CD44 Protein

CD44

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CD44

Official Full Name CD44 molecule (Indian blood group)
Background The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
Synonyms CD44; CD44 molecule (Indian blood group); IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; CD44 antigen; epican; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system;
    • Species :
    • Chicken
    • Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
    • Human
    • Mouse
    • Mus musculus (Mouse)
    • Papio hamadryas (Hamadryas baboon)
    • Rabbit
    • Rat
    • Rattus norvegicus (Rat)
    • Source :
    • CHO
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293F
    • HEK293T
    • Human Cell
    • Human Cells
    • In Vitro Cell Free System
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • DYKDDDDK
    • Fc
    • GST
    • hFc
    • His
    • SUMO
    • His-SUMO
    • human
    • IgG1
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD44-578H Recombinant Human CD44, Fc-tagged, Biotinylated Human Cell Fc
    Mouse Cd44-624M Recombinant Mouse Cd44 Protein, Fc Chimera CHO Fc
    Rat Cd44-1017R Recombinant Rat Cd44 Protein, Fc Chimera Mammalian cells Fc
    Rat Cd44-1017RAF488 Recombinant Rat Cd44 Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells Fc
    Rat Cd44-1017RAF555 Recombinant Rat Cd44 Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells Fc
    Rat Cd44-1017RAF647 Recombinant Rat Cd44 Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells Fc
    Rat Cd44-1017RF Recombinant Rat Cd44 Protein, Fc-tagged, FITC conjugated Mammalian cells Fc
    Mouse Cd44-624MAF488 Recombinant Mouse Cd44 Protein, Fc-tagged, Alexa Fluor 488 conjugated CHO Fc
    Mouse Cd44-624MAF555 Recombinant Mouse Cd44 Protein, Fc-tagged, Alexa Fluor 555 conjugated CHO Fc
    Mouse Cd44-624MAF647 Recombinant Mouse Cd44 Protein, Fc-tagged, Alexa Fluor 647 conjugated CHO Fc
    Mouse Cd44-624MF Recombinant Mouse Cd44 Protein, Fc-tagged, FITC conjugated CHO Fc
    Human CD44-3961H Recombinant Human CD44 protein, His-tagged HEK293 His
    Human CD44-0820H Recombinant Human CD44 Protein Wheat Germ N/A
    Human CD44-10956H Recombinant Human CD44, His-tagged E.coli His
    Human CD44-1412H Recombinant Human CD44 Molecule (Indian Blood Group) N/A
    Human CD44-27238TH Recombinant Human CD44 protein, GST-tagged Wheat Germ GST
    Human CD44-421H Recombinant Human CD44, Fc tagged Human Cell His
    Human CD44-589H Recombinant Human CD44 protein, GST-tagged E.coli GST
    Chicken CD44-6423C Recombinant Chicken CD44 Mammalian Cell His
    Human CD44-1090HCL Recombinant Human CD44 cell lysate Human Cell N/A
    Human CD44-0821H Recombinant Human CD44 Protein, GST-tagged Wheat Germ GST
    Rat Cd44-1270R Recombinant Rat Cd44 Protein, His-tagged E.coli N-His
    Human CD44-151H Recombinant Human CD44 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human CD44-152H Recombinant Human CD44 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human CD44-2152H Recombinant Human CD44 Protein, His-tagged E.coli N-His
    Human CD44-2665H Recombinant Human CD44 protein, His-SUMO-tagged E.coli His-SUMO
    Human CD44-2983HF Recombinant Full Length Human CD44 Protein, GST-tagged In Vitro Cell Free System GST
    Human CD44-3095HAF488 Recombinant Human CD44 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc
    Human CD44-3095HAF555 Recombinant Human CD44 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc
    Human CD44-3095HAF647 Recombinant Human CD44 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc
    Human CD44-3095HF Recombinant Human CD44 Protein, hFc-tagged, FITC conjugated HEK293 hFc
    Human CD44-684H Recombinant Human CD44 Protein, His-tagged HEK293F N-His
    Rabbit CD44-685R Recombinant Rabbit CD44 Protein, His-tagged E.coli N-His
    Human CD44-6873HF Recombinant Full Length Human CD44 Protein, GST-tagged In Vitro Cell Free System GST
    Rattus norvegicus (Rat) RFL22259RF Recombinant Full Length Rat Cd44 Antigen(Cd44) Protein, His-Tagged E.coli expression system His
    Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) RFL23423CF Recombinant Full Length Cricetulus Griseus Cd44 Antigen(Cd44) Protein, His-Tagged E.coli expression system His
    Mus musculus (Mouse) RFL32176MF Recombinant Full Length Mouse Cd44 Antigen(Cd44) Protein, His-Tagged E.coli expression system His
    Papio hamadryas (Hamadryas baboon) RFL8877PF Recombinant Full Length Papio Hamadryas Cd44 Antigen(Cd44) Protein, His-Tagged E.coli expression system His
    Human CD44-001H Recombinant Human CD44 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human CD44-3095H Recombinant Human CD44 protein, Fc-tagged (HPLC-verified) HEK293 human/IgG1/Fc
    Human CD44-3095HA Recombinant Human CD44 protein, Fc-tagged, APC labeled HEK293 Fc
    Human CD44-3095HP Recombinant Human CD44 protein, Fc-tagged, R-PE labeled HEK293 Fc
    Human CD44-3096H Recombinant Human CD44 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CD44-393H Recombinant Human CD44 Protein (21-606 aa), His-SUMO-tagged E.coli His/SUMO
    Human CD44-5781H Recombinant Human CD44 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CD44-6062H Recombinant Human CD44 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Cd44-624MA Recombinant Mouse Cd44 protein, Fc-tagged, APC labeled CHO Fc
    Mouse Cd44-624MP Recombinant Mouse Cd44 protein, Fc-tagged, R-PE labeled CHO Fc
    Mouse Cd44-842M Recombinant Mouse Cd44 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse CD44-891M Recombinant Mouse CD44 Protein (Met1-Thr224), His-tagged HEK293 His
    Rat Cd44-1017RA Recombinant Rat Cd44 protein, Fc-tagged, APC labeled Mammalian cells Fc
    Rat Cd44-1017RP Recombinant Rat Cd44 protein, Fc-tagged, R-PE labeled Mammalian cells Fc

