HLA-E

  • Official Full Name

    major histocompatibility complex, class I, E
  • Overview

    HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
  • Synonyms

    HLA-E;major histocompatibility complex, class I, E;HLA class I histocompatibility antigen, alpha chain E;MHC HLA-E alpha-1;lymphocyte antigen;MHC HLA-E alpha-2.1;MHC class I antigen E;HLA class I histocompatibility antigen, E alpha chain;MHC;QA1;EA1.2;EA2.1;HLA-6.2;DKFZp686P19218

Recombinant Proteins

  • Human
  • E.coli
  • HEK293
  • Insect Cells
  • Mammalian Cells
  • In Vitro Cell Free System
  • His
  • Non
  • Avi
  • Fc
  • Myc
  • Flag
  • GST
  • SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-E-3399H Recombinant Human HLA-E protein, His-tagged E.coli Human His 23-303 aa
HLA-E-1746H Recombinant Human HLA-E protein, His-tagged E.coli Human His Gly22~Leu358
HLA-E-800HCL Recombinant Human HLA-E cell lysate Human Non
HLA-E-038H Recombinant Human HLA-E protein, His-Avi-tagged HEK293 Human Avi&His It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide.
HLA-E-039H Recombinant Human HLA-E protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide.
HLA-E-040HP Recombinant Human HLA-E complex Protein (tetramer), His-Avi-tagged, PE-Labeled HEK293 Human Avi&His Gly25-Ile305(HLA-E*01:03),Ile21-Met119(B2M) and VMAPRTLVL peptide
HLA-E-1076H Recombinant Human HLA-E Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
HLA-E-1076H-B Recombinant Human HLA-E Protein Pre-coupled Magnetic Beads HEK293 Human
HLA-E-2276H Recombinant Human HLA-E protein, His&Myc-tagged Insect Cells Human His&Myc 22-305aa
HLA-E-268HFL Recombinant Full Length Human HLA-E Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
HLA-E-3602HF Recombinant Full Length Human HLA-E Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 358 amino acids
HLA-E-3872H Recombinant Human HLA-E protein, His-SUMO-tagged E.coli Human His&SUMO 22-305aa

    Involved Pathway

    HLA-E involved in several pathways and played different roles in them. We selected most pathways HLA-E participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Viral myocarditis ACTG1,CD86,H2-AB1,RAC3,RAC2,H2-Q10,CASP9,ITGB2,HLA-C,FYN
    Type I diabetes mellitus HLA-DRB3,IL12B,TNF,GAD1,HLA-F,Fasl,HLA-DOA,H2-AA,HLA-DRB4,PTPRN
    Allograft rejection IL5,CD80,HLA-DPB1,HLA-DPA1,Il2,HLA-B,TNF,CD40,HLA-DMB,HLA-DQA2
    Cell adhesion molecules (CAMs) HLA-DQA1,NLGN3A,ITGB1B.2,CLDNE,NRXN2,PDCD1,ITGA8,SELL,CNTN1A,TIGIT
    Epstein-Barr virus infection ENTPD8,RBPJ,MAP2K7,NFKBIB,DDX58,IKBKG,MAP2K3,MAPK13,MAP2K4,PSMD6
    Antigen processing and presentation HLA-DRB5,PSME1,KLRC2,KIR2DL1,HLA-DMB,CTSB,HLA-DRB3,HSPA2,CALR,HSPA1B
    Phagosome ITGAV,CLEC7A,LAMP1,STX7,THBS3,TUBB6,DYNC1LI1,LAMP2,CD209,DYNC1I1
    Graft-versus-host disease HLA-C,IL1A,HLA-DRB5,Il2,CD86,HLA-DRB4,HLA-DRA,Fasl,HLA-DQA1,H2-AB1
    Herpes simplex infection TYK2,TBPL1,IFNGR2,CDC34,CSNK2A2A,HLA-F,H2-Q10,TBP,SRSF5,NXF2

    Protein Function

    HLA-E has several biochemical functions, for example, MHC class I protein binding,beta-2-microglobulin binding,natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-E itself. We selected most functions HLA-E had, and list some proteins which have the same functions with HLA-E. You can find most of the proteins on our site.

    Function Related Protein
    natural killer cell lectin-like receptor binding Raet1a,ULBP2,CLEC2H,RAET1E,ULBP1,RAET1G,SAMD3,MICA,CLEC2G,ULBP3
    peptide antigen binding TRGV3,HLA-DRB4,MHC1UXA2,MHC1UJA,MR1,H2-AA,H2-AB1,TAPBP,HLA-G,MHC1ZKA
    beta-2-microglobulin binding CD1A,CD1C,CD1D,FCGRT,CD1D2,CD1B,CD1d1,HLA-A,H2-Q10,CD1E
    receptor binding Ar,CAV1,NTF3,CCL15,CXCL1,RIPK2,PAOX,IZUMO1,POU2F1,FIS1
    MHC class I protein binding TUBB,CD244,CD8A,TAP1,Pilrb1,TUBB4B,LILRB1,BCAP31,LILRB2,PILRB2

    Interacting Protein

    HLA-E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-E here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-E.

    YPMT1.25Ac;TRAPPC2;fusA;lldD1;q5ni35_fratt;q7chg5_yerpe;proW;q7ckk6_yerpe;deoB;ptsG;y2173_bacan;q81wx2_bacan;dacF;q81z87_bacan;q8cl08_yerpe;sfcA2;leuB;PPP1R16A

    Resources

    Research Area

    References

    • Cheung, PFY; Yip, CW; et al. Granulin-Epithelin Precursor Renders Hepatocellular Carcinoma Cells Resistant to Natural Killer Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1209-1219(2014).
    • Ravindranath, MH; Terasaki, PI; et al. Suppression of blastogenesis and proliferation of activated CD4(+) T cells: intravenous immunoglobulin (IVIg) versus novel anti-human leucocyte antigen (HLA)-E monoclonal antibodies mimicking HLA-I reactivity of IVIg. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:154-177(2014).

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