| Description : |
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. |
| Source : |
Mammalian cells |
| Species : |
Human |
| Tag : |
Flag |
| Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
| Bio-activity : |
ELISA binding assay |
| Molecular Mass : |
79.2 kDa |
| AA Sequence : |
MDKFWWHAAWGLCLVPLSLAQIDLN ITCRFAGVFHVEKNGRYSISRTEAA DLCKAFNSTLPTMAQMEKAL SIGFETCRYGFIEGHVVIPRIHPNS ICAANNTGVYILTSNTSQYDTYCFN ASAPPEEDCTSVTDLPNAFD GPITITIVNRDGTRYVQKGEYRTNP EDIYPSNPTDDDVSSGSSSERSSTS GGYIFYTFSTVHPIPDEDSP WITDSTDRIPATTLMSTSATATETA TKRQETWDWFSWLFLPSESKNHLHT TTQMAGTSSNTISAGWEPNE ENEDERDRHLSFSGSGIDDDEDFIS STISTTPRAFDHTKQNQDWTQWNPS HSNPEVLLQTTTRMTDVDRN GTTAYEGNWNPEAHPPLIHHEHHEE EETPHSTSTIQATPSSTTEETATQK EQWFGNRWHEGYRQTPKEDS HSTTGTAAASAHTSHPMQGRTTPSP EDSSWTDFFNPISHPMGRGHQAGRR MDMDSSHSITLQPTANPNTG LVEDLDRTGPLSMTTQQSNSQSFST SHEGLEEDKDHPTTSTLTSSNRNDV TGGRRDPNHSEGSTTLLEGY TSHYPHTKESRTFIPVTSAKTGSFG VTAVTVGDSNSNVNRSLSGDQDTFH PSGGSHTTHGSESDGHSHGS QEGGANTTSGPIRTPQIPEWLIILA SLLALALILAVCIAVNSRRRCGQKK KLVINSGNGAVEDRKPSGLN
GEASKSQEMVHLVNKESSETPDQFM TADETRNLQNVDMKIGVTRTRPLEQ KLISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
| Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Storage : |
Store at -80 centigrade. |
| Concentration : |
>50 ug/mL as determined by microplate BCA method. |
| Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Protein Families : |
Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway, Transmembrane |
| Protein Pathways : |
ECM-receptor interaction, Hematopoietic cell lineage |
