ALDH1A1

  • Official Full Name

    aldehyde dehydrogenase 1 family, member A1

  • Overview

    The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]
  • Synonyms

    ALDH1A1; aldehyde dehydrogenase 1 family, member A1; ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e; retinal dehydrogenase 1; ALHDII; RALDH 1; ALDH class 1; acetaldehyde dehydrogenase 1; epididymis luminal protein 9; epididymis luminal protein 12; retinaldehyde dehydrogenase 1; aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase, liver cytosolic; epididymis secretory sperm binding protein Li 53e;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Met|His
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALDH1A1-1100H Active Recombinant Human ALDH1A1 protein, His-tagged E.coli Met/His
Human ALDH1A1-01H Active Recombinant Human ALDH1A1 Protein E.coli 501aa
Human ALDH1A1-437H Recombinant Human ALDH1A1 Protein, GST-tagged Wheat Germ GST
Human ALDH1A1-883H Recombinant Human ALDH1A1 protein, His-tagged E.coli His Ser2-Ser501
Human ALDH1A1-484H Recombinant Human Aldehyde Dehydrogenase 1 Family, Member A1 E.coli N/A
Human ALDH1A1-27036TH Recombinant Human ALDH1A1, His-tagged E.coli His
Human ALDH1A1-27035TH Recombinant Human ALDH1A1 protein E.coli N/A
Human ALDH1A1-9550H Recombinant Human ALDH1A1, GST-tagged E.coli GST 403-449a.a.
Human ALDH1A1-8922HCL Recombinant Human ALDH1A1 293 Cell Lysate HEK293 N/A
Human ALDH1A1-111H Active Recombinant Human ALDH1A1 Protein E.coli
Human ALDH1A1-5040H Recombinant Human ALDH1A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ALDH1A1-115H Recombinant Human ALDH1A1 Protein, His-tagged E.coli N-His Met1-Val311
Human ALDH1A1-3443H Recombinant Human ALDH1A1 protein, His-tagged E.coli His 153-501 aa
Human ALDH1A1-1999HFL Recombinant Full Length Human ALDH1A1 Protein, C-Flag-tagged Mammalian cells Flag
Human CAB11478RH Rabbit Anti-Human Aldehyde Dehydrogenase 1 Family, Member A1 Monoclonal Antibody Rabbit N/A
Human ALDH1A1-0341H Recombinant Human ALDH1A1 Protein (M1-S501), Tag Free E.coli No tag M1-S501
Human ALDH1A1-1400HF Recombinant Full Length Human ALDH1A1 Protein, GST-tagged In Vitro Cell Free System GST 501 amino acids
Human ALDH1A1-0342H Recombinant Human ALDH1A1 Protein (M1-S501), His tagged E.coli His M1-S501
Human ALDH1A1-311H-B Recombinant Human ALDH1A1 Protein Pre-coupled Magnetic Beads HEK293
Human ALDH1A1-0568H Recombinant Human ALDH1A1 Protein (Met1-Ser501), N-His-tagged E.coli N-His Met1-Ser501
Human ALDH1A1-311H Recombinant Human ALDH1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ALDH1A1-1518M Recombinant Mouse ALDH1A1 Protein Mammalian Cell His
Mouse Aldh1a1-1356M Recombinant Mouse Aldh1a1 protein, His & T7-tagged E.coli His/T7 Met1~Arg326 (Accession# P24549)
Mouse ALDH1A1-450M Recombinant Mouse ALDH1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ALDH1A1-450M-B Recombinant Mouse ALDH1A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ALDH1A1-1845M Recombinant Mouse ALDH1A1 Protein (2-501 aa), His-tagged Yeast His 2-501 aa
Rat ALDH1A1-614R Recombinant Rat ALDH1A1 Protein Mammalian Cell His
Rat ALDH1A1-270R Recombinant Rat ALDH1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ALDH1A1-270R-B Recombinant Rat ALDH1A1 Protein Pre-coupled Magnetic Beads HEK293
Chicken ALDH1A1-6146C Recombinant Chicken ALDH1A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ALDH1A1 involved in several pathways and played different roles in them. We selected most pathways ALDH1A1 participated on our site, such as Retinol metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Retinol metabolismRDH10;UGT1A2;ADH1;CYP3A7;CYP4A10;RDH10A;CYP3A25;HSD17B6;CYP2B19
Metabolic pathwaysPFKL;MOCS2;HSD3B6;HSD17B10;IPPK;HSD17B2;POC1B-GALNT4;ACSM2;ABO

