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AGT

  • Official Full Name

    angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

  • Overview

    The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
  • Synonyms

    AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; SERPINA8;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Plasma
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|S
  • SUMO
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AGT-517H Recombinant Human AGT Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human AGT-2181H Recombinant Human AGT, His tagged HEK293 His Met 1-Ala 485
Human AGT-442H Recombinant Human AGT Protein, GST-tagged Wheat Germ GST
Human AGT-2183H Recombinant Human Angiotensinogen, His&GST-tagged E.coli His/GST
Human AGT-2182H Recombinant Human Angiotensinogen, His-tagged E.coli His
Human AGT-2575HCL Recombinant Human AGT cell lysate Human Cell N/A
Human AGT-293H Recombinant Human AGT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AGT-53H Human Angiotensin I Reference standard N/A
Human AGT-5413H Recombinant Human AGT Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AGT-152H Native Human Angiotensinogen Human Plasma N/A
Human AGT-0647H Recombinant Human AGT Protein (Arg35-Ala485), N-GST-tagged E.coli N-GST Arg35-Ala485
Human AGT-95H Recombinant Human AGT Protein, His-tagged HEK293F N-His Asp34-Ala485
Human AGT-81H Human Angiotensin I(Synthetic) Reference standard N/A
Human AGT-2493H Recombinant Human AGT protein, His-SUMO-tagged E.coli His-SUMO 44-427aa
Human AGT-52H Human Angiotensin II Reference standard N/A
Human AGT-78HFL Recombinant Full Length Human AGT Protein, C-Flag-tagged Mammalian cells Flag
Human AGT-937HF Recombinant Full Length Human AGT Protein, GST-tagged In Vitro Cell Free System GST 485 amino acids
Human AGT-572H Recombinant Human AGT Protein, His-tagged HEK293 His 485
Human AGT-293H-B Recombinant Human AGT Protein Pre-coupled Magnetic Beads HEK293
Human AGT-0648H Recombinant Human AGT Protein (Asp34-Ala485), C-His-tagged Mammalian cells C-His Asp34-Ala485
Mouse Agt-6860M Recombinant Mouse Agt protein, His-tagged HEK293 His Met1-Val477
Mouse Agt-526M Recombinant Mouse Agt protein, His-tagged HEK293F His
Mouse Agt-253M Recombinant Mouse Agt protein, His/S-tagged E.coli His/S
Mouse AGT-1842MCL Recombinant Mouse AGT cell lysate Human Cell N/A
Mouse Agt-96M Recombinant Mouse Agt Protein, His-tagged HEK293F N-His Phe33-Pro145
Mouse Agt-01M Recombinant Mouse Agt Protein HEK293 N/A
Mouse Agt-554M Recombinant Mouse Agt Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat AGT-565R Recombinant Rat AGT Protein Mammalian Cell His
Rat Agt-510R Recombinant Rat Agt protein, His-tagged HEK293F His Asp25~Val477
Rat Agt-1159R Recombinant Rat Agt Protein, His-tagged HEK293 His
Rat Agt-3459R Recombinant Rat Agt, His-tagged E.Coli or Yeast His 477
Rat Agt-254R Recombinant Rat Agt protein, His/S-tagged E.coli His/S
Rat AGT-221R-B Recombinant Rat AGT Protein Pre-coupled Magnetic Beads HEK293
Rat AGT-221R Recombinant Rat AGT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish AGT-9786Z Recombinant Zebrafish AGT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AGT Related Articles
  • AGT Related Signal Pathway

AGT involved in several pathways and played different roles in them. We selected most pathways AGT participated on our site, such as ACE Inhibitor Pathway, Adipogenesis, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with AGT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ACE Inhibitor PathwayACE;AGTR1;CYP11B2;AGT;AGTR2;CTSG;CMA1;ATP6AP2
AdipogenesisPLIN2;NR1H3;FOXC2;BMP3;SPOCK1;NR2F1A;MIXL1;STIL;MEF2AA
Class A/1 (Rhodopsin-like receptors)HCRT;CCL19A.2;CXCL11.8;DRD4;GPR31;CYSLTR1;NTS;EDNRB;AGTR1
Fatty acid, triacylglycerol, and ketone body metabolismSIN3B;ANKRD1;ABCA1;MED19;GPAT2;THEM5;CYP4A11;PLIN2;ACOT7
G alpha (i) signalling eventsRGS7;RGS21;CCR1;SSTR2;ADRA2C;RGS14;CCR9;CASR;TAS2R13
G alpha (q) signalling eventsEDN1;NMBB;GPR65;PROK2;GPR4;NMB;NMS;FPR-RS3;GPR132B
GPCR downstream signalingSSTR5;PROK1;AKAP13;ARHGEF1B;OR2AP1;SCT;NET1;EDNRAB;SST
GPCR ligand bindingCALCB;CALCA;ADRA2B;PENKA;CCR8;GPR37B;UTS2D;TAS2R7;CCK

AGT has several biochemical functions, for example, growth factor activity, hormone activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGT itself. We selected most functions AGT had, and list some proteins which have the same functions with AGT. You can find most of the proteins on our site.