    CD44 involved in several pathways and played different roles in them. We selected most pathways CD44 participated on our site, such as ECM-receptor interaction, Hematopoietic cell lineage, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD44 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ECM-receptor interaction FN1A; COL1A1; Npnt; LAMB1A; COL24A1; COL6A2; TNC; THBS2; THBS3; COL6A4
    Hematopoietic cell lineage CD4; KIT; CD8B; ITGA5; GP9; FCGR1; Fcer2a; IL6R; IL1R2; IL7
    Shigellosis PFN3; RAC1; ITGB1; U2AF1; U2AF1L4; NFKBIA; WASL; ELMO2; ACTG1; MAPK10
    Epstein-Barr virus infection POLR2G; IKBKG; EIF2AK2; HDAC5; CSNK2B; AKT2; HSPA1B; LYN; HSPA2; POLR2C
    Proteoglycans in cancer IGF2; COL21A1; WNT7B; TIMP3; ANK1; IGF1R; PTCH1; WNT8B; CBL; FZD6
    MicroRNAs in cancer MMP9; NOTCH1; WNT3A; PLCG2; PTGS2; Pdgfa&Pdgfb; HOXD10; SPRY2; SOS1; HMGA2

    CD44 has several biochemical functions, for example, collagen binding, contributes_to cytokine receptor activity, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD44 itself. We selected most functions CD44 had, and list some proteins which have the same functions with CD44. You can find most of the proteins on our site.

    Function Related Protein
    collagen binding ITGA1; PAK1; CTSB; NID2; SMAD3; VWF; GPR56; PCOLCE; DCN; RELL2
    contributes_to cytokine receptor activity IRX1; CD44; IL28RA
    hyaluronic acid binding STAB2; TNFAIP6; ACAN; VCANB; HAPLN4; C1QBP; IMPG2; HMMR; LYVE1; HAPLN1
    hyalurononglucosaminidase activity HYAL4; HYAL6; SPAM1; KIAA1199; HYAL3; HYAL2; MGEA5; HYAL1; CD44
    protein binding CTH; BRCA1; PSMD14; CMKLR1; CLU; FAM96B; C7orf31; ARAP1; CNOT2; SERPINB9

    CD44 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD44 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD44.

    ipaB; SPP1; ganglioside_gm1; SLC7A11; MSN

    Gu, JJ; Fang, XL; et al. Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery. BIOMATERIALS 45:99-114(2015).
    Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).

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