Recombinant Human AGT Protein, GST-tagged

• Cat.No.: AGT-442H
• Product Overview: Human AGT full-length ORF ( AAH11519, 1 a.a. - 485 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 79.09 kDa
• AA Sequence: MRKRAPQSEMAPAGVSLRATILCLL AWAGLAAGDRVYIHPFHLVIHNEST CEQLAKANAGKPKDPTFIPAPIQAK TSPVDEKALQDQLVLVAAKLDTEDK LRAAMVGMLANFLGFRIYGMHSELW GVVHGATVLSPTAVFGTLASLYLGA LDHTADRLQAILGVPWKDKNCTSRL DAHKVLSALQAVQGLLVAQGRADSQ AQLLLSTVVGVFTAPGLHLKQPFVQ GLALYTPVVLPRSLDFTELDVAAEK IDRFMQAVTGWKTGCSLTGASVDST LAFNTYVHFQGKMKGFSLLAEPQEF WVDNSTSVSVPMLSGMGTFQHWSDI QDNFSVTQVSFTESACLLLIQPHYA SDLDKVEGLTFQQNSLNWMKKLSPR TIHLTMPQLVLQGSYDLQDLLAQAE LPAILHTELNLQKLSNDRIRVGEVL NSIFFELEADEREPTESTQQLNKPE VLEVTLNRPFLFAVYDQSATALHFL GRVANPLSTA
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens ]
• Official Symbol: AGT
• Synonyms: AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); SERPINA8; angiotensinogen; alpha 1 antiproteinase; antitrypsin; serpin A8; angiotensin I; angiotensin II; pre-angiotensinogen; alpha-1 antiproteinase, antitrypsin; serine (or cysteine) proteinase inhibitor; ANHU
• Gene ID: 183
• mRNA Refseq: NM_000029
• Protein Refseq: NP_000020
• MIM: 106150
• UniProt ID: P01019