prkacb
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  • Official Full Name
  • protein kinase, cAMP-dependent, catalytic, beta
  • Background
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PRKACB; protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta; PKACb; PKA C-beta; protein kinase A catalytic subunit beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; MGC9320; MG
Cat.#:PRKACB-173HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, His-tagged
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Cat.#:PRKACB-1947HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-30210THTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB
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Cat.#:PRKACB-395HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged, Active
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Cat.#:PRKACB-553HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
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Cat.#:PRKACB-13353MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKACB Protein
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Cat.#:PRKACB-4672RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKACB Protein
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Cat.#:PRKACB-3602RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRKACB Protein, His-tagged
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Cat.#:PRKACB-2868HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB 293 Cell Lysate
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Involved Pathway

PRKACB involved in several pathways and played different roles in them. We selected most pathways PRKACB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACB were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAPK8B; CACNA1BA; MAP2K3; PPM1NA; NTRK2; PLA2G4D; MECOM; SRFA; PPP3CB; NLK1
Ras signaling pathway
AKT2; FGFR4; ANGPT4; SHC4; FASLG; FGF1; VEGFA; RAC2; PLA2G2D; RASGRF2
Calcium signaling pathway
GRIN2D; CALM2B; BDKRB2; ADRB3B; HTR5AL; CAMK2B1; GNA11; PRKCBA; PRKACBB; MYLK3
cAMP signaling pathway
CALML3; FXYD1; NPY1R; PIK3CA; PIK3R2; CREB3L3; HTR6; CNGA1; CNGA2; PDE3A
Chemokine signaling pathway
GNG8; PRKACA; CXCR4; CCL17; PRKCB; GNB2; GSK3B; GM13306; JAK2; PRKCD
Oocyte meiosis
PPP2CB; CPEB4; REC8; PRKACG; FBXO43; SMC1AL; CALM4; PRKACB; PPP1CC; CDC16
Apoptosis
CAPN2A; CASP6; CASP2; AIFM1; DNM1L; DSG2; BIDA; IRF1B; IRAK2; IRAK1
Adrenergic signaling in cardiomyocytes
CACNA2D1A; CALM4; CACNG2A; ATF4; ATP1A3B; AKT1; PPP1CAA; TPM4B; ATP1B3A; VMHC
Vascular smooth muscle contraction
CACNA1SB; GNA15.4; CALM4; PRKCBB; MAP2K2; GNA12; RHOAA; CALM; PRKACAA; RAF1A
Wnt signaling pathway
CXXC4; MAPK9; GPC4; MAP3K7; PORCN; WNT11; WNT2B; CSNK1A1L; WNT11R; VANGL2
Hedgehog signaling pathway
WNT4A; WNT7AA; WNT8B; WNT7B; WNT8A; WNT16; PTCH1; SAP18; PRKACA; PRKACBA
Gap junction
MAP2K2; HTR2C; PLCB1; TUBA3A; HRAS; TUBB6; PRKCBA; PDGFA; TUBA1A; GRM5
Platelet activation
GP5; F2RL3; PIK3CG; PTGS1; PRKCZ; ITPR3; PIK3CB; GNAI2; MAPK3; GUCY1A3
Circadian entrainment
GNAI1; PRKACB; CALML3; PER2; CALM2; MAPK3; PRKCG; CALM1; PRKG2; GRIN1
Long-term potentiation
PRKCA; CALML3; RPS6KA6; GRIN1; ARAF; CAMK2A; GRM5; PRKCB; ATF4; PPP3CC
Retrograde endocannabinoid signaling
GABRR1; ITPR1; GNAI2; GNB4; GNG2; PLCB4; GRM5; GABRQ; PRKACG; FAAH
Glutamatergic synapse
MAPK1; PLCB4; PLA2G4A; PRKCB; GLS2; SLC38A1; SLC17A8; SHANK3; ADRBK2; GRM4
Cholinergic synapse
BCL2; KCNQ2; PRKCB; CHRM3; ITPR3; ATF4; CHRNA3; GNB2; CHRNB4; HRAS
Serotonergic synapse
HTR3A; GABRB1; CYP2D10; HTR2B; GNGT2; ALOX12B; MAPK1; CYP2C38; CYP4X1; GNG4
GABAergic synapse
