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Official Full Name APEX nuclease (multifunctional DNA repair enzyme) 1
Background Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
Synonyms APEX1; APEX nuclease (multifunctional DNA repair enzyme) 1; APE; APX; APE1; APEN; APEX; HAP1; REF1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human APEX1-1330H Recombinant Human APEX1 Protein (32-318 aa), His-tagged Yeast His
    Human APEX1-1538H Recombinant Human APEX1 protein E.coli N/A
    Human APEX1-2497H Recombinant Human APEX1, His tagged E.coli His
    Human APEX1-26987TH Recombinant Human APEX1 N/A
    Human APEX1-27360TH Recombinant Human APEX1, T7 -tagged E.coli T7
    Human APEX1-4224H Recombinant Human APEX1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human APEX1-45H Recombinant Human APEX1 protein, GST-tagged E.coli GST
    Human APEX1-46H Recombinant Human APEX1 protein, His-tagged E.coli His
    Human APEX1-4792H Recombinant Human APEX1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human APEX1-593H Recombinant Human APEX Nuclease 1 E.coli N/A
    Human APEX1-677H Recombinant Human APEX1 protein, GST-tagged Wheat Germ GST
    Human APEX1-8796HCL Recombinant Human APEX1 293 Cell Lysate HEK293 N/A
    Human APEX1-8797HCL Recombinant Human APEX1 293 Cell Lysate HEK293 N/A
    Human APEX1-955H Recombinant Human APEX1, T7-tagged E.coli T7
    Mouse APEX1-1765M Recombinant Mouse APEX1 Protein Mammalian Cell His
    Mouse Apex1-623M Recombinant Mouse Apex1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat APEX1-17R Recombinant Rattus APEX1 Protein, His-tagged E.coli HIS
    Rat APEX1-713R Recombinant Rat APEX1 Protein Mammalian Cell His
    Rhesus Macaque APEX1-353R Recombinant Rhesus monkey APEX1 Protein, His-tagged Mammalian Cell His
    Chicken APEX1-4100C Recombinant Chicken APEX1 Mammalian Cell His
    Zebrafish APEX1-12593Z Recombinant Zebrafish APEX1 Mammalian Cell His

    apex1 involved in several pathways and played different roles in them. We selected most pathways apex1 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with apex1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Base excision repair LIG3; MUTYH; HMGB1; POLE3; PARP2; FEN1; NTHL1; NEIL1; PARP4; PARP3

    apex1 has several biochemical functions, for example, 3-5 exonuclease activity, DNA binding, DNA-(apurinic or apyrimidinic site) lyase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by apex1 itself. We selected most functions apex1 had, and list some proteins which have the same functions with apex1. You can find most of the proteins on our site.

    Function Related Protein
    3-5 exonuclease activity EXOSC10; REXO2; RAD9; WRN; RAD1; EXD1; MRE11A; EXD2; RAD9B; ERI1
    DNA binding PURG; FLI1B; MCM8; HIST2H2BE; ZZZ3; ZNF576; FOXG1D; NPAS2; IRX7; Trl
    DNA-(apurinic or apyrimidinic site) lyase activity NEIL1; HMGA1A; HMGA1B; NEIL3; APLF; APEX1; NEIL2; NTHL1; ALKBH1; HMGA2
    RNA-DNA hybrid ribonuclease activity RNASEH2B; EXO1; APEX1; FEN1; RNASEH2C; RNASEH2A; RNASEH1
    chromatin DNA binding THRA; MYOG; RUVBL2; HIST1H1C; BCL6; H2AFZ; HIST1H1A; RARA; H1F0; NOTCH1
    damaged DNA binding ERCC4; HMGB1; CREBBP; XRCC1; HMGB2; TP53BP1; EP300; TRP53; RAD52; RPA2
    double-stranded DNA 3-5 exodeoxyribonuclease activity APEX2; APEX1
    endodeoxyribonuclease activity RPS3; APEX1; DNASE1; DNASE1L1; DNASE1L3L; DNASE1L2; ERCC5; DNASE2A; ZRANB3; MBD4
    endonuclease activity EAR3; ERN2; RNASEL4; NTHL1; SETMAR; RAG1; RNASE4; G3BP1; DNASE1L3L; ZRANB3
    metal ion binding KLF15; ZNF526; RSAD2; AARS; LNPB; PDZRN3B; RHEB; USP19; ZNF493; GMPR2
    oxidoreductase activity CYP26C1; APEX1; CYP4V8; OXNAD1; OSGIN1; VAT1; CYP2K6; MTO1; QDPRA; CYP2E1
    phosphodiesterase I activity APEX1; FAN1; ENPP1; ENPP2
    phosphoric diester hydrolase activity PLCXD3; APEX1; PLCD1A; PLCD1B; PLCD3A; GDPD4; PLCXD1; PLCXD2; PDE5AB; ENPP6
    poly(A) RNA binding ALDH6A1; MRPL14; DNAJC2; CHERP; NCBP2; GAR1; MAP4; QKI; HMGB2; HNRNPAB
    protein binding RHOG; NADK; PIH1D3; GK; ALAS1; KLB; TMEM183A; SPANXD; ARL2BP; HHLA3
    site-specific endodeoxyribonuclease activity, specific for altered base DNA2; APEX1
    transcription coactivator activity TADA1; NFE2; CALCOCO1; TBPL1; UTF1; ABRA; PPARGC1A; BRCA1; PDLIM1; NFKBIB
    transcription corepressor activity SETD8; ZNF274; CBX4; HDAC7; SFMBT1; SSX1; HOXC6; DDIT3; SKIL; GPS2
    uracil DNA N-glycosylase activity TDG.1; UNGA; TDG; UNG; SMUG1; APEX1; CCNO

    apex1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with apex1 here. Most of them are supplied by our site. Hope this information will be useful for your research of apex1.

    EP300; HSPA1A; SIRT1; mdm2_human_probe; SRPK2

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