Recombinant Human Angiotensinogen, His-tagged
Cat.No. : | AGT-2182H |
Product Overview : | Recombinant Human Angiotensinogen(Ala155~Lys355), fused with N-terminal His-Tag, was expressed in Prokaryotic expression. |
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Description : | The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Form : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
Molecular Mass : | 24.5kDa |
AA Sequence : | The target protein is fused with N-terminal His-Tag, its sequence is listed below.MGHHHHHHSGSEF- ADRLQA ILGVPWKDKN CTSRLDAHKV LSALQAVQGL LVAQGRADSQ AQLLLSTVVG VFTAPGLHLK QPFVQGLALY TPVVLPRSLD FTELDVAAEK IDRFMQAVTG WKTGCSLMGA SVDSTLAFNT YVHFQGKMKG FSLLAEPQEF WVDNSTSVSV PMLSGMGTFQ HWSDIQDNFS VTQVPFTESA CLLLIQPHYA SDLDK |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | > 95% |
Applications : | SDS-PAGE; WB; ELISA; IP. |
Stability : | The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [ Homo sapiens (human) ] |
Official Symbol : | AGT |
Synonyms : | AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; FLJ92595; FLJ97926; SERPINA8; angiotensinogen; serpin A8; angiotensin I; angiotensin II; pre-angiotensinogen; alpha-1 antiproteinase, antitrypsin; serine (or cysteine) proteinase inhibitor; Angiotensin-1; Ang I; Angiotensin-2; Ang II; Angiotensin-3; Ang III; Angiotensin III |
Gene ID : | 183 |
mRNA Refseq : | NM_000029 |
Protein Refseq : | NP_000020 |
MIM : | 106150 |
UniProt ID : | P01019 |
Chromosome Location : | 1q42.2 |
Pathway : | Hypertrophic cardiomyopathy (HCM); Renin-angiotensin system; Vascular smooth muscle contraction |
Function : | acetyltransferase activator activity; growth factor activity; hormone activity; serine-type endopeptidase inhibitor activity; type 1 angiotensin receptor binding; type 2 angiotensin receptor binding |
Products Types
◆ Recombinant Protein | ||
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AGT-95H | Recombinant Human AGT Protein, His-tagged | +Inquiry |
AGT-517H | Recombinant Human AGT Protein, MYC/DDK-tagged | +Inquiry |
AGT-293H | Recombinant Human AGT Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
AGT-152H | Native Human Angiotensinogen | +Inquiry |
◆ Lysates | ||
AGT-1842MCL | Recombinant Mouse AGT cell lysate | +Inquiry |
AGT-2575HCL | Recombinant Human AGT cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAGT is produced and released by the kidneys, and it plays a role in regulating renal blood flow and glomerular filtration rate, thereby impacting overall kidney function.
AGT is the precursor molecule for angiotensin peptides, including angiotensin I and angiotensin II, which are key regulators of blood pressure, fluid balance, and cardiovascular homeostasis.
AGT-derived angiotensin II plays a critical role in vasoconstriction, sodium reabsorption, and the regulation of aldosterone secretion, all of which influence blood pressure.
AGT and the renin-angiotensin system have been implicated in the central regulation of blood pressure, fluid balance, and neuroendocrine functions.
AGT is cleaved by the enzyme renin to generate angiotensin I, which is subsequently converted to angiotensin II by the enzyme angiotensin-converting enzyme (ACE).
AGT expression is regulated by various factors, including hormones (such as aldosterone and glucocorticoids), cytokines, and environmental stimuli.
AGT and its derivatives, such as angiotensin II, can promote inflammation and tissue remodeling through interactions with receptors and signaling pathways.
Experimental techniques used to study AGT include molecular biology approaches, gene expression analysis, protein quantification, immunohistochemistry, and animal models.
Genetic variations in the AGT gene have been associated with an increased risk of hypertension, cardiovascular diseases, and other conditions influenced by the renin-angiotensin system.
AGT levels and the renin-angiotensin system play a role in regulating blood pressure during pregnancy, and dysregulation can contribute to disorders such as preeclampsia.
Customer Reviews (5)
Write a reviewThe proteins offering reliable results and contributing to the success of my experiments.
The customer service team was incredibly helpful and responsive to my inquiries.
The product allowed me to access high-quality reagents while staying within my budget.
The ordering process was seamless, and the company's efficient shipping ensured that I received the recombinant proteins promptly and in excellent condition.
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