prkacb
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  • Official Full Name
  • protein kinase, cAMP-dependent, catalytic, beta
  • Background
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PRKACB; protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta; PKACb; PKA C-beta; protein kinase A catalytic subunit beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; MGC9320; MG
Cat.#:PRKACB-173HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, His-tagged
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Cat.#:PRKACB-1947HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-30210THTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB
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Cat.#:PRKACB-395HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged, Active
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Cat.#:PRKACB-553HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-13353MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKACB Protein
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Cat.#:PRKACB-4672RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKACB Protein
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Cat.#:PRKACB-3602RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRKACB Protein, His-tagged
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Cat.#:PRKACB-2868HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB 293 Cell Lysate
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Involved Pathway

PRKACB involved in several pathways and played different roles in them. We selected most pathways PRKACB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
HSP70L; CACNA2D1A; MAP3K5; FGF12A; MAP3K1; KCNA3; FGF12; FGF1B; FGF10; FGFR2
Ras signaling pathway
MAPK8; RRAS; PLCE1; RASAL2; CALM2; BCL2L1; RASGRF2; VEGFB; PDGFB; ETS2
Calcium signaling pathway
ADRa1A; CALM; CAMK2B1; STIM2; EDNRBA; ERBB4A; SLC8A2; PTK2BB; OXTR; TACR1B
cAMP signaling pathway
CNGA4; NFKB1; PIK3CB; GRIN2B; GRIN3B; GHSR; MAPK8; GRIN2D; CREB3L2; CNGA3
Chemokine signaling pathway
CCR8; PRKACB; SHC2; CXCL8; CCL3L3; SHC4; CRKL; Ccl12; CCR6; CCR5
Oocyte meiosis
CALM4; PPP2R5C; CPEB4; PRKACAA; ADCY1B; PPP2R5CB; PPP2R5E; REC8; SMC1B; RPS6KA1
Apoptosis
CASP3B; CASP6; RNF8; IL1R1; PRKAR2B; CASP6L1; BIDA; CASP6L2; BAXB; CTNNB1
Adrenergic signaling in cardiomyocytes
TNNC1B; ATF2; CACNB2; PLCB3; AKT2L; AKT3A; TNNT2; CACNG1A; GNAI2; PRKCA
Vascular smooth muscle contraction
ITPR1; PLA2G6; PRKCD; RHOAD; GNA13A; PRKACG; MYL9B; NPR1; CALM; PRKCH
Wnt signaling pathway
WNT2B; CAMK2A; GSK3B; CAMK2D2; PRICKLE1A; RAC2; WNT7B; PPP3CCA; GSK3AA; CCND2A
Hedgehog signaling pathway
PTCH1; CSNK1G2; WNT2B; CSNK1A1L; CSNK1G2B; PRKACA; CSNK1DA; GLI2B; WNT3; BMP2B
Gap junction
TUBA4A; TUBA1L2; GNAI1; PLCB3; PDGFAA; PLCB4; MAP2K2; GJD2; TUBA1A; TUBA8L
Platelet activation
P2RX1; PTGIR; GP1BA; SNAP23; MYL12A; FCER1G; ITPR1; PLCG2; ITGB3; MAPK3
Circadian entrainment
GNB2; GNAI2; GNG2; RYR2; Adcy4; NOS1; GUCY1A3; GNG13; GNG3; NOS1AP
Long-term potentiation
PLCB4; PRKCA; ITPR3; GRIN2D; RAP1A; BRAF; PPP3CC; RPS6KA1; PRKACG; PLCB3
Retrograde endocannabinoid signaling
GNAO1; GRIA3; GNGT2; GABRG3; RIMS1; GNG2; GABRA3; GRIA4; PTGS2; PRKACG
Glutamatergic synapse
PPP3R1; PLA2G4D; PRKCA; MAPK1; GRIN2B; GRIK1; GNAI3; GNAO1; GNG12; GNAI2
Cholinergic synapse
KCNJ2; CHRM5; PRKCG; PRKACG; CHRNA3; Adcy4; CREB3L4; FYN; PLCB2; PIK3CA
Serotonergic synapse
GNG4; GNG12; CYP2C55; CYP2C39; GNGT2; HTR5A; GNG7; GABRB3; CYP4X1; TRPC1
GABAergic synapse
SLC6A1; GNG2; GNG13; GABBR2; GABBR1; PRKACA; HAP1; GNB4; GABRE; GAD2
