GRB14 involved in several pathways and played different roles in them. We selected most pathways GRB14 participated on our site, such as Angiopoietin receptor Tie2-mediated signaling, Cell surface interactions at the vascular wall, EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Angiopoietin receptor Tie2-mediated signaling |
AGTR1; BMX; GRB7; DOK2; ELF2; CRK; GRB14; CDKN1A; ELF1 |
| Cell surface interactions at the vascular wall |
SLC7A11; SLC7A10; CXADR; SIRPA; SLC7A6; SLC7A8A; GRB7; TREM1; NADL1.1; FN1B |
| EGFR1 Signaling Pathway |
REPS2; PTPN12; ABI1; RGS5B; ABI1B; ARF4; CEACAM1; GRB14; PTK6; RALBB |
| Hemostasis |
DGKQ; KIF18A; EHD1; PLEK; SCG3; F9A; TREM1; ZFPM1; AKAP1; KIF15 |
| Insulin Pathway |
EXOC6; EXOC1; GRB10; EXOC3; EXOC5; DOK1; GRB14 |
| Insulin Signaling |
STXBP4; MYO1C; MAPK4; MAP3K2; MAP4K1; EHD1; MAP4K5; INPP4AA; STXBP2; STXBP1A |
| Tie2 Signaling |
GRB14; ANGPT2A; DOK2 |
GRB14 has several biochemical functions, for example, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB14 itself. We selected most functions GRB14 had, and list some proteins which have the same functions with GRB14. You can find most of the proteins on our site.
| Function |
Related Protein |
| SH3/SH2 adaptor activity |
SKAP2; SH3BGR; SH3BP2; NCK2; HSH2D; SH2B2; SH3BGRL; BLNK; LAT; STAP1 |
GRB14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB14 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB14.
IGF1R; STK26; rabbit_gsk3_beta; MET; CSNK2A1; INSR; INSR; NFKB1; GSK3B; FRS3; HCK; CDC5L
Nouaille, S; Blanquart, C; et al. Interaction between the insulin receptor and Grb14: A dynamic study in living cells using BRET. BIOCHEMICAL PHARMACOLOGY 72:1355-1366(2006).
Nouaille, S; Blanquart, C; et al. Interaction with Grb14 results in site-specific regulation of tyrosine phosphorylation of the insulin receptor. EMBO REPORTS 7:512-518(2006).
