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HLA-E

Official Full Name

major histocompatibility complex, class I, E
Overview

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
Synonyms

HLA-E; major histocompatibility complex, class I, E; HLA class I histocompatibility antigen, alpha chain E; MHC HLA-E alpha-1; lymphocyte antigen; MHC HLA-E alpha-2.1; MHC class I antigen E; HLA class I histocompatibility antigen, E alpha chain; MHC; QA1; EA1.2; EA2.1; HLA-6.2; DKFZp686P19218;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Insect Cell
Mammalian cells
Wheat Germ

Tag

Flag
GST
His
His (Fc)
Avi
Myc
SUMO
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-E-1746H	Recombinant Human HLA-E protein, His-tagged	E.coli	His	Gly22~Leu358	Inquiry
Human	HLA-E-4847H	Recombinant Human HLA-E Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HLA-E-800HCL	Recombinant Human HLA-E cell lysate		N/A		Inquiry
Human	HLA-E-039H	Recombinant Human HLA-E protein, His-Avi-tagged, Biotinylated	HEK293	His-Avi	It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide.	Inquiry
Human	HLA-E-038H	Recombinant Human HLA-E protein, His-Avi-tagged	HEK293	His-Avi	It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide.	Inquiry
Human	HLA-E-2276H	Recombinant Human HLA-E protein, His&Myc-tagged	Insect Cell	His&Myc	22-305aa	Inquiry
Human	HLA-E-1076H	Recombinant Human HLA-E Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Human	HLA-E-3602HF	Recombinant Full Length Human HLA-E Protein, GST-tagged	In Vitro Cell Free System	GST	358 amino acids	Inquiry
Human	HLA-E-1749H	Recombinant Human HLA-E Protein, MYC/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Human	HLA-E-3399H	Recombinant Human HLA-E protein, His-tagged	E.coli	His	23-303 aa	$319 / 25ug
Human	HLA-E-1076H-B	Recombinant Human HLA-E Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	HLA-E-268HFL	Recombinant Full Length Human HLA-E Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	HLA-E-3872H	Recombinant Human HLA-E protein, His-SUMO-tagged	E.coli	His-SUMO	22-305aa	Inquiry
Human	HLA-E-040HP	Recombinant Human HLA-E complex Protein (tetramer), His-Avi-tagged, PE-Labeled	HEK293	His-Avi	Gly25-Ile305(HLA-E*01:03),Ile21-Met119(B2M) and VMAPRTLVL peptide	Inquiry

Involved Pathway
Protein Function
Interacting Protein
HLA-E Related Articles
HLA-E Related Research Area

HLA-E involved in several pathways and played different roles in them. We selected most pathways HLA-E participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	VPS37C;SH3GL3A;CCR5;SH3GLB1A;IST1;PRKCI;CXCR1;HLA-E;ARPC5LB
Phagosome	TUBA1C;MHC2DAB;ITGB5;ACTB;HLA-E;TUBB;ATP6V1D;CLEC7A;TUBA3A
Cell adhesion molecules (CAMs)	TIGIT;CD22;HLA-DPA1;ITGA6;PDCD1LG2;NLGN4X;ITGB2;CLDN5B;CD40
Antigen processing and presentation	PDIA3;LGMN;KLRC3;CD8B1;KLRC2;TNF;HLA-DOA;CANX;KIR2DS5
Natural killer cell mediated cytotoxicity	Fasl;NFATC2;RAF1;ICAM1;SH2D1A;SYK;RAET1E;FCER1G;NCR2
Type I diabetes mellitus	HLA-DRB5;Fasl;HLA-DMA;CD28;HLA-DOB;LTA;CD80;IL1A;HLA-DQB1
HTLV-I infection	PDGFB;TGFBR1;WNT10B;XBP1;Adcy4;WNT8A;MAP3K1;WNT9A;DVL3
Herpes simplex infection	CASP3A;TAF6;POU2F3;IL12A;CUL1A;EIF2AK2;CDC34;ARNTL1A;HLA-E
Epstein-Barr virus infection	ENTPD3;IL10RB;SNW1;POLR2G;RELA;HLA-DPA1;TRADD;PRKACG;GSK3B
Viral carcinogenesis	HIST1H4H;LYN;TRAF3;HIST1H2BP;HIST1H2BH;HIST1H2BM;TBPL1;SCIN;SP100
Autoi	HLA-DRB3;HLA-DRA;HLA-G;H2-Q10;IL5;IFNA1;GZMB;IFNA13;IFNA10
ne thyroid disease	IFNA14;CD80;HLA-F;IFNA21;IFNA17;HLA-G;Fasl;HLA-DRA;PRF1
Allograft rejection	HLA-DRB5;HLA-DRA;HLA-DMB;CD40;IL12A;FASLG;HLA-F;Il2;H2-AB1
Graft-versus-host disease	IL6;HLA-F;HLA-DOA;KLRC1;IL1A;H2-AA;HLA-DRB5;H2-Q10;HLA-DQA1
Viral myocarditis	HLA-DRB1;SGCD;SGCA;HLA-A;ACTG1;CCND1;HLA-DQB1;CYCS;HLA-DQA1

HLA-E has several biochemical functions, for example, MHC class I protein binding, beta-2-microglobulin binding, natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-E itself. We selected most functions HLA-E had, and list some proteins which have the same functions with HLA-E. You can find most of the proteins on our site.

Function	Related Protein
MHC class I protein binding	TUBB;HLA-E;LILRB2;CD244;ATP5A1;CD8A;TUBB4B;BCAP31;TAP1
beta-2-microglobulin binding	H2-Q10;CD1C;CD1d1;HLA-A;CD1E;CD1A;HLA-E;CD1B;FCGRT
natural killer cell lectin-like receptor binding	RAET1L;Raet1a;MICA;ULBP2;ULBP3;RAET1G;RAET1E;RAET1D;Mill2
peptide antigen binding	HLA-DRB3;HLA-A;HLA-DRB5;H2-Q10;MHC1ZHA;H2-AB1;MHC1UJA;HLA-DQA1;HLA-DPB1
receptor binding	HFE2;ICOSLG;HSPA1A;VTCN1;PKD2;Fert2;BMP3;PANX1;PPY

HLA-E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-E here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-E.

YPMT1.25Ac; TRAPPC2; fusA; lldD1; q5ni35_fratt; q7chg5_yerpe; proW; q7ckk6_yerpe; deoB; ptsG; y2173_bacan; q81wx2_bacan; dacF; q81z87_bacan; q8cl08_yerpe; sfcA2; leuB; PPP1R16A

Cheung, PFY; Yip, CW; et al. Granulin-Epithelin Precursor Renders Hepatocellular Carcinoma Cells Resistant to Natural Killer Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1209-1219(2014).

Ravindranath, MH; Terasaki, PI; et al. Suppression of blastogenesis and proliferation of activated CD4(+) T cells: intravenous immunoglobulin (IVIg) versus novel anti-human leucocyte antigen (HLA)-E monoclonal antibodies mimicking HLA-I reactivity of IVIg. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:154-177(2014).

MHC Class I

MHC Class II