prkacb
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  • Official Full Name
  • protein kinase, cAMP-dependent, catalytic, beta
  • Background
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PRKACB; protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta; PKACb; PKA C-beta; protein kinase A catalytic subunit beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; MGC9320; MG
Cat.#:PRKACB-173HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, His-tagged
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Cat.#:PRKACB-1947HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-30210THTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB
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Cat.#:PRKACB-395HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged, Active
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Cat.#:PRKACB-553HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-13353MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKACB Protein
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Cat.#:PRKACB-4672RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKACB Protein
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Cat.#:PRKACB-3602RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRKACB Protein, His-tagged
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Cat.#:PRKACB-2868HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB 293 Cell Lysate
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Involved Pathway

PRKACB involved in several pathways and played different roles in them. We selected most pathways PRKACB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACB were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
CACNG1A; NLK1; FGFR1; STK3; Casp3; RAF1; HSPA2; HSPA1B; PRKACAB; HRASA
Ras signaling pathway
FGF8; ZAP70; FGF2; PLCG1; NGFR; IKBKB; FGF3; PLA2G2D; PLCG2; PIK3R3
Calcium signaling pathway
PHKB; GRIN1; PDE1C; RYR1B; PHKA1; PPP3R2; CHRM1; SLC25A31; P2RX4A; PDGFRA
cAMP signaling pathway
AMH; CREB3L2; SLC9A1; HTR1E; FFAR2; GRIN2C; LIPE; HTR1A; PPP1CB; FOS
Chemokine signaling pathway
CXCL10; NCF1; SHC1; XCL2; CCL1; ELMO1; Ccl9; GSK3A; CCL25; NFKBIB
Oocyte meiosis
CALM1; SPDYA; PGR; PRKACBA; YWHAQB; YWHAE; PPP2R5D; PPP2R5A; ANAPC1; CCNE2
Apoptosis
PRKAR2A; DSG2; IRAK1; BCL2L1; IL1A; DSG1; TNFRSF1A; CSF2RB; IL1RAP; MYC
Adrenergic signaling in cardiomyocytes
CACNB1; ADRA1BB; GNAIA; PIK3R2; AGTR1A; CACNB2; PPP2R5E; CALML3; MAPK11; PPP2R1A
Vascular smooth muscle contraction
PRKCG; KCNMA1A; MLCK2; BRAF; PRKACB; PLA2G2F; GUCY1A3; ADORA2AB; KCNMB2; RAF1A
Wnt signaling pathway
WNT5A; RAC1; ROCK2A; CUL1; WNT10B; DVL1B; PRKCBB; TCF7L1A; FOSL1A; FBXW11A
Hedgehog signaling pathway
WNT6; CSNK1G1; ZIC2; GSK3B; BMP2B; SMO; GAS1B; SKI; WNT4A; WNT16
Gap junction
GRB2A; GUCY1B3; ADRB3A; PRKACAB; TUBA4A; HTR2CL1; RAF1A; SRC; PLCB3; TJP1
Platelet activation
PRKACG; GP1BB; GP5; NOS3; MYLK; F2RL3; LYN; STIM1; ROCK2; FCGR2A
Circadian entrainment
NOS1; GRIA1; ITPR1; PER2; CAMK2D; PRKACB; FOS; GRIA4; GRIN2D; GRIN2C
Long-term potentiation
CAMK2B; MAPK1; NRAS; MAP2K2; PRKCB; PRKCG; PPP1CA; PPP3CC; HRAS; EP300
Retrograde endocannabinoid signaling
GABRE; GABRR1; GABRR3; GRIA4; GNB3; GNG12; GRIA2; GABRA6; MAPK11; GABRA1
Glutamatergic synapse
GNGT1; PPP3CC; GNG10; GLUL; GRIA4; SLC1A3; MAPK3; GRIN2C; GRM4; GRM5
Cholinergic synapse
PRKACA; CHRM2; JAK2; GNGT1; ITPR1; GNG12; CREB3L3; PIK3R3; CHRNA4; GNG8
Serotonergic synapse
HTR7; HTR1F; ALOX15B; CYP2D10; GNAI2; NRAS; GNG13; HTR3C; CYP2J5; TPH2
GABAergic synapse
