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Official Full Name elastase, neutrophil expressed
Background Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the proteins release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
Synonyms ELANE; elastase, neutrophil expressed; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E; neutrophil elastase; elastase-2; medullasin; PMN elastase; leukocyte elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclear elastase; bone marrow serine protease; granulocyte-derived elastase;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Human Blood
    • Human Cell
    • Human Neutrophil
    • Human Neutrophils
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ELANE-001H Native Human ELANE Protein Human Neutrophils N/A
    Human ELANE-1197H Recombinant Human ELANE Protein, GST-tagged E.coli GST
    Human ELANE-1653H Human Elastase N/A
    Human ELANE-172H Recombinant Human ELANE Protein, His/GST-tagged E.coli His/GST
    Human ELANE-201H Recombinant Human ELANE Mammalian Cell His
    Human ELANE-27537TH Native Human ELANE N/A
    Human ELANE-3221H Native Human ELANE Protein Human Blood N/A
    Human ELANE-3222H Recombinant Human ELANE Protein, GST-tagged Wheat Germ GST
    Human ELANE-8104H Native Human Neutrophil Elastase Human Neutrophil N/A
    Human ELANE-8236H Native Human Neutrophil Elastase (ELA-2) Human Neutrophil N/A
    Mouse ELANE-2381MCL Recombinant Mouse ELANE cell lysate Human Cell N/A
    Mouse Elane-694M Recombinant Mouse Elane Protein, His-tagged NS0 His
    Mouse Elane-906M Recombinant Mouse Elane, His tagged Human Cell His
    Kit-0321 ELANE Inhibitor Screening Kit N/A
    Kit-0322 Neutrophil Elastase Activity Assay Kit N/A
    Kit-0323 Neutrophil elastase colorimetric drug discovery Kit N/A

    elane involved in several pathways and played different roles in them. We selected most pathways elane participated on our site, such as Activation of Matrix Metalloproteinases, C-MYB transcription factor network, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with elane were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of Matrix Metalloproteinases CTSK; CTSL2; MGC174155; CTSLL; MMP15; ELANE; MMP17; MMP8; MGC174857; TIMP2B
    C-MYB transcription factor network SLC25A3; ELANE; CSF1R; CREBBP; COL1A2; MYC; MYOD1; TOM1; CEBPA; MYF6
    Collagen degradation EMID2; MMP20; MMP8; CTS7; COL13A1; ADAM10; MMP10; CTSD; COL9A3; ELANE
    Degradation of the extracellular matrix CTSB; MMP17; TLL2; CTSL2; BMP1B; MMP15; LOC100686744; MMP19; ADAMTS4; COL17A1
    Extracellular matrix organization DDR2; BGNA; MFAP1B; ADAMTS8; CEACAM8; COL10A1A; MMP24; COL2A1; NID1; CTSLL
    Systemic lupus erythematosus SSB; C1QA; CD86; HIST2H3C1; HIST2H3C2; FCGR3B; HIST1H2AM; HIST1H4J; SNRPB; HIST1H2BA
    Transcriptional misregulation in cancer CLSTN2; FCGR1A; PML; ATM; KDM6A; Pdgfa&Pdgfb; SS18; PLAT; RXRG; PAX3
    amb2 Integrin signaling NIPAL1; MST1; LPA; CYR61; MST1R; ELANE; HP

    elane has several biochemical functions, for example, RNA polymerase II transcription corepressor activity, cytokine binding, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by elane itself. We selected most functions elane had, and list some proteins which have the same functions with elane. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription corepressor activity SOX3; ELANE; CITED2; TBX18; SIN3A; TCERG1; RERE; OLIG3; BEND6; SIN3AA
    cytokine binding Fzd4; IL31RA; CXCR4; PARK7; ELANE; GBP1; KIT; CHRD; CD74; LIFR
    endopeptidase activity SENP3; MME; NCSTN; P4HB; PSMB9B; CD46; PSMB9A; PSMA8; REN2; AP1S2
    heparin binding RSPO4; PRG2; BMP7; CTSG; RSPO3; FGF4; ADAMTS8; CCL5; FGFR1; THBS2
    peptidase activity APH1C; PRSS59.1; KLK1B22; SPPL3; GM5077; CASP8; UNC5CL; PARK7; BMP1B; ESPL1
    protein binding TMEM190; BAAT; HTT; MACF1; KHDC1A; INTS9; CALCA; TGFB1; NME2; WDR11
    serine-type endopeptidase activity HP; PRSS39; PRSS52; KLK1B24; GZMK; TMPRSS4B; PRTN3; MASP1; LOC780933; PCSK4

    elane has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with elane here. Most of them are supplied by our site. Hope this information will be useful for your research of elane.

    SERPINA1; SLPI; iovo_melga; Col17a1; GZMB; P/V/C

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