prkacb
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  • Official Full Name
  • protein kinase, cAMP-dependent, catalytic, beta
  • Background
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PRKACB; protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta; PKACb; PKA C-beta; protein kinase A catalytic subunit beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; MGC9320; MG
Cat.#:PRKACB-173HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, His-tagged
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Cat.#:PRKACB-1947HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-30210THTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB
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Cat.#:PRKACB-395HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged, Active
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Cat.#:PRKACB-553HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-13353MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKACB Protein
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Cat.#:PRKACB-4672RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKACB Protein
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Cat.#:PRKACB-3602RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRKACB Protein, His-tagged
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Cat.#:PRKACB-2868HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB 293 Cell Lysate
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Involved Pathway

PRKACB involved in several pathways and played different roles in them. We selected most pathways PRKACB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACB were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
RAC1A; GRB2; TGFB1A; AKT3A; HSPB1; FGF13B; PDGFB; FGF3; FGF18A; NFKB2
Ras signaling pathway
PLA2G4C; CALM2; NF1; GNB4; RALGDS; MLLT4; RAF1; FGF6; PAK2; PLA2G4D
Calcium signaling pathway
ADRB3A; ERBB3A; ITPKA; PRKACAB; NOS2A; PPP3R1B; PLCB1; SLC8A2; SLC8A2B; ATP2B2
cAMP signaling pathway
PTCH1; PDE4D; MAP2K2; ATP1A3; RELA; MAPK8; SLC9A1; ARAP3; FSHR; GNAI1
Chemokine signaling pathway
CCL7; XCL2; ADRBK2; GNB2; ITK; Ccl21a; CCL17; PRKCZ; RAC1; GM10591
Oocyte meiosis
YWHABL; CAMK2D1; YWHABB; RBX1; CAMK2B; PPP2R5EA; INSB; PRKACB; CTH1; IGF1
Apoptosis
PIK3CD; CAPN1B; CRADD; PKP1; PRKAR1A; DAPK1; BIRC3; PRKAR2AA; IRAK1; TNFRSF10D
Adrenergic signaling in cardiomyocytes
SLC8A1; GNAIA; SCN4BA; ATP1A4; CREB3; AGTR1B; PPP2R5C; PRKACBB; CALML3; ADCY1A
Vascular smooth muscle contraction
ROCK1; CACNA1D; MYLK; PRKCB; CACNA1DA; AVPR1B; PRKCH; PLA2G2A; MAP2K2A; PRKACAA
Wnt signaling pathway
WNT3A; FBXW2; FZD8A; RHOAA; TP53; FBXW11; PRKACBB; APC; PPP3CCA; FZD7B
Hedgehog signaling pathway
RAB23; WNT11B; WNT7A; PRKACG; WNT7B; ZIC2A; WNT5B; CSNK1G2; LRP2A; SHHA
Gap junction
SOS1; Pdgfa&Pdgfb; GNAI1; ADRB3B; PRKACG; TUBA1L2; CSNK1DA; PLCB2; TUBAL3; GUCY1B3
Platelet activation
GUCY1A3; PLCB2; Adcy4; GP6; COL27A1; GP5; VASP; FGB; ORAI1; PIK3R2
Circadian entrainment
GRIA4; GNG7; GRIN2B; CAMK2G; RYR3; GNGT1; GNG10; PRKCA; AKR1C1; CALM3
Long-term potentiation
PLCB1; PRKCB; EP300; CALML5; CALM4; PPP1CC; HRAS; CAMK2D; GRIN2D; PLCB2
Retrograde endocannabinoid signaling
PRKACG; PLCB1; PLCB3; GABRA2; GNG12; GNG4; GABRE; SLC17A6; PRKCA; GABRA3
Glutamatergic synapse
GRIK1; PRKACB; GRM2; HOMER2; GRIN3B; PPP3R1; GRM4; PLD1; PLA2G4F; GRM8
Cholinergic synapse
CHRNA3; AKR1C1; GNAI1; CAMK2B; JAK2; NRAS; GNB4; GNG10; GNAI2; MAP2K1
Serotonergic synapse
GNG11; ALOX12B; HTR6; HTR1A; PLA2G4A; PLA2G4C; GNAS; GNG3; CYP2C55; GNG13
GABAergic synapse
