ATP6V0C

  • Official Full Name

    ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c

  • Overview

    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17.
  • Synonyms

    ATP6V0C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATP6C, ATP6L, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD , ATPL; V-type proton ATPase 16 kDa proteolipid subunit; VATL; Vma3; ATP6C; ATP6L; ATPase, H+ transporting, lysosomal, V0 subunit c; ATPL; V ATPase subunit c; Vacuolar ATP synthase 16 kDa proteolipid subunit; Vacuolar H+ ATPase proton channel subunit; Vacuolar proton pump, 16 kDa subunit; V-ATPase 16 kDa proteolipid subunit; vacuolar proton pump 16 kDa proteolipid subunit; H(+)-transporting two-sector ATPase, 16 kDa subunit; VPPC;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Ovis aries (Sheep)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6V0C-996H Recombinant Human ATP6V0C protein, GST-tagged Wheat Germ GST
Human ATP6V0C-8589HCL Recombinant Human ATP6V0C 293 Cell Lysate HEK293 N/A
Human ATP6V0C-4978H Recombinant Human ATP6V0C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ATP6V0C-2129HFL Recombinant Full Length Human ATP6V0C Protein, C-Flag-tagged Mammalian cells Flag
Human ATP6V0C-1526HF Recombinant Full Length Human ATP6V0C Protein, GST-tagged In Vitro Cell Free System GST 155 amino acids
Human ATP6V0C-405H-B Recombinant Human ATP6V0C Protein Pre-coupled Magnetic Beads HEK293
Human ATP6V0C-405H Recombinant Human ATP6V0C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Atp6v0c-678M Recombinant Mouse Atp6v0c Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat ATP6V0C-886R Recombinant Rat ATP6V0C Protein Mammalian Cell His
Rat ATP6V0C-542R-B Recombinant Rat ATP6V0C Protein Pre-coupled Magnetic Beads HEK293
Rat ATP6V0C-542R Recombinant Rat ATP6V0C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bos taurus (Bovine) RFL3341BF Recombinant Full Length Bovine V-Type Proton Atpase 16 Kda Proteolipid Subunit(Atp6V0C) Protein, His-Tagged E.coli expression system His Full Length (1-155)
Homo sapiens (Human) RFL8211HF Recombinant Full Length Human V-Type Proton Atpase 16 Kda Proteolipid Subunit(Atp6V0C) Protein, His-Tagged E.coli expression system His Full Length (1-155)
Mus musculus (Mouse) RFL28873MF Recombinant Full Length Mouse V-Type Proton Atpase 16 Kda Proteolipid Subunit(Atp6V0C) Protein, His-Tagged E.coli expression system His Full Length (1-155)
Ovis aries (Sheep) RFL30169OF Recombinant Full Length Sheep V-Type Proton Atpase 16 Kda Proteolipid Subunit(Atp6V0C) Protein, His-Tagged E.coli expression system His Full Length (1-155)
Rattus norvegicus (Rat) RFL8695RF Recombinant Full Length Rat V-Type Proton Atpase 16 Kda Proteolipid Subunit(Atp6V0C) Protein, His-Tagged E.coli expression system His Full Length (1-155)
Chicken ATP6V0C-5306C Recombinant Chicken ATP6V0C Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ATP6V0C involved in several pathways and played different roles in them. We selected most pathways ATP6V0C participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationNDUFV3;ATP6V0A2B;ATPV0E2;SDHDA;UQCR10;ATP5E;PPA1;ATP6V0A1B;ATP6V0E1
Metabolic pathwaysALLC;G6PCA.2;PNLIPRP3;NMNAT2;ARG2;LPCAT4;COX15;DHRS4;HSD3B2
LysosomeIDS;CTSK;ACP5B;CTSL1B;GNSA;ATP6V0CB;LGMN;ASAH1A;AGA
PhagosomeATP6V1AA;BMA1;STX12;NCF2;ATP6V1C1;ATP6V0A1B;NOS1;STX7;PIK3C3
Synaptic vesicle cycleRAB3A;ATP6V0A4;ATP6V0D1;ATP6V1E2;UNC13A;SLC17A8;UNC13C;ATP6V1B1;ATP6V0C
Collecting duct acid secretionCA2;TCIRG1;ATP6V1G3;CLCNKB;Car2;ATP6V0E1;SLC4A1;ATP6V1B2;ATP6V0D1
Vibrio cholerae infectionATP6V1F;ATP6V1G1;ATP6V1H;ATP6V0A2;ATP6V1E1;ATP6V1E2;KDELR3;GNAS;ERO1L
Epithelial cell signaling in Helicobacter pylori infectionADAM17;MAP2K4;ATP6V1G2;NOD1;GIT1;ATP6V1A;ATP6V0B;PAK1;IL-8
TuberculosisIFNA21;CAMK2B;IL10RB;ITGB2L;HLA-DMB;ATP6V0A4;IFNA4;BCL10;IFNG
Rheumatoid arthritisTNF;HLA-DRB3;ATP6V0D1;CD86;H2-AA;HLA-DPA1;CD28;ATP6V1B2;HLA-DQA1

ATP6V0C has several biochemical functions, for example, protein binding, proton-transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0C itself. We selected most functions ATP6V0C had, and list some proteins which have the same functions with ATP6V0C. You can find most of the proteins on our site.

Function Related Protein
protein bindingGPATCH4;CRYBA1;SYN1;LOXL2;GRB10;CCT6A;BPTF;ANKMY2;MAP3K7IP3
proton-transporting ATP synthase activity, rotational mechanismATP5C1;ATP5O;ATP6AP1B;ATP6V0C;ATP5A1;ATP6AP1;ATP5E;ATP5B
proton-transporting ATPase activity, rotational mechanismATP6AP1B;ATP6V1B2;TCIRG1;ATP6V0B;ATP6V0A1;ATP5B;ATP6V0E1;ATP6V1F;ATP6V1E1B
ubiquitin protein ligase bindingOTUB1;TMBIM6;BAG5;SLC22A18;TNFRSF14;CBS;SUMO2;UBE2K;GPR19

ATP6V0C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0C here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0C.

CERS2; MSR1; PSMA3; EDA; SMIM3; PDGFRB; E5; CLIC1; MARK3

Research Area

Related articles

Mangieri, LR; Mader, BJ; et al. ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease. PLOS ONE 9:-(2014).
Pavelin, J; Reynolds, N; et al. Systematic MicroRNA Analysis Identifies ATP6V0C as an Essential Host Factor for Human Cytomegalovirus Replication. PLOS PATHOGENS 9:-(2013).
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