tdo2
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  • Official Full Name
  • tryptophan 2,3-dioxygenase
  • Background
  • Tryptophan 2,3-dioxygenase (EC 1.13.11.11) plays a role in catalyzing the first and rat-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.
  • Synonyms
  • TDO2; tryptophan 2,3-dioxygenase; TDO; TPH2; 3-dioxygenase; T23O_HUMAN; TDO 2; TO; TRPO; Tryptamin 2 3 dioxygenase; Tryptamin 2; Tryptophan 2 3 dioxygenase; Tryptophan 2; Tryptophan oxygenase; Tryptophan pyrrolase; Tryptophanase; tryptamin 2,3-dioxygenase
Cat.#:TDO2-1535HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human TDO2 Protein (1-406 aa), His-tagged
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Cat.#:TDO2-1536MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse TDO2 Protein (1-406 aa), His-tagged
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Cat.#:TDO2-1958RTag:His-SUMO
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat TDO2 Protein (1-406 aa), His-SUMO-tagged
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Cat.#:TDO2-2503HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tryptophan 2,3-Dioxygenase, His-tagged
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Cat.#:TDO2-823HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Tryptophan 2,3-Dioxygenase, T7-tagged
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Cat.#:TDO2-31212THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TDO2
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Cat.#:TDO2-3171HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TDO2, GST-tagged
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Cat.#:TDO2-385HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TDO2
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Cat.#:TDO2-724HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TDO2 protein, His-tagged
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Cat.#:TDO2-824HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TDO2, MYC/DDK-tagged
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Cat.#:TDO2-825HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human TDO2, GST-tagged
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Cat.#:TDO2-16601MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TDO2 Protein
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Cat.#:TDO2-5997RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TDO2 Protein
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Cat.#:TDO2-1156HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TDO2 293 Cell Lysate
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Involved Pathway

TDO2 involved in several pathways and played different roles in them. We selected most pathways TDO2 participated on our site, such as Tryptophan metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with TDO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Tryptophan metabolism
TPH1; ALDH9A1A.1; CCBL1; CAT; ALDH2.2; AOX3; MAOB; DHCR24; KYNU; ABP1
Metabolic pathways
PTDSS1; CMASA; SAT2; SPHK2; NDUFB9; AMPD1; QDPRA; FDFT1; GULO; NME1

Protein Function

TDO2 has several biochemical functions, for example, amino acid binding, heme binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TDO2 itself. We selected most functions TDO2 had, and list some proteins which have the same functions with TDO2. You can find most of the proteins on our site.
Function
Related Protein
Function amino acid binding
Related Protein GOT2; DDC; GCHFR; TAT; ASS1; OTC; TPH2; AARS; DPYS; TPH1
Function heme binding
Related Protein CYP1A2; CYP2D6; CYP3A25; HBZ; CYP2C18; Adgb; EIF2AK1; CYP3A7; CYP46A1.2; PXDN
Function metal ion binding
Related Protein ZNF865; AIFM3; PHLPP2; JMJD1C; LFNG; RNF144AB; TRIM8A; GDPD1; RNF11B; NT5C
Function oxygen binding
Related Protein CYP2AA2; CYGB; HBAD; HBQ1; CYP2P9; CYP2A4; CYP2A6; HBD; HBB-B2; CYP1A1
Function protein binding
Related Protein NINJ1; VEGFC; SYT2; RAC3; NR2F1; TDGF1; TXK; RUSC1-AS1; MUTYH; MPHOSPH6
Function tryptophan 2,3-dioxygenase activity
Related Protein TDO2B; IDO2; IDO1; TDO2A; TDO2

Interacting Protein

TDO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TDO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TDO2.
ASMTL; SDCBP; DPM1; EIF4E; MOB3C; ZFYVE26