GRPR Protein


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Official Full Name gastrin-releasing peptide receptor
Background Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
Synonyms GRPR; gastrin-releasing peptide receptor; BB2; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Mus musculus (Mouse)
    • Rat
    • Rattus norvegicus (Rat)
    • Rhesus Macaque
    • Source :
    • E.coli
    • E.coli expression system
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRPR-28627TH Recombinant Human GRPR Wheat Germ N/A Inquiry
    Human GRPR-7835H Recombinant Human GRPR protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse GRPR-7295M Recombinant Mouse GRPR Protein Mammalian Cell His Inquiry
    Mouse Grpr-7836M Recombinant Mouse Grpr protein, His & GST-tagged E.coli His/GST Inquiry
    Rat GRPR-2723R Recombinant Rat GRPR Protein Mammalian Cell His Inquiry
    Rhesus Macaque GRPR-1981R Recombinant Rhesus monkey GRPR Protein, His-tagged Mammalian Cell His Inquiry
    Chicken GRPR-5977C Recombinant Chicken GRPR Mammalian Cell His Inquiry
    Human GRPR-209HF Recombinant Full Length Human GRPR Protein In Vitro Cell Free System Inquiry
    Human GRPR-5610HF Recombinant Full Length Human GRPR Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Mus musculus (Mouse) RFL22856MF Recombinant Full Length Mouse Gastrin-Releasing Peptide Receptor(Grpr) Protein, His-Tagged E.coli expression system His Inquiry
    Rattus norvegicus (Rat) RFL24982RF Recombinant Full Length Rat Gastrin-Releasing Peptide Receptor(Grpr) Protein, His-Tagged E.coli expression system His Inquiry
    Human GRPR-5383H Recombinant Human GRPR Protein, GST-tagged Wheat Germ GST Inquiry
    Kit-1337 GRPR U2OS β-Arrestin GPCR Assay Kit N/A Inquiry
    Kit-1338 GRPR Activated GPCR Internalization Assay Kit N/A Inquiry

    GRPR involved in several pathways and played different roles in them. We selected most pathways GRPR participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway ERBB4; GRIN2A; P2RX7; CALM3A; PHKG1A; PLCZ1; P2RX3; CAMK2A; ADORA2B; ORAI2
    Neuroactive ligand-receptor interaction P2RY10; THRA; CHRM5B; GRIA3; TAAR12I; MCHR1; PRSS1; GHRHR; VIPR2; HTR2B

    GRPR has several biochemical functions, for example, G-protein coupled peptide receptor activity, bombesin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRPR itself. We selected most functions GRPR had, and list some proteins which have the same functions with GRPR. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled peptide receptor activity CYSLTR2; LTB4R2; RXFP4; FSHR; LTB4R; GPR84; LHCGR; NPR1; GPR37; CYSLTR1
    bombesin receptor activity GRPR; BRS3; NMBR

    GRPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRPR here. Most of them are supplied by our site. Hope this information will be useful for your research of GRPR.

    Solorzano, C; Villafuerte, D; et al. Primary Afferent and Spinal Cord Expression of Gastrin-Releasing Peptide: Message, Protein, and Antibody Concerns. JOURNAL OF NEUROSCIENCE 35:648-657(2015).
    Goswami, SC; Thierry-Mieg, D; et al. Itch-associated peptides: RNA-Seq and bioinformatic analysis of natriuretic precursor peptide B and gastrin releasing peptide in dorsal root and trigeminal ganglia, and the spinal cord. MOLECULAR PAIN 10:-(2014).

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