MAPK11 Protein


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Official Full Name mitogen-activated protein kinase 11
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
Synonyms MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK11-1045H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged E.coli GST
    Human MAPK11-1134H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged Sf9 Insect Cell GST
    Human MAPK11-27606TH Recombinant Human MAPK11, His-tagged E.coli His
    Human MAPK11-29H Recombinant human biotinylated MAPK11, His-tagged E.coli His
    Human MAPK11-373H Recombinant Human MAPK11, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK11-4496HCL Recombinant Human MAPK11 293 Cell Lysate HEK293 N/A
    Human MAPK11-734H Recombinant Human Mitogen-activated Protein Kinase 11 E.coli N/A
    Human MAPK11-936H Recombinant Human Mitogen-Activated Protein Kinase 11, His-tagged Human His
    Mouse Mapk11-3939M Recombinant Mouse Mapk11 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse MAPK11-9527M Recombinant Mouse MAPK11 Protein Mammalian Cell His
    Chicken MAPK11-1375C Recombinant Chicken MAPK11 Mammalian Cell His
    Zebrafish MAPK11-327Z Recombinant Zebrafish MAPK11 Mammalian Cell His

    MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway PRKCI; GRIN2B; RALGDS; FGF14; FGF22; NGFR; CDC42; FGF3; FGF8; IGF1R
    FoxO signaling pathway SLC2A4; GRB2A; BCL6A; BRAF; TGFB1A; GRM1; MAPK12B; MAP2K2A; SGK2; SOD2
    Sphingolipid signaling pathway PRKCG; OPRD1; PIK3CG; PPP2R5C; TNFRSF1A; MAPK13; PIK3CD; LASS5; SPTLC3; TP53
    Adrenergic signaling in cardiomyocytes PPP1CBL; ACTC1B; CREB3L3L; PPP2R2CA; ATP2B4; PPP1CA; SCN5A; PRKACBB; ADRB2B; CALM1A
    VEGF signaling pathway HRASB; MAPKAPK3; KRAS; BAD; MAPK13; HSPB1; PPP3CC; RAC1A; RAF1A; MAPK12B
    Osteoclast differentiation cgr2b; TYK2; IFNG; LILRA2; TNFSF11; FCGR3A; IFNAR1; STAT1; AKT2; PPARG
    Signaling pathways regulating pluripotency of stem cells SKIL; SMAD9; AKT2; ID3; ZFHX3; MAP2K2; REST; NEUROG1; NRAS; PCGF6
    Platelet activation MAPK13; TBXA2R; TBXAS1; MYL12A; ITGB1; APBB1IP; PPP1R12A; ROCK1; MAPK11; GNAQ
    Toll-like receptor signaling pathway MAPK12B; TLR1LA; RIPK1L; IFNA7; MAP2K7; TLR9; IFNA17; IFNA5; IFNA8; FOS
    NOD-like receptor signaling pathway CXCL2; CASP5; NFKBIA; CARD9; MAP3K7IP3; Ccl12; SGUT1; TRIP6; MAPK9; NAIP6
    RIG-I-like receptor signaling pathway TRIM25; DDX3X; IFNA8; IL12BA; IFNA7; IFNA2; DDX58; TRADD; PIN1; IFNA14
    T cell receptor signaling pathway PDCD1; ZAP70; NFATC1; AKT2; DLG1; DBNLB; PIK3R5; PIK3R3; NFATC2; VAV3
    Fc epsilon RI signaling pathway MAPK11; MAP2K7; PRKCA; PDPK1; MAP2K3; GM-CSF; MAPK3; RAC3; PIK3CG; SYK
