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Official Full Name protein kinase, cAMP-dependent, catalytic, beta
Background cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.
Synonyms PRKACB; protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta; PKACb; PKA C-beta; protein kinase A catalytic subunit beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; MGC9320; MG
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PRKACB-173H Recombinant Human PRKACB, His-tagged E.coli His
    Human PRKACB-1947H Recombinant Human PRKACB, GST-tagged E.coli GST
    Human PRKACB-2868HCL Recombinant Human PRKACB 293 Cell Lysate HEK293 N/A
    Human PRKACB-30210TH Recombinant Human PRKACB N/A
    Human PRKACB-395H Recombinant Human PRKACB, GST-tagged, Active Sf9 Insect Cell GST
    Human PRKACB-553H Recombinant Human PRKACB, GST-tagged Sf9 Insect Cell GST
    Mouse PRKACB-13353M Recombinant Mouse PRKACB Protein Mammalian Cell His
    Rat PRKACB-4672R Recombinant Rat PRKACB Protein Mammalian Cell His
    Rhesus Macaque PRKACB-3602R Recombinant Rhesus monkey PRKACB Protein, His-tagged Mammalian Cell His

    PRKACB involved in several pathways and played different roles in them. We selected most pathways PRKACB participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway HSPA6; ECSIT; MAPK8IP3; TGFB3; SOS1; STMN1B; MAP3K7; MAPK11; MAP2K4B; FGF19
    Ras signaling pathway CALML3; FGF8; PLA2G12B; PIK3CB; PLA2G1B; KSR2; MAP2K2; FGF1; GRB2; BAD
    Calcium signaling pathway DRD1B; PRKCA; AGTR1A; CHRNA7; HTR5AL; CHRM5B; HRH1; GNA15.4; CACNA1C; P2RX5
    cAMP signaling pathway GRIA3; PIK3CB; HHIP; PAK1; PLN; CNGA3; CALML3; PIK3R2; RAP1A; Adcy4
    Chemokine signaling pathway PLCB4; SHC2; Ccl21a; CCL24; CCR3; CXCL6; IKBKB; CCL28; IL-8; JAK3
    Oocyte meiosis RPS6KA3B; Adcy4; CPEB3; YWHABL; CALM1; CALM3A; ANAPC1; PLCZ1; PPP3R1B; PPP1CBL
    Adrenergic signaling in cardiomyocytes PPP2CB; ADRB2A; ADCY1; PPP1CA; ATP1B3A; PPP2CA; TPM4B; PIK3R3B; CACNA1SB; GNA11A
    Vascular smooth muscle contraction PLA2G12A; CALM2B; PLA2G4A; MLCK2; PLCB2; RHOAB; MAP2K2; PRKCHA; ARHGEF12; RAF1
    Wnt signaling pathway FBXW11B; PRKACAB; SIAH1A; CSNK2A2A; WNT3A; PRICKLE2B; CER1; NLK; TRP53; RAC3
    Hedgehog signaling pathway GAS1A; BTRC; CSNK1G2; WNT9B; BMP2B; ZIC2; PRKACB; SAP18; HHIP; WNT5B
    Platelet activation RAP1A; ITPR3; COL27A1; GNAI3; GP1BB; GNAQ; PRKACA; PLCB1; P2RX1; PLA2G4D
    Circadian entrainment GRIN2B; GNB3; PLCB4; RYR1; GNG8; GRIA1; CAMK2D; GNG2; PRKCG; PRKCA
    Long-term potentiation PRKCB; GRM5; CAMK2B; GRIA2; PPP1R1A; CAMK2A; GRIN2B; PRKCA; PPP1CC; GRIA1
