ADCY1 involved in several pathways and played different roles in them. We selected most pathways ADCY1 participated on our site, such as Activation of GABAB receptors, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Adenylate cyclase activating pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Activation of GABAB receptors |
GNB3B; ADCY9; KCNJ3; GNGT2A; ADCY6; GNGT2B; GNB3A; KCNJ12; KCNJ2; KCNJ9 |
| Activation of NMDA receptor upon glutamate binding and postsynaptic events |
CAMKK1B; DLG4; ADCY3; AKAP9; ADCY1; CREB1B; NETO2; ADCY8; SLC14A2; CREB1 |
| Adenylate cyclase activating pathway |
ADCY8; ADCY6; ADCY1; ADCY3; ADCY7; ADCY9 |
| Adenylate cyclase inhibitory pathway |
ADCY1; ADCY7; ADCY9; ADCY8; ADCY3; ADCY6 |
| Adrenergic signaling in cardiomyocytes |
PPP2CB; PIK3R5; ATP1B1A; CACNG7A; ATP1A4; CAMK2A; TPM2; PIK3R3A; MAPK12; ATP1B2A |
| Aldosterone synthesis and secretion |
PRKACB; PRKCG; SLC14A2; ADCY8; DAGLB; CREB3L4; PRKD1; CREB3L1; PRKCB; ADCY7 |
| Amoebiasis |
COL4A1; ARG1; RAB7A; LAMA3; LAMB3; LAMA2; IL12B; TGFB2; SERPINB1A; COL1A2 |
| Aquaporin-mediated transport |
GNB5B; GNB3A; AQP10; AQP3B; AQP9B; AQP6; AQP10A; ADCY8; MYO5B; GNB5A |
ADCY1 has several biochemical functions, for example, ATP binding, adenylate cyclase activity, calcium- and calmodulin-responsive adenylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCY1 itself. We selected most functions ADCY1 had, and list some proteins which have the same functions with ADCY1. You can find most of the proteins on our site.
| Function |
Related Protein |
| ATP binding |
ALPK1; GUCY2C; INSRB; KIF4; ACTA2; AK9; ATAD3A; TLK2; KTI12; SBK1 |
| adenylate cyclase activity |
ADCY3; ADCY1; ADCY7; ADCY1A; ADCY1B; Adcy4; GNAS; ADCY9; ADCY8; ADCY2B |
| calcium- and calmodulin-responsive adenylate cyclase activity |
ADCY3; ADCY8; ADCY1; ADCY6 |
| calmodulin binding |
CALD1B; MARCKSL1; MYH4; PPP3CB; CAMK1; MYH13; EWSR1; AEBP1; CAMKK1; CAMSAP1L1 |
| metal ion binding |
PRKCBB; HINFP; KLF18; GLI1; ZNF74; GALNT11; ZNF821; A3GALT2; KDM4D; DMRTC2 |
ADCY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCY1.
Wang, XZ; Maynard, JA; et al. The Bordetella Adenylate Cyclase Repeat-in-Toxin (RTX) Domain Is Immunodominant and Elicits Neutralizing Antibodies. JOURNAL OF BIOLOGICAL CHEMISTRY 290:3576-3591(2015).
Chae, JJ; Park, YH; et al. Connecting Two Pathways Through Ca2+ Signaling: NLRP3 Inflammasome Activation Induced by a Hypermorphic PLCG2 Mutation. ARTHRITIS & RHEUMATOLOGY 67:563-567(2015).
