CLEC4M

  • Official Full Name

    C-type lectin domain family 4, member M

  • Overview

    This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
  • Synonyms

    CLEC4M; C-type lectin domain family 4, member M; CD209L, CD299, CD299 antigen; C-type lectin domain family 4 member M; DC SIGN2; DC SIGNR; DCSIGNR; HP10347; LSIGN; C type lectin domain family 4, member M; CD209 antigen like; CD209 antigen like protein 1; CD209 antigen-like protein 1; CD209L; CD209L1; CD299; CD299 antigen; CLC4M_HUMAN; DC SIGN related protein; DC-SIGN-related protein; DC-SIGN2; DC-SIGNR; DCSIGN related protein; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; L SIGN; L-SIGN; Liver/lymph node specific ICAM3 grabbing nonintegrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; Mannose binding C type lectin DC SIGNR; MGC129964; MGC47866; mannose binding C-type lectin DC-SIGNR; liver/lymph node-specific ICAM-3 grabbing non-integrin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • Insect cell
  • Mammalian cells
  • Wheat Germ
  • Fc
  • FC
  • Fc Chimera
  • GST
  • hFc
  • hIgG
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Flag
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLEC4M-689H Active Recombinant Human CLEC4M, Fc Chimera Mammalian cells Fc Chimera
Human CLEC4M-26929TH Recombinant Human CLEC4M, FC-tagged FC
Human CLEC4M-1471H Recombinant Human CLEC4M Protein, GST-tagged Wheat Germ GST
Human CLEC4M-3132H Recombinant Human CLEC4M, Fc tagged Human Cell Fc
Human CLEC4M-1855H Recombinant Human CLEC4M protein, His & T7-tagged E.coli His/T7 Pro242~Glu399 (Accession # Q9H2X3)
Human CLEC4M-230H Recombinant Human CLEC4M protein HEK293 N/A Ser78-Glu399
Human CLEC4M-2744HCL Recombinant Human CLEC4M cell lysate Human Cell N/A
Human CLEC4M-179H Recombinant Human CLEC4M Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CLEC4M-3263H Recombinant Human CLEC4M Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CLEC4M-179H-B Recombinant Human CLEC4M Protein Pre-coupled Magnetic Beads HEK293
Human CLEC4M-5236H Recombinant Human CLEC4M Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CLEC4M-1084H Recombinant Human CLEC4M Protein (Leu241-Glu399), N-His tagged E.coli N-His Leu241-Glu399
Human CLEC4M-6556H Recombinant Human CLEC4M Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CLEC4M-0250H Recombinant Human CLEC4M protein, hFc-tagged HEK293 hFc Ser78-Glu399
Human CLEC4M-02H Recombinant Human CLEC4M Protein, hIgG/His-tagged Insect cell hIgG/His 72-399
Human CLEC4M-3264H Recombinant Human CLEC4M Protein, MYC/DDK-tagged HEK293T MYC/DDK
Human CLEC4M-151H Recombinant Human CLEC4M Protein, His-tagged Human Cells His
Human CLEC4M-07H Recombinant Human CLEC4M Protein, His-tagged HEK293 His
Human CLEC4M-08H Recombinant Human CLEC4M(Ser73-Glu376) Protein, N-8*His-Flag-tagged HEK293 His-Flag
Human CLEC4M-007H Recombinant Human CLEC4M Protein, His-tagged E.coli His
Human CLEC4M-3760H Recombinant Human CLEC4M Protein (Ser78-Glu399), N-Fc tagged Mammalian cells N-Fc Ser78-Glu399
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CLEC4M involved in several pathways and played different roles in them. We selected most pathways CLEC4M participated on our site, such as Measles, Phagosome, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLEC4M were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MeaslesCD209C;RAB9A;TLR9;IRF3;MSN;IL1A;Fasl;CD3G;IFNA8
PhagosomeMRC2;ITGB5;NCF4;RAB5B;DYNC1LI1;OLR1;CALRL2;ATP6AP1B;FCGR3
TuberculosisIL10RB;ATP6V0C;CAMP;FADD;TLR9;TGFB1;TNF;HLA-DPB1;PPP3R2

CLEC4M has several biochemical functions, for example, ICAM-3 receptor activity, calcium-dependent protein binding, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CLEC4M itself. We selected most functions CLEC4M had, and list some proteins which have the same functions with CLEC4M. You can find most of the proteins on our site.

Function Related Protein
ICAM-3 receptor activityITGB2;CLEC4M;ITGAL
calcium-dependent protein bindingCD209A;CALM3;S100A11;ANXA3;FCN2;PDCD6;RAC3;CLEC4M;NELF
carbohydrate bindingSELL;Clec4n;CALR3;LGALS3L;ATRN;CHODL;Fcer2a;CLEC10A;GALNT5
mannose bindingCD209A;M6PR;LMAN2;LMAN1;MANBA;MBL2;CD209;BSG;Acr
metal ion bindingTNFSF10;ZNF277;PDLIM5A;TRIM35-7;PHOSPHO1;ZNF789;ZKSCAN6;TFA;CYP2V1
peptide antigen bindingMHC1UFA;H2-AA;HLA-B;HLA-DPB1;H2-AB1;MHC1ZDA;TAP1;HLA-DPA1;HLA-DQA1
receptor activityCADM3;ANTXR2A;P2RY2;NLGN4X;ANTXRL;TLR4;NOTCH4;TLR3;CD86
virion bindingCD209;PTX3;APCS;CLEC4M;PVRL1;HSP90B1;TSG101;PPIA;HIPK2
virus receptor activityLDLR;HSPA1A;HAVCR1;F11R;ICAM1;ITGAV;TYRO3;CCR5;EFNB3

CLEC4M has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLEC4M here. Most of them are supplied by our site. Hope this information will be useful for your research of CLEC4M.

ITGAM; CEACAM1; q03463-pro_0000278734; MME

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any diseases or conditions associated with CLEC4M dysfunction? 12/02/2021

Research suggests that CLEC4M may be involved in the pathogenesis of certain viral infections, as well as in modulating immune responses in conditions such as HIV and hepatitis.

What are the potential clinical applications of CLEC4M in the context of viral infections? 12/13/2020

CLEC4M could potentially be targeted for the development of antiviral therapies or vaccines, as its role in recognizing and responding to viral pathogens is of great interest to researchers.

What are the implications of CLEC4M in the field of vaccine development? 04/27/2019

CLEC4M's role in recognizing viral pathogens makes it an interesting target for vaccine development, as it may be involved in eliciting immune responses against specific viruses.

How does CLEC4M contribute to the immune response in the context of fungal infections? 07/04/2018

CLEC4M has been shown to recognize and bind to specific carbohydrates present on the surface of certain fungi, contributing to immune responses against fungal pathogens.

How does CLEC4M function in the context of viral infections? 02/24/2016

CLEC4M binds to viral glycoproteins, facilitating the uptake of viruses into dendritic cells and promoting antiviral immune responses.

Customer Reviews (3)

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Reviews
04/13/2021

    Its outstanding performance, coupled with its ease of use, has enhanced the overall efficiency and accuracy of my research.

    07/28/2018

      I highly recommend the CLEC4M Protein to researchers seeking a reliable and high-performing protein for their ELISA assays and protein electron microscopy structure analysis.

      07/04/2018

        The CLEC4M Protein has greatly contributed to the success of my experiments, providing reliable and robust data.

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