Official Full Name | gastrin-releasing peptide receptor |
Background | Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008] |
Synonyms | GRPR; gastrin-releasing peptide receptor; BB2; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor; |
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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GRPR involved in several pathways and played different roles in them. We selected most pathways GRPR participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRPR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Calcium signaling pathway | ERBB4; GRIN2A; P2RX7; CALM3A; PHKG1A; PLCZ1; P2RX3; CAMK2A; ADORA2B; ORAI2 |
Neuroactive ligand-receptor interaction | P2RY10; THRA; CHRM5B; GRIA3; TAAR12I; MCHR1; PRSS1; GHRHR; VIPR2; HTR2B |
GRPR has several biochemical functions, for example, G-protein coupled peptide receptor activity, bombesin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRPR itself. We selected most functions GRPR had, and list some proteins which have the same functions with GRPR. You can find most of the proteins on our site.
Function | Related Protein |
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G-protein coupled peptide receptor activity | CYSLTR2; LTB4R2; RXFP4; FSHR; LTB4R; GPR84; LHCGR; NPR1; GPR37; CYSLTR1 |
bombesin receptor activity | GRPR; BRS3; NMBR |
GRPR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRPR here. Most of them are supplied by our site. Hope this information will be useful for your research of GRPR.
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