pik3r2
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 2 (beta)
  • Background
  • The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin r
  • Synonyms
  • PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphatidylinositol 3-kinase regulatory subunit beta; p85; P85B; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory sub
Cat.#:PIK3R2-51HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-kinase, Regulatory Subunit 2 (Beta)
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Cat.#:PIK3R2-180BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine PIK3R2 (Beta)
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Cat.#:PIK3R2-1718HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2, His-tagged
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Cat.#:PIK3R2-316HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2 protein, His/MBP-tagged
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Cat.#:PIK3R2-12807MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIK3R2 Protein
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Cat.#:PIK3R2-3435RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R2 Protein, His-tagged
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Cat.#:PIK3R2-12088ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3R2
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Involved Pathway

PIK3R2 involved in several pathways and played different roles in them. We selected most pathways PIK3R2 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PAK3; PRKCBB; ABL2; CDKN1BB; KRAS; BRAF; GRB2A; NCK1; MAPK8A; ERBB3A
Ras signaling pathway
PLA2G5; PLA2G10; SHOC2; PRKCB; CALM4; RAP1B; ABL1; RASGRF2; FGF13; CALML5
Rap signaling pathway
MET; FGF8; SKAP1; FGF7; PRKCZ; FGF11; ITGB2L; PRKD1; PLCE1; FGF12
cGMP-PKG signaling pathway
PPP3R1; MAPK1; VDAC2; CALM2; ATP1B1; ATF4; PPP1CB; ATP1B4; CREB3L2; PLCB1
cAMP signaling pathway
GPR81; CALML3; TSHR; PIK3R5; GHRL; MAP2K2; PPP1CC; PRKACA; PDE4D; PIK3CB
Chemokine signaling pathway
PIK3R5; CXCL9; CCL20; WASL; PIK3R3; Ccl27a; CXCL14; CXCL10; CCR7; PLCB2
HIF- signaling pathway
HK3; IL6; PIK3R5; VEGFA; FLT1; PIK3CG; RPS6KB1; CUL2; IFNG; TF
FoxO signaling pathway
MAPK14A; GRB2B; MAPK8A; RAG2; SKP2; TGFBR1A; SOS1; RAG1; NLK; SMAD4
Phosphatidylinositol signaling system
CALM; INPP5L; PI4K2A; INPP1; PLCG1; PPIP5K2; CALM4; ITPK1A; TMEM55B; ITPKC
Sphingolipid signaling pathway
PLCB2; SMPD1; PPP2R1A; TNFRSF1A; NSMAF; MAPK8; MS4A2; FCER1G; ASAH1; MAP3K5
Phospholipase D signaling pathway
AGPAT3; MRAS; AVPR1B; CXCR2; PIK3R5; GRM1; TSC1; MAP2K1; RALGDS; Pdgfa&Pdgfb
mTOR signaling pathway
AKT1; IRS1; ULK3; EIF4E2; RRN3; PTENB; EIF4EA; AKT2; INS; MAPK3
PIK-Akt signaling pathway
PDGFA; GNG12; F2R; AKT1; PIK3R3; ITGA9; IGF1R; NRAS; CRTC2; PIK3CG
AMPK signaling pathway
CREB1; CPT1C; HNF4A; PPP2R2C; PPP2R1A; SCD; CPT1A; SREBF1; MTOR; PRKAB1
Apoptosis
BNIP3LB; PPP3CB; TNF; PLECA; CTNNB1; PRKAR1A; CSF2RB; CASP9; DBNLB; PRKACA
Adrenergic signaling in cardiomyocytes
ATP2B3B; CACNG4; MYL4; RAPGEF4; TNNT2; PIK3R5; CACNG2A; PPP2R5D; CREB3L3; AKT1
VEGF signaling pathway
MAP2K2B; PLA2G4D; PTGS2A; HSPB1; MAPKAPK2; PTGS2; MAPK1; HRAS; MAPK14A; PIK3CD
Osteoclast differentiation
