CEACAM6

  • Official Full Name

    CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)

  • Overview

    Carcinoembryonic antigen (CEA; MIM 114890) is one of the most widely used tumor markers in serum immunoassay;determinations of carcinoma. An apparent lack of absolute cancer specificity for CEA probably results in part from the;presence in normal and neoplastic tissues of antigens that share antigenic determinants with the 180-kD form of CEA;(Barnett et al., 1988 (PubMed 3220478)). For background information on the CEA family of genes, see CEACAM1 (MIM;109770).
  • Synonyms

    CEACAM6; carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen); NCA; CEAL; CD66c; carcinoembryonic antigen-related cell; CD66c antigen; Non-specific crossreacting antigen; carcinoembryonic antigen-related cell; adhesion molecule 6; Sulesomab; LeukoScan; 167747-19-5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Cynomolgus
  • Gln35-Gly320
  • Human
  • C-His
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian cells
  • Wheat Germ
  • Fc
  • GST
  • His
  • Avi
  • SUMO
  • T7
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CEACAM6-27919TH Recombinant Human CEACAM6 Wheat Germ Non 110 amino acids
Human CEACAM6-221H Recombinant Human CEACAM6, C13&N15-labeled HEK293 Non Lys35-Gly320
Human CEACAM6-664H Recombinant Human CEACAM6 protein, His-tagged HEK293 His Lys35-Gly320
Human CEACAM6-8197H Recombinant Human CEACAM6 protein, His & T7-tagged E.coli His&T7 Lys35~Pro142
Human CEACAM6-1096H Recombinant Human CEACAM6 Protein, GST-Tagged Wheat Germ GST
Human CEACAM6-2797HCL Recombinant Human CEACAM6 cell lysate Human Cell Non
Human CEACAM6-3191H Recombinant Human CEACAM6 Protein, His-tagged E.coli His
Human CEACAM6-664HB Recombinant Human CEACAM6 protein, His-tagged, Biotinylated HEK293 His Met1-Gly320
Human CEACAM6-199H Recombinant Human CEACAM6 protein, His-Avi-tagged HEK293 His&Avi Lys 35-Gly 320
Human CEACAM6-335H Active Recombinant Human CEACAM6 Protein, His & Avi-tagged, Biotinylated HEK293 His&Avi Lys 35 - Gly 320
Human CEACAM6-3275HF Recombinant Full Length Human CEACAM6 Protein, GST-tagged In Vitro Cell Free System GST 344 amino acids
Human CEACAM6-2684H Recombinant Human CEACAM6 protein, His-SUMO-tagged E.coli His&SUMO 35-320aa
Human CEACAM6-42H Recombinant Human CEACAM6 Protein (ECD), His-tagged(C-ter) HEK293 His Lys35-Gly320
Human CEACAM6-1308H Active Recombinant Human CEACAM6 protein, Fc-tagged HEK293 Fc Lys35-Gly320
Human CEACAM6-179H Recombinant Human CEACAM6 Protein, His-tagged HEK293 His 344
Human CEACAM6-3324H Recombinant Human CEACAM6 protein, His-tagged E.coli His Lys35~Pro142
Human CEACAM6-4661H Recombinant Human CEACAM6 Protein (Met1-Gly320), C-His tagged Mammalian cells His Met1-Gly320
Human CEACAM6-2193H Active Recombinant Human CEACAM6 protein, His-tagged HEK293 His Met1-Gly320
Cynomolgus CEACAM6-046C Recombinant Cynomolgus CEACAM6 Protein, His-tagged HEK293 His Met1-Pro323
Gln35-Gly320 CEACAM6-1536C Recombinant Cynomolgus CEACAM6 protein, His-tagged C-His Gln35-Gly320
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is CEACAM6 protein?

CEACAM6 gene (CEA cell adhesion molecule 6) is a protein coding gene which situated on the long arm of chromosome 19 at locus 19q13. This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The CEACAM6 protein is consisted of 344 amino acids and CEACAM6 molecular weight is approximately 37.2 kDa.

What is the function of CEACAM6 protein?

