sdc2
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  • Official Full Name
  • syndecan 2
  • Background
  • The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SDC2; syndecan 2; HSPG; CD362; HSPG1; SYND2; syndecan-2; fibroglycan; syndecan proteoglycan 2; heparan sulfate proteoglycan core protein; cell surface-associated heparan sulfate proteoglycan 1; heparan sulfate proteoglycan 1, cell surface-associated
Cat.#:SDC2-14790MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SDC2 Protein
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Cat.#:SDC2-529RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat SDC2 Protein, Fc-tagged
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Cat.#:SDC2-846MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SDC2 Protein (Met1-Phe141), His-tagged
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Cat.#:SDC2-501HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human Syndecan 2, His-tagged
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Cat.#:SDC2-213HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SDC2 Protein, His-tagged
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Cat.#:SDC2-2835HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SDC2 protein, His-tagged
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Cat.#:SDC2-334HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human SDC2, His-tagged
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Cat.#:SDC2-5285RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SDC2 Protein
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Cat.#:SDC2-4106RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SDC2 Protein, His-tagged
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Cat.#:SDC2-1105CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SDC2
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Cat.#:SDC2-9497ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SDC2
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Cat.#:SDC2-1575HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SDC2 cell lysate
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Involved Pathway

SDC2 involved in several pathways and played different roles in them. We selected most pathways SDC2 participated on our site, such as Cell adhesion molecules (CAMs), Malaria, Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SDC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell adhesion molecules (CAMs)
CLDN11; CLDN11B; CD274; CADM1A; ICOSLG; HLA-DRB4; HLA-DMB; PECAM1; CLDND; MHC2A
Malaria
CSF3; THBS4; KLRB1; IFNG; CD36; KLRK1; TLR4; TLR9; TGFB2; SDC1
Proteoglycans in cancer
VAV2; VTN; PIK3CD; WNT5A; RHOA; ARHGEF12; MET; FZD6; CD44; ROCK1

Protein Function

SDC2 has several biochemical functions, for example, PDZ domain binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SDC2 itself. We selected most functions SDC2 had, and list some proteins which have the same functions with SDC2. You can find most of the proteins on our site.
Function
Related Protein
Function PDZ domain binding
Related Protein ADRB1; CFTR; FZD8; BAIAP2; SNTB1; Apba1; FZD2; ATP2B2; PTENB; CXXC4
Function protein binding
Related Protein ZNF524; LAIR1; LOR; ORM1; FAM86C; CMTM5; GNB1; SMARCAL1; CREB3; ANXA1

Interacting Protein

SDC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SDC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SDC2.
CASK; SDCBP; MYB; RASA1; GAMMAHV.ORF30; SERPINA1; NF1; CYP2C18; BAG6; PPP3CC; mtlA; CSNK2A2; PYHIN1

SDC2 Related Articles

Ullah, M; Sittinger, M; et al. Extracellular matrix of adipogenically differentiated mesenchymal stem cells reveals a network of collagen filaments, mostly interwoven by hexagonal structural units. MATRIX BIOLOGY 32:452-465(2013).
Zhang, YH; Wang, NN; et al. Targeting of Heparanase-modified Syndecan-1 by Prosecretory Mitogen Lacritin Requires Conserved Core GAGAL plus Heparan and Chondroitin Sulfate as a Novel Hybrid Binding Site That Enhances Selectivity. JOURNAL OF BIOLOGICAL CHEMISTRY 288:12090-12101(2013).