HLA-E
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Official Full Name
major histocompatibility complex, class I, E -
Overview
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. -
Synonyms
HLA-E;major histocompatibility complex, class I, E;HLA class I histocompatibility antigen, alpha chain E;MHC HLA-E alpha-1;lymphocyte antigen;MHC HLA-E alpha-2.1;MHC class I antigen E;HLA class I histocompatibility antigen, E alpha chain;MHC;QA1;EA1.2;EA2.1;HLA-6.2;DKFZp686P19218
Recombinant Proteins
- Human
- E.coli
- HEK293
- Insect Cells
- Mammalian Cells
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- Myc
- Flag
- GST
- SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-E-3399H | Recombinant Human HLA-E protein, His-tagged | E.coli | Human | His | 23-303 aa | |
| HLA-E-1746H | Recombinant Human HLA-E protein, His-tagged | E.coli | Human | His | Gly22~Leu358 |
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| HLA-E-800HCL | Recombinant Human HLA-E cell lysate | Human | Non |
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| HLA-E-038H | Recombinant Human HLA-E protein, His-Avi-tagged | HEK293 | Human | Avi&His | It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide. |
|
| HLA-E-039H | Recombinant Human HLA-E protein, His-Avi-tagged, Biotinylated | HEK293 | Human | Avi&His | It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide. |
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| HLA-E-040HP | Recombinant Human HLA-E complex Protein (tetramer), His-Avi-tagged, PE-Labeled | HEK293 | Human | Avi&His | Gly25-Ile305(HLA-E*01:03),Ile21-Met119(B2M) and VMAPRTLVL peptide |
|
| HLA-E-1076H | Recombinant Human HLA-E Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| HLA-E-1076H-B | Recombinant Human HLA-E Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| HLA-E-2276H | Recombinant Human HLA-E protein, His&Myc-tagged | Insect Cells | Human | His&Myc | 22-305aa |
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| HLA-E-268HFL | Recombinant Full Length Human HLA-E Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| HLA-E-3602HF | Recombinant Full Length Human HLA-E Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 358 amino acids |
|
| HLA-E-3872H | Recombinant Human HLA-E protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 22-305aa |
|
Involved Pathway
HLA-E involved in several pathways and played different roles in them. We selected most pathways HLA-E participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Type I diabetes mellitus | PTPRN,HLA-A,HLA-DRB3,CD80,HLA-DOA,CPE,HLA-C,HLA-DRB4,ICA1,HLA-DQA1 |
| Allograft rejection | HLA-A,HLA-DRB3,HLA-F,IL4,HLA-DQA2,MICA,HLA-DRB5,H2-AB1,HLA-C,IL12B |
| Herpes simplex infection | IKBKG,MAP3K7,IL15,HLA-DRB1,NXF3,IFNAR1,CFP,GTF2IRD1,HLA-DQA1,PML |
| Endocytosis | CHMP4B,EHD1A,STAM,PLD2,HLA-F,TGFB2,GRK7A,ARPC3,PRKCI,GIT2B |
| HTLV-I infection | SLC25A4,HLA-DRB5,IKBKB,RELA,MRAS,FZD9,NFKBIA,TRP53INP1,RANBP1,IL15RA |
| Viral myocarditis | ACTG1,SGCA,LAMA2,ITGB2,H2-AB1,SGCD,CASP8,HLA-DQA2,CYCS,HLA-DOB |
| Graft-versus-host disease | HLA-DMA,KLRD1,IL1A,H2-Q10,IL1B,H2-AA,CD86,KLRC1,KIR3DL1,HLA-DPA1 |
| Autoi | HLA-DRB1,FASLG,IFNA2,HLA-DQA2,HLA-DRA,HLA-B,IFNA7,IFNA16,IFNA1,HLA-DPA1 |
| Antigen processing and presentation | KIR3DL1,HSPA4,TAP2,KLRC4,CD8A,CD74,HSPA2,IFNG,HLA-DMA,HLA-DRB4 |
Protein Function
HLA-E has several biochemical functions, for example, MHC class I protein binding,beta-2-microglobulin binding,natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-E itself. We selected most functions HLA-E had, and list some proteins which have the same functions with HLA-E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| natural killer cell lectin-like receptor binding | SAMD3,Raet1c,Raet1a,MICB,ULBP2,Mill2,RAET1D,H60a,CLEC2G,CLEC2H |
| receptor binding | GSDMA2,PVRL3,RSPO3,HRG,LPL,DECR2,FGF6A,NPPC,UTS2,MAG |
| MHC class I protein binding | BCAP31,PILRB2,LILRB2,DERL1,ATP5A1,TUBB4B,Pilrb1,VCP,ATP5B,TAP1 |
| peptide antigen binding | MHC1UEA,MHC1ZKA,MHC1UHA,H2-AB1,MHC1ZDA,MHC1UXA2,MHC1UJA,HLA-C,CLEC4M,HLA-DQB1 |
| beta-2-microglobulin binding | HFE,CD1E,CD1D,HLA-A,CD1C,CD1B,CD1A,CD1D2,CD1d1,FCGRT |
Interacting Protein
HLA-E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-E here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-E.
YPMT1.25Ac;TRAPPC2;fusA;lldD1;q5ni35_fratt;q7chg5_yerpe;proW;q7ckk6_yerpe;deoB;ptsG;y2173_bacan;q81wx2_bacan;dacF;q81z87_bacan;q8cl08_yerpe;sfcA2;leuB;PPP1R16A
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References
- Cheung, PFY; Yip, CW; et al. Granulin-Epithelin Precursor Renders Hepatocellular Carcinoma Cells Resistant to Natural Killer Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1209-1219(2014).
- Ravindranath, MH; Terasaki, PI; et al. Suppression of blastogenesis and proliferation of activated CD4(+) T cells: intravenous immunoglobulin (IVIg) versus novel anti-human leucocyte antigen (HLA)-E monoclonal antibodies mimicking HLA-I reactivity of IVIg. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:154-177(2014).
