ADRA2A
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Official Full Name
Adrenergic, Alpha-2A-, Receptor
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Overview
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. -
Synonyms
Adra2a; adrenergic, alpha-2A-, receptor; RG20; CA2-47; RATRG20; adrenergic receptor, alpha 2a; Adrenergic alpha 2A receptor; Adrenergic, alpha 2A, receptor; alpha-2AAR; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2A adrenergic receptor; alpha-2D adrenergic receptor;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Bos taurus (Bovine)
- Cavia porcellus (Guinea pig)
- Danio rerio (Zebrafish) (Brachydanio rerio)
- Homo sapiens (Human)
- Human
- Mus musculus (Mouse)
- Pig
- Rat
- Rattus norvegicus (Rat)
- Sus scrofa (Pig)
- Zebrafish
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- ADRA2A Related Articles
- ADRA2A Related Research Area
ADRA2A involved in several pathways and played different roles in them. We selected most pathways ADRA2A participated on our site, such as Adrenaline signalling through Alpha-2 adrenergic receptor, Adrenaline,noradrenaline inhibits insulin secretion, Adrenoceptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRA2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adrenaline signalling through Alpha-2 adrenergic receptor | ADRA2B;ADRA2A;ADRA2C |
| Adrenaline,noradrenaline inhibits insulin secretion | GNB5B;GNB5A;GNB5;ADRA2A;GNB3A;ADCY6;GNB3B;ADRA2C |
| Adrenoceptors | ADRa1A;ADRB1;ADRA2C;ADRA2A;ADRA1B;ADRB2;ADRA1D;ADRA2B;ADRB3 |
| Amine ligand-binding receptors | DRD2;CHRM5;CHRM3;ADRa1A;DRD1;ADRA2B;ADRB3;DRD5;ADRA1B |
| Class A/1 (Rhodopsin-like receptors) | GPBAR1;GPR4;CHRM1;APLN;CXCL11.8;CCL35.2;OPN4;OXER1;LPAR1 |
| G alpha (i) signalling events | PYYA;SSTR1;CCR3;NMS;RGS20;RLN3;CASR;HRH3;CCR6 |
| G alpha (z) signalling events | ADRA2C;RGS20;RGS19;ADRA2B;RGS4;RGS17;ADRA2A |
| GPCR downstream signaling | TAE1;PPY;GAL;APLN;PENKA;SSTR1;FGD4;ANXA1B;NPFFR2 |
ADRA2A has several biochemical functions, for example, alpha-1B adrenergic receptor binding, alpha-2C adrenergic receptor binding, alpha2-adrenergic receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRA2A itself. We selected most functions ADRA2A had, and list some proteins which have the same functions with ADRA2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alpha-1B adrenergic receptor binding | ARRB2;ARRB1;ADRA2A |
| alpha-2C adrenergic receptor binding | APLP1;ADRA2A |
| alpha2-adrenergic receptor activity | ADRA2B;ADRA2DB;ADRA2C;ADRA2DA;ADRA2A |
| epinephrine binding | ADRB1;ADRB3;ADRB2;ADRA2C;ADRA2B;ADRA2A;ADRB2B;ADRB2A;ADRB3B |
| heterotrimeric G-protein binding | ADRA2A;ADORA1;CETN4;CETN1;CETN2 |
| norepinephrine binding | ADRB3B;ADRB3A;ADRB2;ADRA2A;ADRB1 |
| protein binding | ABI3;KPNB1;MEIS1B;GSK3B;MOB4;LBH;USP18;SETDB1;PLCG2 |
| protein heterodimerization activity | TCF12;UGT1A1;HIST1H2BB;IKZF4;P2RY1;SMC1A;CREB3L3;HMG20B;NFE2L2A |
| protein homodimerization activity | G6PD;SNX6;PTPRO;SLC22A1;DPP4;OXCT1;ENG;S100A13;LMLN |
| protein kinase binding | TCF7L2;CD8A;STAT3;C10orf46;TMEM173;MAP3K1;PPP1CC;PPP1R15A;MLKL |
| thioesterase binding | TRAF4;TRAF5;TRAF2;RAC1;CDC42;ADRA2A;HAUS7;TRAF1;CALM3 |
ADRA2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRA2A here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRA2A.
yohimbine; rx-821002; PSMD2; Usp19; Hacd3
- Q&As
- Reviews
Q&As (19)
Ask a questionThe potential side effects of targeting ADRA2A depend on the specific compound used and the dose administered. Alpha-2 adrenergic agonists can cause sedation, dry mouth, constipation, and other side effects, while alpha-2 adrenergic antagonists can cause increased heart rate, blood pressure, and other cardiovascular effects.
