ALAS1 Protein


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Official Full Name aminolevulinate, delta-, synthase 1
Background Delta-aminolevulinate synthase (ALAS; EC catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid. This nuclear-encoded mitochondrial enzyme is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by ALAS2 (MIM 301300).
Synonyms ALAS1; aminolevulinate, delta-, synthase 1; ALAS, ALAS3; 5-aminolevulinate synthase, nonspecific, mitochondrial; mitochondrial; nonspecific; 5 aminolevulinate synthase; 5 aminolevulinate synthase nonspecific mitochondrial; 5 aminolevulinic acid synthase; 5-aminolevulinate synthase; 5-aminolevulinic acid synthase 1; Alas 1; ALAS 3; ALAS; ALAS H; ALAS HOUSEKEEPING TYPE; ALAS N; ALAS-H; ALAS3; ALASH; Aminolevulinate delta synthase 1; Aminolevulinic acid synthase 1; Delta ALA synthetase; Delta aminolevulinate synthase; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1; HEM1_HUMAN; MIG 4; MIG4; Migration inducing protein 4; OTTHUMP00000212619; OTTHUMP00000212620; OTTHUMP00000212621; OTTHUMP00000212622; migration-inducing protein 4
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His&Myc
    • N/A
    • N-His&GST
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALAS1-311H Recombinant Human ALAS1 Protein, His-tagged E.coli His
    Human ALAS1-312H Recombinant Human ALAS1 Protein, His-tagged E.coli His
    Human ALAS1-429H Recombinant Human ALAS1 Protein, GST-tagged Wheat Germ GST
    Rat ALAS1-610R Recombinant Rat ALAS1 Protein Mammalian Cell His
    Chicken ALAS1-2179C Recombinant Chicken ALAS1 Mammalian Cell His
    Zebrafish ALAS1-11435Z Recombinant Zebrafish ALAS1 Mammalian Cell His
    Human ALAS1-8924HCL Recombinant Human ALAS1 293 Cell Lysate HEK293 N/A
    Human ALAS1-8925HCL Recombinant Human ALAS1 293 Cell Lysate HEK293 N/A
    Rat Alas1-111R Recombinant Rat Alas1 Protein, His&GST-tagged E.coli N-His&GST
    Mouse Alas1-4696M Recombinant Mouse Alas1 protein, His&Myc-tagged E.coli His&Myc
    Human ALAS1-26883TH Recombinant Human ALAS1 Wheat Germ N/A

    ALAS1 involved in several pathways and played different roles in them. We selected most pathways ALAS1 participated on our site, such as Glycine, serine and threonine metabolism, Porphyrin and chlorophyll metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALAS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycine, serine and threonine metabolism PSAT1; PIPOX; PGAM1; MAOA; GLDC; ALAS1; AGXTB; ALAS2; PGAM2; GATM
    Porphyrin and chlorophyll metabolism UGT2B15; HMOX1A; EARS2; UGT1A4; UGT1A9; HCCS; UROD; FXN; BLVRB; UGT1A1
    Metabolic pathways CNDP1; RDH8B; INPP5K; ASL2; INPP5B; ADH1C; CYP4A12A; PPAP2CB; AGXT2; CES1

    ALAS1 has several biochemical functions, for example, 5-aminolevulinate synthase activity, protein binding, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALAS1 itself. We selected most functions ALAS1 had, and list some proteins which have the same functions with ALAS1. You can find most of the proteins on our site.

    Function Related Protein
    5-aminolevulinate synthase activity ALAS1; ALAS2
    protein binding C10orf62; WRN; NABP1; VTA1; ARHGDIA; METTL9; EPS8; SPPL3; BARD1; CD1d1
    pyridoxal phosphate binding MARC1; PYGM; ABAT; PYGB; AADAT; PROSC; TAT; CTHL; ACCS; GPT2L

    ALAS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALAS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALAS1.

    DUSP19; EP400; POLDIP2; 7115

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