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Recombinant Human Angiotensinogen, His-tagged

Cat.No. : AGT-2182H
Product Overview : Recombinant Human Angiotensinogen(Ala155~Lys355), fused with N-terminal His-Tag, was expressed in Prokaryotic expression.
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Description : The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Source : E.coli
Species : Human
Tag : His
Form : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Molecular Mass : 24.5kDa
AA Sequence : The target protein is fused with N-terminal His-Tag, its sequence is listed below.MGHHHHHHSGSEF- ADRLQA ILGVPWKDKN CTSRLDAHKV LSALQAVQGL LVAQGRADSQ AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD FTELDVAAEK IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA SDLDK
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : > 95%
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens (human) ]
Official Symbol : AGT
Synonyms : AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; FLJ92595; FLJ97926; SERPINA8; angiotensinogen; serpin A8; angiotensin I; angiotensin II; pre-angiotensinogen; alpha-1 antiproteinase, antitrypsin; serine (or cysteine) proteinase inhibitor; Angiotensin-1; Ang I; Angiotensin-2; Ang II; Angiotensin-3; Ang III; Angiotensin III
Gene ID : 183
mRNA Refseq : NM_000029
Protein Refseq : NP_000020
MIM : 106150
UniProt ID : P01019
Chromosome Location : 1q42.2
Pathway : Hypertrophic cardiomyopathy (HCM); Renin-angiotensin system; Vascular smooth muscle contraction
Function : acetyltransferase activator activity; growth factor activity; hormone activity; serine-type endopeptidase inhibitor activity; type 1 angiotensin receptor binding; type 2 angiotensin receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How is AGT linked to kidney function? 11/19/2022

AGT is produced and released by the kidneys, and it plays a role in regulating renal blood flow and glomerular filtration rate, thereby impacting overall kidney function.

What is the role of AGT in the renin-angiotensin system? 01/14/2022

AGT is the precursor molecule for angiotensin peptides, including angiotensin I and angiotensin II, which are key regulators of blood pressure, fluid balance, and cardiovascular homeostasis.

How is AGT involved in blood pressure regulation? 10/12/2021

AGT-derived angiotensin II plays a critical role in vasoconstriction, sodium reabsorption, and the regulation of aldosterone secretion, all of which influence blood pressure.

Does AGT have a role in the central nervous system? 08/26/2020

AGT and the renin-angiotensin system have been implicated in the central regulation of blood pressure, fluid balance, and neuroendocrine functions.

How is AGT activated in the renin-angiotensin system? 07/15/2020

AGT is cleaved by the enzyme renin to generate angiotensin I, which is subsequently converted to angiotensin II by the enzyme angiotensin-converting enzyme (ACE).

What factors regulate AGT expression? 06/20/2020

AGT expression is regulated by various factors, including hormones (such as aldosterone and glucocorticoids), cytokines, and environmental stimuli.

How does AGT contribute to inflammation and tissue remodeling? 10/03/2019

AGT and its derivatives, such as angiotensin II, can promote inflammation and tissue remodeling through interactions with receptors and signaling pathways.

What techniques are used to study AGT function and regulation? 03/12/2019

Experimental techniques used to study AGT include molecular biology approaches, gene expression analysis, protein quantification, immunohistochemistry, and animal models.

Can genetic variations in AGT affect disease susceptibility? 08/18/2018

Genetic variations in the AGT gene have been associated with an increased risk of hypertension, cardiovascular diseases, and other conditions influenced by the renin-angiotensin system.

How is AGT involved in pregnancy-related disorders? 06/04/2018

AGT levels and the renin-angiotensin system play a role in regulating blood pressure during pregnancy, and dysregulation can contribute to disorders such as preeclampsia.

Customer Reviews (5)

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Reviews
07/29/2020

    The proteins offering reliable results and contributing to the success of my experiments.

    05/09/2020

      The customer service team was incredibly helpful and responsive to my inquiries.

      10/20/2019

        The product allowed me to access high-quality reagents while staying within my budget.

        08/01/2019

          The ordering process was seamless, and the company's efficient shipping ensured that I received the recombinant proteins promptly and in excellent condition.

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