traf6
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  • Official Full Name
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase
  • Background
  • The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012]
  • Synonyms
  • TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase; RNF85; MGC:3310; TNF receptor-associated factor 6; RING finger protein 85; interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6;
Cat.#:TRAF6-3143HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF6 Protein, GST-tagged
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Cat.#:TRAF6-3144HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF6 Protein, His-tagged
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Cat.#:TRAF6-3146HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human TRAF6 Protein, MYC/DDK-tagged
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Cat.#:TRAF6-3147HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF6 Protein, His-SUMO-tagged
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Cat.#:TRAF6-555HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TRAF6 Protein, His-tagged
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Cat.#:Traf6-556MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Traf6 Protein, His-tagged
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Cat.#:TRAF6-31603THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human TRAF6 protein, GST-tagged
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Cat.#:TRAF6-591HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TRAF6
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Cat.#:TRAF6-17291MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse TRAF6 Protein
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Cat.#:TRAF6-6257RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat TRAF6 Protein
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Cat.#:TRAF6-4934RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey TRAF6 Protein, His-tagged
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Cat.#:TRAF6-3905ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TRAF6
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Cat.#:TRAF6-817HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRAF6 293 Cell Lysate
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Cat.#:TRAF6-818HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human TRAF6 293 Cell Lysate
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Involved Pathway

TRAF6 involved in several pathways and played different roles in them. We selected most pathways TRAF6 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
TGFBR1A; LRRK2; MAPK4; ARR3B; NLK; MAPK9; Fgf15; PPP3CCA; MAPK8A; PRKCB
NF-kappa B signaling pathway
LRDD; PIAS4; BCL2L1; MAP3K7IP3; ATM; PRKCB; CXCL12; TRAF1; BCL2A1; LBP
Ubiquitin mediated proteolysis
CBLB; UBE1Y1; PRPF19; MAP3K1; UBE2Z; HERC3; TRIM32; RCHY1; UBE2L3B; UBE3B
Endocytosis
ASAP2; ARPC5L; PARD6B; CHMP5B; AMPH; TGFBR1A; VPS4A; ADRB3B; STAMBPA; RHOA
Osteoclast differentiation
FCGR2C; TRAF2; SPI1; PIK3R2; FCGR3; PPARG; LCP2; NFKB1; TGFB1; IKBKB
Toll-like receptor signaling pathway
SPP1; STAT1B; LY96; MAPK9; Ifna15; IRF7; TLR2-2; IKBKE; TLR4BB; TLR1LB
NOD-like receptor signaling pathway
TRIP6; IL8L2; IKBKG; MAPK14B; CXCL2; NFKBIAA; NFKB1; Ccl12; TNFAIP3; IL18
RIG-I-like receptor signaling pathway
IFNA5; Ifna15; IFNA3; MAPK8; ISG15; TANK; RNF207B; MAPK14A; NT5C3; MAPK11
Neurotrophin signaling pathway
CDC42; PRDM4; MAPK13; MAP2K5; PSEN1; BDNF; NGFR; CAMK2B; MAPK1; IRAK1
Pertussis
C1R; C4BPA; CALM3; C1QB; IL12B; GNAI2; TICAM2; ITGB1; TLR4; IL1B
Leishmaniasis
MAPK3; ITGB1; TRAF6; NFKBIB; HLA-DRB3; MAPK13; PTPN6; PTGS2; TGFB2; HLA-DQA2
Chagas disease (American trypanosomiasis)
CFLAR; C3; IKBKG; IL12A; TGFBR1; TNF; Ccl12; PPP2R1B; NOS2; SERPINE1
Toxoplasmosis
NFKB1; HLA-DMA; PIK3R2; LAMC2; TLR2; IFNGR1; PIK3CA; NFKBIB; AKT1; HSPA6
Tuberculosis
C3; TLR2; VDR; ARHGEF12; MAPK8; IFNA16; Itgam&Itgb2; HLA-DRB1; SPHK2; NOS2
Hepatitis C
OAS1B; MAPK12; CLDN9; IRF7; IFN-a; IFNA6; RXRA; PIK3CG; PIK3R5; IFNAR1
Measles
IFNA1; OAS1B; IFNA21; STAT5B; TNFRSF10C; TLR7; CD3D; CCND3; IFNA16; HSPA1L
Herpes simplex infection
HLA-DRB5; OAS3; MAPK8A; OAS1B; IL1B; IFNA7; HLA-B; IFNA6; CUL1; TAF10
Epstein-Barr virus infection
HLA-DQA1; POLR3GL; VIM; H2-Q10; PIK3R2; EP300; PSMD13; TYK2; MAP3K7; PLCG1
Pathways in cancer
Casp3; RARB; FZD6; LPAR3; APC2; FGF6; SMAD3; RBX1; IL-8; F2R
Small cell lung cancer
PTGS2; LAMB3; IKBKG; TRAF2; APAF1; TRAF6; BIRC7; AKT1; PIK3R5; NFKBIA

