pik3r2
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 2 (beta)
  • Background
  • The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin r
  • Synonyms
  • PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphatidylinositol 3-kinase regulatory subunit beta; p85; P85B; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory sub
Cat.#:PIK3R2-51HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-kinase, Regulatory Subunit 2 (Beta)
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Cat.#:PIK3R2-180BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine PIK3R2 (Beta)
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Cat.#:PIK3R2-1718HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2, His-tagged
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Cat.#:PIK3R2-316HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2 protein, His/MBP-tagged
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Cat.#:PIK3R2-12807MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIK3R2 Protein
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Cat.#:PIK3R2-3435RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R2 Protein, His-tagged
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Cat.#:PIK3R2-12088ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3R2
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Involved Pathway

PIK3R2 involved in several pathways and played different roles in them. We selected most pathways PIK3R2 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
CBLB; PAK7; SHC4; MAP2K2A; GAB1; NCK1; CDKN1BB; ERBB4A; BAD; SHC1
Ras signaling pathway
NGFR; RAC1; FGF21; GNG7; GRB2; CSF1; BCL2L1; PRKACB; FGF6; IKBKB
Rap signaling pathway
VEGFA; ARAP3; RASGRP3; ITGB2L; PFN1; IGF1R; ANGPT4; RAPGEF6; HGF; LAT
cGMP-PKG signaling pathway
MAP2K1; MAP2K2; CREB3L3; AKT1; ATP2B4; NFATC4; PPP3CB; PDE3A; ATP2A2; MEF2A
cAMP signaling pathway
PRKACG; PDE4B; GHRL; HCN4; CNGA3; NPR1; RELA; CAMK4; PTCH1; BAD
Chemokine signaling pathway
PRKACA; RLN1; GNG8; CCL18; GNG7; GM2506; CCR7; CXCR2; PAK1; GM13306
HIF- signaling pathway
SLC2A1; IFNGR1; HK3; PIK3R1; RPS6KB2; PIK3R2; CAMK2D; ENO1; ANGPT2; LDHA
FoxO signaling pathway
SMAD3A; AGAP2; HOMER2; NRAS; CDKN2D; MAPK1; PTEN; INSRB; MAPK12B; G6PC
Phosphatidylinositol signaling system
PI4KA; IP6K2; PIKFYVE; CALM3B; PLCD3A; IPMKB; PIK3CA; MTMR1; CALM2; DGKD
Sphingolipid signaling pathway
PPP2R5C; TNF; TNFRSF1A; NRAS; ASAH1; BCL2; PPP2R2D; ASAH2; PPP2R5A; TRAF2
Phospholipase D signaling pathway
AVPR1A; FCER1G; PLCB2; GRM3; AGTR1A; PIK3CB; PTK2B; PDGFC; RAF1; CXCR1
mTOR signaling pathway
EIF4EA; INS2; PRKCA; RICTOR; CAB39L; PIK3R1; RPTOR; EIF4BB; RPS6KB1; RPS6KA2
PIK-Akt signaling pathway
TSC1; FGF18; LAMA4; TNXB; ITGB3; KITLG; ITGB7; BRCA1; GHR; ITGA3
AMPK signaling pathway
PIK3R2; IRS1; AKT1S1; G6PC; Scd2; TSC1; IRS4; PPP2R2D; TBC1D1; EEF2K
Apoptosis
BNIP3LB; IRF2A; PRKAR2AA; IKBKG; DFFA; BIDA; CTNNB2; TNFRSF10A; PRKACBB; DFFB
Adrenergic signaling in cardiomyocytes
PPP1CA; PIK3R1; SCN1BA; TNNC1A; MAPK12B; MAPK11; ATP1A2; CALM2B; CACNG4; ATP1B2A
VEGF signaling pathway
RAC1A; PPP3CB; MAPKAPK2; PPP3R2; PLA2G4AA; RAC3B; PTGS2B; RAF1; MAPK13; PIK3R2
Osteoclast differentiation
TEC; IKBKB; MAPK12; PIK3CA; FCGR3A; SIRPA; IL1B; LILRB1; IL1A; PIK3R1
