Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human ADRA2A Protein

Cat.No. : ADRA2A-379H
Product Overview : Human ADRA2A full-length ORF (NP_000672.2) recombinant protein without tag.
  • Specification
  • Gene Information
  • Related Products
Description : Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Form : Liquid
Molecular Mass : 49 kDa
AA Sequence : MGSLQPDAGNASWNGTEAPGGGARA TPYSLQVTLTLVCLAGLLMLLTVFG NVLVIIAVFTSRALKAPQNLFLVSL ASADILVATLVIPFSLANEVMGYWY FGKAWCEIYLALDVLFCTSSIVHLC AISLDRYWSITQAIEYNLKRTPRRI KAIIITVWVISAVISFPPLISIEKK GGGGGPQPAEPRCEINDQKWYVISS CIGSFFAPCLIMILVYVRIYQIAKR RTRVPPSRRGPDAVAAPPGGTERRP NGLGPERSAGPGGAEAEPLPTQLNG APGEPAPAGPRDTDALDLEESSSSD HAERPPGPRRPERGPRGKGKARASQ VKPGDSLPRRGPGATGIGTPAAGPG EERVGAAKASRWRGRQNREKRFTFV LAVVIGVFVVCWFPFFFTYTLTAVG CSVPRTLFKFFFWFGYCNSSLNPVI YTIFNHDFRRAFKKILCRGDRKRIV
Applications : Antibody Production
Functional Study
Compound Screening
Usage : Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 25 mM Tris-HCl of pH 8.0 containing 2% glycerol.
Gene Name : ADRA2A adrenoceptor alpha3B[ Homo sapiens ]
Official Symbol : ADRA2A
Synonyms : ADA2A_HUMAN; ADRA2; ADRA2A; ADRA2R; ADRAR; Adrenergic alpha 2A receptor; Alpha 2 adrenergic receptor subtype C10; Alpha 2A adrenergic receptor; Alpha 2AAR subtype C10; Alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; Alpha-2A adrenergic receptor; Alpha-2A adrenoceptor; Alpha-2A adrenoreceptor; Alpha-2AAR; ALPHA2AAR; OTTHUMP00000058849; ZNF32
Gene ID : 150
mRNA Refseq : NM_000681.3
Protein Refseq : NP_000672.3
MIM : 104210
UniProt ID : P08913

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (19)

Ask a question
What are the potential side effects of targeting ADRA2A? 04/03/2023

The potential side effects of targeting ADRA2A depend on the specific compound used and the dose administered. Alpha-2 adrenergic agonists can cause sedation, dry mouth, constipation, and other side effects, while alpha-2 adrenergic antagonists can cause increased heart rate, blood pressure, and other cardiovascular effects.

Are there any genetic variations in the ADRA2A gene that are associated with disease? 02/21/2023

Some genetic variations in the ADRA2A gene have been associated with increased risk of certain diseases, including anxiety disorders, ADHD, and hypertension.

Are there any non-medical interventions that can modulate ADRA2A expression or activity? 08/07/2022

Some research suggests that lifestyle factors such as exercise, diet, and stress reduction may influence ADRA2A expression and activity, although more research is needed in this area.

Are there any other alpha-2 adrenergic receptors that share functions with ADRA2A? 07/22/2022

Yes, the alpha-2 adrenergic receptor family includes three subtypes - ADRA2A, ADRA2B, and ADRA2C - all of which share some common functions, but also have some distinct roles in different tissues and physiological processes.

Are there any genetic variations that affect ADRA2A expression or activity? 02/27/2022

Yes, genetic variations in the ADRA2A gene have been identified that affect receptor expression or activity, and have been associated with various diseases such as ADHD and depression.

Could targeting the ADRA2A receptor be a potential treatment for hypertension? 10/25/2021

Yes, targeting the ADRA2A receptor has been investigated as a potential treatment for hypertension, with studies showing that alpha-2 adrenergic agonists can lower blood pressure by reducing sympathetic nervous system activity.

Where is the ADRA2A receptor present in the body and what is its function? 10/09/2021

The ADRA2A receptor is present in several organs including the brain, kidneys, lungs, blood vessels, and smooth muscle cells. Its function is to regulate the release of neurotransmitters, hormones, and enzymes, and to modulate blood pressure, heart rate, and gastrointestinal motility.

