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AKT3

  • Official Full Name

    v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)

  • Overview

    The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
  • Synonyms

    AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); PKBG; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma; DKFZp434N0250; RAC-gamma serine/threonine-protein kinase; PKB gamma; OTTHUMP00000037911; OTTHUMP00000037912; protein kinase Akt-3; protein kinase B gamma; serine threonine protein kinase, Akt-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • Fc
  • Flag
  • GST
  • GST|His
  • His
  • HIS
  • His (Fc)
  • Avi
  • His|MBP
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKT3-1365H Active Recombinant Human AKT3, GST-tagged Sf9 Insect Cell GST Full length
Human AKT3-104H Active Recombinant Human AKT3, GST-tagged Sf9 Insect Cell GST
Human AKT3-804H Active Recombinant Human AKT3 protein, GST-His-tagged Insect Cell GST/His 106 a.a. - 479 a.a.
Human AKT3-426H Active Recombinant Human AKT3 Protein Insect Cell N/A
Human AKT3-424HFL Active Recombinant Full Length Human AKT3 Protein, C-Flag-tagged Mammalian cells Flag
Human AKT3-17H Active Recombinant Human AKT3(S472D)(117-end) Mutation Protein, N-His-tagged Sf21 His 117-end
Human AKT3-2522H Recombinant Human AKT3, Active E.coli N/A
Human AKT3-550H Recombinant Human AKT3 Protein, His-tagged E.coli His Asp46~Glu338
Human AKT3-166H Recombinant Human AKT3, His-tagged E.coli His
Human AKT3-308H Recombinant Human AKT3 protein, His/MBP-tagged E.coli His/MBP 264-465 aa
Human AKT3-131H Recombinant Human AKT3, GST tagged Insect Cell GST
Human AKT3-165H Recombinant Human AKT3, Active, His-tagged Sf9 Insect Cell His
Human Akt3-159H Recombinant Human Akt3, His-tagged E.coli His
Human AKT3-26H Recombinant Human AKT3 (E17K), GST-tagged Sf9 Insect Cell GST
Human AKT3-427H Recombinant Human AKT3 Protein, GST-tagged Wheat Germ GST
Human Akt3-162H Recombinant Human Akt3, GST-tagged E.coli GST
Human AKT3-728HCL Recombinant Human AKT3 cell lysate Insect Cell N/A
Human AKT3-1566H Recombinant Human AKT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AKT3-0084H Recombinant Human AKT3 Protein (S2-E479), Tag Free Insect Cell No tag S2-E479
Human AKT3-26391TH Recombinant Human AKT3, His-tagged HIS
Human AKT3-0085H Recombinant Human AKT3 Protein (S2-E479), GST tagged Insect Cell GST S2-E479
Human AKT3-01H Recombinant Human AKT3 Protein, His-tagged HEK293 His
Human AKT3-308H-B Recombinant Human AKT3 Protein Pre-coupled Magnetic Beads HEK293
Human AKT3-1385HF Recombinant Full Length Human AKT3 Protein, GST-tagged In Vitro Cell Free System GST 479 amino acids
Human AKT3-26264TH Recombinant Human AKT3 N/A
Human AKT3-0362H Recombinant Human AKT3 Protein (Met1-Lys143), N-His-tagged E.coli N-His Met1-Lys143
Mouse AKT3-3223M Active Recombinant Mouse AKT3 protein(Ala106-Glu479) Insect Cells N/A Ala106-Glu479
Mouse Akt3-8694M Recombinant Mouse Akt3, His-GST tagged Insect Cell Fc
Mouse AKT3-549M Recombinant Mouse Akt3, None tagged Insect Cell Fc
Mouse AKT3-001MCL Recombinant Mouse AKT3 cell lysate Insect Cell N/A
Mouse Akt3-1586M Recombinant Mouse Akt3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse AKT3-0258M Recombinant Mouse AKT3 protein, His&GST-tagged Insect Cells His/GST Ala106-Glu479
Rat AKT3-607R Recombinant Rat AKT3 Protein Mammalian Cell His
Rat AKT3-263R-B Recombinant Rat AKT3 Protein Pre-coupled Magnetic Beads HEK293
Rat AKT3-263R Recombinant Rat AKT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AKT3-298R Recombinant Rhesus monkey AKT3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AKT3-126R Recombinant Rhesus Macaque AKT3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AKT3-126R-B Recombinant Rhesus Macaque AKT3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AKT3 Related Articles
  • AKT3 Related Gene Family
  • AKT3 Related Research Area
  • AKT3 Related Signal Pathway

