TRAF6
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Official Full Name
TNF receptor-associated factor 6, E3 ubiquitin protein ligase
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Overview
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain. Two alternatively spliced transcript variants, encoding an identical protein, have been reported. [provided by RefSeq, Feb 2012] -
Synonyms
TRAF6; TNF receptor-associated factor 6, E3 ubiquitin protein ligase; RNF85; MGC:3310; TNF receptor-associated factor 6; RING finger protein 85; interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- TRAF6 Related Research Area
- TRAF6 Related Signal Pathway
TRAF6 involved in several pathways and played different roles in them. We selected most pathways TRAF6 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRAF6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | TGFBR1;Pdgfa&Pdgfb;CACNA1B;TAB2;CACNA1D;NFATC3;TGFBR1B;FGF6A;CASP3A |
NF-kappa B signaling pathway | TRAF3;IL1R1;MAP3K7IP3;LTBR;MAP3K7;Ccl21a;TAB2;PIDD1;Ccl21c |
Ubiquitin mediated proteolysis | CUL1B;PIAS4A;CUL3;ANAPC11;SIAH1A;UBE2B;PIAS4;TRIP12;UBE2G1A |
Endocytosis | ASAP1;AGAP2;SH3GLB1;KDR;ITCHA;LDLRAP1;CAPZA1B;PARD6B;PIP5K1AB |
Osteoclast differentiation | PIK3CG;NCF4;PIK3R3;TRAF6;PIK3CA;BTK;AKT1;IL1B;ITGB3 |
Toll-like receptor signaling pathway | TLR2-1;MAPK13;IFNA3;MAP2K6;IFNAR2;IL12BA;TAB2;PIK3R3B;CXCL11 |
NOD-like receptor signaling pathway | CARD18;HSP90AB1;MAPK14A;CASP1;TRAF6;HSP90B1;HSP90AA1.1;PYDC1;NFKBIAA |
RIG-I-like receptor signaling pathway | IFNA10;NT5C3;IKBKB;NFKBIAA;IFNA4;CXCL8B.3;IFNK;Ifna15;IFNB1 |
Neurotrophin signaling pathway | GRB2;SOS1;PIK3CD;SH2B2;MAP3K1;TP73;SH2B3;NFKBIE;NTRK2 |
Pertussis | GNAI1;NOS2;MAPK11;CFL2;IRF8;IL12A;CALM1;Hc;IRF1 |
Leishmaniasis | MAPK13;IL4;MYD88;NCF4;MAP3K7;FCGR3A;TRAF6;NCF2;IL1A |
Chagas disease (American trypanosomiasis) | Il2;FOS;SMAD2;C3;IFNB1;MAPK1;PPP2R1A;IKBKB;TLR9 |
Toxoplasmosis | XIAP;NOS2;PIK3R3;NFKBIA;IRAK4;IL10RA;PIK3CA;STAT3;MAPK8 |
Tuberculosis | IFNG;CD209A;FCGR2B;MAPK10;CLEC7A;LBP;SYK;FCGR4;TGFB2 |
Hepatitis C | CLDN4;MAPK10;LDLR;CLDN20;PPP2R1B;AKT2;IKBKG;IFNA14;TRAF6 |
Measles | TLR9;CCNE2;TNFAIP3;IFNA10;CD28;IL6;IFNA17;cgr2b;IFNG |
Herpes simplex infection | CUL1B;TLR2-1;HMGN1;SRPK1A;IFIH1;SRSF2A;PTPN11B;TBPL1;HLA-DPA1 |
Epstein-Barr virus infection | HLA-DQA2;POLR3H;MAP3K7;MAP2K7;PIK3CD;HDAC2;IRAK1;SPN;ENTPD3 |
Pathways in cancer | RALBP1;FGF13;Shh;RUNX1T1;GNB3;MECOM;Kitl;GLI1;BRAF |
Small cell lung cancer | CKS2;RXRB;FHIT;TRAF1;LAMC2;IKBKG;TRAF3;BIRC3;PIK3R5 |
TRAF6 has several biochemical functions, for example, histone deacetylase binding, identical protein binding, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRAF6 itself. We selected most functions TRAF6 had, and list some proteins which have the same functions with TRAF6. You can find most of the proteins on our site.