    TNF signaling pathway MAPK10; AKT1; ITCH; MAPK8; IL1B; CASP10; MAP2K1; CREB3L2; MLKL; MAP3K14
    Leukocyte transendothelial migration ARHGAP35; CLDN17; CYBB; NCF2; RAP1A; THY1; NCF1; NCF4; MYLPF; MAPK13
    Neurotrophin signaling pathway MAPK11; SORT1; PIK3CA; TP73; MAPKAPK2; BDNF; IRAK2; MAPK9; PIK3CB; PIK3R5
    Retrograde endocannabinoid signaling GNG3; GNB1; GNB2; GABRA1; ITPR1; GABRD; PRKCA; PLCB4; GNAI3; DAGLB
    Dopaminergic synapse PPP3CA; CALY; GNAO1; SLC18A1; CALM3; GNB3; GRIN2B; GNAQ; PPP2R2B; GNAI1
    Inflammatory mediator regulation of TRP channels TRPV4; MAP2K3; BDKRB1; PIK3CG; ACCN3; PLA2G4A; PIK3CB; MAPK9; PLCG2; CYP2J6
    GnRH signaling pathway CDC42L; MAP3K3; GNRHR1; MMP14; CAMK2B; CALM2B; ITPR3; PRKACAB; CACNA1D; GRB2B
    Progesterone-mediated oocyte maturation GNAIA; RPS6KA3A; PRKACAB; CPEB1; IGF1; HSP90AA1; CDC25A; CPEB3; IGF1RA; RAF1
    Prolactin signaling pathway MAPK1; INS; SOCS2; NEK3; MAPK8; SIRPA; SOCS6; MAPK9; MAPK3; CCND2
    Amyotrophic lateral sclerosis (ALS) TNFRSF1A; MAP2K3; GRIN1; MAPK11; CYCS; SLC1A2; GRIN2A; PPP3CB; TOMM40; ALS2
    Epithelial cell signaling in Helicobacter pylori infection JAM2; ATP6V1B2; TCIRG1; MAP3K14; IKBKB; ATP6V1E2; MAPK9; ATP6V1F; CXCR1; ATP6V0A4
    Shigellosis CTTN; DIAPH1; ABL1; PFN4; MAPK11; VCL; RHOG; ELMO1; RAC1; CDC42
    Salmonella infection RAC1B; RHOGB; CCL4; MAPK1; ROCK1; RHOG; RILP; IFNGR2; MAPK14B; WASLA
    Pertussis CALM4; IRF3; IL-8; TNF; MAPK13; Itgam&Itgb2; NLRP3; IRF8; AMCF-II; C5
    Leishmaniasis HLA-DPB1; TNF; CYBA; IL1A; ITGB2; IRAK4; TGFB2; PTPN6; HLA-DQA2; HLA-DOA
    Chagas disease (American trypanosomiasis) IKBKB; TLR2; TLR6; CD3E; CD3E; CD3D; FOS; C1QC; PIK3R5; C1QB; MYD88
    Toxoplasmosis TGFB3; TLR4; MAPK9; HLA-DRB4; HLA-DMA; LAMB3; LAMB2; TAB2; GNAO1; MAPK13
    Tuberculosis ATP6V0B; ATP6AP1; cgr2b; MAPK10; RFXANK; H2-AA; IFNA6; CLEC7A; FCGR3A; TLR9
    Hepatitis C CLDN20; IFNB1; IFNA7; TNFRSF1A; STAT2; EIF3E; DDX58; OAS3; CLDN9; MAPK9
    Epstein-Barr virus infection PSMC6; STAT3; TRAF5; LYN; HSPA6; GTF2E2; MAPK13; IRF3; EIF2AK4; EP300
    Proteoglycans in cancer SDC1; Casp3; TGFB1; CAMK2B; MAPK1; HCLS1; WNT10B; ITGAV; WNT3A; GPC1

    MAPK11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase activity MAPK15; MAPK12; MAPK14; NLK2; MAPK8B; MAPK13; MAPK6; MAPK3; MAPK12B; MAPK7
    protein binding JMJD6; NDFIP2; DPYSL4; ZKSCAN3; ZFC3H1; PRKACA; TTC32; DLX2; SCAMP1; BSCL2
    protein serine/threonine kinase activity CSNK1DA; SIK2; DMPK; HIPK4; GAK; NEK7; TAOK3; AKT2L; ADCK2; SGK3

    MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.


    Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
    Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).

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