|Official Full Name||aminolevulinate, delta-, synthase 1|
|Background||Delta-aminolevulinate synthase (ALAS; EC 184.108.40.206) catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid. This nuclear-encoded mitochondrial enzyme is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by ALAS2 (MIM 301300).|
|Synonyms||ALAS1; aminolevulinate, delta-, synthase 1; ALAS, ALAS3; 5-aminolevulinate synthase, nonspecific, mitochondrial; mitochondrial; nonspecific; 5 aminolevulinate synthase; 5 aminolevulinate synthase nonspecific mitochondrial; 5 aminolevulinic acid synthase; 5-aminolevulinate synthase; 5-aminolevulinic acid synthase 1; Alas 1; ALAS 3; ALAS; ALAS H; ALAS HOUSEKEEPING TYPE; ALAS N; ALAS-H; ALAS3; ALASH; Aminolevulinate delta synthase 1; Aminolevulinic acid synthase 1; Delta ALA synthetase; Delta aminolevulinate synthase; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1; HEM1_HUMAN; MIG 4; MIG4; Migration inducing protein 4; OTTHUMP00000212619; OTTHUMP00000212620; OTTHUMP00000212621; OTTHUMP00000212622; migration-inducing protein 4|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ALAS1 involved in several pathways and played different roles in them. We selected most pathways ALAS1 participated on our site, such as Glycine, serine and threonine metabolism, Porphyrin and chlorophyll metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Glycine, serine and threonine metabolism||PHGDH; AMT; PGAM1A; GRHPRB; BPGM; AGXTB; SHMT1; SARDH; MAOB; AGXTA|
|Porphyrin and chlorophyll metabolism||EARS2; UROD; PPOX; UGT1A4; ALAD; EPRS; UGT1AB; FXN; GUSB; HMOX2|
|Metabolic pathways||NDUFAB1A; PLA2G4A; CERS2; AOX3L1; POLA2; ATP6V1F; ACAT1; ACSS1; MAOA; NADK|
ALAS1 has several biochemical functions, for example, 5-aminolevulinate synthase activity, protein binding, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALAS1 itself. We selected most functions ALAS1 had, and list some proteins which have the same functions with ALAS1. You can find most of the proteins on our site.
|5-aminolevulinate synthase activity||ALAS2; ALAS1|
|protein binding||SLC4A1AP; TCEB1; TIPIN; PABPC4; RUSC1-AS1; C9orf78; INTS12; ACYP2; NPLOC4; DOLK|
|pyridoxal phosphate binding||OAT; AGXT2L2; MOSC2; AGXT; MARC2; PYGB; KYNU; SPTLC2B; HINT2; ACCS|
ALAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALAS1.
DUSP19; EP400; POLDIP2; 7115