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Official Full Name mitogen-activated protein kinase 11
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
Synonyms MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin
    • Type:
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK11-1045H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged E.coli GST
    Human MAPK11-1134H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged Sf9 Insect Cell GST
    Human MAPK11-27606TH Recombinant Human MAPK11, His-tagged E.coli His
    Human MAPK11-29H Recombinant human biotinylated MAPK11, His-tagged E.coli His
    Human MAPK11-373H Recombinant Human MAPK11, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK11-4496HCL Recombinant Human MAPK11 293 Cell Lysate HEK293 N/A
    Human MAPK11-734H Recombinant Human Mitogen-activated Protein Kinase 11 E.coli N/A
    Human MAPK11-936H Recombinant Human Mitogen-Activated Protein Kinase 11, His-tagged Human His
    Mouse MAPK11-9527M Recombinant Mouse MAPK11 Protein Mammalian Cell His
    Chicken MAPK11-1375C Recombinant Chicken MAPK11 Mammalian Cell His
    Zebrafish MAPK11-327Z Recombinant Zebrafish MAPK11 Mammalian Cell His

    mapk11 involved in several pathways and played different roles in them. We selected most pathways mapk11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with mapk11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PRKACG; KRAS; PPP3R2; RAC3A; NFKB1; FGF8A; CACNA1D; HSP70L; CACNA2D1; NGF
    Rap signaling pathway FGF14; FGF6; FGFR2; HRAS; VAV2; PIK3CD; FLT4; ITGB3; FGF9; PLCB3
    FoxO signaling pathway GRB2A; SGK2A; INS; CDKN1BB; Fasl; MAPK9; HOMER2; AKT2L; MAPK8; TGFB1A
    Sphingolipid signaling pathway SPHK1; GNAI2; PPP2R2B; RAC3; S1PR5; BAX; TNF; PPP2R5A; PLD2; PIK3CB
    Adrenergic signaling in cardiomyocytes PPP2R2A; ATP1B2A; GNAQ; ATP1B3; TNNC1B; PPP2R5EA; MAPK13; CAMK2G; CALML3; CREB3L3
    VEGF signaling pathway PLA2G4A; PTGS2; BADB; CDC42; RAC1A; PPP3CA; HRAS; VEGFAA; CASP9; KRAS
    Osteoclast differentiation CYBB; FOSL1; CAMK4; RAC1; FCGR3B; FYN; LILRA4; LILRA2; NOX3; ACP5
    Signaling pathways regulating pluripotency of stem cells WNT6; SMAD4; HNF1A; ONECUT1; PCGF5; AKT2; JARID2; LHX5; PAX6; INHBA
    Platelet activation F2R; ACTB; MYLK4; ITPR1; MYL12A; PLA2G4A; RAP1B; PRKCI; TBXA2R; ROCK2
    Toll-like receptor signaling pathway RELA; LY96; CXCL9; MAPK14B; IFNB1; IFNA12; MAPK8B; TLR5; IL12A; MAP3K7
    NOD-like receptor signaling pathway IKBKB; MAP3K7; ERBB2IP; RELA; MAPK12B; CCL5; HSP90AB1; TAB2; TNFAIP3; TRIP6
    RIG-I-like receptor signaling pathway RIPK1L; IFNA12; MAPK11; NFKB1; MAPK14A; CASP8; NFKBIAA; IFNA5; TP-1; IFNA16
    T cell receptor signaling pathway PAK7; PPP3CA; DBNLB; CD4; VAV3; NFATC1; MAPK1; AKT1; NFKBIA; CBLB
    Fc epsilon RI signaling pathway PLA2G4C; PLA2G4B; SOS1; RAC1; LAT; MAPK3; VAV2; PDPK1; IL4; MAPK11