GNGT2; GNG10; GABRE; SLC38A3; GLS2; GNAI3; HAP1; GABBR2; GABRA3; GABBR1
Dopaminergic synapse
CAMK2B; PRKACG; CALML3; GNB2; GNAI2; DDC; GRIA4; PLCB3; DRD1A; DRD5
Olfactory transduction
OR4D6; OLFR477; OR2K2; OLFR494; OLFR18; OLFR498; OR51D1; CAMK2D; OLFR469; PRKG1
Taste transduction
TAS2R118; TAS2R143; SCNN1B; GNAS; PRKACG; TRPM5; GRM4; ITPR3; TAS2R137; TAS2R144
Inflammatory mediator regulation of TRP channels
Adcy4; PLA2G4A; PLA2G4C; CALM1; ALOX12; CALML3; HRH1; PLA2G6; MAPK8; ITPR1
Insulin signaling pathway
PRKAR2A; PHKB; RAPGEF1; PRKAR1B; SLC2A4; PCK2; AKT1; G6PC; CALML3; HK2
Insulin secretion
ATP1B2; KCNMB2; Adcy4; KCNN2; INS; CCKAR; KCNJ11; PDX1; PRKCB; ATP1B4
GnRH signaling pathway
NRAS; RAF1B; CAMK2D2; PRKCBB; MAPK12A; MAP3K2; GNRHR2; MAP2K6; MAPK14B; CACNA1SA
Ovarian steroidogenesis
STAR; BMP6; CYP2J5; FSHR; HSD17B2; LDLR; PLA2G4A; ACOT2; PLA2G4F; SCARB1
Progesterone-mediated oocyte maturation
RPS6KA1; MAPK12A; MAPK9; MAD1L1; ANAPC5; MAPK11; PIK3R1; PRKACBB; MAPK1; HSP90AB1
Estrogen signaling pathway
HSPA2; HSPA8; PIK3CG; GNAS; PLCB2; GRM1; GNAI1; KCNJ5; Adcy4; GNAO1
Melanogenesis
MAP2K2A; CREB3L3; CAMK2D2; FZD6; KIT; CREB3L1; CALM1B; WNT8A; KITLGB; FZD8
Thyroid hormone synthesis
CREB3L2; CANX; PLCB2; DUOXA2; PRKCA; ATF4; ATP1B1; FXYD2; SLC26A4; GNAS
Thyroid hormone signaling pathway
ITGAV; KRAS; HDAC1; KAT2A; HRAS; ATP1B2; TP53; MED1; PLCB1; RXRB
Oxytocin signaling pathway
ACTG1; PIK3R5; CALML3; OXTR; CALM1; ROCK1; PRKACA; CAMK2D; ROCK2; CAMK1G
Glucagon signaling pathway
AKT2; PFKFB1; PPP3R2; LDHB; PRKACG; CALM1; ITPR1; G6PC2; CAMK2G; SIRT1
Regulation of lipolysis in adipocytes
LIPE; PIK3CD; IRS1; PRKACG; IRS4; FABP4; PIK3CG; PTGS2; IRS2; PRKG1
Renin secretion
CLCA4; CALM1; PDE3B; PRKACA; ORAI1; CLCA3; PTGER4; GNAS; PRKACG; ITPR3
Aldosterone synthesis and secretion
CYP11B2; AGTR1B; CAMK1; CREB5; ITPR3; GNAQ; ADCY3; ATF4; CYP11A1; ATF1
Endocrine and other factor-regulated calcium reabsorption
FXYD2; KLK1B22; KLK1B8; KLK1B24; PRKCB; DNM2; PLCB2; ATP1A2; PRKCA; PLCB4
Vasopressin-regulated water reabsorption
RAB5C; ARHGDIG; GNAS; PRKACG; DCTN5; ARHGDIA; AQP2; DYNC1LI1; PRKACA; CREB3L1
Salivary secretion
MUC5B; CALML3; AMY1B; PLCB2; GNAQ; BEST2; MUC7; NOS1; LYZ1; PRKCA
Gastric acid secretion
KCNJ15; KCNJ2; KCNK10; SSTR2; ATP1A3; KCNE2; PLCB1; GNAI3; Car2; SST
Bile secretion
FXYD2; SLC9A3; PRKACA; AQP4; SLCO1B3; OSTB; HMGCR; ABCG8; EPHX1; ABCC3
Parkinsons disease
UQCRB; ATP5G1; SLC25A5; UBA7; SLC25A6; SLC25A31; NDUFA12; NDUFV2; NDUFA6; UCHL1
Prion diseases
MAP2K2; C5; C7; NOTCH1; IL6; BAX; ELK1; C1QC; Hc; SOD1
Cocaine addiction
DRD1A; GRIN2B; DDC; CREB3; MAOB; SLC18A1; GRM2; PDYN; CDK5R1; DRD1
Amphetamine addiction
PRKCB; TH; GRIN3B; CREB5; CAMK2D; MAOB; GNAS; SLC18A1; CREB3L4; CALM4
Morphine addiction
PDE7B; PDE2A; GABRG3; GABRE; GNB4; ARRB2; GNB1; GABRR2; PDE1B; PDE1A
Vibrio cholerae infection
ATP6V1E2; KDELR2; PRKACG; ATP6V0A2; ATP6V0E1; ATP6V1D; PRKCA; ERO1L; ATP6V1A; ATP6V1F
Amoebiasis
CD1D; TNF; ITGAM; PIK3R1; COL1A1; C8A; SERPINB2; IL10; ACTN2; ITGB2L
HTLV-I infection
ITGB2; VCAM1; IKBKG; POLE4; IL1R2; POLE; HLA-DRB5; TGFB1; NRP1; CD40
Epstein-Barr virus infection
HSPA6; HLA-E; PSMD6; PSMC3; TBK1; SKP2; TRAF3; PSMD11; PSMC4; POLR2F
Pathways in cancer
FIGF; CSF3R; ARHGEF12; SPI1; MDM2; LPAR2; CASP8; ARNT; MAPK10; FGF2
Viral carcinogenesis
RELA; SNW1; GTF2H1; HIST2H2BB; SCIN; CREB5; RBL1; BAK1; YWHAG; HPN
Proteoglycans in cancer
FASLG; HOXD10; RPS6KB1; PLAUR; MAPK1; RPS6KB2; WNT16; FZD7; WNT6; SOS1
Dilated cardiomyopathy
TNF; ACTB; ITGA9; ITGB4; ITGA2B; TPM2; LAMA2; ITGA3; MYL2; ITGA4