SLC6A1; GLS; GNAO1; GABRD; GABRA3; GABRA1; GNG11; GABARAPL1; GABRA2; PRKACB
Dopaminergic synapse
DDC; GNB3; GNG3; ITPR3; DRD5; PPP2R5A; GRIA3; PRKCG; GRIA2; PPP2R2B
Olfactory transduction
OR56A1; PRKACA; OLFR508; SLC8A2; OR4N4; OLFR482; OLFR958; OR10H1; OR5K1; OLFR146
Taste transduction
PDE1A; GRM4; GNB1; TAS2R107; TAS2R123; TAS2R104; TAS1R1; KCNB1; TAS2R126; TAS2R139
Inflammatory mediator regulation of TRP channels
ASIC3; TRPV2; ACCN5; ALOX12; IL1RAP; PLCB1; PLA2G4C; PRKACB; CYP2C55; MAPK13
Insulin signaling pathway
PYGM; PHKA2; GSK3AA; NRAS; PPP1CBL; MAPK9; MAP2K2A; SOCS3B; IRS2; SOCS1
Insulin secretion
KCNMB4; PLCB4; PLCB3; GPR119; GIP; CREB3L1; KCNMA1; GCG; SLC2A1; RAB3A
GnRH signaling pathway
ATF4; PRKACBB; MAPK8A; CALM1B; CALML5; MAPK1; CALM; MAPK14A; ADCY2B; HRASB
Ovarian steroidogenesis
PTGS2; INS2; HSD17B1; PRKACA; HSD3B5; BMP15; HSD3B4; SCARB1; IGF1R; LHB
Progesterone-mediated oocyte maturation
CPEB2; RPS6KA3A; RPS6KA3; RPS6KA2; GNAI3; MAPK11; CCNB1; PIK3CD; IGF1; MAPK12
Estrogen signaling pathway
RAF1; PIK3R3; PRKACA; PLCB1; GNAI3; PIK3CB; HSPA1B; ESR1; KCNJ6; Adcy4
Melanogenesis
GNAQ; GNAI3; FZD8A; ASIP; CALM; GNAI1; PRKCBA; FZD1; WNT7A; FZD7
Thyroid hormone synthesis
ATP1B4; PLCB1; TPO; CREB3L2; LRP2; ATP1A2; GPX6; Adcy4; HSP90B1; ITPR3
Thyroid hormone signaling pathway
PIK3CD; WNT4; PLCG2; AKT1; PFKFB2; SRC; SIN3A; ATP1A4; DIO1; MED12
Oxytocin signaling pathway
PPP3R2; PRKAG2; NRAS; PRKACB; NFATC4; CACNG7; PLCB4; PRKAB1; ACTG1; CCND1
Glucagon signaling pathway
CAMK2B; PLCB2; PRKACG; PPP3R2; GNAS; PRKAG3; PFKL; GNAQ; GYS1; SLC2A1
Regulation of lipolysis in adipocytes
PIK3CD; TSHB; PTGS1; PRKACB; ABHD5; NPY1R; PIK3CB; NPR1; GNAS; PIK3R1
Renin secretion
CALML3; CALML5; PRKACG; GUCY1B3; PRKACB; CALM1; AGTR1A; Ren1; PPP3CB; CLCA4
Aldosterone synthesis and secretion
CREB3L1; CAMK2B; DDX1; AKR1C1; LIPE; LDLR; DAGLB; NETO2; PRKD1; CACNA1H
Endocrine and other factor-regulated calcium reabsorption
KLK1B9; KLK2; ATP1A1; ATP1B2; ATP1B1; TRPV5; KLK1B11; KLK1B24; PRKCA; PTH1R
Vasopressin-regulated water reabsorption
CREB3L1; DCTN5; ARHGDIA; DYNC1LI1; CREB5; RAB11A; AVP; NSF; VAMP2; DCTN4
Salivary secretion
Slc4a2; ATP1B1; CALML5; DMBT1; LYZ; ITPR3; MUC7; VAMP2; CST2; FXYD2
Gastric acid secretion
ATP1B2; PLCB4; CALM3; ATP1A3; SLC9A4; SST; ITPR1; MYLK2; ATP1A4; KCNJ1
Bile secretion
SLCO1B1; CA2; ABCB1A; Adcy4; SLC51A; ATP1B4; ADCY6; ATP1A4; BAAT; SLCO1A2
Parkinsons disease
ATP5J; NDUFS4; VDAC2; UQCRB; PPIF; NDUFA3; GPR37; SNCA; SLC25A6; DRD1A
Prion diseases
HSPA1A; NCAM2; C8G; C8A; PRKACG; BAX; IL1B; NCAM1; C7; MAPK1
Cocaine addiction
GRIA2; RELA; DRD2; GRIN2B; DRD1; RGS9; ATF4; BDNF; SLC18A2; GRIN3B
Amphetamine addiction
CREB3L2; SLC14A2; GRIA3; MAOB; CAMK2B; GRIN3B; CREB3L4; PPP3CA; CAMK4; PRKCB
Morphine addiction
DRD1A; PDE1B; GABRA2; GABRA4; PDE4B; ADORA1; GNGT2; GABRP; GNB1; PRKACA
Vibrio cholerae infection
ATP6AP1; PRKACG; PLCG1; ATP6V1D; ATP6V1F; ATP6V1G2; ATP6V1E2; ATP6V0C; ATP6V0A4; MUC2
Amoebiasis
LAMB3; ACTN4; TGFB2; GNA15; C8A; ACTN3; LAMA3; LAMA5; RAB5B; ACTN1
HTLV-I infection
IL6; HLA-G; HLA-DOB; IKBKG; ANAPC2; ANAPC5; CCND1; FZD8; PPP3CA; CRTC1
Epstein-Barr virus infection
NFKB1; HLA-DRB1; EIF2AK3; HLA-B; EP300; POLR3K; ENTPD8; HLA-C; GSK3B; HSPA1A
Pathways in cancer
EGLN3; FGF13; GNAS; DAPK1; FGF10; NTRK1; CCNE2; PIK3R1; NCOA4; ARHGEF12
Viral carcinogenesis
GSN; SYK; MAD1L1; HIST3H2BB-PS; GTF2H2C; PRKACB; RBL1; HIST2H4; STAT3; RBL2
Proteoglycans in cancer
TP53; CTTN; WNT8B; ERBB4; WNT9B; PPP1R12C; PIK3R3; ACTG1; GRB2; FZD3
Dilated cardiomyopathy
RYR2; MYH7; CACNA2D1; ITGA7; MYBPC3; CACNB3; SGCB; MYL2; CACNA2D4; EMD

