Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.
VKORC1; vitamin K epoxide reductase complex, subunit 1; vitamin K dependent clotting factors deficiency 2 , VKCFD2; vitamin K epoxide reductase complex subunit 1; phylloquinone epoxide reductase; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K depen
VKORC1 involved in several pathways and played different roles in them. We selected most pathways VKORC1 participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VKORC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Related Protein
Ubiquinone and other terpenoid-quinone biosynthesis
VKORC1 has several biochemical functions, for example, quinone binding, vitamin-K-epoxide reductase (warfarin-sensitive) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VKORC1 itself. We selected most functions VKORC1 had, and list some proteins which have the same functions with VKORC1. You can find most of the proteins on our site.
Function quinone binding
Related Protein HHIP; AOC2; HHIPL1; SQRDL; TP53I3; ABP1; CBR4; NDUFS2; HHIPL2; AOC3
Function vitamin-K-epoxide reductase (warfarin-sensitive) activity
Related Protein VKORC1; AMOTL1; VKORC1L1
VKORC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VKORC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of VKORC1.