GRB14

  • Official Full Name

    growth factor receptor-bound protein 14

  • Overview

    The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.
  • Synonyms

    GRB14; growth factor receptor-bound protein 14; GRB14 adapter protein; Growth factor receptorbound protein 14;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRB14-538H Recombinant Human GRB14 Protein, MYC/DDK-tagged HEK293T Myc/DDK
Human GRB14-13519H Recombinant Human GRB14, His-tagged E.coli His
Human GRB14-5756HCL Recombinant Human GRB14 293 Cell Lysate HEK293 N/A
Human GRB14-5037H Recombinant Human GRB14 Protein, GST-tagged Wheat Germ GST
Human GRB14-1432H Recombinant Human GRB14 Protein, His-tagged E.coli His
Human GRB14-5405H Recombinant Human GRB14 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Grb14-1736M Recombinant Mouse Grb14 protein, His & T7-tagged E.coli His/T7
Mouse Grb14-3303M Recombinant Mouse Grb14 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat GRB14-2685R Recombinant Rat GRB14 Protein Mammalian Cell His
Rat GRB14-2339R Recombinant Rat GRB14 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Grb14-1737R Recombinant Rat Grb14 protein, His & T7-tagged E.coli His/T7
Rat GRB14-2339R-B Recombinant Rat GRB14 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GRB14 Related Articles
  • GRB14 Related Signal Pathway

GRB14 involved in several pathways and played different roles in them. We selected most pathways GRB14 participated on our site, such as Angiopoietin receptor Tie2-mediated signaling, Cell surface interactions at the vascular wall, EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Angiopoietin receptor Tie2-mediated signalingAGTR1;CDKN1A;ELF2;CRK;GRB7;ELF1;DOK2;GRB14;BMX
Cell surface interactions at the vascular wallSLC7A6;DOK2;ESAMA;NADL1.1;ANGPT2A;F11R.2;SLC7A8A;SLC7A10;GRB14
EGFR1 Signaling PathwayPLSCR1;TNK2;ZPR1;EEF1A1;KRT7;EPS8;DNM1;MTA2;RBBP7
HemostasisOSTN;F3B;RHOB;KIF3B;CLU;SERPINB8;BA1;BSG;KIF22
Insulin PathwayEXOC6;EXOC3;GRB10;EXOC1;EXOC5;DOK1;GRB14
Insulin SignalingMAP4K1;MAPK4;MAP4K5;EHD1;RRAD;REG1A;STXBP3;KIF5B;STXBP4
Tie2 SignalingANGPT2A;DOK2;GRB14

GRB14 has several biochemical functions, for example, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB14 itself. We selected most functions GRB14 had, and list some proteins which have the same functions with GRB14. You can find most of the proteins on our site.

Function Related Protein
SH3/SH2 adaptor activitySHB;SH2D3C;SRC;KHDRBS1;SH3BGR;GRB10;SH2D1A;BLNK;SH3BGRL

GRB14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB14 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB14.

IGF1R; STK26; rabbit_gsk3_beta; MET; CSNK2A1; INSR; INSR; NFKB1; GSK3B; FRS3; HCK; CDC5L

Nouaille, S; Blanquart, C; et al. Interaction between the insulin receptor and Grb14: A dynamic study in living cells using BRET. BIOCHEMICAL PHARMACOLOGY 72:1355-1366(2006).
Nouaille, S; Blanquart, C; et al. Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor. EMBO REPORTS 7:512-518(2006).
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