ybx1
Share
  • Official Full Name
  • Y box binding protein 1
  • Background
  • Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.
    The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.
  • Synonyms
  • YBX1; Y box binding protein 1; YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1; nuclease-sensitive element-binding protein 1; CBF-A; EFI-A; DNA-binding protein B; Y-box-binding protein 1; Y-box transcription factor; enhancer factor I subunit A; nuclease sensitive element binding protein 1; CCAAT-binding transcription factor I subunit A; major histocompatibility complex, class II, Y box-binding protein I;
Cat.#:YBX1-30136THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YBX1, His-tagged
+Inquiry
Cat.#:YBX1-3763HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YBX1, GST-tagged
+Inquiry
Cat.#:YBX1-4838HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human YBX1, GST-tagged
+Inquiry
Cat.#:YBX1-4839HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human YBX1, GST-tagged
+Inquiry
Cat.#:YBX1-636HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Y box binding protein 1, His-tagged
+Inquiry
Cat.#:YBX1-6926HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human YBX1, MYC/DDK-tagged
+Inquiry
Cat.#:YBX1-18652MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse YBX1 Protein
+Inquiry
Cat.#:YBX1-6625RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat YBX1 Protein
+Inquiry
Cat.#:YBX1-5984CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken YBX1
+Inquiry
Cat.#:YBX1-6756ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish YBX1
+Inquiry
Cat.#:YBX1-1945HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human YBX1 cell lysate
+Inquiry

Involved Pathway

YBX1 involved in several pathways and played different roles in them. We selected most pathways YBX1 participated on our site, such as BDNF signaling pathway, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with YBX1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BDNF signaling pathway
EGR1; JAK2; EGR2; FRS3; CDH2; GNB2L1; DOK5; IGF2BP1; EEF2; CNR1
Gene Expression
SUGP1; ALKBH8; NR2F6A; ZFP2; HNRNPH1; ZNF100; SNRNP48; SNAPC3; ZNF701; PTRF
Processing of Capped Intron-Containing Pre-mRNA
PRPF8; HNRNPA0B; ZCRB1; U2AF2; SNRNP25; METTL14; HNRNPA0A; PTBP1A; HNRNPL; SFRS3A
SIDS Susceptibility Pathways
TPPP; KCNQ1; TPH2; CREM; PHOX2B; PKNOX1; KCNJ8; PLP1; SP3; SST
Signaling events mediated by PTP1B
YBX1; DOK1; NOX4; CSN2
mRNA Splicing
ZMAT5; HNRNPF; HNRNPH1L; PTBP1B; HNRNPA2B1; SF3A3; HNRNPD; ZCRB1; SNRNP25; YBX1
mRNA Splicing - Major Pathway
HNRNPH1; PRPF8; CD2BP2; SF3B4; HNRNPL2; HNRNPA0A; HNRNPH1L; PTBP1; RBM5; BCAS2
mRNA Splicing - Minor Pathway
PRPF8; SF3B2; RNPC3; TXNL4A; PDCD7; SNRNP25; YBX1; SF3B4; SNRNP48; ZCRB1

Protein Function

YBX1 has several biochemical functions, for example, DNA binding, GTPase binding, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YBX1 itself. We selected most functions YBX1 had, and list some proteins which have the same functions with YBX1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ENO1; E2F2; ZBTB16; ZFP865; ZNF358; PALB2; HOXA5A; RAD51AP1; KDM1B; ZNF70
Function GTPase binding
Related Protein EPRS; SH3GL1; SPTBN1; IARS; GOLGA4; STOML2; GNB2; GNB3; RAB3D; GM5506
Function RNA binding
Related Protein RANBP2; ACO1; CPSF2; RPF1; MKI67IP; SNRNP70; RBM6; CPEB3; TRIM71; ZNF74
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein HNRNPC; NFIA; FOXJ1; FIGLA; OTX1; HNRNPK; ZNF217; ZIC3; CHD7; JUN
Function chromatin binding
Related Protein PHF21B; SP110; TGIF1; POLR3D; CCDC111; PBRM1L; PRKCBB; SP3; TP73; Ar
Function double-stranded DNA binding
Related Protein XRCC3; KLF6; CRY1; PRKDC; KIN; MCM10; MTERF3; RAD51AP1; NEIL3; MTERF2
Function poly(A) RNA binding
Related Protein PRRC2A; RPL26; DYNC1H1; EXOSC7; ZYX; FAM32A; ZC3H18; HELZ2; GTPBP10; CORO1A
Function protein binding
Related Protein GLS2; PLEKHH2; TLE1; GABPB1; TMPO; ZNF83; MIEF1; MDM2; UBE3C; ARHGAP44
Function single-stranded DNA binding
Related Protein PMS1; RAD51C; XRCC2; PURA; SSBP3; FUBP1; MCM7; HNRNPDL; RPA4; RBMS1
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF133; PGBD1; MAFG; TEAD1A; GTF2H3; ZNF182; IRF1A; NKX2-5; FOXD2; ZFY2
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein MITFB; SFPI1; HOXA10; HOXA7; NR3C1; MEF2B; RAX; PPARA; GLIS2; HOXD13

Interacting Protein

YBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of YBX1.
SYNCRIP; C1QBP; HNRNPR; DHX9

YBX1 Related Articles

Blackwell, E; Ceman, S; et al. A new regulatory function of the region proximal to the RGG box in the Fragile X mental retardation protein. JOURNAL OF CELL SCIENCE 124:3060-3065(2011).