ALDH1A1
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Official Full Name
aldehyde dehydrogenase 1 family, member A1
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Overview
The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011] -
Synonyms
ALDH1A1; aldehyde dehydrogenase 1 family, member A1; ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e; retinal dehydrogenase 1; ALHDII; RALDH 1; ALDH class 1; acetaldehyde dehydrogenase 1; epididymis luminal protein 9; epididymis luminal protein 12; retinaldehyde dehydrogenase 1; aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase, liver cytosolic; epididymis secretory sperm binding protein Li 53e;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Rabbit
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Met|His
- Myc
- DDK
- N/A
- N
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- ALDH1A1 Related Articles
- ALDH1A1 Related Research Area
ALDH1A1 involved in several pathways and played different roles in them. We selected most pathways ALDH1A1 participated on our site, such as Retinol metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Retinol metabolism | RETSAT;UGT1A1;PNPLA4;RETSATL;CYP2C45;HSD17B6;ADH2-2;Aldh1a7;AOX3L1 |
Metabolic pathways | AMT;UGT1A7C;POLR3G;FUT7;GCNT4A;ACY1;RDH8B;IDUA;COX6C |
ALDH1A1 has several biochemical functions, for example, 3-chloroallyl aldehyde dehydrogenase activity, GTPase activator activity, aldehyde dehydrogenase (NAD) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH1A1 itself. We selected most functions ALDH1A1 had, and list some proteins which have the same functions with ALDH1A1. You can find most of the proteins on our site.
Function | Related Protein |
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3-chloroallyl aldehyde dehydrogenase activity | ALDH3A2A;ALDH3A2B;ALDH9A1;ALDH1A1;ALDH3A2;ALDH3A1;ALDH3B1;ALDH3B2;ALDH2.1 |
GTPase activator activity | TBC1D7;BNIP2;RGS16;TBC1D2B;TBC1D26;RAP1GAP;CDC42EP3;ARHGAP27;SRGAP3 |
aldehyde dehydrogenase (NAD) activity | ALDH5A1;ALDH1L1;ALDH9A1A.1;ALDH6A1;ALDH3A1;ALDH1A1;ALDH1B1;ALDH1A3;ALDH1L2 |
androgen binding | TSPO;Ar;SHBG;ALDH1A1 |
benzaldehyde dehydrogenase (NAD+) activity | Aldh1a7;ALDH1A1;ALDH3A1 |
retinal dehydrogenase activity | ALDH1A1;ALDH1A3;AKR1B8;AKR1B10;ALDH8A1;AKR1C6;AKR1C3;Aldh1a7;AKR1C4 |
ALDH1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH1A1.
ALDH2; NUPR1; q5nfd5_fratt; ligA; lplJ; POT1
- Q&As
- Reviews
Q&As (5)
Ask a questionALDH1A1 contributes to cellular detoxification by metabolizing endogenous and exogenous aldehydes, reducing their potential cytotoxic effects.
ALDH1A1's catalytic activity depends on its conserved structural features. Substrate binding involves the aldehyde-binding pocket, and cofactor interaction occurs through the binding of NAD+.
ALDH1A1 contributes to retinoid homeostasis by regulating the levels of active retinoic acid. Dysregulation may lead to diseases associated with vitamin A deficiency or excess.
ALDH1A1 is an aldehyde dehydrogenase enzyme responsible for catalyzing the oxidation of retinaldehyde to retinoic acid, a critical step in the synthesis of retinoids.
ALDH1A1 plays a key role in retinoic acid signaling by generating active retinoic acid. This signaling pathway influences gene expression and cellular differentiation in various tissues.
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