Elane

  • Official Full Name

    elastase, neutrophil expressed

  • Overview

    Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the proteins release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
  • Synonyms

    ELANE; elastase, neutrophil expressed; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E; neutrophil elastase; elastase-2; medullasin; PMN elastase; leukocyte elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclear elastase; bone marrow serine protease; granulocyte-derived elastase;

  • Recombinant Proteins
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Assay Kits
  • Dog
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293F
  • Human Blood
  • Human Cell
  • Human Neutrophil
  • Human Neutrophils
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • Avi
  • 6×His
  • GST
  • His
  • His (Fc)
  • His|GST
  • SUMO
  • MBP
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ELANE-2171H Active Recombinant Human ELANE Protein, His-GST-tagged E.coli His/GST Ile30~Gln247
Human ELANE-3221H Active Native Human ELANE Protein Human Blood N/A
Human ELANE-001H Active Native Human ELANE Protein Human Neutrophils N/A
Human ELANE-1653H Human Elastase N/A
Human ELANE-172H Recombinant Human ELANE Protein, His/GST-tagged E.coli His/GST Ile30~Gln247
Human ELANE-201H Recombinant Human ELANE Mammalian Cell His
Human ELANE-1197H Recombinant Human ELANE Protein, GST-tagged E.coli GST
Human ELANE-3222H Recombinant Human ELANE Protein, GST-tagged Wheat Germ GST
Human ELANE-17H Recombinant Human ELANE Protein (28-252), C-Avi and 6×His tagged, Biotin-Labeled HEK293 C-Avi and 6×His 28-252
Human ELANE-8104H Native Human Neutrophil Elastase Human Neutrophil N/A
Human ELANE-2842H Recombinant Human ELANE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ELANE-2172H Recombinant Human ELANE Protein, His-tagged E.coli N-His Ile30-Gln247
Human ELANE-7584H Recombinant Human ELANE protein E.coli N/A 30-267aa
Human ELANE-3007H Recombinant Human ELANE Protein (Ile30-Gln247), N-GST tagged E.coli N-GST Ile30-Gln247
Human ELANE-3398H Recombinant Human ELANE protein, His-SUMO-tagged E.coli His-SUMO Ile30~Gln247
Human ELANE-4231H Recombinant Human ELANE protein, MBP& His/Avi-tagged E.coli MBP&His-Avi 30-267aa
Human ELANE-16H Recombinant Human ELANE Protein (28-252), C-Avi and 6×His tagged HEK293 C-Avi and 6×His 28-252
Human ELANE-5394H Recombinant Human ELANE protein, His-tagged Yeast His 30-267aa
Human ELANE-27537TH Native Human ELANE N/A
Human ELANE-2842H-B Recombinant Human ELANE Protein Pre-coupled Magnetic Beads HEK293
Human ELANE-8236H Native Human Neutrophil Elastase (ELA-2) Human Neutrophil N/A
Mouse Elane-694M Active Recombinant Mouse Elane Protein, His-tagged Mammalian cells His Ser27-Arg260
Mouse Elane-906M Recombinant Mouse Elane, His tagged Human Cell His
Mouse ELANE-2381MCL Recombinant Mouse ELANE cell lysate Human Cell N/A
Mouse Elane-903M Recombinant Mouse Elane Protein, His-tagged HEK293F N-His Ser27-Asn265
Mouse Elane-2730M-B Recombinant Mouse Elane Protein Pre-coupled Magnetic Beads HEK293
Mouse Elane-1419M Recombinant Mouse Elane Protein, His-tagged E.coli N-His Ile29-Arg247
Mouse Elane-2730M Recombinant Mouse Elane Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Dog ELANE-902D Recombinant Dog ELANE Protein, His-tagged E.coli N-His Ile31-Arg248
Kit-0321 ELANE Inhibitor Screening Kit N/A
Kit-0322 Neutrophil Elastase Activity Assay Kit N/A
Kit-0323 Neutrophil elastase colorimetric drug discovery Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Elane involved in several pathways and played different roles in them. We selected most pathways Elane participated on our site, such as Activation of Matrix Metalloproteinases, C-MYB transcription factor network, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Elane were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of Matrix MetalloproteinasesCTSK;TIMP2A;MGC174155;MMP17;CTSL2;MMP10;LOC100686744;CTSG;MGC174857
C-MYB transcription factor networkCLTA;CBX4;GATA1;LECT2;ADORA2B;SMARCA2;TOM1;ELANE;CDKN1B
Collagen degradationCTSD;CTSLL;MGC174857;MGC174152;COL15A1B;CTSL1;CTSK;MGC174155;COL13A1
Degradation of the extracellular matrixADAMTS8;ACAN;COL9A1;TPSAB1;BMP1;MMP12;MMP15;ELANE;TIMP2B
Extracellular matrix organizationELANE;COL23A1;COL9A1A;COL19A1;FMOD;CRTAP;LOXL2;COL17A1;FAM49BA
Systemic lupus erythematosusHIST1H2BJ;HIST1H3D;H2AFJ;HIST1H2AE;H2AFY;H2-AA;HIST1H2BG;C1QA;HIST1H3C
Transcriptional misregulation in cancerMEIS1;NCOR1;HPGD;SPINT1;SIX4;CD40;SUPT3H;H3F3C;SMAD1
amb2 Integrin signalingCYR61;LPA;ELANE;MST1;HP;NIPAL1;MST1R

Elane has several biochemical functions, for example, RNA polymerase II transcription corepressor activity, cytokine binding, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Elane itself. We selected most functions Elane had, and list some proteins which have the same functions with Elane. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription corepressor activityTCERG1;HEYL;URI1;SIN3B;TXLNB;TLE1;TBX18;CITED2;CTBP1
cytokine bindingTNFRSF11A;NRP1;KITA;CSF1RA;PARK7;KITB;LIFR;IL31RA;CHRD
endopeptidase activityPSMA5;KLK1B1;P4HB;F9;SENP3;TMEM59;Ren1;PCSK6;PSMB7
heparin bindingCFH;POSTN;FGF2;LIPH;CTSG;COL5A1;REG4;SLIT3;RSPO2
peptidase activityATG4C;CPD;SPG7;ZMPSTE24;KLK1B8;KLK1B1;SPPL3;KLK1B3;PPPDE1
protease bindingSerpina1c;CHL1;SEMG2;SERPINA1;TNFAIP3;F3;SERPINA5;IL1R1;TRP53
protein bindingCCNDBP1;FAM46D;GP9;THAP6;CAPG;PAM16;SORBS3;FAM20A;FBXW2
serine-type endopeptidase activityKLK12;MMP2;KLK1B5;F7I;PRSS39;PRSS48;PRSS28;GZMM;MASP2

Elane has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Elane here. Most of them are supplied by our site. Hope this information will be useful for your research of Elane.

SERPINA1; SLPI; iovo_melga; Col17a1; GZMB; P/V/C

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Reviews
06/17/2019

    In terms of performance, it delivers unwavering reliability, meeting the demands of even the most complex experiments.

    07/30/2018

      Stringent quality control measures ensure consistent quality across every batch of the reagent.

      04/29/2016

        Minimal quantities are required, offering cost-saving benefits for both sample and reagent consumption.

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