prkacb
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  • Official Full Name
  • protein kinase, cAMP-dependent, catalytic, beta
  • Background
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PRKACB; protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta; PKACb; PKA C-beta; protein kinase A catalytic subunit beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; MGC9320; MG
Cat.#:PRKACB-173HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, His-tagged
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Cat.#:PRKACB-1947HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-30210THTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB
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Cat.#:PRKACB-395HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged, Active
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Cat.#:PRKACB-553HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-13353MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKACB Protein
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Cat.#:PRKACB-4672RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKACB Protein
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Cat.#:PRKACB-3602RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRKACB Protein, His-tagged
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Cat.#:PRKACB-2868HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB 293 Cell Lysate
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Involved Pathway

PRKACB involved in several pathways and played different roles in them. We selected most pathways PRKACB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACB were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNA2D1A; MAPK3; RPS6KA3; ARRB2B; NRAS; MAPK8; PPP3R2; RAP1AA; DDIT3; CACNB4A
Ras signaling pathway
LAT; NGFR; RHOA; PDGFRB; FGFR1; INS; RGL2; VEGFB; PLA1A; NGF
Calcium signaling pathway
NOS2A; ITPKA; ADCY2B; P2RX3A; LHCGR; PLCD1A; CAMK4; PHKG1A; DRD1B; MYLK2
cAMP signaling pathway
GRIA1; PDE3A; NPY; HTR6; CREB3L3; PPP1CC; PPP1CB; ROCK1; RAC2; ATP2B4
Chemokine signaling pathway
NFKBIB; CXCL5; NCF1; MAPK3; RAC1; CXCR4; SHC4; GRK5; CCL1; CCR10
Oocyte meiosis
ANAPC4; MAP2K1; CALM4; CALM3B; ESPL1; YWHAG; SLK; PPP3CCB; CALML5; YWHAZ
Apoptosis
NFKBIAA; IL1R1; DSG1; AKT3A; PRKACA; H1F0; STK24B; DCC; HIST1H1C; NFKB1
Adrenergic signaling in cardiomyocytes
ATP1A1A.1; CREB3L1; ATP1A3; PPP2R3C; CAMK2B1; AKT3A; MAPK1; AKT1; PRKACAB; CAMK2G1
Vascular smooth muscle contraction
MYL12.1; CACNA1C; KCNMA1A; CALM1A; KCNMB3; PRKACB; PLA2G2E; AVPR1A; PPP1CB; MLCK2
Wnt signaling pathway
WNT8B; MAPK8A; CAMK2G; WNT3; SFRP1A; CCND1; GSK3B; PPP3R2; PPP3R1; FBXW11B
Hedgehog signaling pathway
CSNK1G2; WNT8B; WNT8A; PRKACA; BTRC; PRKACAB; LRP2A; WNT9A; WNT3; GAS1A
Gap junction
PDGFD; TUBA1B; MAP2K2A; KRAS; TUBA8L3; GNAI2; HTR2C; GJD2; CDK1; PRKACG
Platelet activation
PLA2G4C; TLN1; RAP1A; PLA2G4D; PLA2G4F; ARHGEF12; AKT1; ITGA2B; PIK3CB; SYK
Circadian entrainment
PRKCA; GNG2; GNAQ; MTNR1B; GNAO1; GNB1; MAPK3; CAMK2A; CALM4; PER3
Long-term potentiation
GRIN1; GRIN2A; PPP3CC; MAP2K2; PLCB1; ARAF; HRAS; NRAS; PRKCB; PRKACA
Retrograde endocannabinoid signaling
GABRG3; SLC17A7; ITPR3; ABHD6; MAPK8; GABRB3; GNG5; PRKCB; GABRA3; FAAH
Glutamatergic synapse
GNGT1; GRIK3; GRIK1; GNG2; GNGT2; SLC38A3; GRIA4; PRKACG; HOMER3; PLCB3
Cholinergic synapse
NRAS; FOS; CREB3L2; CHRM3; GNA11; PRKACG; GNB2; PIK3R1; CHRM1; GNG12
Serotonergic synapse
MAOA; HTR4; GNG12; HTR6; PLCB2; GNG3; PTGS1; ALOX15; HTR3B; PRKCA
GABAergic synapse
SLC38A2; GABRR1; GABRA1; NSF; GLUL; GAD2; GNG8; GNB3; SLC38A3; GNB4
