FGB

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FGB

Official Full Name fibrinogen beta chain
Background The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
Synonyms FGB; fibrinogen beta chain; fibrinogen, B beta polypeptide; MGC104327; MGC120405
    • Species :
    • Bovine
    • Cattle
    • Chicken
    • Dog
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Zebrafish
    • Source :
    • Bovine Plasma
    • Dog Plasma
    • E.coli
    • HEK293
    • Human plasma
    • Mammalian Cell
    • Porcine plasma
    • Rabbit Plasma
    • Rat plasma
    • Wheat Germ
    • Tag :
    • GST
    • His
    • S
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human FGB-13H Human Fibrinogen Reference Standard N/A
    Human FGB-4088H Recombinant Human FGB Protein, GST-tagged Wheat Germ GST
    Human FGB-6255HCL Recombinant Human FGB 293 Cell Lysate HEK293 N/A
    Human FGB-6H Native Human Fibrinogen, FITC Labeled Human plasma N/A
    Human FGB-74H Recombinant Human FGB, His-tagged E.coli His
    Mouse FGB-37M Mouse Fibrinogen Reference Standard N/A
    Mouse Fgb-5819M Recombinant Mouse Fgb protein, His-tagged E.coli His
    Rat Fgb -68R Native Rat Fibrinogen Rat plasma N/A
    Rat FGB-2321R Recombinant Rat FGB Protein Mammalian Cell His
    Rat Fgb-5820R Recombinant Rat Fgb protein, His & S-tagged E.coli His/S
    Rat Fgb-64R Native Rat Fibrinogen, FITC Labeled Rat plasma N/A
    Rat FGB-79R Rat Fibrinogen Reference Standard N/A
    Dog FGB-19D Dog Fibrinogen Reference Standard N/A
    Dog FGB-35D Native Canine Fibrinogen Dog Plasma N/A
    Dog FGB-43D Native Canine Fibrinogen, FITC Labeled Dog Plasma N/A
    Bovine FGB-31B Native Bovine Fibrinogen Bovine Plasma N/A
    Bovine FGB-40B Native Bovin Fibrinogen, FITC Labeled Bovine Plasma N/A
    Chicken FGB-4008C Recombinant Chicken FGB Mammalian Cell His
    Rabbit FGB-56R Native Rabbit Fibrinogen, FITC Labeled Rabbit Plasma N/A
    Rabbit FGB-59R Native Rabbit Fibrinogen Rabbit Plasma N/A
    Zebrafish FGB-12042Z Recombinant Zebrafish FGB Mammalian Cell His
    Pig FGB-46P Native Porcine Fibrinogen, FITC Labeled Porcine plasma N/A
    Cattle FGB-5818C Recombinant Cattle FGB protein, His & S-tagged E.coli His/S
    Pig FGB-60P Pig Fibrinogen Reference Standard N/A

    FGB involved in several pathways and played different roles in them. We selected most pathways FGB participated on our site, such as Complement and coagulation cascades, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Complement and coagulation cascades SERPINF2; C1RA; PLAUR; PROC; F9; C4BPA; F12; CPB2; CFH; C3AR1
    Platelet activation ROCK2; VWF; PLCB3; PIK3CA; COL24A1; PLA2G4A; RAP1B; ROCK1; SRC; ORAI1

    FGB has several biochemical functions, for example, contributes_to cell adhesion molecule binding, chaperone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGB itself. We selected most functions FGB had, and list some proteins which have the same functions with FGB. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to cell adhesion molecule binding FGB; FGA
    chaperone binding STIP1; DNAJB7; DNAJB1; TG; HSPE1; BAX; BAG3; PFDN6; INS1; DNAJC3
    protein binding KAT2A; PPP1CB; PPARD; NAPA; C20orf195; SETDB1; SUPT6H; VASN; PGBD1; ARIH1
    protein binding, bridging EVPL; SH2D1B; VPS18; DDX20; FSCN2; ANK2; NMD3; CBX5; IVL; NEFH
    contributes_to receptor binding FGB; FGA
    structural molecule activity KRT12; SNTG2; PRPH; PNN; MAP2; KRT24; EPB41L3A; KRTT1C19E; NUMA1; CLDNH

    FGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGB here. Most of them are supplied by our site. Hope this information will be useful for your research of FGB.

    FGA; p27958-pro_0000037566; KLK6; MIS12; GAMMAHV.ORF10; TK1; ANXA7; p29991-pro_0000037940; p29991-pro_0000308465; CDKN1A; CSNK2B; BKLF1; AIMP2; GRB7; SMN1; PIK3R3

    Linden, M; Segersten, U; et al. Tumour expression of bladder cancer-associated urinary proteins. BJU INTERNATIONAL 112:407-415(2013).
    Luyckx, VA; Cairo, LV; et al. Oncostatin M pathway plays a major role in the renal acute phase response. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 296:F875-F883(2009).

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