AKT3 involved in several pathways and played different roles in them. We selected most pathways AKT3 participated on our site, such as AKT phosphorylates targets in the cytosol, AKT phosphorylates targets in the nucleus, AKT-mediated inactivation of FOXO1A, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AKT phosphorylates targets in the cytosolCHUK;AKT3;CDKN1B;CDKN1A
AKT phosphorylates targets in the nucleusCREB1;AKT3;CREB1B
AKT-mediated inactivation of FOXO1A
AMPK signaling pathwayIRS4;CD36;HNF4A;CREB1;IRS1;STRADA;PIK3CD;RAB8A;RAB2A
Activation of BAD and translocation to mitochondriaCDK5RAP2;YWHAQ;AKT3
Activation of BH3-only proteinsAKT3;YWHAQ;DYNLL2;CDK5RAP2;BCL2L11;E2F1
Acute myeloid leukemiaMTOR;RAF1;RARA;RPS6KB2;IKBKG;PIK3CG;SFPI1;CHUK;EIF4EBP1
Adaptive Immune SystemFCGR1B;RNF34;SIGLEC8;ASB18;SPSB4;CYBB;IFI30;IGKV1-5;UBE2U

AKT3 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT3 itself. We selected most functions AKT3 had, and list some proteins which have the same functions with AKT3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPKMYT1;ABCE1;PLK3;MAPK9;UBA7;EPHA6;PGK2;MAGI1;GATC
protein bindingSIVA1;TOP1;RGMA;CYHR1;AHR;EPC1;CCL3;RFC5;FLRT3
protein kinase activityBSK146;ROCK2A;PRKAG1;JAK2A;RNASEL;STK17B;STK38A;DCLK1A;BUB1B
protein serine/threonine kinase activityGRK5;CDC42BPB;STK36;ERN2;MAPK8B;CAMKK1B;ICK;CSNK1A1L;PBK

AKT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT3.

CASP3; CDC37; saicar; PKM; HSP90AA1; PRKCZ; HSP90AB1; NUDCD1

Mias, GI; Chen, R; et al. Specific Plasma Autoantibody Reactivity in Myelodysplastic Syndromes. SCIENTIFIC REPORTS 3:-(2013).
Marchbank, T; Mahmood, A; et al. Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F382-F389(2013).
TGF
  • Q&As
  • Reviews

Q&As (20)

Ask a question
What are the implications of AKT3 dysregulation? 02/10/2023

Dysregulation of AKT3 activity is associated with various human diseases, including cancer, diabetes, neurodegenerative disorders, and cardiovascular diseases. Overactivation of AKT3 can promote uncontrolled cell growth and survival, a hallmark of cancer. In contrast, reduced AKT3 activity is linked to insulin resistance and type 2 diabetes.

Is AKT3 exclusively expressed in certain cell types or can it be found in multiple cell types? 01/23/2023

AKT3 is not exclusively expressed in specific cell types and can be found in multiple cell types. While it is abundantly expressed in neuronal tissues and plays a role in brain development, AKT3 is also expressed in other cell types, including epithelial cells, endothelial cells, and immune cells.

Are there any known diseases or disorders associated with dysregulation of AKT3? 01/03/2023

Yes, dysregulation of AKT3 has been implicated in a variety of diseases and disorders. As mentioned earlier, genetic mutations in AKT3 are associated with diseases such as Proteus syndrome and megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome. Additionally, dysregulation of AKT3 has been observed in various types of cancer, including breast, ovarian, colorectal, and lung cancer, where it promotes cell survival, proliferation, and resistance to therapies. Altered AKT3 activity has also been implicated in neurological disorders such as autism spectrum disorder and epilepsy.