Some genetic variations in the ADRA2A gene have been associated with increased risk of certain diseases, including anxiety disorders, ADHD, and hypertension.
Some research suggests that lifestyle factors such as exercise, diet, and stress reduction may influence ADRA2A expression and activity, although more research is needed in this area.
Yes, the alpha-2 adrenergic receptor family includes three subtypes - ADRA2A, ADRA2B, and ADRA2C - all of which share some common functions, but also have some distinct roles in different tissues and physiological processes.
Yes, genetic variations in the ADRA2A gene have been identified that affect receptor expression or activity, and have been associated with various diseases such as ADHD and depression.
Yes, targeting the ADRA2A receptor has been investigated as a potential treatment for hypertension, with studies showing that alpha-2 adrenergic agonists can lower blood pressure by reducing sympathetic nervous system activity.
The ADRA2A receptor is present in several organs including the brain, kidneys, lungs, blood vessels, and smooth muscle cells. Its function is to regulate the release of neurotransmitters, hormones, and enzymes, and to modulate blood pressure, heart rate, and gastrointestinal motility.
Studies have suggested that targeting the ADRA2A receptor could be beneficial for improving cognitive functions such as working memory and attention in certain populations, such as individuals with ADHD.
Yes, some research suggests that targeting the ADRA2A receptor could be a potential therapeutic strategy for treating addiction, particularly nicotine addiction, as it may modulate dopamine release and reward circuits in the brain.
There is some evidence to suggest that ADRA2A expression levels may be useful as a biomarker for certain diseases, such as ADHD and PTSD, although more studies are needed in this area.
ADRA2A stands for alpha-2A adrenergic receptor, a protein that is part of the adrenergic receptor family.
Targeting the ADRA2A receptor is being investigated for its therapeutic applications in several diseases, such as hypertension, anxiety, depression, and attention deficit hyperactivity disorder (ADHD).
ADRA2A agonists bind to and activate the receptor, resulting in reduced sympathetic nervous system activity and decreased release of norepinephrine. ADRA2A antagonists, on the other hand, block the receptor, leading to increased sympathetic nervous system activity and elevated levels of norepinephrine.
The ADRA2A receptor is part of the alpha-2 adrenergic receptor family, whereas the ADRA1A receptor is part of the alpha-1 adrenergic receptor family. In terms of function, the ADRA2A receptor is primarily responsible for inhibiting the release of noradrenaline, whereas the ADRA1A receptor enhances its release.
ADRA2A is thought to modulate cognitive function by regulating the release of neurotransmitters such as norepinephrine and dopamine, which are involved in attention, working memory, and other cognitive processes.
Alpha-2 adrenergic agonists such as clonidine and dexmedetomidine bind to the ADRA2A receptor and activate it, leading to inhibition of noradrenaline release and decreasing blood pressure, heart rate, and stress response.
Yes, genetic variations in the ADRA2A gene may influence an individual's response to medications that target the receptor, such as clonidine and dexmedetomidine.
Yes, targeting the ADRA2A receptor can have adverse effects, such as sedation, depression, and hypotension, particularly when using high doses or in individuals with certain medical conditions.
ADRA2A-targeted treatments have potential applications in various diseases and conditions, including hypertension, addiction, ADHD, PTSD, and depression. However, more research is needed to fully understand the therapeutic potential and limitations of targeting the receptor in each of these contexts.
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Based on my evaluation, the ADRA2A protein is of exceptional quality and purity, and will undoubtedly meet my experimental needs.
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