    Retrograde endocannabinoid signaling GRIA1; PLCB2; SLC17A6; MAPK1; GNGT1; ABHD6; GABRD; GABRR1; MAPK8; PLCB4
    Glutamatergic synapse SHANK2; GRIN2A; ITPR3; PLCB3; SLC17A7; PPP3CB; GNG11; GNG10; PRKCG; GNGT2
    Cholinergic synapse CHRNA7; CHRNB4; CHRM1; SLC5A7; GNAI3; GNG12; CREB5; CAMK2A; GNG7; PIK3CG
    Serotonergic synapse GNGT1; HTR1A; PTGS1; GNB2; HTR1E; GNGT2; ALOX5; GNAQ; PLA2G4A; ALOX12B
    GABAergic synapse PRKACG; GNAI1; SLC6A1; GNB3; SLC38A5; GAD2; GABARAP; GAD1; GLS; GNG7
    Dopaminergic synapse CREB5; DRD1A; PPP2R2C; PPP2R1B; ATF6B; DRD2; PPP1CC; CALM1; PLCB1; SLC18A2
    Olfactory transduction PDE1B; OR10J1; OR5B2; OLFR495; OR2F1; OLFR1440; OLFR494; OR10W1; OLFR49; CALM1
    Taste transduction TAS2R125; GNAT3; TAS2R129; TAS2R13; TAS2R114; TAS2R103; GNB1; TAS2R40; GRM4; PDE1A
    Inflammatory mediator regulation of TRP channels PRKCB; PIK3R2; PRKCG; PIK3CD; PRKACB; PRKCQ; PPP1CC; PLA2G6; IGF1; PLA2G4D
    Insulin signaling pathway PRKAR1B; EXOC7; PIK3CG; BADB; INPP5K; PRKACBB; PIK3CD; MAPK8; PCK2; MAP2K1
    Insulin secretion ATP1A3; PRKACA; ADCYAP1; ATP1B1; CREB5; PRKACB; ATP1B4; KCNN4; KCNN1; PRKACG
    GnRH signaling pathway EGFRA; MAPK10; CALM; CALM2; RAF1A; CACNA1C; CALML3; HRASA; GRB2B; MAP2K2B
    Ovarian steroidogenesis CYP2J5; GDF9; ACOT2; PLA2G4F; INS2; GNAS; IGF1; PRKACG; IGF1R; PRKACA
    Progesterone-mediated oocyte maturation MAPK8A; PRKACAA; CPEB3; PIK3R1; CPEB1; PPP1R2P9; PIK3R2; INS; MAPK10; GNAI2A
    Estrogen signaling pathway PRKACA; NRAS; CREB5; GRB2; MMP9; HSP90AA1; ITPR3; ATF6B; MAP2K2; KCNJ9
    Melanogenesis WNT11; PRKACBA; PRKACB; CALM4; DCT; TCF7; Adcy4; GSK3B; WNT2BB; WNT9B
    Thyroid hormone synthesis CREB3L2; DUOXA2; CANX; PDIA4; ATP1B3; ATP1B1; GPX1; TSHR; TG; ASGR1
    Thyroid hormone signaling pathway SLC16A2; PIK3CD; TRP53; SLCO1C1; MED12; MDM2; RHEB; PRKACB; MED24; TP53
    Oxytocin signaling pathway ROCK2; PIK3R3; PRKAG3; MEF2C; CAMK4; PIK3CB; CAMK2B; CACNB3; CAMK1G; PRKAA2
    Glucagon signaling pathway PPP3CA; LDHA; PLCB1; PPARA; PRKAA1; PRKACB; PPP3CC; EP300; PDHA2; PHKG2
    Regulation of lipolysis in adipocytes PIK3R3; INS1; PIK3R2; PTGS2; PIK3CB; IRS4; GNAS; PIK3R1; PRKACB; ABHD5
    Renin secretion CLCA4; CALM3; PDE1A; PPP3R1; GNAS; GNAI3; Ren1; CALM1; ITPR3; PRKACB
    Aldosterone synthesis and secretion CREB3L4; ITPR2; HSD3B5; CREB3L1; HSD3B2; CAMK1G; NETO2; ADCY6; KCNK9; CALML5
    Endocrine and other factor-regulated calcium reabsorption KL; PLCB1; ATP1A2; KLK1B1; ATP2B1; BDKRB2; PRKCG; ATP1A1; KLK1B22; FXYD2
    Vasopressin-regulated water reabsorption AVPR2; CREB3L1; DCTN5; AVP; DCTN6; RAB11A; GNAS; AQP2; NSF; VAMP2
