• Official Full Name
  • taxilin alpha
  • Background
  • IL-4 mediates its function by binding to receptors expressed on target cells. The IL-4 receptors exhibit an affinity of approximately 10-10 M.
    Receptors exist on freshly prepared B and T lymphocytes and macrophages, as well as on various cell lines including lymphoid cells, mast cell lines, a variety of other hematopoietic cell lines, fibroblasts and stromal cell lines. On T and B cells, receptors are present in low numbers (appr. 400), which are reported to be upregulated by IL-2 and IL-4.
    IL-4 is produced by a particular subset of T helper cells, the TH2 cells. These cells tend to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13 and GM-CSF and fail to produce IL-2, IFNγ, and lymphotoxin (TNFβ). Apart from T cells, it has been shown that mast cells can produce IL-4.
    IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunological class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. It can promote survival, growth, and differentiation of both T and B lymphocytes, mast cells, and endothelial cells.
    In addition, IL-4 can inhibit the production of TNF, IL-1, and IL-6 by macrophages.
  • Synonyms
  • Il14; Txln; AI425952; AW209241; 2600010N21Rik; Il14; Txln; AI425952; AW209241; 2600010N21Rik; Txlna; taxilin alpha
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human TXLNA Protein, Flag-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human TXLNA, His-tagged
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human TXLNA, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TXLNA Protein, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human TXLNA protein, His & T7-tagged
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Txlna protein, His & GST-tagged
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish TXLNA
Source (Host):Species:Human
Product nameRecombinant Human TXLNA 293 Cell Lysate

Involved Pathway

TXLNA involved in several pathways and played different roles in them. We selected most pathways TXLNA participated on our site, such as TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TXLNA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
TNF-alpha/NF-kB Signaling Pathway

Protein Function

TXLNA has several biochemical functions, for example, cytokine activity, high molecular weight B cell growth factor receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TXLNA itself. We selected most functions TXLNA had, and list some proteins which have the same functions with TXLNA. You can find most of the proteins on our site.
Related Protein
Function cytokine activity
Related Protein BMP15; BMP6; IL7; IFNA13; GM13289; MSTNA; LTA; IL3; GM13279; Il2
Function high molecular weight B cell growth factor receptor binding
Related Protein TXLNA
Function protein binding
Related Protein DYNC1I1; ZNF792; CLASP1; PRMT6; MRPL15; AFG3L2; SELPLG; NR1H4; PSEN1; SCRN2
Function syntaxin binding
Related Protein SYT13; STX7; SYTL1; SYT15; CPLX4B; SYT10; SYT9B; CPLX3; SEC22B; SYT12

Interacting Protein

TXLNA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TXLNA here. Most of them are supplied by our site. Hope this information will be useful for your research of TXLNA.