Focal adhesion
PIK3R3; ROCK2B; RAP1A; COL6A3; BRAF; AKT1; PGF; IGF1RB; THBS2; MYL7
Signaling pathways regulating pluripotency of stem cells
KRAS; WNT8A; INHBC; APC; FZD9; PIK3CB; ZFHX3; LHX5; ESRRB; AXIN2
Platelet activation
SYK; BTK; P2RY12; ARHGEF12; PRKG1; GP5; NOS3; GP1BB; MYL12A; ITPR1
Toll-like receptor signaling pathway
IFNA1; TLR4BA; TLR7; IL12BA; AKT2L; IFNA17; IFNB; MAP2K3; IRF7; LBP
Jak-STAT signaling pathway
PIM1; CRFB2; FHL1A; GM-CSF; GM13305; PIK3CA; IL6R; CCND3; IFNAR2; PIK3R3A
Natural killer cell mediated cytotoxicity
PPP3R2; TNFRSF10B; IFNA1; ITGB2; PTPN11; IFNA2; GZMB; LAT; FCGR3B; PAK1
T cell receptor signaling pathway
MAP3K14; CD40LG; PIK3CB; VAV2; FYN; OXSR1A; PIK3R2; NFKB1; IFNG; MAPK12
B cell receptor signaling pathway
NFATC3; RAP2A; LCP2A; PIK3R5; NEDD9; ARPC2; GSK3AB; FCGR2B; PILRB; BCL2L11
Fc epsilon RI signaling pathway
AKT1; LCP2; MAP2K1; VAV2; MAPK11; FCER1G; RAC3; IL13; MAP2K2; GM-CSF
Fc gamma R-mediated phagocytosis
FCGR2B; VAV3; VAV1; DOCK2; HCK; AMPH; ASAP1; RPS6KB2; ASAP3; MARCKSL1
TNF signaling pathway
PIK3R2; FAS; MAP2K6; IL18R1; PTGS2; BCL3; IL15; FOS; TNF; RPS6KA5
Leukocyte transendothelial migration
TXK; MYL5; CLDN4; PIK3R5; PTK2; MAPK12; CXCL12; CLDN20; GNAI2; PTK2B
Neurotrophin signaling pathway
CALML5; NGF; KIDINS220; SORT1; NFKB1; IRAK4; PLCG2; NFKBIB; ARHGDIG; PIK3CG
Cholinergic synapse
KCNJ2; GNA11; PIK3R3; FYN; HRAS; GNG4; CHRM4; GNGT2; GNB3; GNG13
Inflammatory mediator regulation of TRP channels
CAMK2G; CYP2C54; ITPR3; CYP2C38; CALM2; PLCB4; PLA2G4A; PRKCE; HRH1; CYP4A12A
Regulation of actin cytoskeleton
PIK3CG; RAC2; KRAS; CDC42L2; ITGB8; FN1; ACTG1; ITGA6B; ITGB1A; PIP4K2B
Insulin signaling pathway
RAPGEF1B; MAPK8; MTOR; BRAF; CALML3; SOS1; PYGM; PRKAR2B; RPTOR; INS2
Progesterone-mediated oocyte maturation
HSP90AA1.1; PIK3R3; CCNA1; MAPK14A; MAPK8; SPDYB; ADCY1B; CDH1-A; CPEB4; RAF1
Estrogen signaling pathway
RAF1; HSP90AA1; PRKCD; PRKACG; PLCB1; FOS; ESR2; GRB2; HSP90AB1; KRAS
Prolactin signaling pathway
KRAS; CSH; AKT1; LHCGR; MAPK9; PIK3R1; FOXO3; STAT5B; STAT3; GALT
Thyroid hormone signaling pathway
ACTB; RAF1; NOTCH1; PIK3CG; WNT4; PLCB2; MED12; BAD; ATP1A1; PRKACB
Oxytocin signaling pathway
PRKAB1; MAPK1; GUCY1B3; PPP1R12B; CALM4; PPP1CA; NFATC4; CALM3; PLA2G4F; SRC
Regulation of lipolysis in adipocytes
PIK3CA; IRS1; GNAI3; INS2; PRKG1; PRKACB; PRKACA; AQP7; PTGS1; IRS4
Type II diabetes mellitus
MAPK3; CACNA1G; PIK3R5; SOCS2; HK1; INS; INS2; IRS4; INS1; PKLR
Insulin resistance
MTOR; PPP1CC; IKBKB; G6PC2; RPS6KA1; GSK3B; PRKCDA; INS2; PTPRFB; PIK3CA
Non-alcoholic fatty liver disease (NAFLD)
PRKAB1; NDUFS2; ITCH; Casp3; NR1H3; PRKAG3; Il6ra; NDUFA7; GSK3B; NDUFB11
Aldosterone-regulated sodium reabsorption
ATP1A3; INS1; ATP1A1; ALPHA-ENAC; SCNN1G; PIK3R2; MAPK3; ATP1B1; ATP1A4; KCNJ1
Carbohydrate digestion and absorption
PIK3R2; PIK3CD; ATP1A3; AMY2A2; ATP1B3; AMY1A; HK3; PIK3R3; HKDC1; HK1
Bacterial invasion of epithelial cells
SRC; CDC42; ELMO3; ARPC5; PIK3CB; ARPC1A; SHC2; WASF2; WASL; CTNNA3
Chagas disease (American trypanosomiasis)
CASP8; IFNG; IL10; PPP2R2C; AKT2; IFNB1; MAP2K4; IKBKB; MAPK8; CD3E; CD3D
Toxoplasmosis
HSPA8; MAP3K7; SOCS1; PIK3R3; Toxoplasma Gondii Microneme Protein MIC3; BIRC7; HSPA1L; LAMB2; IL10RA; HLA-DOB
