ATP2A3

  • Official Full Name

    ATPase, Ca++ transporting, ubiquitous

  • Overview

    This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms

    ATP2A3; ATPase, Ca++ transporting, ubiquitous; sarcoplasmic/endoplasmic reticulum calcium ATPase 3; SERCA3; calcium pump 3; SR Ca(2+)-ATPase 3; adenosine triphosphatase, calcium; calcium-translocating P-type ATPase; ATPase, Ca(2+)-transporting, ubiquitous;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP2A3-31352TH Recombinant Human ATP2A3 Wheat Germ N/A 120 amino acids
Human ATP2A3-971H Recombinant Human ATP2A3 protein, GST-tagged Wheat Germ GST
Human ATP2A3-10011H Recombinant Human ATP2A3, GST-tagged E.coli GST 322-770a.a.
Human ATP2A3-2783H Recombinant Human ATP2A3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ATP2A3-1885HFL Recombinant Full Length Human ATP2A3 Protein, C-Flag-tagged Mammalian cells Flag
Human ATP2A3-401H-B Recombinant Human ATP2A3 Protein Pre-coupled Magnetic Beads HEK293
Human ATP2A3-2942H Recombinant Human ATP2A3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ATP2A3-401H Recombinant Human ATP2A3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Atp2a3-1766M Recombinant Mouse Atp2a3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat ATP2A3-860R Recombinant Rat ATP2A3 Protein Mammalian Cell His
Rat ATP2A3-516R Recombinant Rat ATP2A3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP2A3-516R-B Recombinant Rat ATP2A3 Protein Pre-coupled Magnetic Beads HEK293
Sus scrofa (Pig) RFL-19659SF Recombinant Full Length Pig Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 3(Atp2A3) Protein, His-Tagged E.coli expression system His Full Length (1-135)
Chicken ATP2A3-6454C Recombinant Chicken ATP2A3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ATP2A3 involved in several pathways and played different roles in them. We selected most pathways ATP2A3 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP2A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayPPIAA;ITPKA;TNNC1B;P2RX3;GNAS;ATP2B3B;TACR1A;TNNC1;HTR7
cGMP-PKG signaling pathwayPIK3R3;SLC8A1;RAF1;AGTR1B;NFATC4;ROCK1;NPR2;PDE3B;MYLK4
Pancreatic secretionCPB2;SLC26A3;ATP2B4;RAC1;PLA2G2F;CLCA3;CELA3A;ATP1B2;ATP2B1
Alzheimers diseaseAtp5g2;Casp3;NDUFB1;UQCRQ;APOE;PPP3CB;PLCB4;MAPK1;NDUFS6

ATP2A3 has several biochemical functions, for example, ATP binding, calcium-transporting ATPase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP2A3 itself. We selected most functions ATP2A3 had, and list some proteins which have the same functions with ATP2A3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSPEG;FKBP4;GM7168;MYO6A;CDC42BPG;Fert2;JAK2;BMPR2B;CHTF18
calcium-transporting ATPase activityATP2B1B;ATP2A2A;ATP2B2;ATP2B4;ATP2A1;ATP2B1;ATP2B3A;ATP2A2;ATP2C1
metal ion bindingARSH;LMO7B;SIAH1A;DNAJA1;MT2;HPDB;FAM20B;IRF2BPL;ZFP64

ATP2A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP2A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP2A3.

NCK1; HLA-A; BRF2; WRAP73; 15-deoxy-delta(12,14; env; ERBB2; CFTR; ATF2; HDAC11

  • Q&As
  • Reviews

Q&As (6)

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What is the mutation mechanism of ATP2A3 recombinant protein? 05/22/2022

Mutations in the recombinant ATP2A3 protein may lead to abnormal changes in its intracellular localization and function, thereby affecting the normal function of cardiomyocytes.

Does the recombinant ATP2A3 protein interact with specific drugs? 02/11/2022

Certain drugs can affect the function of ATP2A3 recombinant protein, such as calcium modulators and cardiovascular drugs. These drugs may affect the intracellular calcium balance and the normal function of the cardiovascular system.

Are the expression and function of ATP2A3 recombinant protein regulated in the heart? 01/07/2022

Yes, the expression and function of ATP2A3 recombinant protein in the heart are regulated by complex regulatory mechanisms, including endogenous signaling pathways and regulation of the cardiovascular system.

What is the expression pattern of the recombinant ATP2A3 protein in humans? 09/18/2021

ATP2A3 recombinant protein is mainly expressed in muscle tissue, heart, kidney and other tissues and organs in the human body.

Are mutations in the recombinant ATP2A3 protein associated with human cardiovascular disease? 08/18/2019

Yes, mutations in ATP2A3 recombinant protein may be associated with certain cardiovascular diseases (such as myocardial infarction, heart failure, etc.).

What is the function of ATP2A3 recombinant protein in the heart? 07/08/2019

The main role of ATP2A3 recombinant protein in the heart is to regulate the intracellular calcium balance of muscle cells and participate in the regulation of myocardial contraction and relaxation.

Customer Reviews (3)

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Reviews
09/19/2022

    The green production process of ATP2A3 is very environmentally friendly. From the selection of raw materials to the production process, it reflects the concept of green production, without any negative impact on the environment.

    04/02/2020

      Its repeatability can be said to be unparalleled, and the consistent results in every experiment or application is an important manifestation of its superior quality.

      01/31/2019

        ATP2A3 has a short half-life and high clearance, making it more advantageous in emergency situations where a rapid therapeutic effect is required.

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