Protein Function

TRAF6 has several biochemical functions, for example, histone deacetylase binding, identical protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF6 itself. We selected most functions TRAF6 had, and list some proteins which have the same functions with TRAF6. You can find most of the proteins on our site.
Function
Related Protein
Function histone deacetylase binding
Related Protein PKN2; HDAC4; HIC1; ZFP932; BRMS1L; CBX5; XBP1; TOP2A; SKOR2; TOP2B
Function identical protein binding
Related Protein MCM10; SHANK1; CLDN11; ALAD; MID1; GDF5; CLDN14; SMN2; RAF1; GOT2
Function ligase activity
Related Protein RNF40; TRIM17; LIG4; MUL1; TRIM63; HUWE1; UBE2KB; MGRN1; UBE4B; TRIM6
Function mitogen-activated protein kinase kinase kinase binding
Related Protein MAP4K2; TCF3; PPEF2; TRAF2; MAP2K1; MAP3K11; CDC37; MAPK1; STK38; TRAF6
Function protein N-terminus binding
Related Protein TSC1; STX5; ATM; RND2; SYNGR3; CSNK2A2; ALOX5AP; SCT; KCNB1; NBN
Function protein binding
Related Protein ATP6V1B2; SLC16A3; DHX36; TRIM16; PKD2; UBE2Z; DDX17; ZNF165; TIMM23; PDE1B
Function protein kinase B binding
Related Protein ANKRD2; BAD; APPL1; BCL10; CDC37; PINK1; PDE3B; RARA; CCDC88A; TRAF6
Function protein kinase binding
Related Protein PRDX3; CAV2; SHC1; LIMS1; CDKN2B; SHC4; CALM2; AKAP7; RB1CC1; DNM2
Function thioesterase binding
Related Protein CALM2; TRAF1; CALM; TRAF5; TRAF6; ADRA2A; CALM3; CDC42; TRAF2; CALM1
Function tumor necrosis factor receptor binding
Related Protein TNFSF14; FADD; TNFSF10L4; TNFSF9; TRIM37; TNFSF13; Fasl; LTB; TNFSF10; TNF
Function ubiquitin conjugating enzyme binding
Related Protein RNF144A; RNF180; ARIH1; RNF19B; TRAF6; MARCH6; DCUN1D2A; DCUN1D4; RNF19A; SIAH2
Function ubiquitin protein ligase activity
Related Protein RFWD2; HUWE1; ITCHA; UBE2G2; RNF19B; BFAR; UBE2J1; FANCL; AMFR; MED24
Function ubiquitin protein ligase binding
Related Protein TNFRSF1B; HSPA1A; MID1; TCEB2; VCL; PRKAR2A; LTBR; UBE2G2; AICDA; UBE2KA
Function ubiquitin-protein transferase activity
Related Protein RNF144AB; RNF151; RFWD3; TRIM56; UBE2K; NSMCE1; FBXL5; MALT1; FBXO40.1; RCHY1
Function zinc ion binding
Related Protein PCGF5B; RNF144AA; PYGO1; GM757; NR5A1A; ADAMTS3; NR2F1A; PHF2; GTF2B; ABP1

Interacting Protein

TRAF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF6.
TRAF2; TAX1BP1; TRAF5