Amoebiasis
CD1d1; ACTN4; IL12B; PLCB2; SERPINB6B; CSF2; CXCL8; PIK3R5; VCL; RAB5C
Hepatitis C
CLDN22; EIF3E; RNASEL; CLDN7; IFNB1; TBK1; NR1H3; IFNA13; PDPK1; LDLR
Hepatitis B
STAT1; APAF1; SMAD4; CCND1; NFKBIA; MAP3K1; ATP6AP1; NRAS; NFATC1; IRF7
Measles
IFIH1; IFNA10; PIK3R5; FCGR2B; CD3E; CD3D; HSPA2; CCND1; TNFRSF10C; MAP3K7; TP73
Influenza A
MAPK8; TMPRSS2; Ifna15; BLA; IFNA7; MAPK1; IL-8; H2-AB1; FURIN; IFN-a
HTLV-I infection
FDPS; H2-AB1; LTBR; HLA-DOA; PTTG2; ELK1; DVL1; HLA-DRB3; FZD2; TGFBR1
Epstein-Barr virus infection
TAB2; POLR2C; POLR2E; CCNA2; YWHAG; POLR2K; AKAP8L; HSPA1L; POLR2H; PIK3R5
Pathways in cancer
PTGER1; NRAS; FZD1; FGF7; RB1; IL6; ETS1; TGFBR2; LAMC1; EGLN2
Viral carcinogenesis
GSN; HIST1H4C; BAD; CREB3L2; TRAF5; HIST1H4J; EGR3; POLB; PSMC1; CDC20
Proteoglycans in cancer
MRAS; CD63; TLR4; PLCG2; PDCD4; PLAUR; PIK3CB; LUM; WNT3; CBL
MicroRNAs in cancer
CDCA5; FOXP1; MMP9; UBE2I; DNMT1; TTC6; TGFB2; DNMT3A; SLC45A3; PLCG2
Colorectal cancer
APPL1; FOS; AXIN2; SMAD2; RAC3; TP53; MAPK10; RALGDS; GSK3B; TCF7L2
Renal cell carcinoma
EGLN1; RAF1; VHL; VEGFA; PAK2; RBX1; CUL2; GRB2; TCEB1; PIK3CG
Pancreatic cancer
RAC2; CCND1; BRAF; STAT3; PIK3CB; SMAD4; VEGFA; ARHGEF6; TGFB1; IKBKB
Endometrial cancer
MAP2K2; PIK3R2; AKT1; TP53; AKT2; PIK3R1; PDPK1; HRAS; PIK3R3; AXIN1
Glioma
AKT1; Pdgfa&Pdgfb; CALML5; PRKCB; IGF1; PIK3CG; PDGFRB; PIK3R5; CALM1; SHC4
Prostate cancer
ACTL6B; MAP4K1; FOXO1; FOXA1; PTEN; Ar; EP300; MAPK3; HSP90B1; CPN1
Melanoma
TP53; FGF6; PIK3R5; PDGFC; FGF5; PIK3R2; PIK3R3; PDGFRA; MET; IGF1
Chronic myeloid leukemia
CTBP2; GAB2; STAT5A; SOS1; MECOM; NFKB1; PIK3CG; TGFB2; ABL1; IKBKG
Acute myeloid leukemia
RELA; RUNX1; AKT3; SOS1; SFPI1; EIF4EBP1; IKBKG; CEBPA; PIK3R3; CHUK
Small cell lung cancer
CASP9; ITGB1; LAMA3; PTEN; AKT2; NFKB1; RB1; LAMA4; ITGA2; TRAF4
Non-small cell lung cancer
RXRA; MAPK3; PIK3CD; PRKCG; PLCG1; PRKCA; ERBB2; RXRB; CASP9; GRB2
Central carbon metabolism in cancer
PIK3CA; PIK3CB; PFKL; SLC1A5; PIK3CG; MET; RET; ERBB2; HRAS; PIK3R2
Choline metabolism in cancer
MAPK1; DGKB; PLCG1; PIK3R5; PLA2G4B; WAS; FOS; PDGFC; RHEB; RAC2

Protein Function

PIK3R2 has several biochemical functions, for example, contributes_to 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R2 itself. We selected most functions PIK3R2 had, and list some proteins which have the same functions with PIK3R2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3R2
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein PIK3R3; PIK3R3B; PIK3R5; PIK3R1; PIK3R6; PIK3R2; PIK3R3A; CCKBR
Function protein binding
Related Protein ATL2; TBATA; COX6B2; PIK3IP1; PSRC1; KRT14; FRMPD4; PAK1IP1; ID3; AP2A1
Function protein heterodimerization activity
Related Protein MYH7; THRA; CD3G; SIM2; SOX14; NFE2L2A; TCF3B; APITD1; BOKB; BTBD11A
Function protein phosphatase binding
Related Protein ANAPC5; CSK; EIF2AK3; PIK3R1; JAK3; VRK3; ANAPC4; KAT2A; RPA2; ITPR1
Function receptor tyrosine kinase binding
Related Protein PTPN14; NCK1; TP53; SOCS5; FIZ1; FNTA; Flt3l; PCNA; GAS6; FLT3LG

Interacting Protein

PIK3R2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R2.
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