prkacb
Share
  • Official Full Name
  • protein kinase, cAMP-dependent, catalytic, beta
  • Background
  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Several alternatively spliced transcript variants encoding distinct isoforms have been observed.
  • Synonyms
  • PRKACB; protein kinase, cAMP-dependent, catalytic, beta; cAMP-dependent protein kinase catalytic subunit beta; PKACb; PKA C-beta; protein kinase A catalytic subunit beta; cAMP-dependent protein kinase catalytic beta subunit isoform 4ab; MGC9320; MG
Cat.#:PRKACB-173HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, His-tagged
+Inquiry
Cat.#:PRKACB-1947HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
+Inquiry
Cat.#:PRKACB-30210THTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB
+Inquiry
Cat.#:PRKACB-395HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged, Active
+Inquiry
Cat.#:PRKACB-553HTag:GST
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PRKACB, GST-tagged
+Inquiry
Cat.#:PRKACB-13353MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PRKACB Protein
+Inquiry
Cat.#:PRKACB-4672RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PRKACB Protein
+Inquiry
Cat.#:PRKACB-3602RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PRKACB Protein, His-tagged
+Inquiry
Cat.#:PRKACB-2868HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRKACB 293 Cell Lysate
+Inquiry

Involved Pathway

PRKACB involved in several pathways and played different roles in them. We selected most pathways PRKACB participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKACB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
MAP2K4B; MKNK2; TGFBR1A; FGFR4; ARRB2A; FGFR2; PAK2; LRRK2; IL1B; Pdgfa&Pdgfb
Ras signaling pathway
SOS1; PDGFRA; PLA2G3; MAP2K1; RAF1; PLD2; PLA2G4F; PDGFRB; MAP2K2; PLA2G4C
Calcium signaling pathway
TNNC1B; TNNC2; PDE1C; ADRB2A; SLC25A5; PLN; MYLK; TACR3; SLC25A6; OXTR
cAMP signaling pathway
FSHB; MC2R; PRKACB; TSHR; GABBR1; ACOX3; GRIA3; GNAI1; RAC2; CALML3
Chemokine signaling pathway
HRAS; BCAR1; AKT1; CCL27; NCF1; RHOA; CCL19; RAC2; CXCL14; CXCL1
Oocyte meiosis
ESPL1; YWHAB; IGF1; CPEB1B; FBXW11B; PTTG1; PPP3CA; CAMK2A; CPEB2; PKMYT1
Apoptosis
FASLG; IRF2; DBNLB; PIK3R1; BNIP3LB; CDK5RAP2; IRF2A; IRAK4; PIK3R3A; NFKBIAB
Adrenergic signaling in cardiomyocytes
ATP1B3B; PIK3CG; PRKACA; SCN1BA; AGTR2; ACTC1A; TNNT2; KCNQ1; AKT3A; ADRB2B
Vascular smooth muscle contraction
GUCY1A3; NPR1A; PRKACBB; MAP2K2A; CACNA1SA; PLA2G12B; GNAS; AGTR1B; PRKCQ; PPP1R14A
Wnt signaling pathway
MAPK8; PRKCB; SERPINF1; WNT5B; TBL1X; GSK3B; TLE3A; NFATC2; PRICKLE1A; PPARDB
Hedgehog signaling pathway
STK36; DYRK1AA; WNT10B; WNT7B; WNT8A; FBXW11; CSNK1G3; RAB23; WNT3; PRKACAA
Gap junction
PDGFD; PLCB4; PLCB1; TUBA8L3; TUBA3E; HRASB; ADCY2B; HTR2B; PRKG1; PDGFB
Platelet activation
MYLK; VASP; ARHGEF12; PIK3CB; ARHGAP35; MYL12A; LYN; PLCB3; ROCK2; ORAI1
Circadian entrainment
FOS; GNG10; PRKACG; GNB1; GNAS; CALML3; RYR2; PLCB4; GNAI2; GRIA2
Long-term potentiation
RPS6KA2; CALM2; MAPK3; EP300; GRIN2A; PLCB1; PPP3R1; PRKACA; CAMK2A; CALML5
Retrograde endocannabinoid signaling
MAPK12; GNG8; GRIA1; GABRA6; GNG13; GNB2; GRM5; GRM1; GNG10; GABRA4
Glutamatergic synapse
GRIN2C; GNB4; ADRBK2; HOMER3; GRM2; GRM6; GLS; GRIN1; GNG4; GRM7
Cholinergic synapse
PIK3R2; CAMK2G; CREB3L1; PRKACB; PIK3CB; PLCB4; GNG10; PIK3CG; PRKCB; CHRM4
Serotonergic synapse
HTR5A; GNG12; CYP4X1; CYP2J6; PLA2G4F; PLCB4; GNG5; HTR3E; RAF1; GNAI3
GABAergic synapse
PRKCB; SLC38A2; SLC38A5; SLC6A13; GNB4; GLS; SRC; GABRD; GNG11; GABRB3
