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DUX4

Official Full Name

double homeobox 4
Overview

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that contains two homeoboxes; the repeat-array and ORF is conserved in other mammals. There was no evidence for transcription from standard cDNA libraries however RTPCR and in-vitro expression experiments indicate that the ORF is transcribed and the encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the microsatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD).
Synonyms

DUX4; double homeobox 4; double homeobox protein 4; double homeobox protein 10; double homeobox protein 4/10; double homeobox protein DUX10; DUX10;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DUX4-2957H	Recombinant Human DUX4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	DUX4-2958H	Recombinant Human DUX4 Protein, GST-tagged	E.coli	GST	263-424 aa	Inquiry
Human	DUX4-5857H	Recombinant Human DUX4 protein, His-tagged	E.coli	His	327-424aa	Inquiry
Human	DUX4-4133HF	Recombinant Full Length Human DUX4 Protein, GST-tagged	In Vitro Cell Free System	GST	424 amino acids	Inquiry

DUX4 Related Articles

DUX4 involved in several pathways and played different roles in them. We selected most pathways DUX4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DUX4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

DUX4 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by DUX4 itself. We selected most functions DUX4 had, and list some proteins which have the same functions with DUX4. You can find most of the proteins on our site.

Function	Related Protein

DUX4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DUX4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DUX4.

Sacconi, S; Salviati, L; et al. Facioscapulohumeral muscular dystrophy. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:607-614(2015).

Ferri, G; Huichalaf, CH; et al. Direct interplay between two candidate genes in FSHD muscular dystrophy. HUMAN MOLECULAR GENETICS 24:1256-1266(2015).