HLA-E
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Official Full Name
major histocompatibility complex, class I, E -
Overview
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. -
Synonyms
HLA-E;major histocompatibility complex, class I, E;HLA class I histocompatibility antigen, alpha chain E;MHC HLA-E alpha-1;lymphocyte antigen;MHC HLA-E alpha-2.1;MHC class I antigen E;HLA class I histocompatibility antigen, E alpha chain;MHC;QA1;EA1.2;EA2.1;HLA-6.2;DKFZp686P19218
Recombinant Proteins
- Human
- E.coli
- HEK293
- Insect Cells
- Mammalian Cells
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- Myc
- Flag
- GST
- SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-E-3399H | Recombinant Human HLA-E protein, His-tagged | E.coli | Human | His | 23-303 aa | |
| HLA-E-1746H | Recombinant Human HLA-E protein, His-tagged | E.coli | Human | His | Gly22~Leu358 |
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| HLA-E-800HCL | Recombinant Human HLA-E cell lysate | Human | Non |
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| HLA-E-038H | Recombinant Human HLA-E protein, His-Avi-tagged | HEK293 | Human | Avi&His | It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide. |
|
| HLA-E-039H | Recombinant Human HLA-E protein, His-Avi-tagged, Biotinylated | HEK293 | Human | Avi&His | It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide. |
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| HLA-E-040HP | Recombinant Human HLA-E complex Protein (tetramer), His-Avi-tagged, PE-Labeled | HEK293 | Human | Avi&His | Gly25-Ile305(HLA-E*01:03),Ile21-Met119(B2M) and VMAPRTLVL peptide |
|
| HLA-E-1076H | Recombinant Human HLA-E Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
|
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| HLA-E-1076H-B | Recombinant Human HLA-E Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| HLA-E-2276H | Recombinant Human HLA-E protein, His&Myc-tagged | Insect Cells | Human | His&Myc | 22-305aa |
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| HLA-E-268HFL | Recombinant Full Length Human HLA-E Protein, C-Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
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| HLA-E-3602HF | Recombinant Full Length Human HLA-E Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 358 amino acids |
|
| HLA-E-3872H | Recombinant Human HLA-E protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 22-305aa |
|
Involved Pathway
HLA-E involved in several pathways and played different roles in them. We selected most pathways HLA-E participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | IL2RG,WNT7A,EGR2,IKBKB,AKT2,PDGFB,EGR1,PDGFRA,WNT7B,NRAS |
| Endocytosis | DNM2B,KIT,PARD6B,RHOA,EHD1A,ARFGEF1,ADRB3A,GIT1,SH3GLB2B,VTA1 |
| Autoi | HLA-DQA1,IFNA8,IFNA1,H2-Q10,CD86,HLA-DMA,IFNA2,H2-AA,IL5,IFNA21 |
| Natural killer cell mediated cytotoxicity | IFNGR2,PRKCA,PIK3R2,Raet1c,ITGAL,PIK3R5,PTPN11,TNFRSF10C,RAET1G,IFNA1 |
| Viral myocarditis | RAC1,HLA-DMB,HLA-DRA,HLA-DQA2,SGCB,ITGAL,SGCA,EIF4G3,CD80,H2-AB1 |
| Viral carcinogenesis | IRF7,GRB2,MAD1L1,PSMC1,YWHAZ,HRAS,HDAC8,YWHAE,UBE3A,GTF2H4 |
| Herpes simplex infection | Ccl12,TRAF6,SRSF4,HNRPKL,MHC2A,THOC4,IFIT1,IFNA14,PER2,EIF2AK4 |
| Antigen processing and presentation | KLRC4,KIR2DL1,HLA-DPA1,IFNG,CD74,KIR2DS3,CTSS,CANX,IFI30,HLA-G |
| Epstein-Barr virus infection | TYK2,HLA-DRB1,HLA-DRB3,EIF2AK2,MAPK10,MAP2K6,CDK1,RBPJ,POLR3GL,SPI1 |
Protein Function
HLA-E has several biochemical functions, for example, MHC class I protein binding,beta-2-microglobulin binding,natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-E itself. We selected most functions HLA-E had, and list some proteins which have the same functions with HLA-E. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | BF2,MHC1UKA,HLA-A,MHC1UXA2,MHC1UDA,TAPBP,MHC1ZFA,CD209,MAML1,HLA-DRB1 |
| beta-2-microglobulin binding | CD1B,CD1A,CD1C,CD1D2,CD1E,FCGRT,HFE,CD1D,H2-Q10,HLA-A |
| natural killer cell lectin-like receptor binding | CLEC2H,H60a,ULBP1,MICA,ULBP3,Raet1c,RAET1D,Raet1a,Mill2,RAET1E |
| receptor binding | CD276,Fert2,LIF,ADIPOQ,ANG,Itga10&Itgb1,ACOX2,RSPO1,RSPO2,CD200 |
| MHC class I protein binding | TUBB4B,TUBB,CD8A,TAPBP,BCAP31,PILRB,ATP5B,CD8B,VCP,Pilrb1 |
Interacting Protein
HLA-E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-E here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-E.
YPMT1.25Ac;TRAPPC2;fusA;lldD1;q5ni35_fratt;q7chg5_yerpe;proW;q7ckk6_yerpe;deoB;ptsG;y2173_bacan;q81wx2_bacan;dacF;q81z87_bacan;q8cl08_yerpe;sfcA2;leuB;PPP1R16A
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References
- Cheung, PFY; Yip, CW; et al. Granulin-Epithelin Precursor Renders Hepatocellular Carcinoma Cells Resistant to Natural Killer Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1209-1219(2014).
- Ravindranath, MH; Terasaki, PI; et al. Suppression of blastogenesis and proliferation of activated CD4(+) T cells: intravenous immunoglobulin (IVIg) versus novel anti-human leucocyte antigen (HLA)-E monoclonal antibodies mimicking HLA-I reactivity of IVIg. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 178:154-177(2014).