Protein Function

PRKACB has several biochemical functions, for example, ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACB itself. We selected most functions PRKACB had, and list some proteins which have the same functions with PRKACB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein AASDH; MAPK12; ABCB11; ABCF1; GSS; DNAJA2L; UBE2T; LARS; MYO1H; ABCB1
Function cAMP-dependent protein kinase activity
Related Protein PRKAA1; PRKACA; PRKACG; PRKX; AKAP13; PRKAG1; PRKACB
Function magnesium ion binding
Related Protein NIM1K; PPM1NB; STK36; FEN1; PPM1B; ENO3; ITPK1A; ATP8B1; PPA1; GLUL
Function protein binding
Related Protein MYBL2; ISOC1; PRKAG1; BCAS2; SLC16A3; RPL4; PSMD5; SOX17; FAF2; KCTD1
Function ubiquitin protein ligase binding
Related Protein ATP6V0C; UBE2A; FAF1; CD40; RPA2; YOD1; TNFRSF14; BLZF1; PINK1; FBXW7

Interacting Protein

PRKACB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACB here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACB.
HSP90AB1; APPBP2; AKAP5; PRKAR2B; DYNLL1; MAPRE1; FLNA; RCAN1; CBFB; PITX2; ACVR1B; RPL27A; RPS6

PRKACB Related Articles

Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
Yang, L; Nakayama, Y; et al. GABA(C)-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. JOURNAL OF PHARMACOLOGICAL SCIENCES 106:578-584(2008).