Active Human CCL18, Biotin-tagged

• Cat.No.: CCL18-113H
• Product Overview: It is a synthetic Protein with Biotin tag.

Specification

• Description: Pulmonary and activation-regulated chemokine (PARC)-1, which has also been identified as alternative macrophage activation-associated CC chemokine-1 (AMAC-1), Macrophage Inflammatory Protein-4 (MIP-4) and dendritic cell chemokine (DC-CK1), is a novel CC chemokine which shares 61% sequence homology with MIP-1 . PARC-1 cDNA encodes an 89 amino acid protein which contains a 20 amino acid signal peptide that is cleaved to generate the mature 69 amino acid protein lacking glycosylation sites. PARC-1 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells.
• Species: Human
• Tag: Biotin
• Form: Lyophilized
• Bio-activity: Activity measured by ability of the protein to induce chemotaxis in T-lymphocytes. ED50 for this measurement is generally 0.5-2 μg/ml.
• Applications: Activity Assay
• Storage: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles
• Reconstitution: Recommended reconstitution in sterile phosphate buffered saline which contains at least 0.1% human or bovine serum albumin to prepare a stocksolution of no less than 20 μg/ml and vortex thoroughly.

Gene Information

• Gene Name: CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated) [ Homo sapiens ]
• Official Symbol: CCL18
• Synonyms: CCL18; chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated); SCYA18, small inducible cytokine subfamily A (Cys Cys), member 18, pulmonary and activation regulated; C-C motif chemokine 18; AMAC 1; CKb7; DC CK1; DCCK1; MIP 4; PARC; CC chemokine PARC; CC chemokine ligand 18; chemokine (C-C), dendritic; dendritic cell chemokine 1; small inducible cytokine A18; small-inducible cytokine A18; macrophage inflammatory protein 4; pulmonary and activation-regulated chemokine; alternative macrophage activation-associated CC chemokine 1; small inducible cytokine subfamily A (Cys-Cys), member 18, pulmonary and activation-regulated; AMAC1; MIP-4; AMAC-1; DC-CK1; SCYA18
• Gene ID: 6362
• mRNA Refseq: NM_002988
• Protein Refseq: NP_002979
• MIM: 603757
• UniProt ID: P55774
• Chromosome Location: 17q11.2
• Pathway: Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem
• Function: chemokine activity; protein binding