ATP6AP1

  • Official Full Name

    ATPase, H+ transporting, lysosomal accessory protein 1

  • Overview

    This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.
  • Synonyms

    ATP6AP1; ATPase, H+ transporting, lysosomal accessory protein 1; ATP6IP1, ATP6S1, ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; V-type proton ATPase subunit S1; 16A; Ac45; CF2; ORF; VATPS1; XAP 3; XAP3; ATP6IP1; ATP6S1; ATPase H+ transporting lysosomal (vacuolar proton pump) subunit 1; ATPase H+ transporting lysosomal accessory protein 1; ATPase H+ transporting lysosomal interacting protein 1; H ATPase subunit; MGC129781; Protein XAP 3; Protein XAP3; V ATPase Ac45 subunit; V ATPase S1 accessory protein; V ATPase subunit S1; V type proton ATPase subunit S1; Vacuolar ATP synthase subunit S1; protein XAP-3; H-ATPase subunit; OTTHUMP00000032115; OTTHUMP00000196463; V-ATPase subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; vacuolar proton pump subunit S1; ATPase, H+ transporting, lysosomal interacting pro; XAP-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6AP1-992H Recombinant Human ATP6AP1 protein, GST-tagged Wheat Germ GST
Human ATP6AP1-8592HCL Recombinant Human ATP6AP1 293 Cell Lysate HEK293 N/A
Human ATP6AP1-1542HF Recombinant Full Length Human ATP6AP1 Protein, GST-tagged In Vitro Cell Free System GST 470 amino acids
Rat ATP6AP1-883R Recombinant Rat ATP6AP1 Protein Mammalian Cell His
Rat ATP6AP1-539R Recombinant Rat ATP6AP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP6AP1-539R-B Recombinant Rat ATP6AP1 Protein Pre-coupled Magnetic Beads HEK293
Bos taurus (Bovine) RFL30385BF Recombinant Full Length Bovine V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (36-468)
Homo sapiens (Human) RFL24115HF Recombinant Full Length Human V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (42-470)
Mus musculus (Mouse) RFL12719MF Recombinant Full Length Mouse V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (33-463)
Rattus norvegicus (Rat) RFL24987RF Recombinant Full Length Rat V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (33-463)
Chicken ATP6AP1-4576C Recombinant Chicken ATP6AP1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ATP6AP1 involved in several pathways and played different roles in them. We selected most pathways ATP6AP1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6AP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationUQCRFS1;ATP5L;COX8C;ATP6V1E1;ATP6V1G1;NDUFS4;ATP6V1AA;COX17;NDUFA8
Metabolic pathwaysATIC;ST6GAL2;LDHC;LAP3;RDH8A;CKMA;HMBSB;CYP2C70;CHDH
LysosomeACP5B;ATP6V0D2;ATP6V0C;Abca2;CTSK;PSAPL1;LAMP3;AP3M2;GALCB
PhagosomeTUBB1;HLA-E;HLA-DQA1;CD14;THBS3A;MBL1;DYNC1I2A;HLA-DMB;ATP6V1H
Vibrio cholerae infectionPRKACG;KDELR1;KDELR3;ATP6V0A1;ATP6AP1;PRKACB;PRKACA;ATP6V0A2;ATP6V1E2
Epithelial cell signaling in Helicobacter pylori infectionCXCR2;ATP6V1E1;PAK1;PTPN11;JAM3;IKBKG;MAPK13;ATP6V1G1;ATP6V1A
TuberculosisRAB7;SPHK1;STAT1;FCGR3A;RAB5B;Il23a; Il12b;KSR1;BAD;FCER1G
Hepatitis BBAD;EGR3;IFNA7;MAPK8;SMAD4;TRP53;IKBKB;TICAM2;CASP12
Rheumatoid arthritisHLA-DMB;HLA-DRB5;IL23;TNFSF11;ATP6V1D;ATP6V0D1;FOS;ITGAL;TNFSF13

ATP6AP1 has several biochemical functions, for example, ATP binding, Rab GTPase binding, proton-transporting ATP synthase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6AP1 itself. We selected most functions ATP6AP1 had, and list some proteins which have the same functions with ATP6AP1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingSGK2A;FGFR1A;ABCB5;SMARCAD1;KIF27;CAMK2B;FARS2;CCT3;CKMT1
Rab GTPase bindingRABGAP1L;CHML;TMEM127;RABGGTB;CCDC64B;ODF2;SYTL4;RAB3GAP2;RHOBTB3
proton-transporting ATP synthase activity, rotational mechanismATP5B;ATP5A1;ATP6AP1B;ATP5O;ATP5C1;ATP5E;ATP6V0C;ATP6AP1
proton-transporting ATPase activity, rotational mechanismATP6V0CA;ATP6V1E2;ATP6V1A;ATP6V0E2;ATP6AP1B;ATP6V0A2B;ATP6V0A1A;ATP5C1;ATP5A1
transporter activityABCA5;FABP11A;SLC25A31;AP1G1;SLC13A5;SLC13A5A;ABCF2;CSN2;FABP1A

ATP6AP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6AP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6AP1.

NR1I2; ANG; ERBB2; HBA1; Kcnk1; ATP6AP2; cona_canen; Bmpr1a; RAB7A; K3; DBN1; Chmp4b; MYEF2; Spast; Tmed2; GOLT1B

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