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VKORC1

  • Official Full Name

    vitamin K epoxide reductase complex, subunit 1

  • Overview

    Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.
  • Synonyms

    VKORC1; vitamin K epoxide reductase complex, subunit 1; vitamin K dependent clotting factors deficiency 2 , VKCFD2; vitamin K epoxide reductase complex subunit 1; phylloquinone epoxide reductase; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K depen;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian cell
  • Mammalian Cell
  • C
  • 10×His
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • sfGFP,10His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human VKORC1-405HCL Recombinant Human VKORC1 293 Cell Lysate HEK293 N/A
Human VKORC1-4806H Recombinant Human VKORC1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human VKORC1-20H Recombinant Human VKORC1-GFP Protein (S3-E155), C-10×His-tagged Mammalian cell C-10×His S3-E155
Human VKORC1-0609H Recombinant Human VKORC1 Protein (M1-H163 end), sfGFP, 10×His tagged Mammalian cell sfGFP,10His M1-H163 end
Human VKORC1-08H Recombinant Human VKORC1-sfGFP Protein (M1-H163 end), C-10×His-tagged Mammalian cell C-10×His M1-H163 end
Human VKORC1-0608H Recombinant Human VKORC1 Protein (S3-E155), sfGFP, 10×His tagged Mammalian cell sfGFP,10His S3-E155
Mouse VKORC1-18024M Recombinant Mouse VKORC1 Protein Mammalian Cell His
Mouse VKORC1-10023M-B Recombinant Mouse VKORC1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Vkorc1-6925M Recombinant Mouse Vkorc1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse VKORC1-10023M Recombinant Mouse VKORC1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL1890BF Recombinant Full Length Bovine Vitamin K Epoxide Reductase Complex Subunit 1(Vkorc1) Protein, His-Tagged E.coli expression system His Full Length (1-163)
Mus musculus (Mouse) RFL1298MF Recombinant Full Length Mouse Vitamin K Epoxide Reductase Complex Subunit 1(Vkorc1) Protein, His-Tagged E.coli expression system His Full Length (1-161)
Chicken VKORC1-7084C Recombinant Chicken VKORC1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

VKORC1 involved in several pathways and played different roles in them. We selected most pathways VKORC1 participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VKORC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquinone and other terpenoid-quinone biosynthesisCOQ7;HPDB;COQ6;TAT;COQ5;VKORC1;HPDA;VKORC1L1;GGCX

VKORC1 has several biochemical functions, for example, quinone binding, vitamin-K-epoxide reductase (warfarin-sensitive) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VKORC1 itself. We selected most functions VKORC1 had, and list some proteins which have the same functions with VKORC1. You can find most of the proteins on our site.

Function Related Protein
quinone bindingVKORC1L1;AOC2;AMOTL1;HHIP;ABP1;HHIPL1;AOC1;NDUFS2;AOC3
vitamin-K-epoxide reductase (warfarin-sensitive) activityVKORC1;VKORC1L1;AMOTL1

VKORC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VKORC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VKORC1.

CREB3; ILK

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