FCER1G; PIK3R1; P2RY1; MAPK11; PLCB1; MYLK3; MYL12B; AKT2; MYL12A; PIK3CD
Toll-like receptor signaling pathway
AKT1; CCL3L1; PIK3CD; LBP; IL8L1; TLR4BA; CD40; CRFB2; AKT3A; IFNA5
Jak-STAT signaling pathway
IFNE; SOCS6; RNF207B; IFNA10; MCL1; PTPN11A; LIFR; TYK2; AOX4; IFNA21
Natural killer cell mediated cytotoxicity
PIK3R1; PTPN6; PIK3CG; GRB2; PRKCA; KIR2DS4; SH2D1A; SHC2; SH2D1B; ULBP1
T cell receptor signaling pathway
LAT; Il2; DEF6A; DLG1; GRB2; NFKB1; CABIN1; MAPK11; PIK3R1; PIK3R3
B cell receptor signaling pathway
ARPC2; NFATC2; DOK3; BLNK; NFKBIB; BCL10; PIK3R2; KRAS; STAP1; CRK
Fc epsilon RI signaling pathway
VAV3; LYN; MAP2K1; TNF; INPP5D; MAPK3; PIK3CD; FCER1A; VAV1; SOS1
Fc gamma R-mediated phagocytosis
ASAP1; FCGR1A; WASF3; LIMK1; PRKCD; DOCK2; PRKCA; WASF2; CFL2; SPHK1
TNF signaling pathway
MMP9; CXCL2; FAS; MAPK13; CCL5; BIRC3; TRADD; CASP10; MAP3K7; CCL20
Leukocyte transendothelial migration
NIPAL1; ACTN1; CLDN11; CLDN15; THY1; CXCL12; MYL10; PIK3CA; PECAM1; RHOH
Neurotrophin signaling pathway
PIK3CA; SHC4; RPS6KA2; NGFR; RHOA; CALM3; NTF4; PLCG1; NTRK2; MAPK1
Cholinergic synapse
GNGT2; GNA11; SLC5A7; GNAI1; BCL2; PIK3R1; GNAI2; CAMK2B; AKR1C1; GNG4
Inflammatory mediator regulation of TRP channels
CYP4A12A; CAMK2G; CALM2; TRPV1; PIK3CG; HTR2A; PRKCE; ALOX12E; ACCN5; CAMK2A
Regulation of actin cytoskeleton
FGF12; PFN4; CFL2; LIMK1; PIP5K2; LIMK1A; FGF11; ITGA9; CHRM5B; EZR
Insulin signaling pathway
CALM2A; RHEB; MAP2K2B; PIK3R3A; AKT1; PHKG1; CALM3B; HK2; CBLB; RAPGEF1B
Progesterone-mediated oocyte maturation
Adcy4; RPS6KAL; RAF1B; PRKACBA; MAPK14A; MAPK9; SPDYB; CDC25C; MAPK8; PIK3CG
Estrogen signaling pathway
FKBP4; PIK3CG; KCNJ9; AKT2; SRC; PLCB3; PIK3R1; HSPA1L; MAP2K1; PLCB4
Prolactin signaling pathway
GRB2; IRF1; MAPK9; INS1; AKT2; NEK3; GSK3B; PIK3CB; RELA; MAPK1
Thyroid hormone signaling pathway
HDAC1; PLCB2; ATP1B2; MDM2; WNT4; BMP4; PLCD1; AKT1; MAP2K1; RXRG
Oxytocin signaling pathway
CACNB2; PPP1R12B; RAF1; PRKAB1; FOS; PIK3CG; PPP1CC; PRKAB2; CACNB4; GNAO1
Regulation of lipolysis in adipocytes
AKT2; TSHR; PRKACG; LOC100328615; INSR; GNAI1; PIK3R5; PTGS1; INS1; PDE3B
Type II diabetes mellitus
INS1; PKM2; HKDC1; SOCS1; HK3; MAPK10; PIK3R2; MTOR; PIK3R1; PIK3CG
Insulin resistance
PRKCBA; FOXO1A; PRKAG2; SREBF1; NFKBIA; RPS6KA6; PRKAB1B; PRKAA2; PRKAB1A; ACACB
Non-alcoholic fatty liver disease (NAFLD)
PIK3R2; COX7A1; RAC1; NDUFA6; NDUFB1; COX4I2; UQCRC1; IRS2; CASP8; NDUFC1
Aldosterone-regulated sodium reabsorption
INS1; HSD11B2; NEDD4L; SGK1; PIK3R5; ATP1B1; PDPK1; PIK3CB; MAPK3; ATP1B4
Carbohydrate digestion and absorption
SLC2A5; PLCB2; AMY2A2; ATP1B3; G6PC3; HK2; PIK3R5; ATP1B2; Amy1; PIK3CG
Bacterial invasion of epithelial cells
CTNNA2; DNM1; WAS; MAD2L2; PIK3CB; SEPT12; PIK3CD; SHC3; CAV2; MET
Chagas disease (American trypanosomiasis)
CFLAR; PIK3CA; GNAL; SERPINE1; TRAF6; MAPK9; PPP2R1A; MAPK8; GNAS; PPP2R2A
Toxoplasmosis
ALOX5; LY96; PPIF; BAD; PIK3R2; LDLR; BIRC8; IL12A; LAMC1; IL12B
Amoebiasis
COL5A2; LAMB4; LAMB2; LAMC1; IL12B; ARG2; COL3A1; LAMB1; GNAL; CD1d1