Dopaminergic synapse
SLC6A3; DRD1; CREB5; DRD1A; DRD3; KCNJ6; PPP2R5D; PRKACB; GNAI1; MAPK9
Olfactory transduction
OR2A42; OLFR5; OR2C1; OLFR13; OR51E2; OR8A1; OLFR151; RGS2; OR2F1; CALM3
Taste transduction
Adcy4; TAS2R134; TAS2R120; TAS2R140; KCNB1; TAS2R108; TAS2R113; TAS2R42; TAS2R137; GNAS
Inflammatory mediator regulation of TRP channels
MAPK11; PRKCD; CALM4; PRKCA; TRPV3; PLA2G4C; CALML5; MAPK9; IGF1; PRKCG
Insulin signaling pathway
SHC4; MKNK2B; MAP2K1; GYS2; RAPGEF1B; GRB2A; GSK3B; MAPK8B; SH2B2; MAP2K2B
Insulin secretion
GNA11; GIP; INS1; CCKAR; KCNN1; ATP1B2; PLCB2; CAMK2A; KCNN2; PLCB3
GnRH signaling pathway
PRKCB; CDC42L2; PLA2G4A; MMP2; MMP14A; GNRH3; PLA2G4AA; MAPK14B; HBEGFA; RAF1A
Ovarian steroidogenesis
LHCGR; CYP2J5; FSHB; CYP2J6; AKR1C3; PLA2G4A; INS; HSD17B7; PTGS2; FSHR
Progesterone-mediated oocyte maturation
ANAPC1; PRKACA; ANAPC2; HSP90AA1.2; PRKACG; FZR1A; AKT2L; RPS6KA3B; PDE3B; INS
Estrogen signaling pathway
RAF1; Adcy4; CREB3L3; GNAQ; PLCB1; FKBP4; MAP2K2; FKBP5; CALML3; KCNJ3
Melanogenesis
a; WNT7A; FZD7B; MAPK3; WNT4A; MAP2K2; FZD8B; CALM3B; PLCB3; PRKCG
Thyroid hormone synthesis
PRKACA; SLC5A5; CREB3L1; ATP1B4; PLCB3; PDIA4; PRKCA; PRKCB; ATF4; TG
Thyroid hormone signaling pathway
TRP53; DIO3; ACTG1; SLC16A10; PLCD1; MED14; PIK3CG; ATP1B1; NOTCH2; MED12
Oxytocin signaling pathway
CACNA2D4; SRC; CACNG6; PRKCA; PIK3R1; GNAI1; CACNG4; CAMKK1; PLA2G4D; PRKACG
Glucagon signaling pathway
CALML5; PGAM2; CREB3L3; LDHB; CAMK2A; CALM1; PRKAB1; PLCB3; EP300; GYS2
Regulation of lipolysis in adipocytes
GNAI1; AKT2; GNAS; Adcy4; ABHD5; PIK3CG; PRKACG; PIK3CA; NPR1; INS1
Renin secretion
CALM1; AGTR1B; GNAI2; PDE1A; PRKACA; ITPR1; PDE3A; PLCB4; CLCA1; GNAI1
Aldosterone synthesis and secretion
ITPR3; ADCY9; CACNA1H; AGTR1A; CREB5; CAMK2D; PRKCG; HSD3B4; ATF4; CREB3L1
Endocrine and other factor-regulated calcium reabsorption
KLK1; ATP1B4; KL; PLCB4; ATP1B1; KLK1B8; KLK1B11; KLK2; PTH1R; PLCB3
Vasopressin-regulated water reabsorption
AVPR2; CREB3L1; CREB3L3; VAMP2; PRKACB; RAB5B; ARHGDIA; DYNC1I1; DYNC1LI1; DYNC2LI1
Salivary secretion
PRH2; CST2; CALM1; RYR3; CST1; PLCB2; ATP1B2; PRKACA; DMBT1; NOS1
Gastric acid secretion
CAMK2D; PLCB3; PLCB2; GNAS; ATP4B; KCNQ1; PRKCA; CALM4; ATP1A4; MYLK2
Bile secretion
ABCB11; OSTB; CYP7A1; SLCO1B1; SLCO1B3; ATP1B1; BAAT; OSTA; SLC5A1; EPHX1
Parkinsons disease
NDUFV3; COX7A2; ATP5G1; ATP5D; APAF1; TH; DRD1A; NDUFS6; UBB; NDUFA9
Prion diseases
ELK1; C8G; BAX; HSPA1A; FYN; HSPA5; IL1A; LOC100033925; MAPK3; MAP2K2
Cocaine addiction
ATF4; GRM3; FOSB; MAOB; SLC18A2; DRD1; PRKACA; PRKACB; GRIN3A; GRIN2A
Amphetamine addiction
GRIN2C; ATF2; PPP1CA; CAMK2D; CREB5; NETO2; PRKCB; CALML5; MAOB; DRD1A
Morphine addiction
GABRG2; GABBR1; GABRR3; GNB2; PDE4A; GRK6; GNB4; PDE8A; GABRA5; GABBR2
Vibrio cholerae infection
KDELR3; ERO1L; ATP6V1D; ATP6V0B; PRKACG; PRKACB; PLCG2; PLCG1; ATP6V1G1; ATP6V0C
Amoebiasis
PIK3CG; ACTN4; SERPINB3; LAMC2; C8B; HSPB1; ITGB2; CTSG; FN1; TGFB1
HTLV-I infection
SLC2A1; H2-AA; DVL1; HLA-DRB1; ELK4; CD3E; WNT7A; TNFRSF1A; WNT3; LTA
Epstein-Barr virus infection
HLA-DQA2; HLA-DRB4; HLA-DRB5; HSPA1A; PIK3CG; HSPA8; TBPL2; SKP2; PIK3CB; POLR2G
Pathways in cancer
HSP90AA1; GNAI2; FOXO1; PRKCG; GNB4; PTGS2; ETS1; IGF1; Fgf15; WNT6
Viral carcinogenesis
LYN; CCNE1; HDAC7A; TP53; TBPL2; CREB3L1; GTF2E1; RBPJL; RHOA; HIST2H2BE
Proteoglycans in cancer
SDC1; RAC1; MET; PDPK1; IL12B; PPP1R12B; CAV3; FZD9; CAV2; RPS6KB2
Dilated cardiomyopathy
TNNC1; CACNG2; ITGB6; DAG1; PRKACG; PLN; TPM3; ITGA9; TGFB1; ITGB1