Are there any ongoing clinical trials targeting AKT3? 05/06/2022

Yes, there are ongoing clinical trials investigating AKT inhibitors that target the AKT pathway, which includes AKT3. These trials are evaluating the efficacy and safety of AKT inhibitors in various cancer types, such as breast, ovarian, lung, and prostate cancer.

Are there any drugs targeting AKT3 currently available? 03/14/2022

As of now, there are no FDA-approved drugs specifically targeting AKT3. However, there are several ongoing preclinical and clinical studies investigating the efficacy of AKT inhibitors that could potentially target AKT3 in various diseases, including cancer. Some of these compounds include MK-2206, AZD5363, GSK2141795, and ipatasertib.

What are the downstream targets of AKT3? 01/12/2021

AKT3 phosphorylates and modulates the activity of numerous downstream targets involved in cell survival and growth regulation. Examples include the anti-apoptotic protein Bcl-2, the mammalian target of rapamycin (mTOR), glycogen synthase kinase-3 (GSK-3), and several transcription factors, such as forkhead box O (FOXO) and nuclear factor kappa B (NF-κB).

Is AKT3 expressed in all tissues of the body? 11/16/2020

AKT3 is expressed in a wide range of tissues but its expression levels may vary among different tissues. For instance, AKT3 is more abundantly expressed in the brain, heart, and skeletal muscles compared to other tissues. However, it is important to note that the expression levels of AKT3 can be dynamically regulated depending on cellular context, developmental stage, and environmental cues.

Can AKT3 inhibitors be used in combination with other cancer treatments? 02/18/2020

Yes, AKT3 inhibitors can potentially be used in combination with other cancer treatments to enhance their efficacy. Preclinical studies have shown that combining AKT inhibitors with chemotherapy drugs or targeted therapies can improve anti-tumor effects. For example, combining AKT inhibitors with HER2-targeted therapies has been explored in HER2-positive breast cancer. Additionally, AKT inhibitors may also sensitize tumors to radiation therapy. However, more research is needed to optimize the combination strategies and determine the most effective treatment regimens.

Can AKT3 inhibitors be used to treat other diseases besides cancer? 12/04/2019

AKT3 inhibitors primarily have been studied in the context of cancer treatment, but the AKT pathway is involved in various physiological and pathological processes beyond cancer. As a result, AKT inhibitors have been explored for potential therapeutic applications in other diseases.

Can AKT3 be regulated by other signaling pathways? 07/22/2019

Yes, AKT3 can be regulated by various signaling pathways apart from its canonical activation through growth factors. For example, AKT3 can be activated by insulin signaling, which plays a crucial role in glucose metabolism and cellular energy homeostasis. AKT3 can also be influenced by other pathways such as the AMP-activated protein kinase (AMPK) pathway, which regulates cellular energy status, and the Wnt pathway, which is involved in cell proliferation and differentiation.

Are there any genetic mutations associated with AKT3? 02/08/2019

Yes, genetic mutations in the AKT3 gene have been identified in rare human diseases. One well-known condition associated with AKT3 mutations is Proteus syndrome, a complex and highly variable disorder characterized by overgrowth of various tissues. AKT3 mutations are also found in a condition called megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH), which is characterized by overgrowth of the brain, abnormal brain development, and other features.

How is AKT3 activated? 02/04/2019

AKT3 is activated through a phosphorylation cascade. Upon stimulation by growth factors or other extracellular signals, phosphoinositide-dependent kinase-1 (PDK1) phosphorylates AKT3 at threonine 308. This partially activates AKT3. Full activation of AKT3 requires phosphorylation at serine 473, which is carried out by the mammalian target of rapamycin complex 2 (mTORC2).

Are there any known alternative splicing variants of AKT3? 10/22/2018

Yes, alternative splicing events can generate different isoforms of AKT3. One example is AKT3β, which lacks a portion of the N-terminal regulatory region compared to the full-length AKT3α isoform. These isoforms may have distinct functions and regulatory mechanisms, although further research is needed to fully understand their specific roles.

