• Official Full Name
  • double homeobox 4
  • Background
  • This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD).
  • Synonyms
  • DUX4; double homeobox 4; double homeobox protein 4; double homeobox protein 10; double homeobox protein 4/10; double homeobox protein DUX10; DUX10
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DUX4 Protein, GST-tagged

DUX4 Related Articles

Sacconi, S; Salviati, L; et al. Facioscapulohumeral muscular dystrophy. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:607-614(2015).
Ferri, G; Huichalaf, CH; et al. Direct interplay between two candidate genes in FSHD muscular dystrophy. HUMAN MOLECULAR GENETICS 24:1256-1266(2015).