• Official Full Name
  • chemokine-like receptor 1
  • Background
  • Activating CMKLR1 by an agonist mobilizes intracellular calcium and causes the activation of several other signaling cascades like the ERK1 and NF-κB. Initial studies of CMKLR1 suggested that it might have a role in the inflammatory pathways. Its cognate ligand, chemerin was found in joint aspirate from rheumatoid arthritis and absent in aspirate from degenerative arthritis. CMKLR1 expression by plasmacytoid dendritic cells and macrophages also helped foster this idea. In vitro chemotaxis assays showed it to be utilized in attracting these cells. As a adipokine receptor it has a role in adipogenesis and adipocyte maturation.It seems also to have a role in peripheral insulin resistance.
  • Synonyms
  • CMKLR1; chemokine-like receptor 1; chemokine receptor-like 1; G-protein coupled receptor DEZ; G-protein coupled receptor ChemR23; orphan G-protein coupled receptor, Dez; DEZ; ChemR23; CHEMERINR; MGC126105; MGC126106
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CMKLR1 Protein
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CMKLR1 Protein, GST-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CMKLR1 Protein
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CMKLR1
Source (Host):HEK293Species:Human
Product nameRecombinant Human CMKLR1 lysate
Source (Host):Species:
Product nameCMKLR1 Activated GPCR Internalization Assay Kit
Source (Host):Species:
Product nameCMKLR1 CHO-K1 β-Arrestin GPCR Assay Kit
Source (Host):Species:
Product namecAMP CMKLR1 CHO-K1 GPCR Assay Kit
Source (Host):Species:
Product nameEthanol Colorimetric/Fluorometric Assay Kit
Source (Host):Species:
Product namePhosphate Assay Kit II

Involved Pathway

CMKLR1 involved in several pathways and played different roles in them. We selected most pathways CMKLR1 participated on our site, such as GPCRs, Class A Rhodopsin-like, which may be useful for your reference. Also, other proteins which involved in the same pathway with CMKLR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
GPCRs, Class A Rhodopsin-like

Protein Function

CMKLR1 has several biochemical functions, for example, G-protein coupled receptor activity, chemokine receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CMKLR1 itself. We selected most functions CMKLR1 had, and list some proteins which have the same functions with CMKLR1. You can find most of the proteins on our site.
Related Protein
Function G-protein coupled receptor activity
Related Protein VMN1R50; GPR173; TAS2R143; CCR1L1; LANCL1; GPR4; OPN4B; OPNP; OPRD1A; F2RL1.2
Function chemokine receptor activity
Related Protein CXCR4A; CXCR3; CX3CR1; CCR8; CCR5; CXCR3.1; CCR9; CCR12A; RGRA; ACKR3B
Function protein binding
Related Protein VHL; UBR4; WDR74; SCFD1; CBFB; GNA12; APOBEC3G; NSL1; UBOX5; CENPK
Function receptor activity
Related Protein RTN4RL1; TLR6; GRIN2A; GPA33; LRP2; MED12; NOTCH1B; UBXN6; TNFRSF10A; CRLF1

CMKLR1 Related Articles

Reverchon, M; Bertoldo, MJ; et al. CHEMERIN (RARRES2) Decreases In Vitro Granulosa Cell Steroidogenesis and Blocks Oocyte Meiotic Progression in Bovine Species. BIOLOGY OF REPRODUCTION 90:-(2014).
Muruganandan, S; Dranse, HJ; et al. Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis. STEM CELLS 31:2172-2182(2013).