ybx1
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  • Official Full Name
  • Y box binding protein 1
  • Background
  • Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.
    The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation.
  • Synonyms
  • YBX1; Y box binding protein 1; YB1; BP-8; CSDB; DBPB; YB-1; CSDA2; NSEP1; NSEP-1; MDR-NF1; nuclease-sensitive element-binding protein 1; CBF-A; EFI-A; DNA-binding protein B; Y-box-binding protein 1; Y-box transcription factor; enhancer factor I subunit A; nuclease sensitive element binding protein 1; CCAAT-binding transcription factor I subunit A; major histocompatibility complex, class II, Y box-binding protein I;
Cat.#:YBX1-30136THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YBX1, His-tagged
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Cat.#:YBX1-3763HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human YBX1, GST-tagged
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Cat.#:YBX1-4838HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human YBX1, GST-tagged
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Cat.#:YBX1-4839HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human YBX1, GST-tagged
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Cat.#:YBX1-636HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Y box binding protein 1, His-tagged
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Cat.#:YBX1-6926HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human YBX1, MYC/DDK-tagged
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Cat.#:YBX1-18652MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse YBX1 Protein
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Cat.#:YBX1-6625RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat YBX1 Protein
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Cat.#:YBX1-5984CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken YBX1
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Cat.#:YBX1-6756ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish YBX1
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Cat.#:YBX1-1945HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human YBX1 cell lysate
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Involved Pathway

YBX1 involved in several pathways and played different roles in them. We selected most pathways YBX1 participated on our site, such as BDNF signaling pathway, Gene Expression, Processing of Capped Intron-Containing Pre-mRNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with YBX1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
BDNF signaling pathway
GRIP1; EEF2; CDK5; FRS2; BCL2L11; LINGO1; CDH2; EIF4EBP1; DPYSL2; YBX1
Gene Expression
SFRS3A; ZNF143; BRF2; MADD; EHMT2; PTBP1B; MTA2; ZNF12; ZNF792; ZNF200
Processing of Capped Intron-Containing Pre-mRNA
HNRNPA0; PTBP1; PTBP1A; U2AF2; ZCRB1; HNRNPH1L; CCAR1; HNRNPA0L; HNRNPF; CSTF1
SIDS Susceptibility Pathways
MBD1; SST; KCNH2; SCN3B; POU2F2; PLP1; PHOX2A; CC2D1A; EN1; KCNQ1
Signaling events mediated by PTP1B
DOK1; CSN2; YBX1; NOX4
mRNA Splicing
SF3A3; SFRS3A; SF3A1; SNRNP35; HNRNPH2; HNRNPF; HNRNPA0B; HNRNPUL1; HNRNPA0; RBM5
mRNA Splicing - Major Pathway
HNRNPL; HNRNPA0B; HNRNPA0L; HNRNPD; HNRNPA0A; PTBP1A; CCAR1; SF3A3; DNAJC8; HNRNPUL1
mRNA Splicing - Minor Pathway
SNRNP25; RNPC3; SNRNP48; SF3B2; SF3B4; TXNL4A; YBX1; ZMAT5; PDCD7; ZCRB1

Protein Function

YBX1 has several biochemical functions, for example, DNA binding, GTPase binding, RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by YBX1 itself. We selected most functions YBX1 had, and list some proteins which have the same functions with YBX1. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZNF223; ZFP668; HLFB; THAP7; ZFP879; SAP30L; NKX2.7; FAM60AL; HIST1H2B5; RXRBB
Function GTPase binding
Related Protein VPS41; RASA1; EPRS; YBX1; MARCH5; BNIP3; GM5506; STOML2; HSP90AA1; SPTBN1
Function RNA binding
Related Protein NIFK; DHX36; SURF6; TUT1; ADARB2; TNRC6B; DDX3Y; HNRPL; HNRNPL; RBM4.1
Function RNA polymerase II core promoter proximal region sequence-specific DNA binding
Related Protein POU1F1; ETV6; ESRRA; YBX1; BATF3; NFIB; JDP2; ZFP746; ASCL2; GABPA
Function chromatin binding
Related Protein HDAC3; YAP1; HMGXB4A; LEF1; CCNT1; APITD1; CREB3L1; L3MBTL1; CHAF1A; MITF
Function double-stranded DNA binding
Related Protein ZNF638; YBX1; AFF3; HES2; TDP1; RAD51L3; MTERFD3; PRKDC; ERCC5; IFI203
Function poly(A) RNA binding
Related Protein EWSR1; HADHB; ABT1; RPL12; RPL32; PURB; SYNE1; RPF2; NOP14; NKRF
Function protein binding
Related Protein MEP1B; MOXD1; CCDC108; MYH8; SHROOM2; TBX5A; IKBKE; CDKN2A; TBXAS1; SAMHD1
Function single-stranded DNA binding
Related Protein TSNAX; MCM7; HNRPDL; LONP1; MLH3; BRCA2; SETMAR; RPA4; HMGB2; PMS1
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF461; PFDN1; PPARAB; PITX2; HMGA1A; EGR1; KLF7; FOXE1; YBX1; THRAA
Function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
Related Protein KLF4; ETV1; CEBPA; NKX2-8; GABPA; SIX4; HOXC11; GATA2; EGR2; SRF

Interacting Protein

YBX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with YBX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of YBX1.
SYNCRIP; C1QBP; HNRNPR; DHX9

YBX1 Related Articles

Blackwell, E; Ceman, S; et al. A new regulatory function of the region proximal to the RGG box in the Fragile X mental retardation protein. JOURNAL OF CELL SCIENCE 124:3060-3065(2011).