ADCY1

  • Official Full Name

    adenylate cyclase 1 (brain)

  • Overview

    This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern formation of the brain.
  • Synonyms

    ADCY1; adenylate cyclase 1 (brain); adenylate cyclase type 1; adenyl cyclase; Adenylate cyclase 1; adenylate cyclase type I; ATP pyrophosphate lyase; Brain adenylate cyclase 1; OTTHUMP00000207996; adenylyl cyclase 1; ATP pyrophosphate-lyase 1; 3,5-cyclic AMP synthetase; Ca(2+)/calmodulin-activated adenylyl cyclase; AC1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADCY1-137H Recombinant Human ADCY1 Mammalian Cell His
Human ADCY1-6841H Recombinant Human ADCY1 protein, His & T7-tagged E.coli His/T7
Human ADCY1-2429H Recombinant Human ADCY1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ADCY1-2429H-B Recombinant Human ADCY1 Protein Pre-coupled Magnetic Beads HEK293
Human ADCY1-0080H Recombinant Human ADCY1 Protein (Arg835-Asn1061), N-His-tagged E.coli N-His
Mouse ADCY1-1342M Recombinant Mouse ADCY1 Protein Mammalian Cell His
Mouse Adcy1-3171M Recombinant Mouse Adcy1, His-tagged E.Coli or Yeast His
Mouse Adcy1-6842M Recombinant Mouse Adcy1 protein, His & T7-tagged E.coli His/T7
Mouse ADCY1-336M-B Recombinant Mouse ADCY1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ADCY1-336M Recombinant Mouse ADCY1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine ADCY1-3170B Recombinant Bovine ADCY1, GST-tagged E.Coli or Yeast GST
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADCY1 Related Articles
  • ADCY1 Related Gene Family
  • ADCY1 Related Signal Pathway

ADCY1 involved in several pathways and played different roles in them. We selected most pathways ADCY1 participated on our site, such as Activation of GABAB receptors, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Adenylate cyclase activating pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCY1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of GABAB receptorsADCY9;ADCY6;ADCY1;KCNJ3;KCNJ5;KCNJ9;KCNJ2;KCNJ12;ADCY8
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsDLG4;SLC14A2;NETO2;ADCY8;CREB1;NEFLB;PDPK1A;ADCY3;AKAP9
Adenylate cyclase activating pathwayADCY7;ADCY1;ADCY9;ADCY6;ADCY8;ADCY3
Adenylate cyclase inhibitory pathwayADCY3;ADCY8;ADCY6;ADCY9;ADCY7;ADCY1
Adrenergic signaling in cardiomyocytesPPP2R5D;TPM2;PIK3CD;GNAI1;MAPK12;VMHC;CACNA2D4;SCN4BA;PRKCA
Aldosterone synthesis and secretionSLC14A2;ADCY8;NPR1;PRKACG;CACNA1G;AGTR1A;DAGLB;ITPR3;GNAS
AmoebiasisPIK3CA;ACTN3;RAB5B;PRKACB;VCL;LAMA1;GNA15;CD1d1;SERPINB1C
Aquaporin-mediated transportMYO5B;GNB5B;AQP9B;GNB3B;AQP10;AQP8A.1;ADCY9;ADCY8;AQP10A

ADCY1 has several biochemical functions, for example, ATP binding, adenylate cyclase activity, calcium- and calmodulin-responsive adenylate cyclase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCY1 itself. We selected most functions ADCY1 had, and list some proteins which have the same functions with ADCY1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingYARS;NMNAT1;RUNX3;DNAJA3A;ERBB4A;MYH4;AK5L;CHD4A;SRPK3
adenylate cyclase activityADCY1B;ADCY8;GNAS;Adcy4;ADCY3;ADCY6;ADCY9;ADCY7;ADCY1A
calcium- and calmodulin-responsive adenylate cyclase activityADCY6;ADCY3;ADCY8;ADCY1
calmodulin bindingCAMSAP1L1;PLCB3;MYO3A;MKNK1;TRPC2;TTN;PDE1B;MYO5C;KCNN3
metal ion bindingRAB11FIP3;DDHD1;NT5C;CYP3A25;VPS29;NME4;RPAP2;ZNF124;SGSH

ADCY1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCY1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCY1.