Dopaminergic synapse
CREB3L4; SLC6A3; DRD5; CALM1; PLCB4; GRIA1; ITPR3; KIF5C; PPP2R2D; PPP2R3A
Olfactory transduction
OR4N4; GUCY2E; OLFR186; OR2F1; OLFR494; OR5B2; OLFR10; OLFR498; OLFR5; OLFR477
Taste transduction
TAS2R109; TAS2R126; TAS2R144; TAS2R106; TAS2R13; TAS2R38; TAS2R118; Adcy4; TAS2R103; GNB1
Inflammatory mediator regulation of TRP channels
PRKCD; NTRK1; PIK3CB; CYP2C70; IL1B; MAP2K6; PPP1CC; HRH1; ACCN4; CALM3
Insulin signaling pathway
BRAF; SHC3; RAF1A; PPP1R3CA; TSC1; MKNK2A; PRKAB2; HRASB; PPP1R3DA; TSC1B
Insulin secretion
PDX1; CREB3L2; KCNN2; PRKCA; CAMK2B; CAMK2A; TRPM4; SNAP25; ATP1A3; KCNMB4
GnRH signaling pathway
MAPK9; RAF1B; FSHB; HRAS; CALML3; PLD1; MMP14; PRKCBB; ITPR1; PRKCDA
Ovarian steroidogenesis
AKR1C3; GNAS; HSD3B4; INS2; HSD3B6; PLA2G4C; INS1; Adcy4; IGF1; BMP6
Progesterone-mediated oocyte maturation
MAPK3; HSP90AA1.1; CPEB3; BUB1; SPDYB; MAPK14A; MAPK8B; PIK3CD; AKT2L; PIK3R3
Estrogen signaling pathway
CALML3; HSPA1L; SHC4; SOS1; MAP2K2; AKT2; GNAS; ATF6B; MMP2; CALM1
Melanogenesis
GSK3B; KITLGB; WNT11R; WNT9A; CAMK2G1; CAMK2A; Kitl; LEF1; TYRP1B; PRKCBB
Thyroid hormone synthesis
CREB3L2; GNAS; ASGR2; IYD; ATP1B1; ATF4; PRKCB; SLC5A5; ATP1B4; TSHR
Thyroid hormone signaling pathway
PRKACG; NRAS; MAP2K2; SIN3A; AKT2; MED1; PFKFB2; PLCE1; PLN; RXRB
Oxytocin signaling pathway
GUCY1A3; CACNB4; ROCK1; CALM4; CAMK2A; MYL6B; CAMK1G; CAMKK1; CACNG7; PRKCA
Glucagon signaling pathway
PLCB1; CALM1; SMEK1; FOXO1; CALM2; G6PC2; CALML3; AKT2; GCGR; GYS2
Regulation of lipolysis in adipocytes
PRKACG; LIPE; Adcy4; PIK3CG; INS2; PTGER3; PRKG2; INS; PNPLA2; TSHR
Renin secretion
AGTR1B; GNAI1; PRKACG; GNAQ; PPP3CB; NPR1; CALML5; CLCA3; PPP3CA; PPP3R2
Aldosterone synthesis and secretion
ADCY6; PRKD3; HSD3B1; KCNK9; CALM4; CREB3L3; PRKCE; ATF2; CREB3L2; GNAQ
Endocrine and other factor-regulated calcium reabsorption
PLCB1; PRKCA; GNAQ; ATP2B1; KLK1B8; KLK1B1; PLCB4; KLK1B22; ATP1B2; DNM2
Vasopressin-regulated water reabsorption
DCTN4; CREB3L1; PRKACG; DYNC1I1; AQP4; DYNLL1; AVP; AVPR2; ARHGDIB; DYNC1LI1
Salivary secretion
HTN1; CD38; PRKACG; BEST2; KCNN4; ATP1A2; ATP1B2; Adcy4; ATP1A3; STATH
Gastric acid secretion
CALML5; KCNJ2; GNAS; PLCB4; ATP1B1; KCNJ10; Slc4a2; CAMK2B; SST; CALM3
Bile secretion
BAAT; EPHX1; HMGCR; ADCY9; CFTR; SLC10A2; SLC4A4; SULT2A1; Car2; CYP7A1
Parkinsons disease
NDUFC2-KCTD14; MT-ND1; NDUFAB1; UQCRB; PINK1; NDUFA4L2; UBE2J2; UQCRQ; SLC25A6; UCHL1
Prion diseases
LAMC1; C8G; BAX; MAPK1; CASP12; C8A; IL1B; PRNP; LOC100033925; C6
Cocaine addiction
CDK5R1; CREB3L3; GRIA2; DRD1; GRIN3A; SLC18A2; PDYN; GNAI3; GRIN2C; GRM3
Amphetamine addiction
GRIA2; CALM3; SLC18A1; CALM1; HDAC1; ARC; GNAS; CALM2; DRD1A; CREB3
Morphine addiction
GABRR1; Adcy4; GRK5; GABRA5; PDE7A; GABBR1; PDE11A; PDE3B; GABBR2; PDE4A
Vibrio cholerae infection
ATP6V0E1; ATP6V0A4; ATP6V0D2; ATP6V0B; ATP6V0A2; ATP6V1H; TJP1; PLCG2; GNAS; ATP6V1E1
Amoebiasis
COL2A1; SERPINB6B; Casp3; LAMB3; IL12A; IL-8; IL12B; PIK3CB; PRKACA; CD14
HTLV-I infection
HLA-DOB; DVL2; ANAPC1; BAX; ATF4; IL1R2; POLD4; NFKB2; KAT2B; WNT16
Epstein-Barr virus infection
SFPI1; AKAP8L; EIF2AK4; HLA-DRB4; PSMD4; SHFM1; TAB2; CD58; YWHAE; LYN
Pathways in cancer
GNB3; BAD; IL-8; TP53; LAMB1; FH1; ROCK1; Pdgfa&Pdgfb; FGF12; CCNE2
Viral carcinogenesis
HIST1H4H; TRAF2; HIST2H2BB; HLA-C; ACTN3; VAC14; HIST1H2BG; MDM2; BAX; TBP
Proteoglycans in cancer
RPS6; PTCH1; PTPN11; ELK1; TWIST2; PIK3CG; PPP1CC; MAPK12; ACTB; ARHGEF1
Dilated cardiomyopathy
GNAS; PRKACA; TGFB1; PRKACG; ACTC1; PLN; RYR2; ITGA5; DMD; CACNG2

