ATP6V0C
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Official Full Name
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
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Overview
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. This gene encodes the V0 subunit c. Alternative splicing results in transcript variants. Pseudogenes have been identified on chromosomes 6 and 17. -
Synonyms
ATP6V0C; ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c; ATP6C, ATP6L, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD , ATPL; V-type proton ATPase 16 kDa proteolipid subunit; VATL; Vma3; ATP6C; ATP6L; ATPase, H+ transporting, lysosomal, V0 subunit c; ATPL; V ATPase subunit c; Vacuolar ATP synthase 16 kDa proteolipid subunit; Vacuolar H+ ATPase proton channel subunit; Vacuolar proton pump, 16 kDa subunit; V-ATPase 16 kDa proteolipid subunit; vacuolar proton pump 16 kDa proteolipid subunit; H(+)-transporting two-sector ATPase, 16 kDa subunit; VPPC;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Ovis aries (Sheep)
- Rat
- Rattus norvegicus (Rat)
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ATP6V0C involved in several pathways and played different roles in them. We selected most pathways ATP6V0C participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative phosphorylation | ATP6V1AA;ATP6V1C1B;NDUFA13;ATP6V0E1;COX17;ATP6V0A1;ATP6AP1B;NDUFA12;MT-ND4 |
| Metabolic pathways | AMY2A;AGPAT6;B3GNT2B;DPM2;PLCB4;UGT1A6A;GCDHB;ATP6V1F;ALLC |
| Lysosome | ARSG;HEXA;AP1S3;AP3M2;AP3B2;IGF2R;ACP5A;CTSG;AGA |
| Phagosome | ATP6V0A1;ATP6V1AA;COLEC12;DYNC1I2A;HLA-DQB1;SEC22BA;STX12;ACTB;ATP6V0A2 |
| Synaptic vesicle cycle | DNM3;CPLX3;ATP6V1C1;ATP6V0E;STX1A;ATP6V1C2;SLC18A2;ATP6V0A2;ATP6V1A |
| Collecting duct acid secretion | ATP6V1F;ATP6V1G1;ATP6V0E2;ATP6V0C;CA2;SLC4A1;ATP6V1B1;ATP6V1B2;ATP6V0E |
| Vibrio cholerae infection | ATP6V1H;GNAS;ACTG1;PRKACA;ATP6V0D1;PLCG1;ATP6V0E1;TJP1;ATP6V1E2 |
| Epithelial cell signaling in Helicobacter pylori infection | CCL5;MET;RELA;ATP6V1B2;ATP6V0A1;ATP6AP1;ATP6V0B;TJP1;MAP2K4 |
| Tuberculosis | CAP18;KSR1;PMAP-36;HLA-DPA1;TNF;PPP3R1;ITGAM;IL12B;IFNA1 |
| Rheumatoid arthritis | TLR4;CCL20;IL18;VEGFA;ATP6V0D1;HLA-DRA;ITGB2;ATP6V0B;HLA-DOB |
ATP6V0C has several biochemical functions, for example, protein binding, proton-transporting ATP synthase activity, rotational mechanism, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0C itself. We selected most functions ATP6V0C had, and list some proteins which have the same functions with ATP6V0C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAM20A;NUMBL;SNX7;FNTB;TPI1;ERCC6L;STK3;USP2;MAGEB18 |
| proton-transporting ATP synthase activity, rotational mechanism | ATP5E;ATP6AP1;ATP6V0C;ATP6AP1B;ATP5O;ATP5C1;ATP5B;ATP5A1 |
| proton-transporting ATPase activity, rotational mechanism | ATP6V1E1B;ATP6V1B2;ATP6V0A2B;ATP5D;ATP6V0A1A;ATP6AP1B;ATP6V1AA;ATP6V0A1B;ATP5B |
| ubiquitin protein ligase binding | PRR5L;UCHL1;MDM2;VCL;DNAJA1;USP2;PIAS2;BAG6;GGN |
ATP6V0C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0C here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0C.
CERS2; MSR1; PSMA3; EDA; SMIM3; PDGFRB; E5; CLIC1; MARK3
Research Area
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