Dopaminergic synapse
GNG12; GNG7; CALM4; PRKCB; CREB3L3; GNAI1; PLCB3; PPP2R1B; GNAO1; DRD5
Olfactory transduction
SLC8A2; OR11A1; PRKACA; OLFR1002; SLC24A4; OR12D3; NCALD; OLFR154; OR10A4; OR10A5
Taste transduction
TAS2R13; TAS2R126; TAS2R130; Adcy4; TAS2R3; TRPM5; TAS2R40; TAS2R113; GNB3; GNB1
Inflammatory mediator regulation of TRP channels
PIK3CD; CYP4A14; CYP4A12A; PIK3R5; PLA2G4C; PPP1CB; KLK1B4; MAP2K3; TRPA1; ALOX12
Insulin signaling pathway
PRKACB; CALM; PKLR; MAPK8B; NRAS; G6PC3; PIK3R1; EIF4E2RS1; MAP2K2A; BRAF
Insulin secretion
RIMS2; PDX1; PRKCG; KCNMB2; GPR119; KCNN4; CAMK2D; SNAP25; CREB3L3; SLC2A2
GnRH signaling pathway
LHBETA1; MAPK13; MAP3K3; MAP2K1; Adcy4; PLA2G4D; SOS1; CALML5; RAF1A; CDC42L
Ovarian steroidogenesis
PRKACG; PTGS2; ALOX5; Adcy4; HSD3B5; BMP6; AKR1C3; PRKACB; PLA2G4A; HSD17B2
Progesterone-mediated oocyte maturation
MAPK8B; CPEB3; ADCY1A; PRKACBB; PRKACAB; RPS6KA3; HSP90AB1; MAPK12B; INSB; MOS
Estrogen signaling pathway
GNAI3; KRAS; HRAS; PRKACG; SHC4; CALML5; MMP2; HSPA2; PIK3R2; SHC3
Melanogenesis
Adcy4; CAMK2D1; KIT; TCF7L2; TYR; ASIP; CAMK2B1; CREB1A; GNAI1; WNT9A
Thyroid hormone synthesis
CREB3L3; TPO; ASGR2; TG; FXYD2; GPX7; SLC5A5; PRKCB; TTF2; ASGR1
Thyroid hormone signaling pathway
CCND1; STAT1; GATA4; PRKACA; RXRB; PFKFB2; RCAN2; HDAC3; TP53; ATP1A1
Oxytocin signaling pathway
CAMK2D; NFATC3; CAMKK2; PPP1R12B; PRKAB2; ROCK2; CACNA2D3; CACNG7; MYL9; PRKACB
Glucagon signaling pathway
PRKAA1; CAMK2B; ATF4; PLCB1; PLCB3; PHKA1; GYS2; ACACA; AKT2; GNAQ
Regulation of lipolysis in adipocytes
GNAI2; PNPLA2; ABHD5; LOC100328615; GNAI1; PIK3CA; NPY1R; PTGS1; GNAI3; PDE3B
Renin secretion
GNAI3; NPR1; CLCA1; CALM4; PDE3B; CLCA4; CALM1; PDE1B; AQP1; PLCB1
Aldosterone synthesis and secretion
SLC14A2; CREB5; PRKD1; HSD3B6; CALML5; PLCB4; ATF1; CACNA1H; AGTR1B; ITPR1
Endocrine and other factor-regulated calcium reabsorption
TRPV5; ATP1B2; KLK2; KL; ATP1B4; KLK1B24; ATP1B3; PTH1R; GNAQ; ATP2B1
Vasopressin-regulated water reabsorption
RAB5C; AVP; GNAS; CREB3L2; RAB11A; ARHGDIA; DCTN4; PRKACG; AQP4; CREB3L1
Salivary secretion
PLCB2; DMBT1; ATP1A1; TRPV6; ATP1B4; Slc4a2; ATP1A4; ATP1A2; CAMP; ATP2B4
Gastric acid secretion
KCNJ2; CALM2; GNAQ; Adcy4; PLCB2; ATP1B2; GNAS; ATP1B3; CA2; ATP4A
Bile secretion
SLC51A; ABCC2; SLC4A4; PRKACB; AQP8; ATP1B4; SULT2A1; ADCY8; OSTA; EPHX1
Parkinsons disease
COX6B2; UBE2J1; ATP5E; COX7B2; UQCRC2; SDHA; NDUFA1; UCHL1; ATP5G3; Atp5g2
Prion diseases
SOD1; MAP2K1; HSPA1A; C1QC; PRKACG; BAX; Hc; LOC100033925; C8A; PRKACB
Cocaine addiction
CDK5; GRM2; CREB3L4; CDK5R1; PRKACA; GNAI3; ATF4; CREB3L1; GRIA2; PDYN
Amphetamine addiction
CAMK2D; CAMK2B; PRKACG; MAOB; GRIN3A; PPP1CB; ATF4; FOSB; CALM1; DDC
Morphine addiction
GABRR3; GABRA1; PRKACB; PDE10A; GNAO1; PDE4D; GABBR1; PDE7B; GRK5; PDE8B
Vibrio cholerae infection
ATP6V1G2; PLCG1; ACTG1; ATP6V0B; ATP6V0C; ATP6V1E2; ATP6V1D; ATP6V1A; ATP6V1C1; PRKACA
Amoebiasis
TGFB1; TLR4; ITGB2L; COL2A1; GNAL; AASS; CXCL8; ITGB2; SERPINB13; IL12B
HTLV-I infection
BUB1B; FZD3; FZD7; HLA-DOB; SPI1; CRTC1; POLD2; HLA-B; MYBL1; POLB
Epstein-Barr virus infection
POLR2H; NEDD4; PSMD1; MAP2K4; TYK2; PIK3R5; TRAF5; HDAC4; PSMD8; YWHAG
Pathways in cancer
AKT1; Flt3l; GLI3; PTCH2; WNT16; WNT2; IL-8; WNT9A; Fzd4; NFKBIA
Viral carcinogenesis
NFKBIA; NFKB2; POLB; HIST1H4J; HIST1H4A; TBPL1; HIST1H2BJ; HLA-F; TRAF5; UBR4
Proteoglycans in cancer
DROSHA; TGFB1; WNT3A; WNT1; CDC42; MMP9; AKT1; PLCE1; MAPK12; ITGB1
Dilated cardiomyopathy
ITGB6; CACNG7; TPM2; CACNA2D4; TTN; ACTB; ITGA2; TPM4; ITGA7; ITGA1