CEACAM6 is a cell adhesion molecule belonging to the CEA family. It plays an important role in a variety of cancers, including promoting tumor proliferation, invasion, and metastasis. CEACAM6 is usually upregulated in a variety of cancers, including pancreatic, breast, non-small cell lung, gastric, and colorectal cancers, and is associated with poor prognosis. It promotes tumor cell proliferation, invasion, migration, resistance to apoptosis and chemotherapy, and angiogenesis by activating downstream signaling pathways such as ERK1/2/MAPK or SRC/FAK/PI3K/AKT, directly or through EGFR. In addition, CEACAM6 expression is regulated by a variety of factors, including the CD151/TGF-β1/Smad3 axis, multiple micrornas (such as miR-146, miR-26a, miR-29a/b/c, etc.), and DNA methylation. In terms of clinical applications, CEACAM6 is a potential diagnostic biomarker and therapeutic target, and monoclonal antibodies and molecular therapeutic strategies targeting CEACAM6 are being developed for the diagnosis and treatment of cancer.

CEACAM6 related signaling pathway

CEACAM6 is a cell surface molecule that plays a role in a variety of biological processes, including cell adhesion, signaling, and cell migration. In cancer, CEACAM6 promotes tumor invasion and metastasis by interacting with multiple signaling pathways. It can activate signaling pathways such as PI3K/AKT and ERK/MAPK, thereby promoting epithelial-mesenchymal transformation (EMT) and increasing the migration and invasion ability of tumor cells. In addition, CEACAM6 is involved in the regulation of tumor angiogenesis and immune responses in the tumor microenvironment. Clinically, CEACAM6 expression levels are associated with the prognosis of a variety of cancers, making it a potential diagnostic marker and therapeutic target.

CEACAM6-7.jpg

Fig1. Signaling initiated by epithelial CEACAMs. (Arnaud Kengmo Tchoupa, 2014)

CEACAM6 related diseases

CEACAM6 plays an important role in a variety of cancers, including pancreatic, lung, stomach, colorectal, breast, cholangiocarcinoma, ovarian, head and neck cancer, osteosarcoma, acute leukemia, and urinary system tumors. It is commonly upregulated in these cancers and is associated with tumor aggressiveness, metastasis, drug resistance, and poor prognosis. CEACAM6 promotes the proliferation, migration and invasion of tumor cells by activating various signaling pathways, such as PI3K/AKT, ERK/MAPK, etc. In addition, CEACAM6 expression is regulated by multiple factors, including miRNA, DNA methylation, and protein glycosylation. Clinically, high expression of CEACAM6 is associated with poor prognosis in a variety of cancers, making it a potential diagnostic and therapeutic target.

Bioapplications of CEACAM6

CEACAM6 plays a catalytic role in a variety of cancers, including pancreatic, stomach, lung, colorectal, and more. It plays a key role in tumor occurrence and development by promoting tumor invasion, metastasis and angiogenesis, inhibiting tumor apoptosis, and increasing tumor resistance to chemotherapy drugs. High expression of CEACAM6 is often associated with poor patient outcomes. Therapeutic strategies targeting CEACAM6, such as the development of specific antibodies, have been shown to inhibit tumor invasion and metastasis and increase the sensitivity of tumor cells to apoptosis, providing new research directions for early diagnosis and treatment of cancer. In addition, CEACAM6 also plays an important role in modulating the immune response in the tumor microenvironment, and its potential in cancer therapy is gradually being explored, including as a target for cancer therapy and as a component of immunotherapy.

High Purity

SDS-PAGE (CEACAM6-664H).jpg

Fig1. SDS-PAGE (CEACAM6-664H)

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SDS-PAGE (CEACAM6-8197H).jpg

Fig2. SDS-PAGE (CEACAM6-8197H)

Case Study 1: Shah Kamranur Rahman, 2021

Influenza A virus (IAV) enters human lung cells by binding to the host glycoprotein CD66c, a receptor not previously identified. This study demonstrates that IAV's neuraminidase protein interacts with CD66c on the cell surface, and increasing CD66c levels enhances viral entry. CD66c's binding capacity surpasses that of other glycoproteins like EGFR and DC-SIGN, which are known to aid IAV entry. Reducing CD66c with siRNA or blocking it with antibodies inhibits viral binding and entry. CD66c specificity for IAV is confirmed by its lack of impact on Hepatitis C virus entry. Moreover, pre-incubating IAV with recombinant CD66c protein and administering it intranasally in mice reduces lung cytopathic effects, suggesting CD66c's role in IAV infection.

CEACAM6-1.jpg

Fig1. Lec2 CHO-CD66c is CD66c overexpressing Lec2 CHO cell lines.

