pik3r2
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  • Official Full Name
  • phosphoinositide-3-kinase, regulatory subunit 2 (beta)
  • Background
  • The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin r
  • Synonyms
  • PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphatidylinositol 3-kinase regulatory subunit beta; p85; P85B; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory sub
Cat.#:PIK3R2-51HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Phosphoinositide-3-kinase, Regulatory Subunit 2 (Beta)
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Cat.#:PIK3R2-180BTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Bovine
Product nameRecombinant Bovine PIK3R2 (Beta)
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Cat.#:PIK3R2-1718HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2, His-tagged
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Cat.#:PIK3R2-316HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3R2 protein, His/MBP-tagged
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Cat.#:PIK3R2-12807MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIK3R2 Protein
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Cat.#:PIK3R2-3435RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PIK3R2 Protein, His-tagged
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Cat.#:PIK3R2-12088ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PIK3R2
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Involved Pathway

PIK3R2 involved in several pathways and played different roles in them. We selected most pathways PIK3R2 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
CAMK2D2; PAK6; TGFA; PTK2AB; KRAS; CAMK2G1; BTC; PIK3R3; MAP2K2; ARAF
Ras signaling pathway
FOXO4; FGF2; GNG8; KIT; FGF20; MAPK1; SHC4; GNG10; NFKB1; PLA2G12A
Rap signaling pathway
RAP1A; PLCB4; GRIN2A; FGF2; HGF; FGFR3; KRIT1; RASSF5; RHOA; PGF
cGMP-PKG signaling pathway
ATP1B1; INS2; GNA12; CALM3; PPP1CB; PLN; PIK3CD; GUCY1A3; FXYD2; INS
cAMP signaling pathway
CAMK2A; PDE4A; HTR1A; FXYD1; MAP2K2; CALML3; GHRL; PAK1; PIK3R2; PDE4B
Chemokine signaling pathway
PTK2B; CX3CL1; CCL7; IKBKB; CX3CR1; CRKL; HRAS; Ccl9; FGR; CXCL2
HIF- signaling pathway
PIK3R3; INSR; SERPINE1; EP300; TEK; PDK1; PIK3R5; PLCG2; ALDOA; MKNK2
FoxO signaling pathway
CCND1; TGFBR1B; GABARAP; IL6; G6PC; HRASA; GADD45BB; MAPK8B; FOXG1A; GABARAPL1
Phosphatidylinositol signaling system
MTMR3; ITPKC; PI4KB; PIP4K2A; IP6K1; MTMR1A; IP6K3; PRKCG; PLCD4; CALML5
Sphingolipid signaling pathway
GNAI2; PPP2R2D; PPP2R1B; ABCC1; AKT1; CERS4; S1PR2; DEGS2; PIK3R5; PPP2R2C
Phospholipase D signaling pathway
MAP2K2; PIK3CB; PDGFRB; AGTR1A; DGKE; GRM4; AGPAT4; DGKZ; RHOA; PLD2
mTOR signaling pathway
PIK3R3; PTENA; PIK3CG; RPS6KB2; IKBKB; PIK3R3B; PTENB; PIK3R5; RPTOR; ULK2
PIK-Akt signaling pathway
ITGA7; VTN; PPP2R5C; PIK3CD; FGF16; GNG7; IFNA13; FLT1; COL24A1; ITGA5
AMPK signaling pathway
LEPR; PFKP; ADIPOQ; CD36; ADIPOR1; SLC2A4; CPT1B; MLYCD; G6PC3; CPT1C
Apoptosis
PIK3CA; DFFB; CASP9; AKT2; PRKAR2AA; DSG1; CASP3A; BID; MYC; CFLARA
Adrenergic signaling in cardiomyocytes
GNAQ; AGTR1B; TNNC1; CALM3; CACNG4; CREM; ATF4B1; CREB3L4; TPM4A; PIK3CB
VEGF signaling pathway
RAC1B; NRAS; MAPKAPK2; AKT3A; SH2D2A; PLA2G4C; HRAS; PRKCBB; MAPK14B; RAC3
Osteoclast differentiation
CYLD; FOSL2; LILRA4; PIK3CG; STAT1; PIK3CA; PPP3R2; MAPK12; SIRP-BETA; MAPK11
Focal adhesion
TNR; MAPK8A; PPP1CBL; PDGFB; CDC42L; RAC3A; ITGA1; KDRL; PPP1CB; SHC3
Signaling pathways regulating pluripotency of stem cells
INHBA; PIK3CB; KRAS; ID2; Fzd4; POU5F1; FGFR3; WNT1; FGFR2; SMAD3
Platelet activation
P2RY1; GP5; VASP; PLA2G4F; F2R; VAMP8; MAPK3; SYK; ARHGEF1; GP6
Toll-like receptor signaling pathway
MAPK14A; TAB2; MAP2K3; MAP2K4B; IRAK1; MAP2K7; MAPK9; STAT1A; PIK3CB; FOS
Jak-STAT signaling pathway
IFNA16; PIAS4A; PIK3CD; SOCS6; IL11RA2; IFNA5; AOX3L1; CSH1; EPO; PRLR
Natural killer cell mediated cytotoxicity
NFATC2; Casp3; MICA; SYK; FASLG; IFNAR2; RAET1E; TNFSF10; Ifna15; FAS
T cell receptor signaling pathway
Il2; MAP2K1; MAPK3; CD40LG; PPP3R2; IKBKB; SHB; LAT; VAV2; MAP3K7
B cell receptor signaling pathway
ARPC4; RAC3; MALT1; PIK3CD; CD79A; IFITM1; IKBKG; BLNK; FOS; DOK1B
Fc epsilon RI signaling pathway
SYK; RAC3; INPP5D; PLCG1; PIK3R2; BTK; IL5; LYN; MAP2K6; AKT1
Fc gamma R-mediated phagocytosis
