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ATP6AP1

Official Full Name

ATPase, H+ transporting, lysosomal accessory protein 1
Overview

This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules.
Synonyms

ATP6AP1; ATPase, H+ transporting, lysosomal accessory protein 1; ATP6IP1, ATP6S1, ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; V-type proton ATPase subunit S1; 16A; Ac45; CF2; ORF; VATPS1; XAP 3; XAP3; ATP6IP1; ATP6S1; ATPase H+ transporting lysosomal (vacuolar proton pump) subunit 1; ATPase H+ transporting lysosomal accessory protein 1; ATPase H+ transporting lysosomal interacting protein 1; H ATPase subunit; MGC129781; Protein XAP 3; Protein XAP3; V ATPase Ac45 subunit; V ATPase S1 accessory protein; V ATPase subunit S1; V type proton ATPase subunit S1; Vacuolar ATP synthase subunit S1; protein XAP-3; H-ATPase subunit; OTTHUMP00000032115; OTTHUMP00000196463; V-ATPase subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; vacuolar proton pump subunit S1; ATPase, H+ transporting, lysosomal interacting pro; XAP-3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Bos taurus (Bovine)
Chicken
Homo sapiens (Human)
Human
Mus musculus (Mouse)
Rat
Rattus norvegicus (Rat)

Source

E.coli expression system
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ATP6AP1-992H	Recombinant Human ATP6AP1 protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ATP6AP1-8592HCL	Recombinant Human ATP6AP1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ATP6AP1-1542HF	Recombinant Full Length Human ATP6AP1 Protein, GST-tagged	In Vitro Cell Free System	GST	470 amino acids	Inquiry
Rat	ATP6AP1-883R	Recombinant Rat ATP6AP1 Protein	Mammalian Cell	His		Inquiry
Rat	ATP6AP1-539R	Recombinant Rat ATP6AP1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	ATP6AP1-539R-B	Recombinant Rat ATP6AP1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Bos taurus (Bovine)	RFL30385BF	Recombinant Full Length Bovine V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (36-468)	Inquiry
Homo sapiens (Human)	RFL24115HF	Recombinant Full Length Human V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (42-470)	Inquiry
Mus musculus (Mouse)	RFL12719MF	Recombinant Full Length Mouse V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (33-463)	Inquiry
Rattus norvegicus (Rat)	RFL24987RF	Recombinant Full Length Rat V-Type Proton Atpase Subunit S1(Atp6Ap1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (33-463)	Inquiry
Chicken	ATP6AP1-4576C	Recombinant Chicken ATP6AP1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

ATP6AP1 involved in several pathways and played different roles in them. We selected most pathways ATP6AP1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6AP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Oxidative phosphorylation	NDUFA4L;NDUFS4;ATP6V1D;ATP6V0B;UQCRC2B;ATP6V1E2;ATP6V1C1A;ATP5G3A;NDUFB10
Metabolic pathways	ME3;NME1;MTAP;INPP4AB;EXT1;KL;FUT1;NDUFA13;GLS
Lysosome	ATP6V0C;AP1M3;ABCB9;CTSBB;CTSA;GNS;DNASE2B;SLC17A5;ATP6V1H
Phagosome	TUBA3C;ATP6V0D2;CD36;CTSSB.1;ATP6V1A;CD209A;HLA-B;TUBA4A;ATP6V1B1
Vibrio cholerae infection	ATP6V1A;ATP6V1E2;ATP6V0E1;KDELR3;ATP6V1F;ATP6V1G2;ATP6V1C1;PDIA4;GNAS
Epithelial cell signaling in Helicobacter pylori infection	ATP6V1G1;TCIRG1;MAPK9;ATP6V0A2;MAPK11;GIT1;NOD1;ATP6V1B1;ATP6V1G2
Tuberculosis	CASP8;FCGR2B;H2-AB1;RAF1;CAMK2D;STAT1;BAD;MAPK1;IFNGR1
Hepatitis B	CREB3L1;IFNA6;PTK2B;CCND1;CCNE2;TLR4;Fasl;IKBKG;IFNAR1
Rheumatoid arthritis	ATP6V1A;ITGB2;ATP6V1E2;IL11;MMP3;IL17A;CD86;CCL20;HLA-DRB1

ATP6AP1 has several biochemical functions, for example, ATP binding, Rab GTPase binding, proton-transporting ATP synthase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6AP1 itself. We selected most functions ATP6AP1 had, and list some proteins which have the same functions with ATP6AP1. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	CAMK2A;DDX20;STK40;P2RX8;PPIP5K2;IGF1RA;HK1;MAP2K4A;MAP3K1
Rab GTPase binding	AP1G1;RABGEF1;RAB11FIP3;EXPH5;RPH3AL;RAB3GAP2;MYO5B;TBC1D20;RILP
proton-transporting ATP synthase activity, rotational mechanism	ATP5A1;ATP5B;ATP6V0C;ATP5C1;ATP5O;ATP6AP1;ATP6AP1B;ATP5E
proton-transporting ATPase activity, rotational mechanism	ATP5C1;ATP6V0A1A;ATP6AP1;ATP6V0E1;ATP6V1B2;ATP6V0CB;ATP6V0B;ATP6V1E1B;ATP6V1H
transporter activity	SLC6A18;ABCD1;SLC12A10.1;ABCA6;SYPL2;AQP8A.2;FABP7;SLC22A17;SYPL1

ATP6AP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6AP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6AP1.

NR1I2; ANG; ERBB2; HBA1; Kcnk1; ATP6AP2; cona_canen; Bmpr1a; RAB7A; K3; DBN1; Chmp4b; MYEF2; Spast; Tmed2; GOLT1B