agt
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  • Official Full Name
  • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
  • Background
  • The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
  • Synonyms
  • AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; SERPINA8
Cat.#:AGT-517HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGT Protein, MYC/DDK-tagged
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Cat.#:Agt-01MTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Agt Protein
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Cat.#:AGT-2181HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGT, His tagged
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Cat.#:AGT-2182HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Angiotensinogen, His-tagged
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Cat.#:AGT-2183HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Angiotensinogen, His&GST-tagged
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Cat.#:AGT-442HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AGT Protein, GST-tagged
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Cat.#:Agt-253MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Agt protein, His/S-tagged
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Cat.#:Agt-526MTag:His
Source (Host):HEK293FSpecies:Mouse
Product nameRecombinant Mouse Agt protein, His-tagged
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Cat.#:Agt-6860MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Agt, His tagged
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Cat.#:Agt-1159RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Agt Protein, His-tagged
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Cat.#:Agt-254RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Agt protein, His/S-tagged
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Cat.#:Agt-3459RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Agt, His-tagged
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Cat.#:Agt-510RTag:His
Source (Host):HEK293FSpecies:Rat
Product nameRecombinant Rat Agt protein, His-tagged
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Cat.#:AGT-565RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AGT Protein
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Cat.#:AGT-9786ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AGT
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Cat.#:AGT-152HTag:
Source (Host):Human plasmaSpecies:Human
Product nameNative Human Angiotensinogen
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Cat.#:AGT-2575HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human AGT cell lysate
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Cat.#:AGT-1842MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse AGT cell lysate
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Cat.#:AGT-52HTag:
Source (Host):Species:Human
Product nameHuman Angiotensin II Reference standard
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Cat.#:AGT-53HTag:
Source (Host):Species:Human
Product nameHuman Angiotensin I Reference standard
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Cat.#:AGT-81HTag:
Source (Host):Species:Human
Product nameHuman Angiotensin I(Synthetic) Reference standard
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Involved Pathway

AGT involved in several pathways and played different roles in them. We selected most pathways AGT participated on our site, such as ACE Inhibitor Pathway, Adipogenesis, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with AGT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ACE Inhibitor Pathway
ACE; AGTR1; AGT; CMA1; ATP6AP2; CTSG; CYP11B2; AGTR2
Adipogenesis
KLF7; AGPAT2; AHR; CDKN1A; CEBPB; GDF10; AGT; KCNA3; NRIP1; EGR2B
Class A/1 (Rhodopsin-like receptors)
HRH3; PROKR1; SSTR5; EDNRAB; PNOCB; ZFPM2B; NMBA; SSTR1; OXGR1A.1; TAC3
Fatty acid, triacylglycerol, and ketone body metabolism
CYP4A11; DECR1; TMEM195; CCNC; GPAT2; MED21; GLIPR1; ACOT7; YAP1; AGPAT1
G alpha (i) signalling events
HEBP1; OPN5; GPR18; RGS18; RGS4; ANXA1; PENKA; OPN1LW2; RGS7; DRD2
G alpha (q) signalling events
PROKR2; NMBB; CHRM3; OXTRL; EDN1; TAC3; ABHD12; MGLL; GCGB; EDNRA
GPCR downstream signaling
CHRM3; NMBA; PYY; TAS2R7; OXTRL; OXGR1A.1; DRD3; GPR132B; GNA13; PROKR1A
GPCR ligand binding
OPN4B; GPR65; GPR132B; GCGA; CYSLTR1; PNOCB; GPR37B; PENK; CCR3; KISS1

Protein Function

AGT has several biochemical functions, for example, growth factor activity, hormone activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGT itself. We selected most functions AGT had, and list some proteins which have the same functions with AGT. You can find most of the proteins on our site.
Function
Related Protein
Function growth factor activity
Related Protein Pdgfa&Pdgfb; IGF2B; FGF1B; MDK; TIMP1; TGFB3; FGF6; AGT; FGF18A; IL6
Function hormone activity
Related Protein UTS2D; TTR; PRL7A1; PYY; PYYA; INSL5A; GH1; INSB; PRL2C3; POMCA
Function protein binding
Related Protein SOCS4; SYTL4; IGFN1; AIM2; ARPC4; CCS; ATMIN; SH3BP1; SREK1; TBXA2R
Function serine-type endopeptidase inhibitor activity
Related Protein KAL1; SPINK2; SERPINB1C; WFIKKN2; SERPINE2; CCNH; OVST; SPINK10; APP; FURIN
Function sodium channel regulator activity
Related Protein SGK2B; YWHAH; SCN1B; FXYD6; FXYD3; SGK2; PTPN3; FXYD7; FXYD2; SGK3
Function superoxide-generating NADPH oxidase activator activity
Related Protein NOXO1; PDGFB; AGT; NOXA1; NCF4
Function type 1 angiotensin receptor binding
Related Protein TYK2; JAK2; GNG3; GNA13; ARAP1; BDKRB2; GNA13A; ARRB2; AGT; GNA13B
Function type 2 angiotensin receptor binding
Related Protein AGT

Interacting Protein

AGT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGT here. Most of them are supplied by our site. Hope this information will be useful for your research of AGT.
Ance; Agtr1; f_hcvh; GRB2; EWSR1; GSDMB

AGT Related Articles

Betensky, M; Witmer, C; et al. Immune hemolytic anemia with drug-induced antibodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma. TRANSFUSION 54:2901-2905(2014).
Dihazi, H; Dihazi, GH; et al. Secretion of ERP57 is important for extracellular matrix accumulation and progression of renal fibrosis, and is an early sign of disease onset. JOURNAL OF CELL SCIENCE 126:3649-3663(2013).