ALDH1A1 has several biochemical functions, for example, 3-chloroallyl aldehyde dehydrogenase activity, GTPase activator activity, aldehyde dehydrogenase (NAD) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH1A1 itself. We selected most functions ALDH1A1 had, and list some proteins which have the same functions with ALDH1A1. You can find most of the proteins on our site.

Function Related Protein
3-chloroallyl aldehyde dehydrogenase activityALDH3A1;ALDH2.1;ALDH3A2A;ALDH3B1;ALDH3A2B;Aldh1a7;ALDH3A2;ALDH9A1;ALDH3B2
GTPase activator activitySGSM2;ARHGAP28;RAP1GAP2B;OCRL;ARHGAP40;ARHGAP42;ARHGAP11A;ALS2CL;ARHGAP27
aldehyde dehydrogenase (NAD) activityALDH1A1;ALDH9A1B;ALDH1L1;ALDH1B1;ALDH1L2;ALDH3A2A;ALDH16A1;ALDH4A1;ALDH3B2
androgen bindingAr;SHBG;TSPO;ALDH1A1
benzaldehyde dehydrogenase (NAD+) activityALDH1A1;Aldh1a7;ALDH3A1
retinal dehydrogenase activityAKR1B8;Aldh1a7;AKR1B10;AKR1C4;ALDH8A1;ALDH1A3;ALDH1A1;AKR1C3;AKR1C6

ALDH1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH1A1.

ALDH2; NUPR1; q5nfd5_fratt; ligA; lplJ; POT1

Research Area

Related articles

Liu, Y; Lv, DL; et al. ALDH1A1 expression correlates with clinicopathologic features and poor prognosis of breast cancer patients: a systematic review and meta-analysis. BMC CANCER 14:-(2014).
Thomas, AG; Henry, JJ; et al. Retinoic acid regulation by CYP26 in vertebrate lens regeneration. DEVELOPMENTAL BIOLOGY 386:291-301(2014).
  • Q&As
  • Reviews

Q&As (5)

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How does ALDH1A1 contribute to cellular detoxification by metabolizing endogenous and exogenous aldehydes? 09/26/2021

ALDH1A1 contributes to cellular detoxification by metabolizing endogenous and exogenous aldehydes, reducing their potential cytotoxic effects.

What are the structural features of ALDH1A1 that are crucial for its catalytic activity, and how do substrate binding and cofactor interaction occur? 08/07/2021

ALDH1A1's catalytic activity depends on its conserved structural features. Substrate binding involves the aldehyde-binding pocket, and cofactor interaction occurs through the binding of NAD+.

How does ALDH1A1 participate in retinoid homeostasis, and what are the consequences of its dysregulation in diseases like vitamin A deficiency or excess? 12/04/2020

ALDH1A1 contributes to retinoid homeostasis by regulating the levels of active retinoic acid. Dysregulation may lead to diseases associated with vitamin A deficiency or excess.

What is the enzymatic function of ALDH1A1, and how does it catalyze the conversion of aldehydes? 08/14/2020

ALDH1A1 is an aldehyde dehydrogenase enzyme responsible for catalyzing the oxidation of retinaldehyde to retinoic acid, a critical step in the synthesis of retinoids.

Can you explain the role of ALDH1A1 in retinoic acid signaling and its impact on cellular processes, including gene expression and differentiation? 05/07/2018

ALDH1A1 plays a key role in retinoic acid signaling by generating active retinoic acid. This signaling pathway influences gene expression and cellular differentiation in various tissues.

Customer Reviews (3)

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Reviews
08/05/2020

    The attention to detail in quality assurance is commendable. It's a lab favorite for a reason.

    03/12/2019

      Great for assays and experiments. Dependable results make it a lab favorite.

      11/23/2018

        A lab staple! Quality is never compromised, and the shipping is always reliable.

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