prkacb
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  • Official Full Name
  • protein kinase, cAMP-dependent, catalytic, beta
  • Background
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PRKACB; protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta; PKACb; PKA C-beta; protein kinase A catalytic subunit beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; MGC9320; MG
Cat.#:PRKACB-173HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, His-tagged
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Cat.#:PRKACB-1947HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-30210THTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB
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Cat.#:PRKACB-395HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged, Active
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Cat.#:PRKACB-553HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-13353MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKACB Protein
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Cat.#:PRKACB-4672RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKACB Protein
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Cat.#:PRKACB-3602RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRKACB Protein, His-tagged
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Cat.#:PRKACB-2868HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB 293 Cell Lysate
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Involved Pathway

PRKACB involved in several pathways and played different roles in them. We selected most pathways PRKACB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPK3; PRKACAA; NTF4; PPP3CCA; MAP3K14; MRAS; MAPK8IP2; PAK2A; FGF13; MAX
Ras signaling pathway
VEGFB; PAK7; GNGT1; HRAS; PLA2G6; RAB5B; SHC1; ETS2; RIN1; CALM4
Calcium signaling pathway
ADORA2AB; PRKACBB; PTGER3; CAMK2D2; SPHK2; GNAL; PTGER1A; DRD1B; ADCY1B; GRIN2C
cAMP signaling pathway
NFKBIA; GRIN3A; PDE4C; HTR6; DRD1A; RHOA; PPP1CB; FOS; GRIA3; GHRL
Chemokine signaling pathway
CCL17; IKBKG; CCL8; DOCK2; CXCL16; PRKACA; SHC4; CXCL10; RELA; JAK3
Oocyte meiosis
BTRC; RPS6KA1; CDC20; CAMK2A; RPS6KA3A; ANAPC2; CAMK2G1; MAP2K1; PPP1CBL; CAMK2D2
Apoptosis
CAPN1B; IL3RA; CSF2RB; FASLG; HIST1H1D; PPP3CB; BIRC7; ATM; TNFRSF1A; DIABLOB
Adrenergic signaling in cardiomyocytes
PPP2CB; TNNC1A; CREB3L3L; CACNG2A; MAPK14B; CALM2B; CACNB4; ATP1A1B; PPP2R3A; ATP1B1B
Vascular smooth muscle contraction
PRKCDA; MAP2K1; PLCB2; PRKG1; PRKCA; ROCK1; ARAF; PLA2G12B; CYP4A14; PPP1R12B
Wnt signaling pathway
PPP3R1; PPARD; RAC3B; SOST; LEF1; CAMK2A; FZD6; WNT6; WNT4; NFATC2
Hedgehog signaling pathway
WNT2BA; GLI2B; IHHA; ZIC2; PRKACA; SAP18; GLI2A; WNT1; PRKACBB; WNT11B
Gap junction
TUBA3A; TUBA3D; GUCY1B3; TUBA1L2; MAP2K2A; RAF1A; GRB2B; PDGFRB; TUBA8; TUBA1L
Platelet activation
PLCB4; ACTG1; PIK3CB; GNAI1; RHOA; FYN; PLCB2; ITGB1; MYL12A; ROCK1
Circadian entrainment
PRKG1; GNG10; NOS1; PLCB2; NOS1AP; GUCY1B3; Adcy4; GRIN2C; GNB2; CALM3
Long-term potentiation
PPP1CB; CAMK2B; GRIN2B; CAMK2G; RAF1; EP300; CALML3; GRIN2C; PPP1R1A; PLCB4
Retrograde endocannabinoid signaling
GABRA2; GABRQ; GABRA6; MAPK10; PLCB4; GNGT2; GNB2; GNB3; RIMS1; GABRB1
Glutamatergic synapse
HOMER3; GRIN3A; SLC1A1; GLUL; GNG13; PLCB3; PRKCG; GRIA4; PRKCA; SLC1A6
Cholinergic synapse
JAK2; ITPR1; BCL2; GNAI3; ACHE; CHRNB4; CAMK2D; NRAS; PRKCA; KCNJ3
Serotonergic synapse
ALOX12B; Casp3; HTR3A; GNGT2; GNG13; PRKCG; PRKACA; MAPK3; GNB3; MAP2K1
GABAergic synapse