TNFRSF11B; SIRPB1; GAB2; MAPK11; LILRB1; NFATC2; FCGR3; TNFRSF11A; FCGR1; ITGB3
Focal adhesion
PDGFAA; RHOB; PDGFA; SOS1; CCND2A; BADB; ITGB5; RAP1B; IGF1; PDGFRA
Signaling pathways regulating pluripotency of stem cells
ZFHX3; AXIN2; FZD3; FGFR3; WNT1; LHX5; PIK3R5; WNT8B; BMP2; FZD2
Platelet activation
MAPK13; F2RL3; ROCK1; MYLK3; GP1BB; PRKCZ; VASP; AKT1; P2RY1; BTK
Toll-like receptor signaling pathway
TLR2; TBK1; IL12BA; IL12B; MAP2K2A; IFNA12; IL12A; CD86; IRAK4; IFNPHI1
Jak-STAT signaling pathway
RAF1A; IFNA10; EPO; GRB2A; CSH1; OSM; IFNGR1; HRASB; Il23a; CRFB16
Natural killer cell mediated cytotoxicity
LAT; PIK3CA; KIR2DS5; SAMD3; PTK2B; NCR2; KIR2DS4; KIR3DL2; PPP3CC; FASLG
T cell receptor signaling pathway
MAPK12; MAP2K2; MUC1; CD3G; CD3E; CD3D; PAK3; VAV2; PTPRC; CD8B1; PDCD1
B cell receptor signaling pathway
LCP2A; MAPK1; ARPC5; NFKBIA; PILRB; IKBKG; PRKCB; INPP5D; RAC2; TTC6
Fc epsilon RI signaling pathway
PIK3CG; RAC2; GRB2; PIK3CA; FCER1A; MAPK9; PLA2G4D; VAV1; SYK; PIK3R2
Fc gamma R-mediated phagocytosis
GAB2; ASAP2; FCGR2A; CFL2; RAF1; INPPL1; WAS; SCIN; PLA2G4F; PLD1
TNF signaling pathway
PIK3R1; MAP2K3; MAPK13; VCAM1; LIF; PIK3CG; MAGI2; IL1B; IL6; TAB2
Leukocyte transendothelial migration
PIK3CD; JAM3; RAC2; CLDN20; NOX1; CD99; CDH5; VAV2; CLDN10; ACTN1
Neurotrophin signaling pathway
RPS6KA3; Fasl; YWHAE; AKT2; NTRK2; AKT1; PRDM4; PIK3R5; IRAK1; SHC2
Cholinergic synapse
GNG12; JAK2; CHRM2; CAMK2D; GNB3; FYN; GNB4; CHRNA7; KCNJ12; CHRNA3
Inflammatory mediator regulation of TRP channels
PRKCE; CYP2C50; CALM1; TRPV4; CYP2C37; PIK3R1; BDKRB2; PLA2G4F; PLA2G4C; SRC
Regulation of actin cytoskeleton
GNA12; PDGFRB; ROCK2; PAK6B; ARPC5L; ARAF; RRAS; FGF8; ARHGEF4; GIT1
Insulin signaling pathway
CALM2; PIK3R3A; PCK1; MAPK9; MTOR; PYGMA; CALM2A; PHKG1; INPPL1A; PRKAB1A
Progesterone-mediated oocyte maturation
INS1; RAF1B; RAF1A; PIK3R1; CCNB2; SPDYB; MAD2L2; FZR1; RPS6KA3; SPDYA
Estrogen signaling pathway
PRKCD; PRKACB; PRKACG; PLCB3; FOS; HSP90B1; KCNJ5; HSPA6; SHC1; ITPR3
Prolactin signaling pathway
MAPK3; HRAS; SHC3; SRC; INS1; FOXO3; SOCS2; KRAS; STAT5B; PIK3R5
Thyroid hormone signaling pathway
FXYD2; PLCB4; NCOA1; NCOR1; AKT2; MED12; BMP4; MAPK3; ATP1A4; NOTCH3
Oxytocin signaling pathway
KCNJ14; CAMK1D; PPP1R12B; PLA2G4D; MYLK4; PIK3R2; MYL9; NRAS; NPR1; CALM3
Regulation of lipolysis in adipocytes
NPR1; INS; PIK3CA; PRKACB; AKT1; TSHB; PIK3CG; AQP7; IRS2; AKT2
Type II diabetes mellitus
PIK3CD; MAFA; IKBKB; SOCS4; MAPK9; TNF; SOCS1; INS1; PIK3R1; HK1
Insulin resistance
PIK3CB; SLC27A2; RPS6KB1; PPARGC1A; RPS6KA3; CREB3L3L; NFKBIA; GSK3AA; PRKCQ; PDPK1
Non-alcoholic fatty liver disease (NAFLD)
MAPK8; SDHC; PIK3CG; CASP8; PRKAB2; FASLG; NDUFS1; CEBPA; PIK3R5; NDUFB7
Aldosterone-regulated sodium reabsorption
NEDD4L; PIK3CB; INS2; PRKCG; ATP1B2; ATP1A1; INS1; PIK3R5; ATP1B3; INS
Carbohydrate digestion and absorption
ATP1B3; SLC5A1; ATP1A2; AMY2A; AKT2; GNAT3; TAS1R3; AMY1B; PIK3CB; ATP1A1
Bacterial invasion of epithelial cells
SRC; ARPC1B; WASF2; ELMO1; ARPC5; PTK2; ILK; CTTN; SEPT9; CAV1
Chagas disease (American trypanosomiasis)
PPP2R1B; SERPINE1; IKBKG; CD3E; PPP2CB; IL12B; GNAI1; NFKB1; IRAK4; PIK3R1
Toxoplasmosis
LAMB4; TGFB2; IFNGR1; HLA-DRB4; TAB2; LAMC2; PIK3R1; PPIF; HLA-DMA; HLA-DRB3
