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Official Full Name C-type lectin domain family 4, member M
Background This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Synonyms CLEC4M; C-type lectin domain family 4, member M; CD209L, CD299, CD299 antigen; C-type lectin domain family 4 member M; DC SIGN2; DC SIGNR; DCSIGNR; HP10347; LSIGN; C type lectin domain family 4, member M; CD209 antigen like; CD209 antigen like protein 1; CD209 antigen-like protein 1; CD209L; CD209L1; CD299; CD299 antigen; CLC4M_HUMAN; DC SIGN related protein; DC-SIGN-related protein; DC-SIGN2; DC-SIGNR; DCSIGN related protein; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; L SIGN; L-SIGN; Liver/lymph node specific ICAM3 grabbing nonintegrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; Mannose binding C type lectin DC SIGNR; MGC129964; MGC47866; mannose binding C-type lectin DC-SIGNR; liver/lymph node-specific ICAM-3 grabbing non-integrin
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human Cells
    • Insect cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • Fc Chimera
    • GST
    • hIgG/His
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLEC4M-07H Recombinant Human CLEC4M Protein, His-tagged HEK293 His
    Human CLEC4M-151H Recombinant Human CLEC4M Protein, His-tagged Human Cells His
    Human CLEC4M-02H Recombinant Human CLEC4M Protein, hIgG/His-tagged Insect cell hIgG/His
    Human CLEC4M-1471H Recombinant Human CLEC4M Protein, GST-tagged Wheat Germ GST
    Human CLEC4M-1855H Recombinant Human CLEC4M protein, His & T7-tagged E.coli His/T7
    Human CLEC4M-230H Recombinant Human CLEC4M Protein HEK293 N/A
    Human CLEC4M-26929TH Recombinant Human CLEC4M, FC-tagged FC
    Human CLEC4M-2744HCL Recombinant Human CLEC4M cell lysate Human Cell N/A
    Human CLEC4M-3132H Recombinant Human CLEC4M, Fc tagged Human Cell Fc
    Human CLEC4M-3263H Recombinant Human CLEC4M Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CLEC4M-3264H Recombinant Human CLEC4M Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human CLEC4M-5236H Recombinant Human CLEC4M Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CLEC4M-6556H Recombinant Human CLEC4M Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CLEC4M-689H Recombinant Human CLEC4M, Fc Chimera Mammalian cells Fc Chimera

    clec4m involved in several pathways and played different roles in them. We selected most pathways clec4m participated on our site, such as Measles, Phagosome, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with clec4m were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Measles IL1A; PIK3CG; IFNAR2; TLR9; CD209C; Fasl; HSPA8; CD3E; CD3D; TP73; HSPA6
    Phagosome TLR2; CLEC7A; MRC1; BF1; TUBA8L3; ATP6V0B; ATP6V1C1; ATPV0E2; ATP6V1C1B; THBS2
    Tuberculosis PPP3CC; CALM3; PMAP-36; PPP3R2; HSPD1; FCGR2A; AKT2; Cd209g; IFNA5; NFYC

    clec4m has several biochemical functions, for example, ICAM-3 receptor activity, calcium-dependent protein binding, carbohydrate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by clec4m itself. We selected most functions clec4m had, and list some proteins which have the same functions with clec4m. You can find most of the proteins on our site.

    Function Related Protein
    ICAM-3 receptor activity ITGAL; ITGB2; CLEC4M
    calcium-dependent protein binding SLC9A1; CALM3; S100B; ANXA11; CALM1; ALG2; PDCD6; S100A4; ANXA7; S100A6
    carbohydrate binding LPHN1; CLEC4A; GALNT9; CLEC4A2; NPTX2; PKD1L3; Siglece; CHIA; ILLR1; HBL3
    mannose binding LMAN1; CD209B; IGF2R; DPM1; BSG; CD209A; MBL2; LMAN2L; CD209; CD207
    metal ion binding GTPBP8; TSSK1; AGBL4; ANTXR2B; GDE1; PON3; Adamts19; ZBTB1; ZNF558; RPS27L
    peptide antigen binding HLA-G; AZGP1; HLA-DQB1; HLA-B; MHC1ZKA; HLA-DRA; MHC1UDA; HLA-DRB1; MHC1UXA2; MHC1UFA
    receptor activity ICAM1; TNFRSF11A; LILRA2; CD93; PAQR3B; PROCR; GABRA5; GRIN1A; PVR; TREM1
    virion binding HSP90B1; TSG101; CD209; PVRL1; PPIA; PTX3; CLEC4M; APCS; HIPK2
    virus receptor activity NPC1; ITGB6; HSPA1B; ITGA2; SIVA1; CXADR; SLC1A5; SLC52A2; MOG; SCARB2

    clec4m has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with clec4m here. Most of them are supplied by our site. Hope this information will be useful for your research of clec4m.

    ITGAM; CEACAM1; q03463-pro_0000278734; MME

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