GABRR1; GNAI3; GNG10; GNB1; GNG4; GABRA1; GNGT2; GABRG2; GABARAPL1; GNB4
Dopaminergic synapse
COMT; PPP2R2B; GNB3; KCNJ9; GRIA4; GRIA1; GNG3; CREB3; PPP1CB; KIF5A
Olfactory transduction
OR5H1; PDE1B; CALM3; OLFR8; OLFR474; OLFR498; OLFR478; OR4D2; OR10C1; OR7C1
Taste transduction
TAS2R114; GNAS; Adcy4; TAS2R136; TAS1R2; GNG13; TAS2R38; TAS2R109; TAS2R42; TAS2R121
Inflammatory mediator regulation of TRP channels
PLCG1; ASIC2; P2RY2; NTRK1; CALM4; PRKACB; PPP1CB; ACCN5; NGF; CYP2C37
Insulin signaling pathway
SREBF1; PYGMA; BADB; G6PC; IRS4; FLOT1; GYS1; HRASB; FLOT1A; ACACB
Insulin secretion
ATP1A3; GLP1R; RIMS2; FXYD2; KCNN1; PRKCA; INS; FFAR1; Adcy4; KCNJ11
GnRH signaling pathway
PRKCDA; ELK1; MMP14B; MAPK3; CACNA1D; ITPR1; PRKACBB; CACNA1C; MAPK7; GNRH2
Ovarian steroidogenesis
PTGS2; PLA2G4C; Adcy4; GDF9; INS; IGF1; FSHB; PRKACG; HSD3B6; LHB
Progesterone-mediated oocyte maturation
PIK3R1; RAF1; ANAPC4; PIK3CA; ADCY1B; ARAF; AKT1; HSP90AA1; RPS6KA3; CDC25A
Estrogen signaling pathway
PIK3R2; CREB3L1; HSPA8; PLCB1; PIK3R3; PIK3CB; CALM2; PIK3R1; HSPA1L; HSPA2
Melanogenesis
WNT4; HRAS; WNT2B; Adcy4; PRKACBA; CREB1A; WNT10B; ASIP; PRKCBA; FZD8A
Thyroid hormone synthesis
CREB3L2; PLCB1; ATP1B3; GPX5; GPX6; PRKCB; SLC26A4; HSP90B1; ATP1B4; GSR
Thyroid hormone signaling pathway
PRKACB; THRA; PIK3R1; PLCG1; CASP9; PIK3CG; AKT1; PRKCB; DIO1; KAT2A
Oxytocin signaling pathway
PRKAB1; CALM4; PLA2G4A; CACNA2D2; TRPM2; CALM2; NRAS; OXT; PLCB1; CALM1
Glucagon signaling pathway
PPP3CC; PHKG2; G6PC3; AKT1; PGAM1; PDE3B; LDHC; PPP3CB; PYGL; GYS1
Regulation of lipolysis in adipocytes
NPY1R; PIK3R1; AKT2; PRKACA; PRKG1; PTGS1; IRS1; LOC100328615; AQP7; AKT1
Renin secretion
ITPR3; GNAI2; GNAS; AQP1; REN2; CALML5; GNAI3; PTGER4; PDE1A; ITPR1
Aldosterone synthesis and secretion
ATF2; PRKD1; PRKCB; CYP11A1; NR4A2; MC2R; LIPE; PRKD3; SCARB1; CALM4
Endocrine and other factor-regulated calcium reabsorption
FXYD2; KLK1B24; KLK1B5; PLCB2; CALB1; KLK1; GNAS; PLCB1; PRKACA; PRKACG
Vasopressin-regulated water reabsorption
RAB11A; GNAS; DYNC2H1; RAB5C; STX4; ARHGDIG; VAMP2; RAB5B; RAB11B; DYNC2LI1
Salivary secretion
PLCB3; PRKCB; STATH; BEST2; CALM1; CAMP; ITPR1; ATP1B1; DMBT1; CAP18
Gastric acid secretion
CAMK2G; GNAQ; PRKACB; KCNE2; CALML5; GNAI2; ITPR3; CAMK2A; PRKACA; CCKBR
Bile secretion
Abcb1b; ABCG2; OSTB; EPHX1; SLC51A; GNAS; ABCC2; SLC22A8; SLCO1A6; CA2
Parkinsons disease
NDUFB3; NDUFS2; ATP5D; NDUFA5; PPIF; UQCRC1; COX6A2; SDHB; GNAI3; COX4I2
Prion diseases
CASP12; MAPK1; MAP2K2; C8G; C7; C8B; IL1B; PRKACG; IL6; ELK1
Cocaine addiction
DDC; PRKACB; GNAI1; CREB3L3; PRKACG; GNAI3; SLC6A3; FOSB; PRKACA; SLC18A1
Amphetamine addiction
CREB3L3; SLC18A2; FOSB; CALML5; GNAS; PPP1CC; MAOA; PRKACG; NETO2; GRIN2B
Morphine addiction
PDE3B; PDE4B; GRK6; PDE3A; GABRQ; GNB4; GABRR2; PDE10A; GNG4; GNB1
Vibrio cholerae infection
ATP6V1E1; MUC2; ATP6V0A2; ATP6V0D1; KDELR3; ATP6V1G1; PLCG1; ATP6AP1; ATP6V1D; TJP2
Amoebiasis
LAMA3; SERPINB1; C8A; CD1d1; RAB7A; LAMA4; ITGB2L; PLCB4; PLCB3; PTK2
HTLV-I infection
EP300; WNT5A; SFPI1; AKT1; IKBKG; AKT2; WNT4; ATF4; LCK; MAP3K3
Epstein-Barr virus infection
PSMD4; TRAF6; HDAC4; PRKACG; POLR2F; POLR2H; MAPK13; AKAP8L; NFKB1; HLA-G
Pathways in cancer
BIRC2; GNG7; FGF1; RARA; RXRG; WNT3A; EPAS1; PTCH1; APC2; IGF1
Viral carcinogenesis
PRKACG; HDAC4; HLA-G; GRB2; TRAF1; MAD1L1; DLG1; HIST1H2BC; RELA; KRAS
Proteoglycans in cancer
WNT10B; FZD8; STAT3; Fasl; IGF1R; PRKCA; CDC42; CAMK2B; KRAS; FZD9
Dilated cardiomyopathy
DAG1; Itga10&Itgb1; Adcy4; CACNA2D3; RYR2; TNNC1; CACNG2; TTN; ITGB4; ITGA4

