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Official Full Name 5-hydroxytryptamine (serotonin) receptor 2B
Background This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
Synonyms HTR2B; 5-hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine receptor 2B; 5 HT(2B); 5 HT2B; 5 HT 2B; 5 hydroxytryptamine (serotonin) receptor 2B; 5 hydroxytryptamine 2B receptor; 5 hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; 5HT(2B); 5HT2B_HUMAN; 5HT2F; Htr 2b; NP75 protein; SEROTONIN 5HT2B RECEPTOR; Serotonin receptor 2B; Stomach fundus serotonin receptor; 5-HT 2B receptor; OTTHUMP00000164294; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B variant b; 5-HT(2B)
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • in vitro E. coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HTR2B-26027TH Recombinant Human HTR2B Wheat Germ N/A
    Human HTR2B-2707H Recombinant Human HTR2B Protein (1-481 aa), His-SUMO-tagged in vitro E. coli His/SUMO
    Human HTR2B-5243H Recombinant Human HTR2B Protein, GST-tagged Wheat Germ GST
    Human HTR2B-5335HCL Recombinant Human HTR2B 293 Cell Lysate HEK293 N/A
    Mouse HTR2B-7933M Recombinant Mouse HTR2B Protein Mammalian Cell His
    Rat HTR2B-2963R Recombinant Rat HTR2B Protein Mammalian Cell His
    Chicken HTR2B-5494C Recombinant Chicken HTR2B Mammalian Cell His
    Zebrafish HTR2B-3901Z Recombinant Zebrafish HTR2B Mammalian Cell His

    htr2b involved in several pathways and played different roles in them. We selected most pathways htr2b participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with htr2b were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathway P2RX3; PPP3R1; TACR3A; VDAC1; CALM3; HTR7; CACNA1B; CACNA1G; ADORA2A; EDNRA
    Neuroactive ligand-receptor interaction CHRNA3; TAAR13D; TAAR10; ADRB3A; F2RL2; ADORA2AB; GALR2; GRIN3A; MCHR1; NTSR1
    Gap junction GNAI2B; TUBA1B; PDGFC; Adcy4; GJA1; TUBA3A; GNAIA; ADCY1A; PRKG1A; GNA11B
    Serotonergic synapse HTR3A; GNGT1; KCNN2; HTR1E; GNB1; TPH1; GNG5; GNB3; GNG4; HTR7
    Inflammatory mediator regulation of TRP channels KLK1B4; PLA2G4A; PLCG1; ALOX12; BDKRB2; TRPM8; HTR2C; ASIC5; PRKCH; PIK3CB

    htr2b has several biochemical functions, for example, G-protein alpha-subunit binding, GTPase activator activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by htr2b itself. We selected most functions htr2b had, and list some proteins which have the same functions with htr2b. You can find most of the proteins on our site.

    Function Related Protein
    G-protein alpha-subunit binding ARHGEF11; DRD1A; IGF1R; AGTR1A; CRHR1; HTR2A; F2R; OPRM1; F2RL1; LPAR1
    GTPase activator activity TBC1D13; GAPVD1; TBC1D10C; TBC1D9; GARNL3; RGS12; SGSM2; RAP1GDS1; CDC42EP1B; RASAL3
    drug binding MT2A; PDE4D; P2RX2; GPR30; CYP2D6; GLRB; CHRNB3; GRIK1; DRD3; DCK
    serotonin binding HTR2C; MAOA; HTR1F; HTR1B; HTR3A; HTR2A; HTR1E; HTR2B
    serotonin receptor activity HTR3A; HTR2CL1; HTR1F; HTR4; HTR1AB; HTR2A; HTR3C; HTR2C; HTR1AA; HTR1B

    htr2b has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with htr2b here. Most of them are supplied by our site. Hope this information will be useful for your research of htr2b.


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