HTR2B

  • Official Full Name

    5-hydroxytryptamine (serotonin) receptor 2B

  • Overview

    This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
  • Synonyms

    HTR2B; 5-hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine receptor 2B; 5 HT(2B); 5 HT2B; 5 HT 2B; 5 hydroxytryptamine (serotonin) receptor 2B; 5 hydroxytryptamine 2B receptor; 5 hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; 5HT(2B); 5HT2B_HUMAN; 5HT2F; Htr 2b; NP75 protein; SEROTONIN 5HT2B RECEPTOR; Serotonin receptor 2B; Stomach fundus serotonin receptor; 5-HT 2B receptor; OTTHUMP00000164294; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B variant b; 5-HT(2B);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cavia porcellus (Guinea pig)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HTR2B-26027TH Recombinant Human HTR2B Wheat Germ N/A 56 amino acids
Human HTR2B-5335HCL Recombinant Human HTR2B 293 Cell Lysate HEK293 N/A
Human HTR2B-5243H Recombinant Human HTR2B Protein, GST-tagged Wheat Germ GST
Human HTR2B-5684HF Recombinant Full Length Human HTR2B Protein, GST-tagged In Vitro Cell Free System GST 481 amino acids
Human HTR2B-2707H Recombinant Human HTR2B Full Length Transmembrane protein (1-481 aa), His-SUMO-tagged In vitro E. coli expression system His-SUMO 1-481aa
Human HTR2B-1091HFL Recombinant Human HTR2B protein, His&Flag-tagged HEK293 His&Flag 1-481 aa
Mouse HTR2B-7933M Recombinant Mouse HTR2B Protein Mammalian Cell His
Mouse HTR2B-4375M Recombinant Mouse HTR2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse HTR2B-4375M-B Recombinant Mouse HTR2B Protein Pre-coupled Magnetic Beads HEK293
Rat HTR2B-2963R Recombinant Rat HTR2B Protein Mammalian Cell His
Rat HTR2B-2618R Recombinant Rat HTR2B Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat HTR2B-2618R-B Recombinant Rat HTR2B Protein Pre-coupled Magnetic Beads HEK293
Cavia porcellus (Guinea pig) RFL34021CF Recombinant Full Length Guinea Pig 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged E.coli expression system His Full Length (1-96)
Homo sapiens (Human) RFL5388HF Recombinant Full Length Human 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged E.coli expression system His Full Length (1-481aa)
Rattus norvegicus (Rat) RFL33072RF Recombinant Full Length Rat 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged E.coli expression system His Full Length (1-479)
Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis) RFL1319TF Recombinant Full Length Tetraodon Fluviatilis 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged E.coli expression system His Full Length (1-471)
Zebrafish HTR2B-3901Z Recombinant Zebrafish HTR2B Mammalian Cell His
Chicken HTR2B-5494C Recombinant Chicken HTR2B Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

HTR2B involved in several pathways and played different roles in them. We selected most pathways HTR2B participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium signaling pathwayADCY1B;ATP2B4;CD38;P2RX6;MYLK2;STIM1A;SLC8A4A;PPP3R1B;GNAL
Neuroactive ligand-receptor interactionCHRM2A;C5AR1;GRIA4B;GHRHRL;BDKRB2;OPRD1B;CALCR;LOC100328615;TACR1A
Gap junctionDRD2L;TUBB6;TUBA4L;GNAQ;GNAI3;GNAI2A;PLCB3;ADCY1B;Adcy4
Serotonergic synapseMAP2K1;ALOX5;GNAO1;ALOX12B;PRKACB;GNAQ;GNB3;PLCB2;GNGT1
Inflammatory mediator regulation of TRP channelsPLCB1;F2RL1;IL1RAP;ALOX12;PLCB4;CYP2C37;HTR2C;P2RY2;CYP2C70

HTR2B has several biochemical functions, for example, G-protein alpha-subunit binding, GTPase activator activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR2B itself. We selected most functions HTR2B had, and list some proteins which have the same functions with HTR2B. You can find most of the proteins on our site.

Function Related Protein
G-protein alpha-subunit bindingLPAR1;DRD1;HTR2B;CRHR1;RIC8;F2R;OPRM1;NUCB1;ARHGEF11
GTPase activator activityDOCK4;RGS4;DEPDC1B;RANGAP1;RGS10;RAP1GAP2;MURC;AGAP2;ALDH1A2
drug bindingDRD1A;FSCN1;GRIK1;CYP2D6;SETD6;FNTB;HTR2C;P2RX1;NAMPT
serotonin bindingHTR2B;HTR2A;HTR2C;HTR1F;HTR1B;MAOA;HTR1E;HTR3A
serotonin receptor activityHTR3B;HTR1E;HTR5A;HTR1F;HTR3A;HTR1B;HTR1AA;HTR6;HTR2A

HTR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR2B.

MPDZ

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