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Recombinant Human CLEC4M Protein, GST-tagged

Cat.No. : CLEC4M-1471H
Product Overview : Human CLEC4M partial ORF ( NP_055072, 285 a.a. - 394 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 37.84 kDa
AA Sequence : SQRNWHDSVTACQEVRAQLVVIKTA EEQNFLQLQTSRSNRFSWMGLSDLN QEGTWQWVDGSPLSPSFQRYWNSGE PNNSGNEDCAEFSGSGWNDNRCDVD NYWICKKPAA
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CLEC4M C-type lectin domain family 4, member M [ Homo sapiens ]
Official Symbol : CLEC4M
Synonyms : CLEC4M; C-type lectin domain family 4, member M; CD209L, CD299, CD299 antigen; C-type lectin domain family 4 member M; DC SIGN2; DC SIGNR; DCSIGNR; HP10347; LSIGN; CD299 antigen; DC-SIGN-related protein; CD209 antigen-like protein 1; mannose binding C-type lectin DC-SIGNR; dendritic cell-specific ICAM-3-grabbing non-integrin 2; liver/lymph node-specific ICAM-3 grabbing non-integrin; liver/lymph node-specific ICAM-3-grabbing non-integrin; CD299; CD209L; L-SIGN; DC-SIGN2; DC-SIGNR; MGC47866; MGC129964;
Gene ID : 10332
mRNA Refseq : NM_001144904
Protein Refseq : NP_001138376
MIM : 605872
UniProt ID : Q9H2X3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any diseases or conditions associated with CLEC4M dysfunction? 12/02/2021

Research suggests that CLEC4M may be involved in the pathogenesis of certain viral infections, as well as in modulating immune responses in conditions such as HIV and hepatitis.

What are the potential clinical applications of CLEC4M in the context of viral infections? 12/13/2020

CLEC4M could potentially be targeted for the development of antiviral therapies or vaccines, as its role in recognizing and responding to viral pathogens is of great interest to researchers.

What are the implications of CLEC4M in the field of vaccine development? 04/27/2019

CLEC4M's role in recognizing viral pathogens makes it an interesting target for vaccine development, as it may be involved in eliciting immune responses against specific viruses.

How does CLEC4M contribute to the immune response in the context of fungal infections? 07/04/2018

CLEC4M has been shown to recognize and bind to specific carbohydrates present on the surface of certain fungi, contributing to immune responses against fungal pathogens.

How does CLEC4M function in the context of viral infections? 02/24/2016

CLEC4M binds to viral glycoproteins, facilitating the uptake of viruses into dendritic cells and promoting antiviral immune responses.

Customer Reviews (3)

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Reviews
04/13/2021

    Its outstanding performance, coupled with its ease of use, has enhanced the overall efficiency and accuracy of my research.

    07/28/2018

      I highly recommend the CLEC4M Protein to researchers seeking a reliable and high-performing protein for their ELISA assays and protein electron microscopy structure analysis.

      07/04/2018

        The CLEC4M Protein has greatly contributed to the success of my experiments, providing reliable and robust data.

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