CD44

  • Official Full Name

    CD44 molecule (Indian blood group)

  • Overview

    The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
  • Synonyms

    CD44; CD44 molecule (Indian blood group); IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; CD44 antigen; epican; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Papio hamadryas (Hamadryas baboon)
  • Rabbit
  • Rat
  • Rattus norvegicus (Rat)
  • CHO
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • DYKDDDDK
  • Fc
  • Flag
  • GST
  • hFc
  • His (Fc)
  • Avi
  • Strep
  • His|SUMO
  • SUMO
  • human|IgG1|Fc
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD44-578H Active Recombinant Human CD44, Fc-tagged, Biotinylated Human Cell Fc
Human CD44-3961H Recombinant Human CD44 protein, His-tagged HEK293 His
Human CD44-589H Recombinant Human CD44 protein, GST-tagged E.coli GST
Human CD44-421H Recombinant Human CD44, Fc tagged Human Cell His
Human CD44-1412H Recombinant Human CD44 Molecule (Indian Blood Group) N/A
Human CD44-10956H Recombinant Human CD44, His-tagged E.coli His
Human CD44-0820H Recombinant Human CD44 Protein Wheat Germ N/A
Human CD44-27238TH Recombinant Human CD44 protein, GST-tagged Wheat Germ GST
Human CD44-1090HCL Recombinant Human CD44 cell lysate Human Cell N/A
Human CD44-3095HAF647 Recombinant Human CD44 Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc
Human CD44-3095HAF555 Recombinant Human CD44 Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc
Human CD44-3095H Recombinant Human CD44 protein, Fc-tagged (HPLC-verified) HEK293 human/IgG1/Fc
Human CD44-0821H Recombinant Human CD44 Protein, GST-tagged Wheat Germ GST
Human CD44-393H Recombinant Human CD44 Protein (21-606 aa), His-SUMO-tagged E.coli His/SUMO
Human CD44-001H Active Recombinant Human CD44 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human CD44-3096H Recombinant Human CD44 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD44-684H Recombinant Human CD44 Protein, His-tagged HEK293F N-His
Human CD44-3095HAF488 Recombinant Human CD44 Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc
Human CD44-6062H Recombinant Human CD44 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD44-3095HP Recombinant Human CD44 protein, Fc-tagged, R-PE labeled HEK293 Fc
Human CD44-2152H Recombinant Human CD44 Protein, His-tagged E.coli N-His
Human CD44-160H Recombinant Human CD44 Protein, His and Strep-tagged HEK293 His and Strep
Human CD44-152H Recombinant Human CD44 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CD44-3095HA Recombinant Human CD44 protein, Fc-tagged, APC labeled HEK293 Fc
Human CD44-541H-B Recombinant Human CD44 Protein Pre-coupled Magnetic Beads HEK293
Human CD44-1191H Recombinant Human CD44 Protein (Gln21-Pro220), N-His tagged E.coli N-His
Human CD44-2665H Recombinant Human CD44 protein, His-SUMO-tagged E.coli His-SUMO
Human CD44-5781H Recombinant Human CD44 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD44-2168H Recombinant Human CD44 protein, hFc-tagged HEK293 hFc
Human CD44-151H Recombinant Human CD44 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CD44-3095HF Recombinant Human CD44 Protein, hFc-tagged, FITC conjugated HEK293 hFc
Human CD44-6873HF Recombinant Full Length Human CD44 Protein, GST-tagged In Vitro Cell Free System GST
Human CD44-2983HF Recombinant Full Length Human CD44 Protein In Vitro Cell Free System
Human CD44-198H Recombinant Human CD44 Protein, C-His-tagged E.coli C-His
Human CD44-161H Recombinant Human CD44 Protein, Fc-tagged HEK293 Fc
Human CD44-143HFL Active Recombinant Full Length Human CD44 Protein, C-Flag-tagged Mammalian cells Flag
Human CD44-5352H Recombinant Human CD44 Protein (Met1-Pro220), C-His tagged Mammalian cells C-His
Human CD44-541H Recombinant Human CD44 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD44-0234H Recombinant Human CD44 protein HEK293 N/A
Mouse Cd44-624M Active Recombinant Mouse Cd44 Protein, Fc Chimera CHO Fc
Mouse Cd44-624MAF647 Active Recombinant Mouse Cd44 Protein, Fc-tagged, Alexa Fluor 647 conjugated CHO Fc
Mouse Cd44-624MF Active Recombinant Mouse Cd44 Protein, Fc-tagged, FITC conjugated CHO Fc
Mouse Cd44-624MAF488 Active Recombinant Mouse Cd44 Protein, Fc-tagged, Alexa Fluor 488 conjugated CHO Fc
Mouse Cd44-624MAF555 Active Recombinant Mouse Cd44 Protein, Fc-tagged, Alexa Fluor 555 conjugated CHO Fc
Mouse Cd44-842M Recombinant Mouse Cd44 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cd44-624MA Recombinant Mouse Cd44 protein, Fc-tagged, APC labeled CHO Fc
Mouse CD44-891M Recombinant Mouse CD44 Protein (Met1-Thr224), His-tagged HEK293 His
Mouse Cd44-624MP Recombinant Mouse Cd44 protein, Fc-tagged, R-PE labeled CHO Fc
Mouse CD44-3295M Recombinant Mouse CD44 protein, His-GST-tagged E.coli His/GST
Rat Cd44-1017R Active Recombinant Rat Cd44 Protein, Fc Chimera Mammalian cells Fc
Rat Cd44-1017RAF488 Active Recombinant Rat Cd44 Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells Fc
Rat Cd44-1017RAF647 Active Recombinant Rat Cd44 Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells Fc
Rat Cd44-1017RAF555 Active Recombinant Rat Cd44 Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells Fc
Rat Cd44-1017RF Active Recombinant Rat Cd44 Protein, Fc-tagged, FITC conjugated Mammalian cells Fc
Rat Cd44-3R Recombinant Rat Cd44 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cd44-1017RA Recombinant Rat Cd44 protein, Fc-tagged, APC labeled Mammalian cells Fc
Rat Cd44-1017RP Recombinant Rat Cd44 protein, Fc-tagged, R-PE labeled Mammalian cells Fc
Rat Cd44-1270R Recombinant Rat Cd44 Protein, His-tagged E.coli N-His
Rat Cd44-3R-B Recombinant Rat Cd44 Protein Pre-coupled Magnetic Beads HEK293
Rabbit CD44-685R Recombinant Rabbit CD44 Protein, His-tagged E.coli N-His
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) RFL23423CF Recombinant Full Length Cricetulus Griseus Cd44 Antigen(Cd44) Protein, His-Tagged E.coli expression system His
Mus musculus (Mouse) RFL32176MF Recombinant Full Length Mouse Cd44 Antigen(Cd44) Protein, His-Tagged E.coli expression system His
Papio hamadryas (Hamadryas baboon) RFL8877PF Recombinant Full Length Papio Hamadryas Cd44 Antigen(Cd44) Protein, His-Tagged E.coli expression system His
Rattus norvegicus (Rat) RFL22259RF Recombinant Full Length Rat Cd44 Antigen(Cd44) Protein, His-Tagged E.coli expression system His
Chicken CD44-6423C Recombinant Chicken CD44 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD44 Related Articles
  • CD44 Related Research Area
  • CD44 Related Signal Pathway