PRKACB; GNG13; GABRA5; GNGT1; GNG12; GABRD; SLC6A13; PRKACA; PRKACG; GNG3
Dopaminergic synapse
MAOA; CALML5; SLC18A1; TH; GRIN2A; KCNJ9; KIF5A; PPP3CB; PPP2R5C; PRKACG
Olfactory transduction
OR2A4; OR2H1; PRKACB; NCALD; OR2B3; OR10C1; CNGA4; PRKACA; OR5V1; GNB1
Taste transduction
TAS2R104; PRKACG; TAS2R109; ALPHA-ENAC; TAS2R103; TAS2R7; TAS2R129; SCNN1G; TAS2R121; TAS2R38
Inflammatory mediator regulation of TRP channels
ASIC3; PIK3CA; PLCB2; CYP2J6; PLCB1; MAP2K3; TRPM8; PLA2G4C; PLCG2; CYP2C50
Insulin signaling pathway
PHKG1; PPP1R3D; PIK3R2; PPP1R3CB; G6PC2; PRKAR1AB; PRKAG3B; IKBKB; GRB2B; MKNK2A
Insulin secretion
STX1A; GPR119; INS1; KCNN2; ATP1A1; FFAR1; PLCB1; ADCYAP1; ATP1B1; CAMK2G
GnRH signaling pathway
SRC; MAP3K4; MAPK12B; PTK2B; MMP2; PLD1; GNRH2; HRASA; MAPK14B; GNRH1
Ovarian steroidogenesis
PRKACG; INSR; HSD17B2; HSD17B7; BMP6; IGF1; GNAS; HSD3B2; HSD3B1; CYP2J6
Progesterone-mediated oocyte maturation
PIK3CB; MAPK12; MAPK8A; MAPK8B; IGF1RB; BUB1; CCNA2; SPDYA; MAD1L1; RPS6KA3A
Estrogen signaling pathway
HSPA1A; HSPA8; RAF1; SHC3; GABBR1; MMP9; PIK3R5; MAPK3; GPR30; ITPR1
Melanogenesis
PRKCBB; CAMK2B1; MITF; WNT9A; KITA; GNAO1; FZD3B; GNAI2; WNT7B; GNA15.4
Thyroid hormone synthesis
TG; PDIA4; GPX2; PLCB1; PLCB3; ATF4; DUOXA2; FXYD2; CREB3L2; PLCB4
Thyroid hormone signaling pathway
SLCO1C1; PLN; MED13L; HDAC1; PLCB2; NCOA3; MED12; PLCG1; ATP1A4; MED1
Oxytocin signaling pathway
NFATC4; RGS2; CALM1; NFATC3; MYLK; MAPK3; CALM4; ITPR3; MYL6B; PPP3CC
Glucagon signaling pathway
CREB3L3; SLC2A2; PYGM; PPARGC1A; PRKAA2; LDHAL6B; PLCB2; CREB3L1; CPT1C; G6PC3
Regulation of lipolysis in adipocytes
PRKACB; INS1; PIK3CD; NPR1; Adcy4; IRS4; PDE3B; PIK3R3; PIK3CG; PTGER3
Renin secretion
CALM3; PPP3CA; PDE1A; PDE3B; PRKG2; CALML5; AGTR1A; CALM1; PRKACA; PRKACB
Aldosterone synthesis and secretion
GNA11; NPR1; NETO2; DDX1; KCNK3; KCNK9; PRKACA; NR4A2; PRKD1; CACNA1G
Endocrine and other factor-regulated calcium reabsorption
PRKCB; ATP1B4; KLK1; ATP1A2; KLK1B22; TRPV5; KL; ATP1B2; PTH1R; BDKRB2
Vasopressin-regulated water reabsorption
ARHGDIB; DCTN5; RAB11A; DCTN6; PRKACB; AVPR2; CREB3L2; VAMP2; AQP4; NSF
Salivary secretion
PLCB3; CST1; GUCY1A3; ATP1A1; STATH; AMY1A; CALM1; CAMP; PLCB1; PRH2
Gastric acid secretion
MYLK3; KCNK2; ITPR3; CAMK2B; PLCB2; PLCB4; Adcy4; SLC9A1; MYLK2; ATP1B3
Bile secretion
SLC5A1; CFTR; SLCO1A5; ATP1B3; SLC22A7; ATP1A2; FXYD2; Car2; AQP9; SLC4A4
Parkinsons disease
SLC25A6; ATP5H; COX5A; SEPT5; SLC18A2; NDUFC2-KCTD14; NDUFB10; UBE2G1; NDUFA10; UBE1Y1
Prion diseases
C9; NCAM1; MAP2K2; C8A; HSPA1A; PRKACA; C1QA; C8B; C1QB; LOC100033925
Cocaine addiction
DLG4; CREB5; GNAI3; GRIN2C; CREB3; FOSB; ATF6B; DRD1; DRD1A; SLC18A2
Amphetamine addiction
DDC; STX1A; GRIN1; GRIA1; PRKCB; CAMK2A; JUN; SLC18A1; SLC18A2; CALM3
Morphine addiction
GABRA6; GABRR1; GNB2; GABRA1; GNG3; GABRQ; GABRB1; PRKCG; PDE3A; GNGT2
Vibrio cholerae infection
ACTG1; ACTB; ATP6AP1; ATP6V0A4; KDELR2; ATP6V0C; ATP6V1C2; ATP6V1G1; ATP6V0D1; ATP6V1C1
Amoebiasis
COL27A1; CXCL8; RAB7B; SERPINB6B; SERPINB1A; COL5A2; CD1D; LAMC2; ACTN1; PLCB3
HTLV-I infection
ATF4; CDC26; RELA; HLA-DPB1; NFATC4; IL2RA; WNT16; PRKACA; MAP3K14; FDPS
Epstein-Barr virus infection
HSPB1; HLA-F; POLR3K; TRAF6; MAPK13; SND1; HLA-DQB1; MAP3K7; CD40; HDAC5
Pathways in cancer
Fzd4; FZD5; GNB2; NFKB2; Shh; FH; FGF11; APPL1; HDAC1; FGF13
Viral carcinogenesis
HLA-C; MRPS18B; CCND3; HIST1H2BD; TBPL2; SKP2; HNRNPK; CDK1; REL; HDAC7
Proteoglycans in cancer
FZD10; LUM; ITPR1; PPP1R12A; PPP1CA; PLCG1; WNT3A; ITGA5; SDC4; ITGB3
Dilated cardiomyopathy
TGFB1; TPM4; LMNA; ITGB5; PRKACA; ITGA7; ITGA1; ITGA6; SGCD; DES