    Leukocyte transendothelial migration VCL; MAPK11; Itgam&Itgb2; MYL7; GNAI3; GNAI1; RAC1; CLDN2; PIK3R3; PRKCG
    Neurotrophin signaling pathway NTRK1; CALM4; NFKB1; SH2B3; ZFP110; PLCG2; SHC3; RAPGEF1; MAP2K1; RPS6KA5
    Retrograde endocannabinoid signaling PTGS2; PLCB2; GNAI1; MAPK1; GNG12; PRKACA; GNG3; GRIA1; DAGLB; GNG4
    Dopaminergic synapse PLCB4; PPP1CA; GNGT2; GNB2; AKT1; GRIA3; COMT; CREB3L2; MAPK11; MAOA
    Inflammatory mediator regulation of TRP channels PPP1CC; PIK3R5; NGF; MAP2K6; ASIC2; PIK3CB; PLA2G6; CAMK2B; ITPR1; HRH1
    GnRH signaling pathway MAPK13; GRB2A; GRB2; EGFRA; ADCY1B; CALM2A; CGNRH-R; GNA11A; CAMK2D; MMP14A
    Progesterone-mediated oocyte maturation CCNA2; BUB1; AKT2L; ADCY1B; CCNB1; PRKACAB; HSP90AA1.2; RPS6KA3; PIK3R3A; PIK3R5
    Prolactin signaling pathway MAP2K2; SOCS1; SHC4; FOS; PIK3CG; PRP2; INS2; LHB; PIK3CA; SOCS2
    Amyotrophic lateral sclerosis (ALS) MAP2K3; MAP2K6; GRIN2C; NEFM; GRIN2A; MAPK14; CAT; PPP3CB; TOMM40L; BAD
    Epithelial cell signaling in Helicobacter pylori infection ATP6V0D2; IKBKB; MAP2K4; F11R; MAPK9; MET; MAPK10; TCIRG1; MAPK8; MAPK13
    Shigellosis CTTN; PFN2; MAPK3; NFKBIA; RELA; PFN4; MAPK12; VCL; ROCK1; PFN3
    Salmonella infection MAPK14A; CCL4L2; ARPC5LB; RAB7B; MAPK1; PFN3; MYD88; IL6; CDC42; IL1B
    Pertussis MAPK9; CXCL5; MAPK11; IL1A; RHOA; CALM4; GM5077; IRAK4; C1R; GNAI1
    Leishmaniasis FCGR3; ELK1; PTPN6; TLR4; MAPK3; IL1A; TLR2; TGFB1; NCF4; NFKB1
    Chagas disease (American trypanosomiasis) IFNB1; CD3D; RELA; MAPK8; IL10; PIK3CA; FADD; NFKB1; PIK3R5; GNA15
    Toxoplasmosis Toxoplasma Gondii Major Surface Antigen P30; IL10RB; ITGB1; Casp3; TAB2; MAP3K7; BIRC7; HSPA1A; GNAI1; PIK3R5
    Tuberculosis RELA; TNFRSF1A; CD14; MAPK8; CARD9; BCL10; IFNGR2; RAB5B; TLR4; PPP3CC
    Hepatitis C TRAF2; RAF1; PIK3CD; TRAF3; IFNB1; CLDN14; EIF2AK4; MAPK8; IFN-a; AKT2
    Epstein-Barr virus infection SPI1; HSPA1L; RBPJ; PSMD12; PSMC5; PSMD11; CD44; RB1; POLR2C; HLA-DRB5
    Proteoglycans in cancer MMP2; PIK3R5; Fzd4; TLR4; HPSE2; IGF1; ITPR1; WNT7A; FGF2; PXN

    mapk11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by mapk11 itself. We selected most functions mapk11 had, and list some proteins which have the same functions with mapk11. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase activity MAPK11; MAPK8A; MAPK14A; MAPK12; NLK1; MAPK8B; MAPK7; MAPK14; MAPK12A; MAPK3
    protein binding ABCF3; KCNA3; GNGT1; TEF; GRAP; ZNF593; RP2; TNS1; HES1; ZNF317
    protein serine/threonine kinase activity ULK2; PAK6; AKT1; STK32C; RPS6KA3B; DYRK1A; PAK4; NEK2; MAPK12B; SRPK3

    mapk11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mapk11 here. Most of them are supplied by our site. Hope this information will be useful for your research of mapk11.


    Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
    Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).

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