HTR2B
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Official Full Name
5-hydroxytryptamine (serotonin) receptor 2B
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Overview
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. -
Synonyms
HTR2B; 5-hydroxytryptamine (serotonin) receptor 2B; 5-hydroxytryptamine receptor 2B; 5 HT(2B); 5 HT2B; 5 HT 2B; 5 hydroxytryptamine (serotonin) receptor 2B; 5 hydroxytryptamine 2B receptor; 5 hydroxytryptamine receptor 2B; 5-HT-2B; 5-HT2B; 5HT(2B); 5HT2B_HUMAN; 5HT2F; Htr 2b; NP75 protein; SEROTONIN 5HT2B RECEPTOR; Serotonin receptor 2B; Stomach fundus serotonin receptor; 5-HT 2B receptor; OTTHUMP00000164294; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B variant b; 5-HT(2B);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cavia porcellus (Guinea pig)
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Rat
- Rattus norvegicus (Rat)
- Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis)
- Zebrafish
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- In vitro E. coli expression system
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Flag
- SUMO
- Non
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | HTR2B-26027TH | Recombinant Human HTR2B | Wheat Germ | Non | 56 amino acids | |
Human | HTR2B-5335HCL | Recombinant Human HTR2B 293 Cell Lysate | HEK293 | Non | ||
Human | HTR2B-5243H | Recombinant Human HTR2B Protein, GST-tagged | Wheat Germ | GST | ||
Human | HTR2B-5684HF | Recombinant Full Length Human HTR2B Protein, GST-tagged | In Vitro Cell Free System | GST | 481 amino acids | |
Human | HTR2B-2707H | Recombinant Human HTR2B Full Length Transmembrane protein (1-481 aa), His-SUMO-tagged | In vitro E. coli expression system | His&SUMO | 1-481aa | |
Human | HTR2B-1091HFL | Recombinant Human HTR2B protein, His&Flag-tagged | HEK293 | His&Flag | 1-481 aa | |
Mouse | HTR2B-7933M | Recombinant Mouse HTR2B Protein | Mammalian Cell | His | ||
Mouse | HTR2B-4375M | Recombinant Mouse HTR2B Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi | ||
Mouse | HTR2B-4375M-B | Recombinant Mouse HTR2B Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | HTR2B-2963R | Recombinant Rat HTR2B Protein | Mammalian Cell | His | ||
Rat | HTR2B-2618R | Recombinant Rat HTR2B Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi | ||
Rat | HTR2B-2618R-B | Recombinant Rat HTR2B Protein Pre-coupled Magnetic Beads | HEK293 | |||
Cavia porcellus (Guinea pig) | RFL34021CF | Recombinant Full Length Guinea Pig 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-96) | |
Homo sapiens (Human) | RFL5388HF | Recombinant Full Length Human 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-481aa) | |
Rattus norvegicus (Rat) | RFL33072RF | Recombinant Full Length Rat 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-479) | |
Tetraodon fluviatilis (Green pufferfish) (Chelonodon fluviatilis) | RFL1319TF | Recombinant Full Length Tetraodon Fluviatilis 5-Hydroxytryptamine Receptor 2B(Htr2B) Protein, His-Tagged | E.coli expression system | His | Full Length (1-471) | |
Zebrafish | HTR2B-3901Z | Recombinant Zebrafish HTR2B | Mammalian Cell | His | ||
Chicken | HTR2B-5494C | Recombinant Chicken HTR2B | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
HTR2B involved in several pathways and played different roles in them. We selected most pathways HTR2B participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with HTR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Calcium signaling pathway | MLCK2;CHRNA7;SLC8A2B;PPP3CC;RYR3;SLC8A1;ATP2B2;ORAI1B;CAMK2D |
Neuroactive ligand-receptor interaction | F2RL1.2;P2RY1;GRIA1;DRD1B;TAAR11;CCKBR;NTSR1;LHBETA1;TRHRB |
Gap junction | TUBA1A;GUCY1B3;GNAI3;TUBAL3;GJD2;PRKCB;TUBA7L;MAPK1;EGFRA |
Serotonergic synapse | HTR3A;ALOX8;PLA2G4A;PTGS2;HTR1E;ALOX15B;CYP2J6;MAOA;MAPK1 |
Inflammatory mediator regulation of TRP channels | CAMK2B;CALM2;PRKCG;CYP2C50;CYP4A14;MAPK8;BDKRB2;TRPV2;CALML3 |
HTR2B has several biochemical functions, for example, G-protein alpha-subunit binding, GTPase activator activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HTR2B itself. We selected most functions HTR2B had, and list some proteins which have the same functions with HTR2B. You can find most of the proteins on our site.
Function | Related Protein |
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G-protein alpha-subunit binding | AGTR1A;RIC8B;F2R;HTR2A;F2RL1;DRD1A;RIC8A;NUCB1;RIC8 |
GTPase activator activity | AGFG1B;ALS2CL;RGS20;SGSM3;DOCK2;RAP1GDS1;CDC42EP4A;ALDH1A1;NF1 |
drug binding | SMO;RARB;PPARG;FNTB;CNR1;PDE4C;PPARA;TLR8;PPP3CA |
serotonin binding | MAOA;HTR3A;HTR2C;HTR2B;HTR1B;HTR2A;HTR1F;HTR1E |
serotonin receptor activity | HTR1AA;HTR3A;HTR1D;HTR3B;HTR2CL1;HTR1B;HTR1A;HTR2A;HTR6 |
HTR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HTR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of HTR2B.
MPDZ
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