Protein Function

PRKACB has several biochemical functions, for example, ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACB itself. We selected most functions PRKACB had, and list some proteins which have the same functions with PRKACB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PDK4; UBE2K; MYO7A; KHK; LATS1; ADCY3; ACTBL2; UBE2U; PIK3C2B; PRKCD
Function cAMP-dependent protein kinase activity
Related Protein PRKAG1; PRKACA; PRKACG; PRKAA1; PRKACB; PRKX; AKAP13
Function magnesium ion binding
Related Protein STK4; ZNF143B; MAP2K7; PI4K2A; RPS6KA3A; PGM1; PRKACB; DYRK3; ENOSF1; ABL2
Function protein binding
Related Protein PIP5K1C; NCF1; ARFRP1; POLR2C; PKD2L1; NBL1; HBD; CSNK1D; NMI; RHPN1
Function ubiquitin protein ligase binding
Related Protein YOD1; TRAF5; SNX9; DIO2; RNF40; RBX1; ATP6V0C; FZD6; CCDC50; CALR

Interacting Protein

PRKACB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACB here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACB.
HSP90AB1; APPBP2; AKAP5; PRKAR2B; DYNLL1; MAPRE1; FLNA; RCAN1; CBFB; PITX2; ACVR1B; RPL27A; RPS6

PRKACB Related Articles

Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
Yang, L; Nakayama, Y; et al. GABA(C)-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. JOURNAL OF PHARMACOLOGICAL SCIENCES 106:578-584(2008).