Are there any specific mutations or alterations in AKT3 that are associated with cancer? 09/04/2018

Yes, alterations in AKT3 have been identified in various types of cancer. These alterations include genetic mutations, gene amplifications, and overexpression of AKT3. For example, AKT3 mutations have been reported in certain types of human cancers, such as endometrial cancer and melanoma.

Is AKT3 involved in any cellular processes besides cell survival and growth? 06/23/2018

Yes, AKT3 is involved in a variety of cellular processes besides cell survival and growth. It plays a role in regulating cellular metabolism, including glucose uptake and lipid metabolism. AKT3 is also involved in cell migration and invasion, as well as the regulation of cell cycle progression and apoptosis. Additionally, AKT3 has been implicated in neuronal development and synaptic plasticity, playing a role in brain development and function.

Are there any known interactions between AKT3 and other proteins or signaling pathways? 05/19/2017

Yes, AKT3 interacts with a wide range of proteins and signaling pathways. It can interact with various upstream activators, such as PI3K, PDK1, and mTORC2, to be phosphorylated and activated. AKT3 can also interact with numerous downstream effectors, including mTOR, GSK3, FOXO transcription factors, and Bad, among others. Additionally, AKT3 can be regulated by cross-talk with other signaling pathways, such as MAPK, NF-κB, and Wnt signaling, which can modulate its activity and downstream functions.

Can AKT3 inhibition alone be sufficient for cancer treatment or is it often combined with other therapies? 08/03/2016

While AKT3 inhibition has shown promise as a potential cancer treatment strategy, it is often used in combination with other therapies. The AKT pathway is complex and interconnected with various cellular processes, and targeting only AKT3 may not be sufficient to fully inhibit AKT signaling in all contexts. Additionally, combination therapies can help overcome potential resistance mechanisms and enhance treatment efficacy. Therefore, AKT3 inhibitors are frequently investigated in combination with chemotherapy, targeted therapies, immunotherapy, or radiation therapy to determine the optimal treatment strategies for different cancer types.

Can AKT3 be therapeutically targeted in diseases? 05/20/2016

Yes, targeting AKT3 therapeutically is an active area of research, especially in the context of cancer treatment. Several AKT inhibitors are being developed and tested in preclinical and clinical studies with the aim of blocking AKT3-mediated signaling and inhibiting tumor growth. However, it is important to note that AKT is also essential for normal cellular functions, so the development of selective inhibitors that specifically target the disease-associated dysregulation of AKT3 without affecting normal AKT activity is crucial.

Can AKT3 be targeted therapeutically? 05/16/2016

AKT3 has been under investigation as a potential target for therapeutic intervention. Inhibitors of AKT3 and its upstream regulators are being developed to selectively inhibit aberrant AKT3 signaling in diseases such as cancer. However, more research is needed to fully understand the complexities of AKT3 signaling and improve the specificity and efficacy of AKT3-targeted therapies.

Are there any potential side effects or limitations associated with AKT3 inhibition? 04/30/2016

While AKT3 inhibitors show promise as potential therapeutics, they can also have side effects and limitations. AKT is crucial for normal cellular functions, so inhibiting its activity may affect normal physiological processes.

Customer Reviews (5)

Write a review
Reviews
03/25/2023

    I am confident that utilizing the AKT3 protein will empower me to uncover crucial insights into cellular mechanisms with precision.

    12/31/2022

      The AKT3 protein is an exceptional protein solution that exceeds expectations in terms of quality and suitability for my experimental requirements.

      12/22/2020

        Their expertise and guidance will undoubtedly prove valuable in overcoming hurdles and maximizing the potential of this protein in my research endeavors.

        07/29/2016

          In addition to its outstanding quality, the AKT3 protein comes with exceptional technical support from its manufacturer.

          02/01/2016

            Researchers can confidently rely on this high-quality protein to produce accurate and reproducible results, thereby accelerating their research progress

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