Hepatitis C
IFNB1; IFNA21; MAPK9; TYK2; IFNA13; PIK3CG; EIF2AK1; PIK3CD; CLDN15; ARAF
Hepatitis B
BCL2; YWHAB; DDX58; FOS; TICAM2; IFN-a; AKT1; CASP9; MAVS; CCNE2
Measles
STAT2; STAT3; IFNB1; EIF2AK2; IL2RA; IFNA5; CCNE1; MSN; IL12B; PIK3CB
Influenza A
HLA-DPB1; IFNA3; HLA-DQB1; TNFRSF10B; SLC25A6; AKT2; IL8L1; RAE1; TLR7; PRSS3
HTLV-I infection
HLA-F; WNT4; HLA-E; CD3E; CD3D; FZD8; KAT2A; FZD1; MAP3K14; WNT9B; POLB
Epstein-Barr virus infection
SND1; PSMC1; PIK3CA; HLA-G; HLA-DQA2; MDM2; MAP2K4; IL10RB; PSMD12; HDAC1
Pathways in cancer
TP53; BDKRB1; GNB4; SFPI1; PIK3R2; WNT10B; PPARD; MAX; PDGFB; GNB1
Viral carcinogenesis
ATF4; PIK3CG; CDK1; HIST1H2BL; HIST2H2BE; HDAC1; YWHAH; TP53; GTF2A1L; TBPL2
Proteoglycans in cancer
FAS; KRAS; WNT6; PRKACG; HRAS; ESR1; TRP53; PPP1CA; MAP2K1; WNT4
MicroRNAs in cancer
TNR; TP63; CCND2; KRAS; TRP53; NOTCH3; BAK1; GLS; RHOA; CCNG1
Colorectal cancer
AKT1; CCND1; PIK3CB; BIRC5; AXIN1; BCL2; BAX; PIK3CG; APC2; PIK3CA
Renal cell carcinoma
MAPK1; AKT2; PIK3CA; PAK1; PTPN11; MAP2K1; PIK3R1; PIK3R5; HGF; FH1
Pancreatic cancer
BRCA2; SMAD2; CASP9; BAD; TGFA; SMAD4; PIK3CG; MAPK1; CDC42; ERBB2
Endometrial cancer
APC; PIK3R1; AKT1; PIK3R5; APC2; TCF7; LEF1; TRP53; PTEN; FOXO3
Glioma
TRP53; TGFA; RAF1; PIK3CA; SHC1; IGF1R; MAPK3; PIK3CG; CAMK2A; MAP2K1
Prostate cancer
SMARCA4; EP300; LEF1; NDRG1; MAPK1; AKT1; BRAF; CREB5; BAD; NKX3
Melanoma
Pdgfa&Pdgfb; TRP53; FGF5; FGF3; PDGFC; MAPK3; MAP2K2; MET; FGF21; FGF7
Chronic myeloid leukemia
CBL; TGFBR1; TGFBR2; CRKL; PIK3CD; ABL1; SHC2; CBLC; HDAC2; RUNX1
Acute myeloid leukemia
MAP2K2; CHUK; KRAS; MAPK3; JUP; AKT3; PIK3R3; SPI1; RUNX1T1; EIF4EBP1
Small cell lung cancer
RARB; FHIT; BCL2L1; PTEN; RELA; LAMA1; TRAF1; IKBKG; AKT1; PIK3CG
Non-small cell lung cancer
RXRB; RARB; MAPK3; ERBB2; NRAS; RASSF5; PIK3CA; PIK3CD; FHIT; BRAF
Central carbon metabolism in cancer
PDK1; PIK3R2; G6PDX; PDHA1; MAPK1; GLS; PIK3CD; PGAM2; HKDC1; AKT2
Choline metabolism in cancer
RHEB; DGKD; FOS; DGKB; PLCG1; SP1; PDGFD; PIK3CA; Pdgfa&Pdgfb; PDPK1

Protein Function

PIK3R2 has several biochemical functions, for example, contributes_to 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R2 itself. We selected most functions PIK3R2 had, and list some proteins which have the same functions with PIK3R2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3R2
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein PIK3R3B; PIK3R3A; PIK3R2; PIK3R5; PIK3R6; PIK3R1; CCKBR; PIK3R3
Function protein binding
Related Protein TMEM64; JMY; ZNF670; NAP1L4; VPS4A; MEI4; MSH4; NHP2L1; SCRIB; JPH2
Function protein heterodimerization activity
Related Protein NFYB; HIF1A; APITD1; SOX15; BMP2B; HAND1; CABYR; INHA; HEXA; RELA
Function protein phosphatase binding
Related Protein MAP2K7; RPA2; ITGA1; IRS2; DRD1A; AP3B1; PIK3R2; VCAN; CDKN1B; PPP6R1
Function receptor tyrosine kinase binding
Related Protein ANXA5; PCNA; NRG1; HYAL2; ANGPT2; TP53; CPNE3; NRG3; DOCK4; FIZ1

Interacting Protein

PIK3R2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R2.
ERBB3