• Official Full Name

    fibrinogen beta chain

  • Overview

    The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.
  • Synonyms

    FGB; fibrinogen beta chain; fibrinogen, B beta polypeptide; MGC104327; MGC120405;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Native Proteins
  • Bovine
  • Cattle
  • Chicken
  • Dog
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Zebrafish
  • Bovine Plasma
  • Dog Plasma
  • E.coli
  • HEK293
  • Human plasma
  • Mammalian Cell
  • Porcine plasma
  • Rabbit Plasma
  • Rat plasma
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|S
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FGB-74H Recombinant Human FGB, His-tagged E.coli His
Human FGB-6255HCL Recombinant Human FGB 293 Cell Lysate HEK293 N/A
Human FGB-13H Active Human Fibrinogen Reference Standard N/A
Human FGB-6H Native Human Fibrinogen, FITC Labeled Human plasma N/A
Human FGB-2901H Recombinant Human FGB protein, His-tagged E.coli His
Human FGB-4088H Recombinant Human FGB Protein, GST-tagged Wheat Germ GST
Human FGB-2871H Recombinant Human FGB Protein (Thr108-Gln491), N-His tagged E.coli N-His
Human FGB-2872H Recombinant Human FGB Protein (Gly45-Gln491), His tagged E.coli His
Mouse Fgb-5819M Recombinant Mouse Fgb protein, His-tagged E.coli His
Mouse FGB-37M Mouse Fibrinogen Reference Standard N/A
Rat FGB-2321R Recombinant Rat FGB Protein Mammalian Cell His
Rat Fgb-5820R Recombinant Rat Fgb protein, His & S-tagged E.coli His/S
Rat Fgb-1479R Recombinant Rat Fgb Protein, His-tagged E.coli N-His
Rat FGB-1978R Recombinant Rat FGB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FGB-79R Rat Fibrinogen Reference Standard N/A
Rat FGB-1978R-B Recombinant Rat FGB Protein Pre-coupled Magnetic Beads HEK293
Rat Fgb -68R Native Rat Fibrinogen Rat plasma N/A
Rat Fgb-64R Native Rat Fibrinogen, FITC Labeled Rat plasma N/A
Rabbit FGB-56R Native Rabbit Fibrinogen, FITC Labeled Rabbit Plasma N/A
Rabbit FGB-59R Native Rabbit Fibrinogen Rabbit Plasma N/A
Dog FGB-43D Native Canine Fibrinogen, FITC Labeled Dog Plasma N/A
Dog FGB-19D Dog Fibrinogen Reference Standard N/A
Dog FGB-35D Native Canine Fibrinogen Dog Plasma N/A
Bovine FGB-31B Native Bovine Fibrinogen Bovine Plasma N/A
Bovine FGB-40B Native Bovin Fibrinogen, FITC Labeled Bovine Plasma N/A
Cattle FGB-5818C Recombinant Cattle FGB protein, His & S-tagged E.coli His/S
Zebrafish FGB-12042Z Recombinant Zebrafish FGB Mammalian Cell His
Pig FGB-927P Recombinant Pig FGB Protein, His-tagged E.coli N-His
Pig FGB-46P Native Porcine Fibrinogen, FITC Labeled Porcine plasma N/A
Pig FGB-60P Pig Fibrinogen Reference Standard N/A
Chicken FGB-4008C Recombinant Chicken FGB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • FGB Related Articles
  • FGB Related Research Area

FGB involved in several pathways and played different roles in them. We selected most pathways FGB participated on our site, such as Complement and coagulation cascades, Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement and coagulation cascadesSERPINA1D;C2;CR2;F9;THBD;C3;FGA;C1QB;CD59

FGB has several biochemical functions, for example, contributes_to cell adhesion molecule binding, chaperone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FGB itself. We selected most functions FGB had, and list some proteins which have the same functions with FGB. You can find most of the proteins on our site.

Function Related Protein
contributes_to cell adhesion molecule bindingFGB;FGA
protein binding, bridgingMEN1;DSP;FSCN3;NEFL;FLRT3;COL1A2;FBXW7;EVPL;CNKSR1
contributes_to receptor bindingFGB;FGA
structural molecule activityLCE1F;LELP1;LCE3C;KRT85;KRT72-PS;MAP7D2A;CLDN4;FGG;LLGL1

FGB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGB here. Most of them are supplied by our site. Hope this information will be useful for your research of FGB.

FGA; p27958-pro_0000037566; KLK6; MIS12; GAMMAHV.ORF10; TK1; ANXA7; p29991-pro_0000037940; p29991-pro_0000308465; CDKN1A; CSNK2B; BKLF1; AIMP2; GRB7; SMN1; PIK3R3

Linden, M; Segersten, U; et al. Tumour expression of bladder cancer-associated urinary proteins. BJU INTERNATIONAL 112:407-415(2013).
Luyckx, VA; Cairo, LV; et al. Oncostatin M pathway plays a major role in the renal acute phase response. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 296:F875-F883(2009).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there specific genetic disorders associated with FGB protein abnormalities? 02/21/2023

Yes, congenital fibrinogen disorders, such as afibrinogenemia and hypofibrinogenemia, are genetic disorders characterized by deficient or low FGB protein levels.

What are the potential consequences of low FGB protein levels? 10/07/2022

Low FGB protein levels can result in impaired blood clotting, leading to an increased risk of bleeding and hemorrhage.

How are high FGB protein levels clinically significant? 06/13/2022

High FGB protein levels can be associated with conditions such as inflammation, infection, and certain cancers.

How can FGB protein be used in the diagnosis of coagulation disorders? 06/30/2021

FGB protein levels can be measured to assess the risk of thrombosis or bleeding in patients with coagulation disorders.

What conditions can lead to a decrease in FGB protein levels? 05/22/2017

Conditions such as liver disease, DIC (disseminated intravascular coagulation), and certain genetic disorders can lead to decreased FGB protein levels.

Customer Reviews (3)

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    Their team of experts has been instrumental in addressing any issues or concerns I have encountered during my experiments.


      The FGB Protein boasts remarkable stability, ensuring its integrity is maintained during storage and experimentation.


        Equally noteworthy is the remarkable technical support provided by the manufacturer.

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