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Official Full Name v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Background The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
Synonyms AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); PKBG; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma; DKFZp434N0250; RAC-gamma serine/threonine-protein kinase; PKB gamma; OTTHUMP00000037911; OTTHUMP00000037912; protein kinase Akt-3; protein kinase B gamma; serine threonine protein kinase, Akt-3
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • MBP
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AKT3-104H Recombinant Human AKT3, GST-tagged, Active Sf9 Insect Cell GST
    Human AKT3-131H Recombinant Human AKT3, GST tagged Insect Cell GST
    Human AKT3-1365H Recombinant Human AKT3 (Active), GST-tagged Sf9 Insect Cell GST
    Human AKT3-1566H Recombinant Human AKT3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human Akt3-159H Recombinant Human Akt3, His-tagged E.coli His
    Human Akt3-162H Recombinant Human Akt3, GST-tagged E.coli GST
    Human AKT3-165H Recombinant Human AKT3, Active, His-tagged Sf9 Insect Cell His
    Human AKT3-166H Recombinant Human AKT3, His-tagged E.coli His
    Human AKT3-2522H Recombinant Human AKT3, Active E.coli N/A
    Human AKT3-26264TH Recombinant Human AKT3 N/A
    Human AKT3-26391TH Recombinant Human AKT3, His-tagged HIS
    Human AKT3-26H Recombinant Human AKT3 (E17K), GST-tagged Sf9 Insect Cell GST
    Human AKT3-308H Recombinant Human AKT3 protein, His/MBP-tagged E.coli His/MBP
    Human AKT3-426H Recombinant Human AKT3 Protein Insect Cell N/A
    Human AKT3-427H Recombinant Human AKT3 Protein, GST-tagged Wheat Germ GST
    Human AKT3-550H Recombinant Human AKT3 Protein, His-tagged E.coli His
    Human AKT3-728HCL Recombinant Human AKT3 cell lysate Insect Cell N/A
    Human AKT3-804H Recombinant Human AKT3 protein, GST-His-tagged Insect Cell GST/His
    Mouse AKT3-001MCL Recombinant Mouse AKT3 cell lysate Insect Cell N/A
    Mouse Akt3-1586M Recombinant Mouse Akt3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse AKT3-549M Recombinant Mouse Akt3, None tagged Insect Cell Fc
    Mouse Akt3-8694M Recombinant Mouse Akt3, His-GST tagged Insect Cell Fc
    Rat AKT3-607R Recombinant Rat AKT3 Protein Mammalian Cell His
    Rhesus Macaque AKT3-298R Recombinant Rhesus monkey AKT3 Protein, His-tagged Mammalian Cell His

    AKT3 involved in several pathways and played different roles in them. We selected most pathways AKT3 participated on our site, such as AKT phosphorylates targets in the cytosol, AKT phosphorylates targets in the nucleus, AKT-mediated inactivation of FOXO1A, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AKT phosphorylates targets in the cytosol CDKN1B; CDKN1A; AKT3; CHUK
    AKT phosphorylates targets in the nucleus AKT3; CREB1; CREB1B
    AKT-mediated inactivation of FOXO1A AKT3
    AMPK signaling pathway CAMKK1; STRADB; RHEB; CRTC2; PPP2R3C; CAB39; INS2; PPARGC1A; PFKFB2; CD36
    Activation of BAD and translocation to mitochondria CDK5RAP2; AKT3; YWHAQ
    Activation of BH3-only proteins BCL2L11; E2F1; YWHAQ; DYNLL2; AKT3; CDK5RAP2
    Acute myeloid leukemia RPS6KB1; PIK3CG; RUNX1T1; ARAF; MAP2K2; JUP; PIK3CD; SOS1; RAF1; CEBPA
    Adaptive Immune System LILRA3; FRS2; ITGB1B.1; PAG1; RNF138; KIF2A; NCR3LG1; ITK; AGO2; FBXO3

    AKT3 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT3 itself. We selected most functions AKT3 had, and list some proteins which have the same functions with AKT3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding FKBP4; MYH15; DDX51; ABCC12; PSMC1; EIF4A1; SYN1; MAP3K2; PIP5K1C; Acsm2a
    protein binding KIAA0408; FGFR1; POLM; SFPI1; CD8B; SSX1; CCND3; ZBTB32; CAPNS1; C16orf59
    protein kinase activity HIPK3A; PRKDC; STK17B; IKBKB; DYRK1AA; RPS6KB1B; CDKL5; PHKG1B; ULK1A; CAMKVB
    protein serine/threonine kinase activity PLK2; ICK; STK10; MAP2K1; MAP3K14; KSR2; MAP4K6; TGFBR1; GRK5; AURKA

    AKT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT3.

    CASP3; CDC37; saicar; PKM; HSP90AA1; PRKCZ; HSP90AB1; NUDCD1

    Mias, GI; Chen, R; et al. Specific Plasma Autoantibody Reactivity in Myelodysplastic Syndromes. SCIENTIFIC REPORTS 3:-(2013).
    Marchbank, T; Mahmood, A; et al. Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F382-F389(2013).


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