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Official Full Name chemokine (C-C motif) receptor 6
Background This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene.
Synonyms CCR6; chemokine (C-C motif) receptor 6; C-C chemokine receptor type 6; CCR-6; KY411; Cmkbr6; CC-CKR-6
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E. coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • His-SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CCR6-0695H Recombinant Human CCR6 Protein Wheat Germ N/A
    Human CCR6-10H Recombinant Human CCR6 Protien, His-tagged E. coli His
    Human CCR6-11H Recombinant Human CCR6 Protien, His-SUMO-tagged E. coli His-SUMO
    Human CCR6-7692HCL Recombinant Human CCR6 293 Cell Lysate HEK293 N/A
    Mouse CCR6-3017M Recombinant Mouse CCR6 Protein Mammalian Cell His
    Rhesus Macaque CCR6-709R Recombinant Rhesus monkey CCR6 Protein, His-tagged Mammalian Cell His
    Chicken CCR6-3814C Recombinant Chicken CCR6 Mammalian Cell His
    Kit-0871 Continuous PRPP-S Assay Kit N/A
    Kit-1049 Neprilysin Activity Assay Kit (Fluorometric) N/A
    Kit-1156 cAMP CCR6 CHO-K1 GPCR Assay Kit N/A
    Kit-1157 CCR6 Activated GPCR Internalization Assay Kit N/A
    Kit-1158 CCR6 CHO-K1 β-Arrestin GPCR Assay Kit N/A

    ccr6 involved in several pathways and played different roles in them. We selected most pathways ccr6 participated on our site, such as Beta defensins, Chemokine receptors bind chemokines, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ccr6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Beta defensins CCR6; DEFB121; DEFB4B; DEFB129; DEFB4A; DEFB104A; DEFB106A; DEFB116; DEFB1; DEFB119
    Chemokine receptors bind chemokines CCL35.1; CCR9; CCL27; CXCL11.8; CXCR6; CCR1; CXCL13; CCL19A.2; CCBP2; AMCF-II
    Chemokine signaling pathway CXCL11; PTK2; CXCL1; CCL15; CCL24; GNG11; CCR1L1; GNGT1; FOXO3; PIK3CA
    Class A/1 (Rhodopsin-like receptors) OPN4; FPR-RS3; CCL35.2; CHRM3; AGTR2; PPY; INSL3; AGT; S1PR3; TAC3
    Cytokine-cytokine receptor interaction KITLGA; CCL4L1; CXCL9; IL12A; GHRA; IFNK; FIGF; MET; IFNAR2; CXCR5
    Defensins DEFB4A; DEFB119; DEFB121; DEFB1; DEFB106A; ART1; DEFB103A; DEFB129; DEFB116; DEFB125
    G alpha (i) signalling events CNR2; OPN1LW2; OPN1SW1; ADRA2B; CCL35.2; PTGDR2; CCL19A.2; ADORA3; NMU; PENKA
    GPCR downstream signaling NMBB; PMCH; PTH; CYSLTR1; DGKG; NTS; ANXA1B; AMCF-II; ADORA1; ADM2A

    ccr6 has several biochemical functions, for example, C-C chemokine receptor activity, chemokine receptor activity, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ccr6 itself. We selected most functions ccr6 had, and list some proteins which have the same functions with ccr6. You can find most of the proteins on our site.

    Function Related Protein
    C-C chemokine receptor activity CCR6A; CCR7; CCR9; CCR6; CCR3; CCR10; CCR8; CCR1; CCR5; CCBP2
    chemokine receptor activity CCR12A; CXCR1; CX3CR1; CXCR3; RGRB; ACKR3B; XCR1; CCR6A; CXCR3.1; CXCR4A
    receptor activity ANTXR2; GFRA1A; ANTXR2B; NOTCH2; GRIN2A; MED1; GP6; CALCR; P2RY11; MED17

    ccr6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ccr6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ccr6.

    Tan, JF; Jin, XF; et al. Beneficial effect of T follicular helper cells on antibody class switching of B cells in prostate cancer. ONCOLOGY REPORTS 33:1512-1518(2015).
    Bulati, M; Buffa, S; et al. Double Negative (IgG(+)IgD(-)CD27(-)) B Cells are Increased in a Cohort of Moderate-Severe Alzheimer's Disease Patients and Show a Pro-Inflammatory Trafficking Receptor Phenotype. JOURNAL OF ALZHEIMERS DISEASE 44:1241-1251(2015).

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