Function Related Protein
growth factor activityAMBN;TFF1;FGF10A;FGF6A;NRG1;EFEMP1;FGF2;THBS4B;FIGF
hormone activityPRL7A1;PRL8A9;ADIPOQ;FSD1;LEP;TSHB;INSL6;RLN3;FSHB
protein bindingIGF2BP1;KSR1;TRIP4;UBE3A;C4orf19;SSBP1;PBRM1;SCEL;MYO6
serine-type endopeptidase inhibitor activitySERPINB2;SPINT1B;SPINK8;SERPINF1;WFDC12;SERPINB1C;SERPINB11;TFPIA;SERPINE2
sodium channel regulator activitySGK3;CAV3;PTPN3;FXYD5;SCN3B;SCN1BB;FXYD1;SGK1;SGK2
superoxide-generating NADPH oxidase activator activityNCF4;NOXO1;PDGFB;AGT;NOXA1
type 1 angiotensin receptor bindingBDKRB2;JAK2;GNA13B;GNA13A;ARAP1;GNB1;ARRB2;AGT;TYK2
type 2 angiotensin receptor binding

AGT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGT here. Most of them are supplied by our site. Hope this information will be useful for your research of AGT.

Ance; Agtr1; f_hcvh; GRB2; EWSR1; GSDMB

Betensky, M; Witmer, C; et al. Immune hemolytic anemia with drug-induced antibodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma. TRANSFUSION 54:2901-2905(2014).
Dihazi, H; Dihazi, GH; et al. Secretion of ERP57 is important for extracellular matrix accumulation and progression of renal fibrosis, and is an early sign of disease onset. JOURNAL OF CELL SCIENCE 126:3649-3663(2013).
  • Q&As
  • Reviews

Q&As (10)

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How is AGT linked to kidney function? 11/19/2022

AGT is produced and released by the kidneys, and it plays a role in regulating renal blood flow and glomerular filtration rate, thereby impacting overall kidney function.

What is the role of AGT in the renin-angiotensin system? 01/14/2022

AGT is the precursor molecule for angiotensin peptides, including angiotensin I and angiotensin II, which are key regulators of blood pressure, fluid balance, and cardiovascular homeostasis.

How is AGT involved in blood pressure regulation? 10/12/2021

AGT-derived angiotensin II plays a critical role in vasoconstriction, sodium reabsorption, and the regulation of aldosterone secretion, all of which influence blood pressure.

Does AGT have a role in the central nervous system? 08/26/2020

AGT and the renin-angiotensin system have been implicated in the central regulation of blood pressure, fluid balance, and neuroendocrine functions.

How is AGT activated in the renin-angiotensin system? 07/15/2020

AGT is cleaved by the enzyme renin to generate angiotensin I, which is subsequently converted to angiotensin II by the enzyme angiotensin-converting enzyme (ACE).

What factors regulate AGT expression? 06/20/2020

AGT expression is regulated by various factors, including hormones (such as aldosterone and glucocorticoids), cytokines, and environmental stimuli.

How does AGT contribute to inflammation and tissue remodeling? 10/03/2019

AGT and its derivatives, such as angiotensin II, can promote inflammation and tissue remodeling through interactions with receptors and signaling pathways.

What techniques are used to study AGT function and regulation? 03/12/2019

Experimental techniques used to study AGT include molecular biology approaches, gene expression analysis, protein quantification, immunohistochemistry, and animal models.

Can genetic variations in AGT affect disease susceptibility? 08/18/2018

Genetic variations in the AGT gene have been associated with an increased risk of hypertension, cardiovascular diseases, and other conditions influenced by the renin-angiotensin system.

How is AGT involved in pregnancy-related disorders? 06/04/2018

AGT levels and the renin-angiotensin system play a role in regulating blood pressure during pregnancy, and dysregulation can contribute to disorders such as preeclampsia.

Customer Reviews (5)

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Reviews
07/29/2020

    The proteins offering reliable results and contributing to the success of my experiments.

    05/09/2020

      The customer service team was incredibly helpful and responsive to my inquiries.

      10/20/2019

        The product allowed me to access high-quality reagents while staying within my budget.

        08/01/2019

          The ordering process was seamless, and the company's efficient shipping ensured that I received the recombinant proteins promptly and in excellent condition.

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