WAS; SPHK2; RPS6KB1; LYN; AMPH; PAK1; SYK; PRKCG; GSN; RAF1
TNF signaling pathway
TNFAIP3; CREB5; MAP3K7; MAPK13; PIK3CA; SELE; PIK3R1; MMP9; MAP3K14; MAPK1
Leukocyte transendothelial migration
PLCG2; ACTN1; MMP9; CLDN15; VCL; ACTN4; MYL5; PIK3R5; PIK3R1; ACTB
Neurotrophin signaling pathway
NTRK2; TP53; NGFR; MATK; CAMK2A; PRDM4; TRAF6; NTF3; PIK3CB; RHOA
Cholinergic synapse
AKT2; PLCB3; CHRM1; AKR1C1; KCNQ2; GNG2; GNAI2; GNG7; KCNJ2; HRAS
Inflammatory mediator regulation of TRP channels
PLA2G4C; ACCN5; CYP2C38; PIK3R1; ITPR1; ASIC1; Adcy4; PRKCH; PRKCE; PIK3CD
Regulation of actin cytoskeleton
PIP5K1AB; FGF7; FGF12; RAC2; NRAS; BDKRB2; VAV2; PIP5K2; PAK1; ACTB2
Insulin signaling pathway
FLOT1B; RHEB; PRKAB1; RPS6; INPPL1; SOCS2; ACACB; CALM3; PPP1CBL; SHC4
Progesterone-mediated oocyte maturation
GNAI2B; IGF1RA; MAPK8; GNAIA; RPS6KA3A; CCNA2; GNAI2A; HSP90AA1.1; ANAPC2; PLK1
Estrogen signaling pathway
PLCB4; CALM3; SOS1; CREB3L2; PRKACG; PIK3R5; RAF1; NOS3; NRAS; MMP9
Prolactin signaling pathway
TNFRSF11A; MAPK11; CSH; PIK3R5; AKT1; HRAS; LHCGR; GALT; SIRPA; STAT5B
Thyroid hormone signaling pathway
KRAS; WNT4; ITGAV; NOTCH2; PFKP; ITGB3; PFKFB2; PLCD4; PLCG2; HRAS
Oxytocin signaling pathway
GNAS; GNAI1; CAMKK2; CAMK1G; GNAI2; PIK3R5; RYR1; CAMK2G; Adcy4; NOS3
Regulation of lipolysis in adipocytes
Adcy4; PIK3CA; INSR; FABP4; PIK3CD; NPY; PIK3R5; PIK3CB; GNAS; TSHR
Type II diabetes mellitus
HKDC1; SOCS2; HK3; PRKCZ; IRS1; PKLR; SLC2A2; HK1; PIK3CB; PIK3CD
Insulin resistance
PRKAG2; CREB1A; RPS6KA2; SOCS3B; IRS1; PRKAB1B; INS; PRKCBA; RPS6KA1; SLC27A1A
Non-alcoholic fatty liver disease (NAFLD)
PRKAA2; NDUFV1; Fasl; NDUFV3; NDUFA10; NDUFS6; UQCRQ; FAS; Casp3; NR1H3
Aldosterone-regulated sodium reabsorption
FXYD2; PRKCG; SFN; PDPK1; PRKCA; PIK3R3; NEDD4L; MAPK3; INS1; PIK3R1
Carbohydrate digestion and absorption
PIK3R1; AKT2; HK1; ATP1B1; HK2; PIK3R3; GNAT3; PIK3CB; SLC37A4; G6PC3
Bacterial invasion of epithelial cells
CRKL; CTNNA2; SEPT2; SEPT3; DOCK1; CBLC; SEPT6; SHC3; CLTA; CTNNA1
Chagas disease (American trypanosomiasis)
CCL3; PIK3R5; LOC100033925; Fasl; MAP2K4; MAPK12; PPP2R2D; PPP2CA; PPP2CB; MAPK13
Toxoplasmosis
LAMC2; IRGM1; IL10RB; LAMB4; HSPA8; HSPA1L; Toxoplasma Gondii Major Surface Antigen P30; TGFB2; IFNGR2; LY96
Amoebiasis
PLCB3; TLR4; TNF; PIK3R1; IL12A; RAB7A; C8A; SERPINB1C; IFNG; IL12B
Hepatitis C
STAT2; MAPK10; EIF3E; MAVS; MAPK3; CLDN2; IRF9; IKBKE; TBK1; CLDN11
Hepatitis B
TGFB1; MAPK8; MAPK9; KRAS; YWHAZ; IFNA7; MMP9; CREB3L2; HSPG2; YWHAB
Measles
Cd209g; PIK3R5; TNFRSF10A; IFNA13; PIK3R1; TAB2; CCNE2; TLR4; CD3E; AKT1
Influenza A
EIF2AK2; CASP1; MAP2K2; HLA-DMA; BLA; PLG; IL8L1; IRF3; IFNA12; CCL5
HTLV-I infection
DVL1; MSX1; RANBP3; ELK4; CRTC1; FZD3; FZD8; HLA-DMA; VDAC3; POLB
Epstein-Barr virus infection
PSMD12; XPO1; CD38; POLR3C; SPN; POLR2D; TBK1; AKT1; PLCG1; GSK3B
Pathways in cancer
GNAI2; GNGT1; FGF17; GNG10; PPARD; ARAF; TGFB3; IKBKB; PDGFB; SOS1
Viral carcinogenesis
GTF2A2; ACTN3; HIST1H2BO; UBE3A; CCNE1; SRC; DLG1; CREB3L2; REL; HDAC11
Proteoglycans in cancer
KRAS; CCND1; ITPR1; MMP9; PRKACB; ELK1; MAPK1; VEGFA; GRB2; ITGB5
MicroRNAs in cancer
PIK3CA; SOX4; STMN1; PTEN; CCNE2; SHC1; APC; NOTCH4; DNMT3A; ABCB1A
Colorectal cancer
LEF1; FOS; BAX; APC; PIK3R1; RAC2; AKT1; TGFBR2; TRP53; SMAD4
Renal cell carcinoma
EPAS1; AKT1; MAPK1; TCEB2; HIF1A; ARNT; BRAF; PIK3R5; TGFB3; RAF1
Pancreatic cancer
AKT2; SMAD3; MAPK1; MAPK8; PIK3R5; SMAD2; BCL2L1; TRP53; VEGFA; RALBP1
Endometrial cancer
PIK3CD; MAPK1; TCF7; PIK3R1; AXIN2; CTNNA2; BRAF; MAP2K2; LEF1; TCF7L2
Glioma
PDGFRA; SHC1; Pdgfa&Pdgfb; CALML3; PIK3R3; PRKCG; PRKCA; MAPK1; SHC4; CALML5
Prostate cancer
PIK3CD; SOS1; IKBKB; PIK3R5; NFKB1; MAP2K2; HSP90B1; CREB3L1; CASP9; GRB2
Melanoma
MAPK1; MAP2K1; TP53; FGF8; FGF2; Fgf15; FGF1; FGF16; FGF10; MAPK3
Chronic myeloid leukemia
RUNX1; PIK3CG; RAF1; TGFB3; MECOM; TGFB1; TP53; RELA; AKT2; MAP2K2
Acute myeloid leukemia
MAP2K1; PIM1; AKT2; AKT1; RELA; PIM2; JUP; RUNX1; PIK3R3; ARAF
Small cell lung cancer
RELA; PTGS2; AKT2; PIK3CA; BIRC8; RXRA; COL4A1; CKS2; TRAF1; LAMC1
Non-small cell lung cancer
MAP2K1; PRKCB; RXRG; BRAF; RAF1; BAD; PIK3CG; FOXO3; PLCG1; PIK3R3
Central carbon metabolism in cancer
HK1; GLS2; AKT2; PFKM; G6PD; FLT3; PDGFRB; SCO2; NTRK1; HKDC1
Choline metabolism in cancer
EGF; PIK3R3; MAPK8; GPCPD1; MAP2K2; PCYT1A; RALGDS; PIK3CD; PLA2G4D; DGKQ