Protein Function

PRKACB has several biochemical functions, for example, ATP binding, cAMP-dependent protein kinase activity, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKACB itself. We selected most functions PRKACB had, and list some proteins which have the same functions with PRKACB. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein STK39; SUCLA2; ACSBG2; CLK4B; TEK; MAP4K3; CAMK2D2; MAP2K2; STK35; ATP1A4
Function cAMP-dependent protein kinase activity
Related Protein PRKACG; PRKAA1; PRKAG1; PRKACB; PRKX; AKAP13; PRKACA
Function magnesium ion binding
Related Protein NT5C3B; ADPRHL1; TDP2; PDXK; EYA2; FIGNL1; CDC42BPG; CDC42BPB; ABL2; PKLR
Function protein binding
Related Protein ZMYM5; DDX19A; ZWINT; MINK1; MAPK6; GSTA2; HMGB2; HIF1A; BCAM; RND3
Function ubiquitin protein ligase binding
Related Protein UBE2R2; KDM4A; BRCA1; CDC34B; RBX1; AMBRA1; PRKAR1A; DNAJA1; USP13; MAGEA2B

Interacting Protein

PRKACB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKACB here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKACB.
HSP90AB1; APPBP2; AKAP5; PRKAR2B; DYNLL1; MAPRE1; FLNA; RCAN1; CBFB; PITX2; ACVR1B; RPL27A; RPS6

PRKACB Related Articles

Han, YS; Arroyo, J; et al. Human heart failure is accompanied by altered protein kinase A subunit expression and post-translational state. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 538:25-33(2013).
Yang, L; Nakayama, Y; et al. GABA(C)-receptor stimulation activates cAMP-dependent protein kinase via A-kinase anchoring protein 220. JOURNAL OF PHARMACOLOGICAL SCIENCES 106:578-584(2008).