• Official Full Name

    gastrin-releasing peptide receptor

  • Overview

    Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    GRPR; gastrin-releasing peptide receptor; BB2; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRPR-029H Active Recombinant Human GRPR Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human GRPR-28627TH Recombinant Human GRPR Wheat Germ N/A 384 amino acids
Human GRPR-7835H Recombinant Human GRPR protein, His & T7-tagged E.coli His/T7 Met1~Lys114 (Accession # P30550)
Human GRPR-5383H Recombinant Human GRPR Protein, GST-tagged Wheat Germ GST
Human GRPR-5610HF Recombinant Full Length Human GRPR Protein, GST-tagged In Vitro Cell Free System GST 384 amino acids
Human GRPR-209HF Recombinant Full Length Human GRPR Protein In Vitro Cell Free System 384 amino acids
Human GRPR-3349H Recombinant Human GRPR Protein (Met1-Lys114), N-GST tagged E.coli N-GST Met1-Lys114
Mouse Grpr-7836M Recombinant Mouse Grpr protein, His & GST-tagged E.coli His/GST Met1~Leu116
Mouse GRPR-7295M Recombinant Mouse GRPR Protein Mammalian Cell His
Mouse GRPR-3946M-B Recombinant Mouse GRPR Protein Pre-coupled Magnetic Beads HEK293
Mouse GRPR-3946M Recombinant Mouse GRPR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GRPR-2723R Recombinant Rat GRPR Protein Mammalian Cell His
Rat GRPR-2377R Recombinant Rat GRPR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GRPR-2377R-B Recombinant Rat GRPR Protein Pre-coupled Magnetic Beads HEK293
Mus musculus (Mouse) RFL22856MF Recombinant Full Length Mouse Gastrin-Releasing Peptide Receptor(Grpr) Protein, His-Tagged E.coli expression system His Full Length (1-384)
Rattus norvegicus (Rat) RFL24982RF Recombinant Full Length Rat Gastrin-Releasing Peptide Receptor(Grpr) Protein, His-Tagged E.coli expression system His Full Length (1-384)
Rhesus Macaque GRPR-1981R Recombinant Rhesus monkey GRPR Protein, His-tagged Mammalian Cell His
Rhesus Macaque GRPR-1802R Recombinant Rhesus Macaque GRPR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque GRPR-1802R-B Recombinant Rhesus Macaque GRPR Protein Pre-coupled Magnetic Beads HEK293
Chicken GRPR-5977C Recombinant Chicken GRPR Mammalian Cell His
Kit-1337 GRPR U2OS β-Arrestin GPCR Assay Kit N/A
Kit-1338 GRPR Activated GPCR Internalization Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

GRPR involved in several pathways and played different roles in them. We selected most pathways GRPR participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayGRM1;ATP2A3;ADORA2AA;HTR2CL1;TRHR2;HRH1;TACR1B;HTR5AL;CAMK2G1
Neuroactive ligand-receptor interactionCHRNE;GRIK2;RXFP2;GRIN2BB;ADORA1;GRIN3A;CHRNB3B;GHRA;CHRNB3A

GRPR has several biochemical functions, for example, G-protein coupled peptide receptor activity, bombesin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRPR itself. We selected most functions GRPR had, and list some proteins which have the same functions with GRPR. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled peptide receptor activityLHCGR;NPR3;GPR37L1;FSHR;GRPR;CYSLTR1;GPR37;RXFP4;MCHR2
bombesin receptor activityNMBR;BRS3;GRPR

GRPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRPR here. Most of them are supplied by our site. Hope this information will be useful for your research of GRPR.

Gene Family


Research Area

Related articles

Solorzano, C; Villafuerte, D; et al. Primary Afferent and Spinal Cord Expression of Gastrin-Releasing Peptide: Message, Protein, and Antibody Concerns. JOURNAL OF NEUROSCIENCE 35:648-657(2015).
Goswami, SC; Thierry-Mieg, D; et al. Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord. MOLECULAR PAIN 10:-(2014).
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