WDR83 Protein, WD repeat domain 83

WDR83

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WDR83

Official Full Name WD repeat domain 83
Background This gene encodes a member of the WD-40 protein family. The protein is proposed to function as a molecular scaffold for various multimeric protein complexes. The protein associates with several components of the extracellular signal-regulated kinase (ERK) pathway, and promotes ERK activity in response to serum or other signals. The protein also interacts with egl nine homolog 3 (EGLN3, also known as PHD3) and regulates expression of hypoxia-inducible factor 1, and has been purified as part of the spliceosome. Alternative splicing results in multiple transcript variants.
Synonyms MORG1; MGC4238; WD repeat domain-containing protein 83; MAPK organizer 1; mitogen-activated protein kinase organizer 1; WDR83; WD repeat domain 83
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human WDR83-331HCL Recombinant Human WDR83 293 Cell Lysate HEK293 N/A
    Human WDR83-5286H Recombinant Human WDR83 Protein, GST-tagged Wheat Germ GST
    Mouse WDR83-18508M Recombinant Mouse WDR83 Protein Mammalian Cell His
    Rat WDR83-6579R Recombinant Rat WDR83 Protein Mammalian Cell His
    Rhesus Macaque WDR83-5207R Recombinant Rhesus monkey WDR83 Protein, His-tagged Mammalian Cell His
    Zebrafish WDR83-563Z Recombinant Zebrafish WDR83 Mammalian Cell His

    WDR83 involved in several pathways and played different roles in them. We selected most pathways WDR83 participated on our site, such as ARMS-mediated activation, Axon guidance, Cytokine Signaling in Immune system, which may be useful for your reference. Also, other proteins which involved in the same pathway with WDR83 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ARMS-mediated activation DUSP2; PAQR3A; NETO2; PSMD9; SPNA1; JAK2; PSMA8; FRS2; JAK3; PSMD10
    Axon guidance EPHB3; PAK3; SIAH2; CSNK2B; MAPK3; Plxna2; EFNA5; MYL9; SCN3A; NTN4
    Cytokine Signaling in Immune system DUSP6; IFI35; IFI30; KPNA3; FCGR1B; MX2; FRS2; EGR1; KPNA5; CRK
    DAP12 interactions FGFR1B; FGF20A; FRS2; TREM1; PRKAR1AA; SPNA2; AHCYL1; LAMTOR2; AGO1; MARK3
    DAP12 signaling THEM4; CNKSR1; TRAT1; NEFLB; SPRED2; RASGRP4; PRKAR1AA; GRAP2A; KLB; DUSP1
    Developmental Biology SPTBN2; MED20; ARPC2; DNM2; CDK19; MED23; EFNA4; EPHB4B; JAK1; BOC
    Downstream signal transduction FGF10B; FGFR1B; LAMTOR2; SPNA1; FRS2B; RASGRP4; DUSP9; FRS3; PTPRA; PEA15
    Downstream signaling of activated FGFR1 CNKSR1; PAQR3A; DUSP9; DAB2IPB; SPRED2; PEA15; WDR83; PEA15A; AGO2; RASGEF1A

    WDR83 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WDR83 itself. We selected most functions WDR83 had, and list some proteins which have the same functions with WDR83. You can find most of the proteins on our site.

    Function Related Protein
    protein binding TMEM139; OAZ1; CLEC16A; GPBP1; BCS1L; HIST1H3G; CARKD; RGP1; TMEM203; RYR1

    WDR83 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WDR83 here. Most of them are supplied by our site. Hope this information will be useful for your research of WDR83.

    KEAP1; SNRPC; SF3B4; PRPF8; UBL5; PPIL1; AQR; KDM1A; BAG2; HSPB1; CRK; CRK; HNRNPH2

    Ono, K; Hayashi, H; et al. Uterine superficial serous carcinomas and extensive serous endometrial intraepithelial carcinomas: clinicopathological analysis of 6 patients. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7:7979-7988(2014).
    Zambonelli, P; Davoli, R; et al. SNPs detection in DHPS-WDR83 overlapping genes mapping on porcine chromosome 2 in a QTL region for meat pH. BMC GENETICS 14:-(2013).

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