Elane
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Official Full Name
elastase, neutrophil expressed
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Overview
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the proteins release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009] -
Synonyms
ELANE; elastase, neutrophil expressed; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E; neutrophil elastase; elastase-2; medullasin; PMN elastase; leukocyte elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclear elastase; bone marrow serine protease; granulocyte-derived elastase;
- Recombinant Proteins
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Assay Kits
- Dog
- Human
- Mouse
- E.coli
- HEK293
- HEK293F
- Human Blood
- Human Cell
- Human Neutrophil
- Human Neutrophils
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- GST
- His
- Avi
- Fc
- MBP
- SUMO
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Elane involved in several pathways and played different roles in them. We selected most pathways Elane participated on our site, such as Activation of Matrix Metalloproteinases, C-MYB transcription factor network, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Elane were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of Matrix Metalloproteinases | FURINB;FURINA;MMP13;CMA1;ELANE;CTSG;MMP11;MMP8;MMP15 |
| C-MYB transcription factor network | MYC;SMARCA2;PIAS3;COL1A2;GATA1;SKI;CDKN1B;CEBPB;PPID |
| Collagen degradation | COL15A1B;MMP13;ELANE;CTS7;CTSB;MGC174155;ADAM10;TLDC2;MGC174857 |
| Degradation of the extracellular matrix | BMP1;ELANE;FAM49BA;CTSB;EMID2;CTSL2;TIMP2A;TIMP2;MMP10 |
| Extracellular matrix organization | COL8A2;ADAMTS18;CTSB;P3H2;MUSK;ADAMTS1;BMP1A;TLL2;ADAMTS3 |
| Systemic lupus erythematosus | H3F3A;TRIM21;HLA-DPB1;HIST1H2AC;HIST1H4A;GM14482;HIST1H2AN;HIST1H4B;HIST1H2BC |
| Transcriptional misregulation in cancer | PBX3;HHEX;TCF3;HIST3H3;Itgam&Itgb2;NR4A3;ETV6;HIST1H3G;SSX1 |
| amb2 Integrin signaling | HP;LPA;ELANE;CYR61;NIPAL1;MST1R;MST1 |
Elane has several biochemical functions, for example, RNA polymerase II transcription corepressor activity, cytokine binding, endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Elane itself. We selected most functions Elane had, and list some proteins which have the same functions with Elane. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription corepressor activity | TXLNB;TCERG1;HEYL;SIN3B;TBX18;UXT;CITED2;TLE1;BEND6 |
| cytokine binding | LIFR;GBP1;TNFRSF11A;NRP1;CRLF1;CD74;KIT;CSF1R;IFNGR1 |
| endopeptidase activity | SENP5;PARL;CTSH;PSMA3;ADAM10;MMP12;PSMA6B;TMEM59;PSMB8F |
| heparin binding | PCOLCE2;APOH;UBE4A;COL5A1;LPL;CCL5;LIPC;COMP;HDGF |
| peptidase activity | HE2;Acr;lon;MEP1A.1;MMP25;ST14A;IHHA;PM20D1;F9A |
| protease binding | HSPA6;CSTA;FADD;LRP1;CCBE1;Casp3;IL1R1;OS9;BDKRB2 |
| protein binding | PTEN;PLCG2;GAD1;CTLA4;PTTG1IP;EN1;BANP;MYL12B;TXNRD1 |
| serine-type endopeptidase activity | TMPRSS3;FURINB;PROCA;Gzmg;KLK1B3;CLPP;PREP;PREPL;CMA1 |
Elane has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Elane here. Most of them are supplied by our site. Hope this information will be useful for your research of Elane.
SERPINA1; SLPI; iovo_melga; Col17a1; GZMB; P/V/C
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Write a reviewIn terms of performance, it delivers unwavering reliability, meeting the demands of even the most complex experiments.
Stringent quality control measures ensure consistent quality across every batch of the reagent.
Minimal quantities are required, offering cost-saving benefits for both sample and reagent consumption.
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