    Salivary secretion PRKG1; ATP1B1; CALM4; MUC5B; PLCB1; ATP1A3; KCNN4; CST3; GNAS; PLCB2
    Gastric acid secretion GNAQ; GNAI1; CAMK2B; KCNJ15; KCNE2; Car2; ATP1B1; SST; PRKCB; CAMK2A
    Bile secretion SCARB1; AQP8; CA2; SLC5A1; SLC10A1; NCEH1; SLC9A1; ATP1A1; SLC10A2; CFTR
    Parkinsons disease PPIF; NDUFB9; ATP5C1; NDUFA1; GNAI2; COX5A; NDUFA12; NDUFS2; NDUFB1; COX7A2L
    Prion diseases MAPK3; C1QA; NCAM2; C6; NOTCH1; C8A; FYN; IL1B; BAX; C1QB
    Cocaine addiction PRKACG; ATF6B; DRD1A; CREB3L1; GNAI2; CDK5; GRIN3A; DRD2; GRM3; BDNF
    Amphetamine addiction HDAC1; SIRT1; GRIN2D; GRIA2; MAOA; CAMK2A; TH; GRIN2B; DRD1A; CALM3
    Morphine addiction GNAO1; PRKCG; ADRBK2; GABRR1; PDE11A; GABRE; OPRM1; GNG10; GABRB2; GABRG3
    Vibrio cholerae infection PLCG2; TJP1; ATP6V1C1; PRKACA; ATP6V0A1; PRKACG; PLCG1; ATP6V1F; ATP6V0A2; ATP6V0D2
    Amoebiasis COL5A2; COL4A6; GNA15; GNA11; TGFB3; PRKCG; PLCB1; SERPINB1; IL12A; Itgam&Itgb2
    HTLV-I infection ELK1; CCNB2; RAN; CDC20; ANAPC5; MSX2; IL2RA; TGFB1; FZD1; CDC23
    Epstein-Barr virus infection PSMD12; NEDD4; POLR2G; RELB; POLR2J; RBPJL; PSMC1; YWHAE; TRAF2; POLR3B
    Pathways in cancer FOXO1; GNG12; RAF1; PML; BDKRB1; GNG4; CXCL12; SOS1; RAC2; RBX1
    Viral carcinogenesis GTF2E2; HRAS; HIST1H4K; HIST1H4B; CREB3L2; GTF2H1; HDAC2; SCRIB; HDAC8; GTF2H3
    Proteoglycans in cancer PRKACG; PTCH1; FLNA; FZD7; HRAS; FZD10; PRKCA; MET; SDC4; FGFR1
    Dilated cardiomyopathy ITGA7; ACTC1; Adcy4; CACNA2D1; ITGAV; PRKACA; TPM4; CACNB2; ITGB6; ITGA8

    PRKACB has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACB itself. We selected most functions PRKACB had, and list some proteins which have the same functions with PRKACB. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NTRK2; CDC6; ABCB5; ACSL4; CKBA; POMK; DHX36; FGFR4; DHX30; MAP2K1
    cAMP-dependent protein kinase activity PRKACG; PRKACA; PRKAG1; PRKACB; PRKAA1; PRKX; AKAP13
    magnesium ion binding ATP8A1; STK36; PGM3; IMPA1; PDXK; CLYBL; NT5C3L; SRR; ENO3; PPA1A
    protein binding TBC1D10C; MRPL12; RPP38; GK; NR4A1; CCDC108; HIST1H1E; KCNIP2; KCNMB4; UBAP2L
    ubiquitin protein ligase binding SCN5A; PRKAR2B; UBE2K; ERLIN2; STUB1; PA2G4; GRIK2; DNAJA1; UBE2Z; UBE2NA

    PRKACB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACB here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACB.


    Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
    Yang, L; Nakayama, Y; et al. GABA(C)-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. JOURNAL OF PHARMACOLOGICAL SCIENCES 106:578-584(2008).

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