CEACAM6-2.jpg

Fig2. siRNA knockdown of CD66c in Huh7.5 cells have not inhibited entry of another non-IAV virus.

Case Study 2: Jacqueline I Keenan, 2014

Exclusive enteral nutrition (EEN) is a recognized first-line treatment for inducing remission in active Crohn's disease (CD), particularly in pediatric patients, yet the specific mechanisms behind its efficacy are not completely understood. This study utilized the Caco-2 human adenocarcinoma cell line to demonstrate that exposure to a polymeric formula (PF), a form of EEN, leads to a dose-dependent upregulation of CEACAM6, an adhesion molecule that plays a role in CD pathogenesis by facilitating the binding of adherent-invasive Escherichia coli (AIEC) to the intestinal lining. Notably, the increase in CEACAM6 expression was most pronounced on the cell surface. Additionally, PF treatment doubled the secretion of soluble CEACAM6 by Caco-2 cells, and this elevated release was associated with a reduced capacity of AIEC to adhere to intestinal epithelial cells.

CEACAM6-3.jpg

Fig3. Detection of CEACAM6 in a Caco-2 cell lysate.

CEACAM6-4.jpg

Fig4. PF added to Caco-2 cells for 24 h had a dose-dependent effect on CEACAM6 expression.

CEACAM6 involved in several pathways and played different roles in them. We selected most pathways CEACAM6 participated on our site, such as Cell surface interactions at the vascular wall, Extracellular matrix organization, Fibronectin matrix formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CEACAM6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell surface interactions at the vascular wallMERTK;AMICA1;SLC3A2A;PROCR;NADL1.1;ESAMA;CXADR;DOK2;GLG1B
Extracellular matrix organizationCOL4A6;MFAP5;MMP24;LAMB1B;COL8A1;SERPINH1;COL9A1;COL25A1;MMP13
Fibronectin matrix formationCEACAM6;CEACAM8;CEACAM1;FN1B
HemostasisESAMA;MFN1;SLC3A2B;CFHL3;F11R.2;DGKB;BSG;TAE1;CLU

CEACAM6 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CEACAM6 itself. We selected most functions CEACAM6 had, and list some proteins which have the same functions with CEACAM6. You can find most of the proteins on our site.

Function Related Protein
protein bindingPRKAR2AA;HMGB3;ELMO2;CBY1;CHMP4B;PTGES3;CEP68;KRTAP12-4;HDAC7A

CEACAM6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEACAM6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CEACAM6.

CARTPT; CEACAM5; CEACAM1; CEACAM8; CEACAM7

Research Area

Related articles

Aleandri, M; Conte, MP; et al. Influenza A Virus Infection of Intestinal Epithelial Cells Enhances the Adhesion Ability of Crohn's Disease Associated Escherichia coli Strains. PLOS ONE 10:-(2015).
Lee, OJ; Son, SM; et al. CEACAM6 as detected by the AP11 antibody is a marker notable for mucin-producing adenocarcinomas. VIRCHOWS ARCHIV 466:151-159(2015).
  • Reviews
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Customer Reviews (3)

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Reviews
05/23/2022

    They provide a wealth of technical information and extensive documentation about the CEACAM6 protein, ensuring I have a comprehensive understanding of its characteristics, handling protocols, and storage requirements.

    11/13/2021

      the manufacturer ensures a streamlined supply chain management system to meet my trial's requirements.

      11/16/2020

        the manufacturer facilitates access to the latest scientific advancements and developments related to CEACAM6 protein research.

        Q&As (5)

        Ask a question
        How does CEACAM6 contribute to inflammation? 04/19/2022

        CEACAM6 is involved in regulating the inflammatory response in the gut, making it relevant to inflammatory bowel disease.

        Are there diagnostic tests for CEACAM6 in inflammatory bowel disease? 09/01/2020

        CEACAM6 levels can be measured in clinical tests to assess inflammation in the gastrointestinal tract.

        Can CEACAM6 be used for monitoring disease progression? 10/10/2018

        Yes, CEACAM6 levels can be monitored to track the progression of certain diseases.

        Are there therapeutic strategies targeting CEACAM6 in infections? 12/16/2017

        Research is ongoing to develop therapies that inhibit CEACAM6 interactions with pathogens to prevent infection.

        Is CEACAM6 protein used in immunotherapy for cancer? 03/02/2016

        Some immunotherapeutic approaches involve targeting CEACAM6 to enhance the immune response against cancer cells.

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