• Official Full Name

    mitogen-activated protein kinase 11

  • Background

    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
  • Synonyms

    MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • N/A
    • No tag
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken MAPK11-1375C Recombinant Chicken MAPK11 Mammalian Cell His
    Human MAPK11-4496HCL Recombinant Human MAPK11 293 Cell Lysate HEK293 N/A
    Human MAPK11-734H Recombinant Human Mitogen-activated Protein Kinase 11 E.coli N/A
    Human MAPK11-373H Recombinant Human MAPK11, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK11-29H Recombinant human biotinylated MAPK11, His-tagged E.coli His
    Human MAPK11-27606TH Recombinant Human MAPK11, His-tagged E.coli His
    Human MAPK11-1084H Recombinant Human MAPK11 Protein (S2-Q364), Tag Free Insect Cell No tag
    Human MAPK11-1045H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged E.coli GST
    Human MAPK11-1085H Recombinant Human MAPK11 Protein (S2-Q364), GST tagged Insect Cell GST
    Human MAPK11-1134H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged Sf9 Insect Cell GST
    Human MAPK11-936H Recombinant Human Mitogen-Activated Protein Kinase 11, His-tagged Human His
    Mouse MAPK11-5344M Recombinant Mouse MAPK11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse MAPK11-9527M Recombinant Mouse MAPK11 Protein Mammalian Cell His
    Mouse MAPK11-5344M-B Recombinant Mouse MAPK11 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Mapk11-3939M Recombinant Mouse Mapk11 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Zebrafish MAPK11-327Z Recombinant Zebrafish MAPK11 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • MAPK11 Related Articles
    • MAPK11 Related Research Area
    • MAPK11 Related Signal Pathway

    MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathwayKIT;RAC2;FGF2;GNAI3;PDGFD;NGF;FGF3;ITGAL;PLCB4
    FoxO signaling pathwayINS;G6PCA.1;INSB;PRKAB1;MAP2K2B;AKT2;PIK3R3;MAPK1;PIK3CA
    Sphingolipid signaling pathwayCERS5;MAPK1;PRKCE;PPP2R5E;SPTLC3;SGPP2;PPP2R2B;GNAI1;MAPK11
    Adrenergic signaling in cardiomyocytesSLC14A2;BCL2;ADRA1BB;PPP2R5A;PRKACBB;CACNG7A;CREB3L1;CALM3B;CAMK2D1
    Osteoclast differentiationCALCR;IFNGR2;FCGR2A;NFATC1;TGFB1;PLCG2;FOSL1;PIK3CB;IL1B
    Signaling pathways regulating pluripotency of stem cellsBMP4;RAF1;SMAD9;FGFR3;HRAS;PIK3R5;IGF1;INHBE;STAT3
    Platelet activationAKT2;ARHGEF1;PIK3CD;COL27A1;LCP2;ORAI1;AKT1;PLCB4;GP1BB
    Toll-like receptor signaling pathwayCXCL11;IFNA4;STAT1;AKT2L;AKT1;RAC1;IFNAR1;MAP2K7;LY96
    NOD-like receptor signaling pathwayNFKBIAB;MAPK1;MAPK3;NFKBIAA;TRAF6;MAPK12;MAPK8B;ERBB2IP;IKBKG
    RIG-I-like receptor signaling pathwayTRAF6;IFNA2;TRAF2;FADD;MAPK9;IFNPHI3;MAPK10;IFNE;IFIH1
    T cell receptor signaling pathwayTNF;RHOA;MUC1;NRAS;NFKBIE;DBNLB;CD8B;NCK1;PAK1
    Fc epsilon RI signaling pathwayIL13;PIK3CD;MAP2K1;PLA2G4A;LAT;GAB2;TNF;INPP5D;MAP2K4
    TNF signaling pathwayTRAF3;SELE;RPS6KA4;LTA;TNFRSF1B;MAP2K3;MAP3K14;MAPK11;TRAF2
    Leukocyte transendothelial migrationMAPK12;PRKCG;ITGB2L;ARHGAP5;ICAM1;NCF2;CDC42;PLCG1;CLDN3
    Neurotrophin signaling pathwayMAPK9;CALML3;ARHGDIG;ABL1;PIK3CG;NTF4;RPS6KA2;MAP3K5;PSEN1
    Retrograde endocannabinoid signalingGABRG3;MAPK3;PRKCG;GNG2;GABRB3;MAPK10;GABRA3;PLCB3;PRKCA
    Dopaminergic synapseKCNJ6;PPP2R1B;ARRB2;CREB3L2;GNAI2;GNG12;PPP2R5B;GRIA1;GRIA4
    Inflammatory mediator regulation of TRP channelsHTR2A;PIK3R2;PLCG2;CAMK2G;PLA2G4C;HRH1;PIK3CB;IL1B;PRKACA
    GnRH signaling pathwayMAP3K1;MAP3K3;GRB2;MAPK13;MAP2K2B;HRAS;PLD1;MAP2K1;GNRHR2
    Progesterone-mediated oocyte maturationMAPK1;ANAPC4;MAD1L1;PRKACBA;RPS6KA3;INS;MAD2L1;ARAF;AKT2L
    Prolactin signaling pathwayPIK3CD;MAP2K2;FOS;PRL;RELA;PPIB;PRP2;GALT;PIK3R1
    Amyotrophic lateral sclerosis (ALS)Casp3;PRPH;CYCS;GPX1;MAPK11;GRIN1;MAP2K6;PPP3CA;CASP12
    Epithelial cell signaling in Helicobacter pylori infectionATP6V1C1;ATP6V0E1;RAC1;ATP6V1H;ATP6V1B2;PLCG2;ATP6V0D1;MAP3K14;ATP6V0A1
    Salmonella infectionIFNGR2;PFN1;IL18;MAPK12;CCL3L3;KLC1A;ACTB1;RAB7B;WASLA
    Chagas disease (American trypanosomiasis)IL10;CD3E;BDKRB2;GNAS;MAPK1;CD3D;TNF;C1QB;FASLG
    Epstein-Barr virus infectionTAB1;NFKB1;PIK3R5;STAT3;HDAC4;CD40;PSMC4;POLR3C;MAPK11
    Proteoglycans in cancerITGB5;CAMK2A;Fasl;PRKACA;MAPK3;WNT5A;PIK3R5;NANOG;PRKACG

    MAPK11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase activityNLK;MAPK7;MAPK12;NLK2;MAPK14B;MAPK6;MAPK11;MAPK14A;MAPK1
    protein bindingMAD1L1;ODF1;ACTN3;TBC1D20;STAT5B;DOK2;KCNJ6;WFS1;AGPS
    protein serine/threonine kinase activityPLK3;CAMK2D;STK32C;RAF1B;MAP3K10;CLK2;TAF1L;AAK1;BCR

    MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.


    Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
    Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).
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