Protein Function

PIK3R2 has several biochemical functions, for example, contributes_to 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R2 itself. We selected most functions PIK3R2 had, and list some proteins which have the same functions with PIK3R2. You can find most of the proteins on our site.
Function
Related Protein
Function contributes_to 1-phosphatidylinositol-3-kinase activity
Related Protein PIK3R2
Function 1-phosphatidylinositol-3-kinase regulator activity
Related Protein CCKBR; PIK3R5; PIK3R3; PIK3R1; PIK3R3B; PIK3R3A; PIK3R2; PIK3R6
Function protein binding
Related Protein SOX9A; RFPL3; HPS4; ZNHIT1; SEPT10; SND1; CD200; JAM2; ATOX1; PSG1
Function protein heterodimerization activity
Related Protein PHC2B; HMG20A; HIST1H2B7; MEIS1; GRIN1; BCL2A; UBA3; TIRAP; PPP2R4; CXCL13
Function protein phosphatase binding
Related Protein DRD1; STAT6; VCP; HSP90B1; HSF4; PPP6R1; PPP1R3G; GRB2; PARD3; DLG3
Function receptor tyrosine kinase binding
Related Protein GAS6; FLT3LG; TP53; SHC3; ANXA5; GNB2L1; CPNE3; FNTA; NRG1; PTPN14

Interacting Protein

PIK3R2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R2.
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