Protein Function

PRKACB has several biochemical functions, for example, ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACB itself. We selected most functions PRKACB had, and list some proteins which have the same functions with PRKACB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ALDH18A1; HSPA9; NLRC3; BMPR1BB; MATK; ADCY7; ENTPD2; UCK2B; DCAMKL2; PTK7
Function cAMP-dependent protein kinase activity
Related Protein PRKACG; AKAP13; PRKACA; PRKACB; PRKAG1; PRKAA1; PRKX
Function magnesium ion binding
Related Protein MTPAP; GTPBP10; ERN1; DUT; NCS1; DYRK2; MARK1; SRPK1; MAPK12; IRAK3
Function protein binding
Related Protein LRFN2; RPS16; NDUFS7; DNAL4; MZT1; RYK; H2-AA; KCTD13; F2RL1; GMCL1
Function ubiquitin protein ligase binding
Related Protein FAF2; TNFRSF14; BECN1; BCL2; PRKACA; SNCAIP; ACTG1; FHIT; RNF31; CXCR4

Interacting Protein

PRKACB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACB here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACB.
HSP90AB1; APPBP2; AKAP5; PRKAR2B; DYNLL1; MAPRE1; FLNA; RCAN1; CBFB; PITX2; ACVR1B; RPL27A; RPS6

PRKACB Related Articles

Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
Yang, L; Nakayama, Y; et al. GABA(C)-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. JOURNAL OF PHARMACOLOGICAL SCIENCES 106:578-584(2008).