CD44 involved in several pathways and played different roles in them. We selected most pathways CD44 participated on our site, such as ECM-receptor interaction, Hematopoietic cell lineage, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD44 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM-receptor interactionCOL27A1B;GP5;COL5A1;ITGA9;COL4A4;ITGA1;COL6A2;THBS4B;CD47
Hematopoietic cell lineageANPEP;Fcer2a;FLT3LG;ITGA3;HLA-DRB4;CR2;CD14;CD33;FCER2
ShigellosisPFN4;CD44;ACTG1;MAPK9;VCL;MAPK1;RELA;PFN3;ABL1
Epstein-Barr virus infectionITGAL;POLR3D;TYK2;HLA-DRA;MAPK11;TAB1;HSPA1A;TRP53;MDM2
Proteoglycans in cancerWNT7B;PPP1CA;RPS6KB2;STAT3;FZD1;MAP2K1;IGF1;PPP1R12A;RPS6KB1
MicroRNAs in cancerABCB1A;NOTCH4;HDAC1;SLC7A1;CDC25C;SHC1;SLC45A3;PRKCB;CD44

CD44 has several biochemical functions, for example, collagen binding, contributes_to cytokine receptor activity, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD44 itself. We selected most functions CD44 had, and list some proteins which have the same functions with CD44. You can find most of the proteins on our site.