Is the ADRA2A receptor a potential target for improving cognitive function? 02/20/2021

Studies have suggested that targeting the ADRA2A receptor could be beneficial for improving cognitive functions such as working memory and attention in certain populations, such as individuals with ADHD.

Could ADRA2A-targeted treatments have potential applications in addiction therapy? 02/16/2021

Yes, some research suggests that targeting the ADRA2A receptor could be a potential therapeutic strategy for treating addiction, particularly nicotine addiction, as it may modulate dopamine release and reward circuits in the brain.

Can ADRA2A expression be used as a biomarker for certain diseases? 02/01/2021

There is some evidence to suggest that ADRA2A expression levels may be useful as a biomarker for certain diseases, such as ADHD and PTSD, although more studies are needed in this area.

What does ADRA2A stand for and what kind of protein is it? 01/20/2021

ADRA2A stands for alpha-2A adrenergic receptor, a protein that is part of the adrenergic receptor family.

What are the therapeutic applications of targeting the ADRA2A receptor? 01/20/2021

Targeting the ADRA2A receptor is being investigated for its therapeutic applications in several diseases, such as hypertension, anxiety, depression, and attention deficit hyperactivity disorder (ADHD).

How do ADRA2A agonists and antagonists differ in their mechanism of action? 10/18/2020

ADRA2A agonists bind to and activate the receptor, resulting in reduced sympathetic nervous system activity and decreased release of norepinephrine. ADRA2A antagonists, on the other hand, block the receptor, leading to increased sympathetic nervous system activity and elevated levels of norepinephrine.

How does the ADRA2A receptor differ from other alpha adrenergic receptors such as the ADRA1A receptor? 10/14/2019

The ADRA2A receptor is part of the alpha-2 adrenergic receptor family, whereas the ADRA1A receptor is part of the alpha-1 adrenergic receptor family. In terms of function, the ADRA2A receptor is primarily responsible for inhibiting the release of noradrenaline, whereas the ADRA1A receptor enhances its release.

How does ADRA2A modulate cognitive function? 09/15/2019

ADRA2A is thought to modulate cognitive function by regulating the release of neurotransmitters such as norepinephrine and dopamine, which are involved in attention, working memory, and other cognitive processes.

How do alpha-2 adrenergic agonists such as clonidine and dexmedetomidine act on the ADRA2A receptor? 06/02/2019

Alpha-2 adrenergic agonists such as clonidine and dexmedetomidine bind to the ADRA2A receptor and activate it, leading to inhibition of noradrenaline release and decreasing blood pressure, heart rate, and stress response.

Can polymorphisms in the ADRA2A gene influence response to medications that target the receptor? 07/21/2018

Yes, genetic variations in the ADRA2A gene may influence an individual's response to medications that target the receptor, such as clonidine and dexmedetomidine.

Can targeting the ADRA2A receptor have any adverse effects? 03/21/2017

Yes, targeting the ADRA2A receptor can have adverse effects, such as sedation, depression, and hypotension, particularly when using high doses or in individuals with certain medical conditions.

What are the potential therapeutic applications of ADRA2A-targeted treatments? 01/04/2017

ADRA2A-targeted treatments have potential applications in various diseases and conditions, including hypertension, addiction, ADHD, PTSD, and depression. However, more research is needed to fully understand the therapeutic potential and limitations of targeting the receptor in each of these contexts.

Customer Reviews (5)

Write a review
Reviews
06/22/2022

    After carefully considering various sources of protein, I have confidently chosen the protein from this particular supplier.

    06/27/2019

      I was impressed with the superb technical support provided by the manufacturer, which has been instrumental in addressing any questions or concerns I have had with ease.

      01/04/2018

        Based on my evaluation, the ADRA2A protein is of exceptional quality and purity, and will undoubtedly meet my experimental needs.

        11/29/2017

          I am highly satisfied with the quality of the product as well as the exceptional customer service and technical support I have received.

          09/05/2016

            With their experienced team readily available, I feel confident in my ability to achieve accurate and reliable results.

            Ask a Question for All ADRA2A Products

            Required fields are marked with *

            My Review for All ADRA2A Products

            Required fields are marked with *

            0

            Inquiry Basket

            cartIcon
            logo

            FOLLOW US

            Terms and Conditions        Privacy Policy

            Copyright © 2024 Creative BioMart. All Rights Reserved.

            Contact Us

            • /

            Stay Updated on the Latest Bioscience Trends