Function | Related Protein |
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histone deacetylase binding | HDAC1;DNMT3B;RAD9A;KAT2B;SRF;DDX20;SP1;NCOR1;GCM1 |
identical protein binding | BAIAP2;SERPINA1A;CLDN15;BCHE;DRD4;DAAM1;MMP9;TRIM8;DYNLT1C |
ligase activity | RNF31;UBR5;CBX4;ADSSL;TRIM28;TRIM9;BIRC7;UBE3C;RNF111 |
mitogen-activated protein kinase kinase kinase binding | CDC37;TCF3;MAPK9;DUSP19;PPEF2;MAP4K2;CDC42;TRAF6;MAPK1 |
protein N-terminus binding | SLC6A3;APTX;MYO7A;UNC13A;TRP53;SCFD1;SCT;LACRT;KCNIP2 |
protein binding | IL2RB;SPI1;RCN2;IL11;FBXO18;USP8;RBP7;PRRC1;AMPH |
protein kinase B binding | BCL10;CCDC88A;APPL1;RARA;CDC37;PINK1;PDE3B;BAD;ANKRD2 |
protein kinase binding | DLG1L;LSM2;SNAP91;MAML1;PIFO;PPP1R12C;PTEN;CCNL1B;SMAD3 |
thioesterase binding | CALM;CALM2;CALM3;TRAF4;HAUS7;ADRA2A;RAC1;CDC42;TRAF5 |
tumor necrosis factor receptor binding | TNFSF11;TNF;TRAF4;TRAP1;TNFSF14;TRAF2;TNFSF10L3;EDA;TNFSF10L4 |
ubiquitin conjugating enzyme binding | TCHP;DCUN1D3;TRAF6;SIAH2;DCUN1D4;DCUN1D1;TOLLIP;DCUN1D2A;DCUN1D5 |
ubiquitin protein ligase activity | HERC6;TRIM3;FBXO40;UHRF2;CCNC;CDK8;PDZRN3;UBE2A;SIAH2 |
ubiquitin protein ligase binding | TRIB2;FBXW7;UBE2K;ACVR1B;ATXN3;RNF40;SMC6;CDC34;CDKN1A |
ubiquitin-protein transferase activity | UBE2G2;LNX2B;PAX6;SKP1;FBXL21;TRIM13;MARCH1;FBXO30B;RNF43 |
zinc ion binding | SYVN1;KDM7AB;RNF168;TRIM35-20;ZNF276;CPZ;PCGF1;ADAMTSL5;RABGEF1 |
TRAF6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRAF6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRAF6.
TRAF2; TAX1BP1; TRAF5
- Q&As
- Reviews
Q&As (5)
Ask a questionTRAF6 has been implicated in promoting the survival, proliferation, and metastasis of cancer cells, and its overexpression has been linked to poor prognosis in various types of cancer.
Research is underway to develop small molecule inhibitors and antibodies targeting TRAF6 for the treatment of inflammatory and autoimmune diseases, as well as cancer.
Elevated levels of TRAF6 expression have been detected in the blood and tissue samples of patients with autoimmune diseases and certain types of cancer, making it a potential biomarker for disease diagnosis and prognosis.
TRAF6 interacts with various receptors and adaptor proteins to activate downstream signaling pathways, including the NF-κB, MAPK, and JNK pathways, which are critical for immune and inflammatory responses.
TRAF6 is involved in the regulation of osteoclast differentiation and bone resorption, making it a potential target for the treatment of bone-related diseases such as osteoporosis.
Customer Reviews (3)
Write a reviewThe TRAF6 protein comes highly recommended due to its exceptional performance in ELISA assays.
I am genuinely excited to embark on this scientific journey, empowered by the superior TRAF6 protein and the manufacturer's unwavering commitment to ensuring my success.
The TRAF6 protein's superior performance in ELISA paves the way for robust and precise data analysis, providing invaluable insights into various biological processes.
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