Function Related Protein
collagen bindingVWF;RELL2;CCBE1;C1QTNF1;ASPN;PCOLCE2;ACHE;ITGA9;Pdgfa&Pdgfb
contributes_to cytokine receptor activityIL28RA;IRX1;CD44
hyaluronic acid bindingSTAB2;CD44;HAPLN1A;LAYN;VCAN;LYVE1;TNFAIP6;HYAL2;HAPLN2
hyalurononglucosaminidase activityKIAA1199;CD44;MGEA5;HYAL3;HYAL2;SPAM1;HYAL1;HYAL6;HYAL4
protein bindingDLAT;POLDIP2;NOD1;KRTAP4-12;EMID2;TNFSF14;ARHGAP33;LDHA;SPATA8

CD44 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD44 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD44.

ipaB; SPP1; ganglioside_gm1; SLC7A11; MSN

Gu, JJ; Fang, XL; et al. Reversal of P-glycoprotein-mediated multidrug resistance by CD44 antibody-targeted nanocomplexes for short hairpin RNA-encoding plasmid DNA delivery. BIOMATERIALS 45:99-114(2015).
Kaneko, K; Higuchi, C; et al. Hyaluronan inhibits BMP-induced osteoblast differentiation. FEBS LETTERS 589:447-454(2015).
  • Q&As
  • Reviews

Q&As (7)

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What is the role of CD44 in cancer? 04/27/2023

CD44 is implicated in cancer progression and metastasis. It promotes tumor cell invasion, migration, and adhesion to the extracellular matrix. CD44 also plays a role in cancer stem cell maintenance and drug resistance. Its overexpression is associated with poor prognosis in various types of cancer.

 Can CD44 be targeted for therapeutic purposes? 05/19/2021

Targeting CD44 has been explored as a potential therapeutic strategy in cancer and inflammatory diseases. Strategies include blocking CD44-ligand interactions, inhibiting CD44 signaling pathways, and targeting CD44-positive cancer stem cells. However, further research is needed to fully understand the complex roles of CD44 in different disease contexts and to develop effective CD44-targeted therapies.

How is the expression of CD44 regulated? 03/10/2021

The expression of CD44 is regulated at multiple levels, including transcriptional control, alternative splicing, and post-translational modifications. Transcription factors such as Sp1 and NF-κB can bind to the CD44 promoter region to regulate its gene expression. Additionally, alternative splicing of CD44 pre-mRNA generates CD44 isoforms with different functions and expression patterns.

 How does CD44 contribute to immune regulation? 11/02/2019

CD44 is involved in immune cell activation, trafficking, and homing. It participates in the recruitment of leukocytes to sites of inflammation and mediates T cell adhesion and migration. CD44 can also modulate immune responses by interacting with other immune receptors and cytokines, and it is involved in the regulation of T cell activation and differentiation.

How is CD44 involved in immune regulation? 05/12/2019

CD44 plays a vital role in immune regulation by participating in immune cell activation, migration, and modulation of T-cell activation and differentiation. CD44 is expressed on various immune cell populations, including T cells, B cells, natural killer cells, and dendritic cells. It serves as an adhesion molecule and facilitates immune cell trafficking to lymphoid tissues and inflammatory sites. CD44 also functions as a co-stimulatory receptor, enhancing T-cell activation and cytokine production upon interaction with its ligands. Moreover, CD44 isoforms have been implicated in the differentiation of T helper cell subsets, such as Th1, Th2, and Th17 cells. These findings highlight the multifaceted role of CD44 in immune regulation and its potential as a therapeutic target for immune-related disorders.

What is the cellular localization of the protein CD44? 02/11/2016

CD44 is a transmembrane glycoprotein predominantly localized on the cell surface, specifically in the plasma membrane of various cell types, including epithelial cells, leukocytes, and mesenchymal cells.

 What are the signaling pathways associated with CD44? 01/03/2016

CD44 can activate various signaling pathways, including PI3K/AKT, MAPK/ERK, and NF-κB pathways. These pathways mediate downstream cellular processes such as cell survival, proliferation, migration, and immune responses. CD44 can also interact with other cell surface receptors, such as receptor tyrosine kinases, to modulate their signaling activities.

Customer Reviews (3)

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Reviews
03/08/2022

    Using this reagent, I can gain a better understanding of the functionality and regulatory mechanisms of proteins.

    04/26/2019

      This reagent has long-lasting performance, enduring prolonged experimental use.

      03/14/2019

        A miraculous reagent driving us towards the frontiers, inviting a glance into an expanded world.

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