HLA-E

  • Official Full Name

    major histocompatibility complex, class I, E
  • Overview

    HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.
  • Synonyms

    HLA-E;major histocompatibility complex, class I, E;HLA class I histocompatibility antigen, alpha chain E;MHC HLA-E alpha-1;lymphocyte antigen;MHC HLA-E alpha-2.1;MHC class I antigen E;HLA class I histocompatibility antigen, E alpha chain;MHC;QA1;EA1.2;EA2.1;HLA-6.2;DKFZp686P19218

Recombinant Proteins

  • Human
  • E.coli
  • HEK293
  • Insect Cells
  • Mammalian Cells
  • In Vitro Cell Free System
  • His
  • Non
  • Avi
  • Fc
  • Myc
  • Flag
  • GST
  • SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-E-3399H Recombinant Human HLA-E protein, His-tagged E.coli Human His 23-303 aa
HLA-E-1746H Recombinant Human HLA-E protein, His-tagged E.coli Human His Gly22~Leu358
HLA-E-800HCL Recombinant Human HLA-E cell lysate Human Non
HLA-E-038H Recombinant Human HLA-E protein, His-Avi-tagged HEK293 Human Avi&His It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide.
HLA-E-039H Recombinant Human HLA-E protein, His-Avi-tagged, Biotinylated HEK293 Human Avi&His It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide.
HLA-E-040HP Recombinant Human HLA-E complex Protein (tetramer), His-Avi-tagged, PE-Labeled HEK293 Human Avi&His Gly25-Ile305(HLA-E*01:03),Ile21-Met119(B2M) and VMAPRTLVL peptide
HLA-E-1076H Recombinant Human HLA-E Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
HLA-E-1076H-B Recombinant Human HLA-E Protein Pre-coupled Magnetic Beads HEK293 Human
HLA-E-2276H Recombinant Human HLA-E protein, His&Myc-tagged Insect Cells Human His&Myc 22-305aa
HLA-E-268HFL Recombinant Full Length Human HLA-E Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
HLA-E-3602HF Recombinant Full Length Human HLA-E Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 358 amino acids
HLA-E-3872H Recombinant Human HLA-E protein, His-SUMO-tagged E.coli Human His&SUMO 22-305aa

    Involved Pathway

    HLA-E involved in several pathways and played different roles in them. We selected most pathways HLA-E participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ne thyroid disease CD40LG,TSHR,IFNA17,IFNA5,IFNA13,FAS,HLA-DRB1,IFNA1,IFNA6,TG
    Epstein-Barr virus infection POLR2I,NFKBIE,SHFM1,CD44,MAP3K7,POLR2B,HDAC5,HLA-DQA2,PSMD4,PRKACA
    Viral carcinogenesis H2BFWT,YWHAH,GTF2A2,SKP2,MAPKAPK2,EP300,HIST1H2BH,RELA,GTF2A1,HIST1H4N
    HTLV-I infection SLC25A31,RANBP3,CDC23,NFATC2,ANAPC7,H2-AB1,STAT5A,RRAS,HLA-DOA,H2-AA
    Allograft rejection HLA-DRA,HLA-DRB4,HLA-DRB1,HLA-DOB,HLA-DRB3,IL10,IL12B,IFNG,HLA-DOA,H2-Q10
    Phagosome ATP6V0CA,THBS2,Itgam&Itgb2,NCF2,BF1,RAB7,ITGB2,DYNC1I2A,TUBA8L3,C3
    Endocytosis D6WSU116E,CBLC,SH3GL1A,ASAP1A,IL2RGB,CAV2,CHMP4C,CHMP6B,CHMP3,SH3GLB1B
    Natural killer cell mediated cytotoxicity IFNAR1,PTPN6,IFNAR2,ICAM1,PIK3CG,ICAM2,IFNA12,MICB,NFATC2,PIK3R1
    Antigen processing and presentation HSPA8,HLA-DMA,KLRC4,TAPBP,KIR3DL2,KLRC3,H2-Q10,PSME1,HSP90AA1,HSPA5

    Protein Function

    HLA-E has several biochemical functions, for example, MHC class I protein binding,beta-2-microglobulin binding,natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-E itself. We selected most functions HLA-E had, and list some proteins which have the same functions with HLA-E. You can find most of the proteins on our site.

    Function Related Protein
    receptor binding NRG4,GFRA1,BLK,TRDN,JAK2,FKBP1B,GFRA3,PKD2,LAMA1,CX3CL1
    peptide antigen binding MHC1UXA2,CLEC4M,HLA-C,HLA-DPB1,HLA-DRB3,H2-AA,HLA-F,MHC1UEA,MHC1ZDA,MHC1UBA
    natural killer cell lectin-like receptor binding CLEC2H,ULBP3,MICA,RAET1E,RAET1G,MICB,RAET1D,H60a,ULBP1,SAMD3
    beta-2-microglobulin binding CD1d1,HFE,H2-Q10,CD1A,CD1D,CD1D2,CD1B,FCGRT,CD1E,CD1C
    MHC class I protein binding PILRB2,TUBB4B,BCAP31,LILRB1,CD8B,TUBB,CD244,ATP5A1,PILRB,VCP

    Interacting Protein

    HLA-E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-E here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-E.

    YPMT1.25Ac;TRAPPC2;fusA;lldD1;q5ni35_fratt;q7chg5_yerpe;proW;q7ckk6_yerpe;deoB;ptsG;y2173_bacan;q81wx2_bacan;dacF;q81z87_bacan;q8cl08_yerpe;sfcA2;leuB;PPP1R16A

    Resources

    Research Area

    References

    • Cheung, PFY; Yip, CW; et al. Granulin-Epithelin Precursor Renders Hepatocellular Carcinoma Cells Resistant to Natural Killer Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1209-1219(2014).
    • Ravindranath, MH; Terasaki, PI; et al. Suppression of blastogenesis and proliferation of activated CD4(+) T cells: intravenous immunoglobulin (IVIg) versus novel anti-human leucocyte antigen (HLA)-E monoclonal antibodies mimicking HLA-I reactivity of IVIg. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:154-177(2014).

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