• Official Full Name

    chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)

  • Background

    This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses.
  • Synonyms

    CCL18; chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated); CKb7; PARC; AMAC1; DCCK1; MIP-4; AMAC-1; DC-CK1; SCYA18; C-C motif chemokine 18; CC chemokine PARC; OTTHUMP00000163954; CC chemokine ligand 18; chemokine (C-C), dendritic; dendritic cell chemokine 1; small inducible cytokine A18; small-inducible cytokine A18; macrophage inflammatory protein 4; pulmonary and activation-regulated chemokine; alternative macrophage activation-associated CC chemokine 1; small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Biotin
    • Fc
    • GST
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCL18-164H Recombinant Human CCL18, 22-89 aa, His-tagged E.coli His
    Human CCL18-02H Recombinant Human CCL18 protein E.coli N/A
    Human CCL18-244H Recombinant Human CCL18 protein, His-tagged Yeast His
    Human CCL18-113H Active Human CCL18, Biotin-tagged Biotin
    Human CCL18-200H Recombinant Human CCL18 protein E.coli N/A
    Human CCL18-300H Active Recombinant Human Chemokine (C-C Motif) Ligand 18 (Pulmonary And Activation-Regulated) E.coli N/A
    Human CCL18-251H Active Recombinant Human Chemokine (C-C Motif) Ligand 18, HIgG1 Fc-tagged, mutant CHO Fc
    Human CCL18-30163TH Recombinant Human CCL18, His-tagged E.coli His
    Human CCL18-2892H Recombinant Human CCL18 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CCL18-0616H Recombinant Human CCL18 Protein, GST-Tagged Wheat Germ GST
    Human CCL18-45H Recombinant Human CCL18 Protein E.coli
    Human CCL18-253H Active Recombinant Human Chemokine (C-C Motif) Ligand 18, HIgG1 Fc-tagged CHO Fc
    Human CCL18-59H Recombinant Human CCL18 Protein, Biotin-tagged E.coli Biotin
    Human CCL18-2347H Recombinant Human CCL18 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CCL18-519H Recombinant Human CCL18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human CCL18-252H Active Recombinant Human Chemokine (C-C Motif) Ligand 18, MIgG2a Fc-tagged CHO Fc
    Human CCL18-519H-B Recombinant Human CCL18 Protein Pre-coupled Magnetic Beads HEK293
    Human CCL18-11H Recombinant Human CCL18 Protein E.coli
    Human CCL18-0884H Recombinant Human CCL18 Protein (Ala21-Ala89), His tagged E.coli His
    Human CCL18-03H Recombinant Human CCL18 Protein, His-tagged E.coli His
    Human CCL18-071C Recombinant Human CCL18 Protein (69 aa) E.coli
    Human CCL18-151H Recombinant Human CCL18 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Rhesus Macaque CCL18-509R-B Recombinant Rhesus Macaque CCL18 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque CCL18-509R Recombinant Rhesus Macaque CCL18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque CCL18-681R Recombinant Rhesus monkey CCL18 Protein, His-tagged Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • CCL18 Related Articles
    • CCL18 Related Gene Family
    • CCL18 Related Research Area

    CCL18 involved in several pathways and played different roles in them. We selected most pathways CCL18 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionOSTN;CXCR7;Ifnlr1;IL15RA;CCL21;Fasl;IFNL3;IFNB1;IL13
    Chemokine signaling pathwayGM13304;WAS;PTK2;WASL;CXCL10;RAC1;GNB1;PF4;LOC100033925

    CCL18 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL18 itself. We selected most functions CCL18 had, and list some proteins which have the same functions with CCL18. You can find most of the proteins on our site.

    Function Related Protein
    CCR chemokine receptor bindingCCL15;CCL38.1;CCL20B;XCL1;CCL34B.4;CCL20;CCL44;CCL19A.2;CCL3L1
    chemokine activityCCL23;CCL4;CXCL11.8;CXCL32B.1;IL-8;CCL35.1;CCL14;CXCL20;CCL16
    protein bindingZNF346;ABCB1;EIF4E2;CCDC101;RNF2;PLEKHB1;GPR37;UBL7;MED26

    CCL18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL18 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL18.

    PITPNM3; TP53; EEF1A1; TLE1; UNC119; CRMP1; C14orf1

    Xu, Y; Zhang, L; et al. CC Chemokine Ligand 18 and IGF-Binding Protein 6 as Potential Serum Biomarkers for Prostate Cancer. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 233:25-31(2014).
    Suga, H; Sugaya, M; et al. The Role of IL-32 in Cutaneous T-Cell Lymphoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:1428-1435(2014).
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