Protein Function

PRKACB has several biochemical functions, for example, ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACB itself. We selected most functions PRKACB had, and list some proteins which have the same functions with PRKACB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein RTCB; PIP4K2A; DALRD3; HSPE1; AK1; NRBP2; CARS; RAD51D; BBS10; GM7168
Function cAMP-dependent protein kinase activity
Related Protein PRKAA1; PRKACA; PRKX; PRKACG; PRKAG1; AKAP13; PRKACB
Function magnesium ion binding
Related Protein RPS6KAL; SPHK1; PRPS1A; NIM1K; IMPA1; CIB3; PGM2; ATP9B; NME1; ATP11C
Function protein binding
Related Protein PRKRIR; CENPJ; PRKAA1; SMAD2; ASB9; ASNA1; SFTPC; NPY1R; NAA35; ZNF652
Function ubiquitin protein ligase binding
Related Protein ARRB1; ANKRD32; RNF34; HSPA1B; GABARAPL1; NPLOC4; SMAD6; PRR5L; TXNIP; UBE2G1B

Interacting Protein

PRKACB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACB here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACB.
HSP90AB1; APPBP2; AKAP5; PRKAR2B; DYNLL1; MAPRE1; FLNA; RCAN1; CBFB; PITX2; ACVR1B; RPL27A; RPS6

PRKACB Related Articles

Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
Yang, L; Nakayama, Y; et al. GABA(C)-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. JOURNAL OF PHARMACOLOGICAL SCIENCES 106:578-584(2008).