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  • Official Full Name

    cardiotrophin-like cytokine factor 1

  • Overview

    Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3), is a protein that in humans is encoded by the CLCF1 gene.
  • Synonyms

    BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6; B-cell stimulating factor 3; B-cell stimulatory factor 3; B-cell-stimulating factor 3; CRLF1 associated cytokine-like factor 1; neurotrophin-1/B-cell stimulating factor-3; novel neurotrophin-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CRLF1&CLCF1-1036H Active Recombinant Human CRLF1&CLCF1 Mammalian cells N/A
Human CLCF1-351H Recombinant Human CLCF1, Fc-tagged Human Cell Fc Leu28-Phe225
Human CLCF1-29299TH Recombinant Human CLCF1, His-tagged E.coli His 198 amino acids
Human CLCF1-11277H Recombinant Human CLCF1, His-tagged E.coli His 1-225a.a.
Human CLCF1-953H Recombinant Human Cardiotrophin-like Cytokine Factor 1 E.coli N/A
Human CLCF1-3626H Recombinant Human CLCF1, His-tagged Human His
Human CLCF1-1413H Recombinant Human CLCF1 Protein, GST-tagged Wheat Germ GST
Human CLCF1-30449TH Recombinant Human CLCF1 protein E.coli N/A 198
Human CLCF1-001HCL Recombinant Human CLCF1 cell lysate Human Cell N/A
Human CLCF1-5167H Recombinant Human CLCF1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CLCF1-3242H Recombinant Human CLCF1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CLCF1-618H Recombinant Human CLCF1 Protein, His-tagged E.coli His Thr88~Glu190
Human CLCF1-1964HF Recombinant Full Length Human CLCF1 Protein, GST-tagged In Vitro Cell Free System GST 225 amino acids
Human CLCF1-2065H Recombinant Human CLCF1 Protein (Leu28-Phe225), N-His tagged E.coli N-His Leu28-Phe225
Mouse CLCF1-3511M Recombinant Mouse CLCF1 Protein Mammalian Cell His
Mouse Clcf1-619M Recombinant Mouse Clcf1 Protein, His-tagged E.coli His Leu28~Phe225
Mouse CLCF1-1716M Recombinant Mouse CLCF1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CLCF1-1716M-B Recombinant Mouse CLCF1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Clcf1-2178M Recombinant Mouse Clcf1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CLCF1 Related Articles
  • CLCF1 Related Gene Family
  • CLCF1 Related Research Area

CLCF1 involved in several pathways and played different roles in them. We selected most pathways CLCF1 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLCF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionM17;TNFRSF14;IL18R1;IL28A;GM1987;IFNK;Il4ra;CSF2RA;MET

CLCF1 has several biochemical functions, for example, ciliary neurotrophic factor receptor binding, contributes_to ciliary neurotrophic factor receptor binding, contributes_to cytokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLCF1 itself. We selected most functions CLCF1 had, and list some proteins which have the same functions with CLCF1. You can find most of the proteins on our site.

Function Related Protein
ciliary neurotrophic factor receptor bindingCNTF;CLCF1;LIFR;IL6ST;Ctf2
contributes_to ciliary neurotrophic factor receptor bindingCLCF1;CRLF1
contributes_to cytokine activityIL12B;CLCF1;CRLF1;IL12A
cytokine activityIL1B;ILTIFB;IL10;CMTM4;Il23a; Il12b;IL32;GDF7;Il1f6;IL24
growth factor activityNODAL;COL20A1;AREG;AMH;FGF21;CSF2;IGF2B;PDGFC;IL34
protein bindingSIGIRR;STIP1;HER11;C11orf54;NARG2;GLP1R;C21orf7;BAZ1A;RFC2
protein heterodimerization activityZBTB1;HIST1H2AA;SFRP5;BCL2A1;SOX5;TBX15;GABRR1;H2AFX;ITGA3

CLCF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLCF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLCF1.


Dernyanets, S; Huber, K; et al. Vascular effects of glycoprotein130 ligands - Part II: Biomarkers and therapeutic targets. VASCULAR PHARMACOLOGY 57:29-40(2012).
Silver, JS; Hunter, CA; et al. gp130 at the nexus of inflammation, autoimmunity, and cancer. JOURNAL OF LEUKOCYTE BIOLOGY 88:1145-1156(2010).
  • Q&As
  • Reviews

Q&As (5)

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Can CLCF1 be measured as a biomarker for certain diseases? 07/22/2021

Research suggests that levels of CLCF1 in blood or tissues may serve as potential biomarkers for specific diseases, aiding in early diagnosis and prognosis.

How is CLCF1 production regulated in the human body? 09/05/2020

The production of CLCF1 is tightly regulated at the transcriptional and post-translational levels, involving various signaling pathways.

Are there any clinical trials exploring the use of CLCF1 in medical interventions? 12/04/2018

Yes, there are ongoing clinical trials investigating the therapeutic potential of CLCF1 in various diseases, including autoimmune disorders and neurodegenerative conditions.

How does CLCF1 interact with other cytokines in the IL-6 family? 08/17/2018

CLCF1 can interact with various receptors and signaling molecules within the IL-6 cytokine family, influencing a range of physiological processes.

In what ways does CLCF1 contribute to neurodegenerative disorders? 10/19/2017

Studies have indicated that CLCF1 may play a role in neurodegenerative conditions, and understanding its function could lead to potential therapies for diseases like Alzheimer's and Parkinson's.

Customer Reviews (3)

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    With their meticulous documentation and support, I am confident that my utilization of CLCF1 protein in clinical trials will meet all necessary regulations and guidelines.


      the manufacturer's supply management capabilities assure a seamless and continuous provision of the CLCF1 protein.


        In addition to the remarkable quality of the protein, the manufacturer's support extends beyond the provision of the product itself.

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