Protein Function

PRKACB has several biochemical functions, for example, ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACB itself. We selected most functions PRKACB had, and list some proteins which have the same functions with PRKACB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DDX11; cka1; DHX16; MAPKAPK2A; SYN2; DHX33; CSNK1G2; FGFR3; MKNK1; MARS2
Function cAMP-dependent protein kinase activity
Related Protein PRKACG; PRKX; AKAP13; PRKACB; PRKAG1; PRKACA; PRKAA1
Function magnesium ion binding
Related Protein ATP8B5; ATP9A; IMPA2; NUDT7; NUAK2; PSPH; SIK3; NIM1K; NUDT3; PGP
Function protein binding
Related Protein PAK1IP1; BEX2; FCRL2; IL1R1; SERPINF2; MAPKAPK3; CROP; AHSP; GNE; ZNF69
Function ubiquitin protein ligase binding
Related Protein UBE2W; PTPN22; ACTG1; BCL10; UBE2L3; STX8; CDC34; FZD6; MC1R; EGFR

Interacting Protein

PRKACB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACB here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACB.
HSP90AB1; APPBP2; AKAP5; PRKAR2B; DYNLL1; MAPRE1; FLNA; RCAN1; CBFB; PITX2; ACVR1B; RPL27A; RPS6

PRKACB Related Articles

Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
Yang, L; Nakayama, Y; et al. GABA(C)-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. JOURNAL OF PHARMACOLOGICAL SCIENCES 106:578-584(2008).