Wang, XZ; Maynard, JA; et al. The Bordetella Adenylate Cyclase Repeat-in-Toxin (RTX) Domain Is Immunodominant and Elicits Neutralizing Antibodies. JOURNAL OF BIOLOGICAL CHEMISTRY 290:3576-3591(2015).
Chae, JJ; Park, YH; et al. Connecting Two Pathways Through Ca2+ Signaling: NLRP3 Inflammasome Activation Induced by a Hypermorphic PLCG2 Mutation. ARTHRITIS & RHEUMATOLOGY 67:563-567(2015).
  • Q&As
  • Reviews

Q&As (13)

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How is Adcy1 protein regulated? 09/25/2022

Adcy1 protein activity is regulated by various mechanisms, including post-translational modifications such as phosphorylation and by interaction with other proteins that can modulate its activity. Adcy1 protein is also subject to regulation by various extracellular signals that activate or inhibit cAMP signaling, including hormones and neurotransmitters.

Are there any ongoing clinical trials involving Adcy1 protein? 06/06/2022

Currently, there are no clinical trials specifically focused on Adcy1 protein. However, some clinical trials are investigating the potential therapeutic effects of drugs that target cAMP signaling, which may indirectly affect Adcy1 activity.

How can Adcy1 protein be targeted for therapeutic use? 10/26/2020

There are several ways to target Adcy1 protein for therapeutic use. One approach is to use small molecule inhibitors to block the activity of Adcy1. Another approach is to use gene therapy to increase or decrease the expression of Adcy1 in specific cells or tissues.

What are the potential therapeutic applications of Adcy1 protein? 09/24/2020

Adcy1 protein has been implicated in a variety of physiological and pathophysiological processes, suggesting that it may have therapeutic potential in a number of conditions. For example, manipulating the activity of Adcy1 could be useful in the treatment of various diseases, such as inflammatory disorders, metabolic disorders, and neurological disorders.

Is Adcy1 protein involved in cancer? 05/16/2020

Dysregulation of cAMP signaling, which is regulated by Adcy1 protein, has been implicated in the development and progression of various types of cancer. For example, decreased Adcy1 expression has been associated with the progression of colorectal cancer. However, more research is needed to fully understand the role of Adcy1 protein in cancer and to evaluate its potential use as a therapeutic target.

Can Adcy1 protein be used to improve cognitive function? 08/13/2019

Adcy1 protein has been shown to play a role in the regulation of synaptic plasticity, which is important for learning and memory. However, more research is needed to fully understand the effects of Adcy1 protein on cognitive function and to determine whether Adcy1-targeted therapies could be useful in treating cognitive disorders such as Alzheimer's disease and other dementias.

Are there any drugs that target Adcy1 protein? 08/28/2018

There are currently no drugs approved for therapeutic use that specifically target Adcy1 protein. However, several drugs that indirectly affect Adcy1 and cAMP signaling, such as beta-blockers and phosphodiesterase inhibitors, are already in clinical use for the treatment of cardiovascular and respiratory disorders.

What are the potential therapeutic applications of Adcy1 protein? 07/06/2018

Adcy1 protein plays a role in the regulation of cyclic AMP (cAMP) signaling, which is involved in many cellular processes. Therapeutic applications of Adcy1 protein may include the treatment of disorders related to abnormal cAMP signaling, such as heart disease, diabetes, and certain types of cancer.

How is Adcy1 protein being studied in research? 12/15/2017

Adcy1 protein is being studied in various research settings to better understand its role in cAMP signaling and cellular processes. This includes studies using cell-based models, animal models, and genetic analyses of patients with disorders related to cAMP signaling. Researchers are also exploring the potential therapeutic effects of Adcy1-targeted drugs on various conditions.

What are the potential side effects of Adcy1-targeted therapies? 11/02/2017

As Adcy1 protein is involved in many cellular processes, targeted therapy for Adcy1 may have off-target effects on other cellular functions. The potential side effects of Adcy1-targeted therapies are not yet fully understood as research in this area is ongoing. However, as with any targeted therapy, potential adverse effects will need to be thoroughly evaluated before clinical use.

What is the structure of Adcy1 protein? 12/10/2016

Adcy1 protein is an enzyme composed of a single protein chain that forms a complex three-dimensional structure. The protein contains multiple domains, including a C1 domain involved in signaling lipids, a catalytic domain that mediates the production of cAMP, and a regulatory domain that modulates its activity in response to various stimuli.

Can Adcy1 protein be used as a drug target? 03/22/2016

Adcy1 protein may be a target for drug development aimed at modulating cAMP signaling. However, the development of Adcy1-targeted drugs is still in the early stages of research and more work is needed to fully understand the role of Adcy1 protein in disease and to identify potential drug targets.

What are some potential advantages and disadvantages of targeting Adcy1 protein therapeutically? 01/17/2016

Potential advantages of targeting Adcy1 protein include the specificity of the therapy, as Adcy1 is not involved in many essential cellular processes, and the potential for personalized medicine, as the activity of Adcy1 can vary depending on the individual and the disease state. However, potential disadvantages include the risk of off-target effects on other cellular processes and the possibility of resistance to therapy developing over time.

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