Amoebiasis
RELA; COL24A1; GNA15; SERPINB4; CD14; SERPINB3; COL4A5; PLCB3; Casp3; ACTN4
Hepatitis C
MAPK8; IL-8; IFIT1; IFNA16; ARAF; CLDN22; OSTN; RAF1; MAPK1; CD81
Hepatitis B
IFNA4; NFKB1; DDB2; IFNA17; IFIH1; HSPG2; NFATC3; PRKCB; TGFB3; HBXIP
Measles
FCGR2B; IL12A; GSK3B; FAS; PIK3R1; TAB2; IKBKE; IFNA7; IRF7; TLR9
Influenza A
Ifna11; IFNA3; MAPK8; MAP2K3; Ifna15; PIK3CD; PABPN1L; BLA; IRF3; IFNA5
HTLV-I infection
XBP1; MSX2; PRKACA; HLA-E; PDGFRA; IL2RG; HLA-DRB1; PPP3R1; PIK3R3; XIAP
Epstein-Barr virus infection
POLR3K; PSMD11; MAPK11; PIK3R5; XPO1; TRP53; POLR3G; POLR3D; PIK3R2; SKP2
Pathways in cancer
PTGER4; GNGT2; FGFR3; FZD7; PRKACG; ROCK1; GSTP1; ARHGEF12; F2R; RASGRP3
Viral carcinogenesis
TP53; CCND1; GTF2A2; HIST2H2BB; SKP2; GSN; HIST1H2BN; HLA-E; DDX3X; KAT2A
Proteoglycans in cancer
WNT11; WNT7B; WNT5A; CDC42; CAMK2B; SLC9A1; GAB1; EZR; ITGB1; AKT2
MicroRNAs in cancer
SIRT1; ABCB1A; FZD3; Casp3; ABCC1; PDCD4; SLC45A3; MTOR; CCNE1; RDX
Colorectal cancer
LEF1; APC2; BRAF; SMAD3; APC; BAX; TGFB1; DCC; PIK3CA; TRP53
Renal cell carcinoma
HGF; RAP1B; ETS1; VEGFA; PAK1; PAK2; EGLN1; RBX1; PIK3R3; HIF1A
Pancreatic cancer
TP53; PIK3R3; MAP2K1; ARHGEF6; MAPK10; RAD51; CDC42; SMAD4; RALGDS; BRCA2
Endometrial cancer
PIK3CB; CASP9; NRAS; AXIN1; KRAS; RAF1; PIK3CA; TCF7L2; MAPK3; TP53
Glioma
PIK3R3; PDGFB; GRB2; PIK3CD; TGFA; RAF1; MTOR; Pdgfa&Pdgfb; PDGFRB; BRAF
Prostate cancer
MAPK3; NFKB1; ATF4; INS; KRAS; SPRY1; PDPK1; MAPK1; NRAS; SRD5A2
Melanoma
FGF17; FGF3; FGF22; AKT2; Pdgfa&Pdgfb; HRAS; TRP53; CDH1; PIK3R1; PIK3R3
Chronic myeloid leukemia
KRAS; SHC3; MAP2K2; STAT5A; SMAD3; RELA; BAD; CBL; ABL1; SOS1
Acute myeloid leukemia
CCND1; RUNX1T1; STAT5B; PIM2; PPARD; CCNA1; SOS1; TCF7L2; RAF1; RPS6KB2
Small cell lung cancer
PIK3R2; AKT2; CYCS; RB1; PIK3CG; LAMC1; LAMB4; PIK3R5; TRAF1; AKT1
Non-small cell lung cancer
RARB; PRKCB; FHIT; BRAF; RXRA; PDPK1; RXRG; PLCG2; RXRB; RASSF1
Central carbon metabolism in cancer
AKT1; PFKM; GLS2; HIF1A; PIK3CB; HKDC1; SCO2; PDGFRB; PGAM2; KIT
Choline metabolism in cancer
PPAP2B; PPAP2C; EGF; RAC3; PIP5K1A; SLC44A1; RALGDS; PDGFRA; TAE1; PIK3CB

Protein Function

PIK3R2 has several biochemical functions, for example, contributes_to 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R2 itself. We selected most functions PIK3R2 had, and list some proteins which have the same functions with PIK3R2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3R2
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein PIK3R5; PIK3R3; PIK3R2; PIK3R3B; PIK3R6; PIK3R1; CCKBR; PIK3R3A
Function protein binding
Related Protein RPS20; RPL23; RAB27B; CENPJ; STIM1; APPL2; HECTD3; KIRREL3; KITLG; AGPS
Function protein heterodimerization activity
Related Protein SLC51B; HNF1B; ABCG1; HIST1H4I; ABCG8; DRD2; NEUROD1; IKBKG; TFAP2B; KCNK9
Function protein phosphatase binding
Related Protein CSK; MET; DLG3; EGFR; FGF19; IRS2; CDH5; NEK2; HSP90B1; CTNNB1
Function receptor tyrosine kinase binding
Related Protein SHC4; ANGPT1; PIK3R2; NRG1; NRG3; Flt3l; SHC3; TP53; CPNE3; ELMO2

Interacting Protein

PIK3R2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R2.
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