GRB14
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Official Full Name
growth factor receptor-bound protein 14 -
Overview
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date. -
Synonyms
GRB14;growth factor receptor-bound protein 14;GRB14 adapter protein;Growth factor receptorbound protein 14
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- His
- DDK
- Myc
- Non
- T7
- Avi
- Fc
- GST
Involved Pathway
GRB14 involved in several pathways and played different roles in them. We selected most pathways GRB14 participated on our site, such as Angiopoietin receptor Tie2-mediated signaling,Cell surface interactions at the vascular wall,EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tie2 Signaling | ANGPT2A,DOK2 |
| Insulin Signaling | MAP4K1,STXBP3,STXBP4,STXBP1A,EHD1,MAP4K5,ARHGAP33,STXBP2,MAPK4,CAP1 |
| Hemostasis | AKAP10,DOCK9,IGF2B,HBBE1.1,KCNMB1,HBB-Y,IRF1B,KIF4A,ZFPM1,D-AKAP2 |
| Angiopoietin receptor Tie2-mediated signaling | ELF1,CDKN1A,AGTR1,BMX,DOK2,ELF2,CRK,GRB7 |
| EGFR1 Signaling Pathway | REPS1,EEF1A1,RGS5B,RALBA,CRKL,DOK2,CEBPA,KRT17,PITPNA,KRT7 |
| Cell surface interactions at the vascular wall | JAM2B,PPIA,CEACAM6,NADL1.1,ESAMA,SLC3A2B,CD84,BSG,SLC7A6,MERTK |
| Insulin Pathway | DOK1,GRB10,EXOC1,EXOC6,EXOC3,EXOC5 |
Protein Function
GRB14 has several biochemical functions, for example, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB14 itself. We selected most functions GRB14 had, and list some proteins which have the same functions with GRB14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3/SH2 adaptor activity | FCRL2,SH3BP2,SH2D1A,CRK,SH3BGRL,SOCS2,SH2D3C,PTPN11,BLNK,CHN2 |
Interacting Protein
GRB14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB14 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB14.
IGF1R;STK26;rabbit_gsk3_beta;MET;CSNK2A1;INSR;INSR;NFKB1;GSK3B;FRS3;HCK;CDC5L
GRB14 Related Signal Pathway
Resources
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References
- Nouaille, S; Blanquart, C; et al. Interaction between the insulin receptor and Grb14: A dynamic study in living cells using BRET. BIOCHEMICAL PHARMACOLOGY 72:1355-1366(2006).
- Nouaille, S; Blanquart, C; et al. Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor. EMBO REPORTS 7:512-518(2006).
