MAPK11
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Official Full Name
mitogen-activated protein kinase 11
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Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase. -
Synonyms
MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin;
- Involved Pathway
- Protein Function
- Interacting Protein
- MAPK11 Related Articles
- MAPK11 Related Research Area
- MAPK11 Related Signal Pathway
MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | AKT2;NFATC1;FGFR2;PDGFRB;FGFR3;RPS6KA3;MAPK14A;CD14;RPS6KA6 |
| Rap signaling pathway | KIT;RAC2;FGF2;GNAI3;PDGFD;NGF;FGF3;ITGAL;PLCB4 |
| FoxO signaling pathway | INS;G6PCA.1;INSB;PRKAB1;MAP2K2B;AKT2;PIK3R3;MAPK1;PIK3CA |
| Sphingolipid signaling pathway | CERS5;MAPK1;PRKCE;PPP2R5E;SPTLC3;SGPP2;PPP2R2B;GNAI1;MAPK11 |
| Adrenergic signaling in cardiomyocytes | SLC14A2;BCL2;ADRA1BB;PPP2R5A;PRKACBB;CACNG7A;CREB3L1;CALM3B;CAMK2D1 |
| VEGF signaling pathway | CASP9;SRC;MAPK11;PLA2G4AA;PIK3CG;RAF1A;MAPK12A;PPP3R1B;RAC1A |
| Osteoclast differentiation | CALCR;IFNGR2;FCGR2A;NFATC1;TGFB1;PLCG2;FOSL1;PIK3CB;IL1B |
| Signaling pathways regulating pluripotency of stem cells | BMP4;RAF1;SMAD9;FGFR3;HRAS;PIK3R5;IGF1;INHBE;STAT3 |
| Platelet activation | AKT2;ARHGEF1;PIK3CD;COL27A1;LCP2;ORAI1;AKT1;PLCB4;GP1BB |
| Toll-like receptor signaling pathway | CXCL11;IFNA4;STAT1;AKT2L;AKT1;RAC1;IFNAR1;MAP2K7;LY96 |
| NOD-like receptor signaling pathway | NFKBIAB;MAPK1;MAPK3;NFKBIAA;TRAF6;MAPK12;MAPK8B;ERBB2IP;IKBKG |
| RIG-I-like receptor signaling pathway | TRAF6;IFNA2;TRAF2;FADD;MAPK9;IFNPHI3;MAPK10;IFNE;IFIH1 |
| T cell receptor signaling pathway | TNF;RHOA;MUC1;NRAS;NFKBIE;DBNLB;CD8B;NCK1;PAK1 |
| Fc epsilon RI signaling pathway | IL13;PIK3CD;MAP2K1;PLA2G4A;LAT;GAB2;TNF;INPP5D;MAP2K4 |
| TNF signaling pathway | TRAF3;SELE;RPS6KA4;LTA;TNFRSF1B;MAP2K3;MAP3K14;MAPK11;TRAF2 |
| Leukocyte transendothelial migration | MAPK12;PRKCG;ITGB2L;ARHGAP5;ICAM1;NCF2;CDC42;PLCG1;CLDN3 |
| Neurotrophin signaling pathway | MAPK9;CALML3;ARHGDIG;ABL1;PIK3CG;NTF4;RPS6KA2;MAP3K5;PSEN1 |
| Retrograde endocannabinoid signaling | GABRG3;MAPK3;PRKCG;GNG2;GABRB3;MAPK10;GABRA3;PLCB3;PRKCA |
| Dopaminergic synapse | KCNJ6;PPP2R1B;ARRB2;CREB3L2;GNAI2;GNG12;PPP2R5B;GRIA1;GRIA4 |
| Inflammatory mediator regulation of TRP channels | HTR2A;PIK3R2;PLCG2;CAMK2G;PLA2G4C;HRH1;PIK3CB;IL1B;PRKACA |
| GnRH signaling pathway | MAP3K1;MAP3K3;GRB2;MAPK13;MAP2K2B;HRAS;PLD1;MAP2K1;GNRHR2 |
| Progesterone-mediated oocyte maturation | MAPK1;ANAPC4;MAD1L1;PRKACBA;RPS6KA3;INS;MAD2L1;ARAF;AKT2L |
| Prolactin signaling pathway | PIK3CD;MAP2K2;FOS;PRL;RELA;PPIB;PRP2;GALT;PIK3R1 |
| Amyotrophic lateral sclerosis (ALS) | Casp3;PRPH;CYCS;GPX1;MAPK11;GRIN1;MAP2K6;PPP3CA;CASP12 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V1C1;ATP6V0E1;RAC1;ATP6V1H;ATP6V1B2;PLCG2;ATP6V0D1;MAP3K14;ATP6V0A1 |
| Shigellosis | WASF1;WAS;NFKBIA;ACTG1;ACTB;MAD2L2;NFKB1;ATG5;IKBKB |
| Salmonella infection | IFNGR2;PFN1;IL18;MAPK12;CCL3L3;KLC1A;ACTB1;RAB7B;WASLA |
| Pertussis | IL12B;IRF3;ITGB2;ITGA5;AMCF-II;CALML5;NFKB1;CALM1;Hc |
| Leishmaniasis | FCGR1;FCGR3A;HLA-DQA1;TGFB2;IL12A;TNF;FOS;NOS2;MAPK11 |
| Chagas disease (American trypanosomiasis) | IL10;CD3E;BDKRB2;GNAS;MAPK1;CD3D;TNF;C1QB;FASLG |
| Toxoplasmosis | LAMB2;IKBKG;PDPK1;STAT3;TGFB2;TGFB1;HLA-DQA2;HLA-DMA;GNAI1 |
| Tuberculosis | HLA-DRA;Pla2r1;PPP3CA;IFNA7;CAMK2A;IL1B;Il23a;CD14;FADD |
| Hepatitis C | IRF7;PIK3R1;EIF2AK3;EIF2AK4;CLDN9;LDLR;MAPK12;TNFRSF1A;CLDN8 |
| Influenza A | Ifna15;MAPK13;IFIH1;CCL2;TMPRSS2;CASP1;MAP2K4;NFKBIA;IL1B |
| Epstein-Barr virus infection | TAB1;NFKB1;PIK3R5;STAT3;HDAC4;CD40;PSMC4;POLR3C;MAPK11 |
| Proteoglycans in cancer | ITGB5;CAMK2A;Fasl;PRKACA;MAPK3;WNT5A;PIK3R5;NANOG;PRKACG |
MAPK11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | TTLL1;RIMKLA;HSPA6;RPS6KB1B;CFTR;HELLS;UBE2S;CHD4;P2RX3 |
| MAP kinase activity | NLK;MAPK7;MAPK12;NLK2;MAPK14B;MAPK6;MAPK11;MAPK14A;MAPK1 |
| protein binding | MAD1L1;ODF1;ACTN3;TBC1D20;STAT5B;DOK2;KCNJ6;WFS1;AGPS |
| protein serine/threonine kinase activity | PLK3;CAMK2D;STK32C;RAF1B;MAP3K10;CLK2;TAF1L;AAK1;BCR |
MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.
MAPK14; MAPKAPK3; ZNHIT1; TP53; ATF2; ATF2; TAB1; SOCS3; CPNE6; POLR3D; C9orf78; OBSL1; KRT1; SP1; MYB; VARS
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