HLA-E

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HLA-E

Official Full Name major histocompatibility complex, class I, E
Background HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
Synonyms HLA-E; major histocompatibility complex, class I, E; HLA class I histocompatibility antigen, alpha chain E; MHC HLA-E alpha-1; lymphocyte antigen; MHC HLA-E alpha-2.1; MHC class I antigen E; HLA class I histocompatibility antigen, E alpha chain; MHC; QA1; EA1.2; EA2.1; HLA-6.2; DKFZp686P19218
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His&Myc
    • His-Avi
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-E-2276H Recombinant Human HLA-E protein, His&Myc-tagged Insect Cell His&Myc
    Human HLA-E-038H Recombinant Human HLA-E protein, His-Avi-tagged HEK293 His-Avi
    Human HLA-E-039H Recombinant Human HLA-E protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human HLA-E-1746H Recombinant Human HLA-E protein, His-tagged E.coli His
    Human HLA-E-1749H Recombinant Human HLA-E Protein, MYC/DDK-tagged HEK293T Myc/DDK
    Human HLA-E-4847H Recombinant Human HLA-E Protein, GST-tagged Wheat Germ GST
    Human HLA-E-800HCL Recombinant Human HLA-E cell lysate N/A

    HLA-E involved in several pathways and played different roles in them. We selected most pathways HLA-E participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis SMAD2; EHD1B; RAB11FIP4A; CHMP6B; FLT1; WASL; HSPA2; RAB22A; ITCHA; IL2RGB
    Phagosome SEC61A1; CTSLA; TUBA3B; ATP6V1C1A; CTSL1B; BMA1; CD209A; MHC2A; ATP6V1F; STX18
    Cell adhesion molecules (CAMs) CLDN10A; CD40LG; CLDN5A; HLA-G; TIGIT; BF1; CLDN19; CDH3; BLA; CLDNK
    Antigen processing and presentation HSPA5; HLA-DMA; HLA-DRB3; LGMN; HLA-DRB1; PSME1; KLRC4; IFNG; CD8B; HLA-DMB
    Natural killer cell mediated cytotoxicity KLRD1; TNFRSF10C; IFNA14; IFNA21; KIR2DL4; KLRC4-KLRK1; PRKCB; SH2D1A; RAF1; TNFSF10
    Type I diabetes mellitus PTPRN2; PTPRN; FAS; GAD2; HLA-DRB4; HLA-DPB1; ICA1; HLA-DPA1; H2-Q10; HLA-DRB3
    HTLV-I infection RANBP3; TNF; VDAC2; VAC14; FZD10; PIK3R5; IKBKB; TGFB3; ATM; SLC25A6
    Herpes simplex infection MHC2DCB; PML; TNFRSF14; MYD88; HMGN1; HNRNPK; Ccl12; NFKBIAB; MAPK8A; HCFC1A
    Epstein-Barr virus infection CD19; POLR3E; POLR2L; DDX58; POLR2A; FCER2; MAPK10; HSPA8; HLA-C; RELB
    Viral carcinogenesis HDAC9; IRF3; HIST1H2BB; CDK1; H2-Q10; SRC; GTF2A2; HLA-F; HIST1H4D; TBPL1
    Autoi HLA-DMB; IFNA4; TSHB; FAS; H2-AB1; Fasl; TPO; IFNA1; Ifna11; IFNA13
    ne thyroid disease H2-AB1; TSHB; HLA-F; HLA-DOA; IFNA8; IFNA21; IFNA10; HLA-DQA1; IFNA12; H2-AA
    Allograft rejection PRF1; CD80; Fasl; HLA-DRB4; HLA-DMB; HLA-DQB1; HLA-E; IFNG; CD40LG; HLA-DRB1
    Graft-versus-host disease IL1A; HLA-DOB; HLA-DPA1; CD80; FAS; HLA-DRB3; IL6; FASLG; KLRD1; H2-AB1
    Viral myocarditis HLA-B; CD40LG; CD86; HLA-DOA; ABL1; HLA-DPB1; SGCA; MYH7; HLA-DQB1; HLA-DRB5

    HLA-E has several biochemical functions, for example, MHC class I protein binding, beta-2-microglobulin binding, natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-E itself. We selected most functions HLA-E had, and list some proteins which have the same functions with HLA-E. You can find most of the proteins on our site.

    Function Related Protein
    MHC class I protein binding BCAP31; LILRB1; HLA-E; Pilrb1; VCP; TUBB4B; ATP5A1; CD8A; PILRB; TAP1
    beta-2-microglobulin binding CD1A; CD1D2; HLA-A; CD1E; HLA-E; CD1D; FCGRT; CD1B; CD1C; HFE
    natural killer cell lectin-like receptor binding H60a; MICB; SAMD3; Raet1a; RAET1E; CLEC2G; Raet1c; ULBP1; ULBP3; Mill2
    peptide antigen binding HLA-DQB1; MHC1UJA; MHC1UBA; CD209; TUBB3; H2-Q10; MHC1UEA; HLA-G; HLA-C; H2-AA
    receptor binding TNFSF13; TNFSF10; FGF13B; CXCL10; ANGPTL2; SSTR3; FGF10B; LGI1; SEMA4D; FGF20B

    HLA-E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-E here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-E.

    YPMT1.25Ac; TRAPPC2; fusA; lldD1; q5ni35_fratt; q7chg5_yerpe; proW; q7ckk6_yerpe; deoB; ptsG; y2173_bacan; q81wx2_bacan; dacF; q81z87_bacan; q8cl08_yerpe; sfcA2; leuB; PPP1R16A

    Cheung, PFY; Yip, CW; et al. Granulin-Epithelin Precursor Renders Hepatocellular Carcinoma Cells Resistant to Natural Killer Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1209-1219(2014).
    Ravindranath, MH; Terasaki, PI; et al. Suppression of blastogenesis and proliferation of activated CD4(+) T cells: intravenous immunoglobulin (IVIg) versus novel anti-human leucocyte antigen (HLA)-E monoclonal antibodies mimicking HLA-I reactivity of IVIg. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:154-177(2014).

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