Protein Function

PRKACB has several biochemical functions, for example, ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACB itself. We selected most functions PRKACB had, and list some proteins which have the same functions with PRKACB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PIP5K1A; CLK2; CDKL5; AK7; MYH13; TTBK1; ABCA6; TNK2B; NAV2; TP53
Function cAMP-dependent protein kinase activity
Related Protein PRKACG; PRKACB; PRKAG1; PRKACA; PRKAA1; PRKX; AKAP13
Function magnesium ion binding
Related Protein WRN; PGM3; PRPS1; PPA2; DUT; TDP2B; NT5C1AA; SIK2; ABL1; TSSK4
Function protein binding
Related Protein KRT86; HNRNPK; SDCCAG8; TUBB4A; LBX1; MAP1LC3B; C7orf42; HIST1H1C; EIF3G; PITPNC1
Function ubiquitin protein ligase binding
Related Protein DBT; DNAJA1; TRAF5; BCL2; KCNH2; UBXN6; GPR37; STUB1; YWHAE; C10orf46

Interacting Protein

PRKACB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACB here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACB.
HSP90AB1; APPBP2; AKAP5; PRKAR2B; DYNLL1; MAPRE1; FLNA; RCAN1; CBFB; PITX2; ACVR1B; RPL27A; RPS6

PRKACB Related Articles

Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
Yang, L; Nakayama, Y; et al. GABA(C)-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. JOURNAL OF PHARMACOLOGICAL SCIENCES 106:578-584(2008).