MAPK11 Protein

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MAPK11

Official Full Name	mitogen-activated protein kinase 11
Background	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
Synonyms	MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin

Species :
Chicken
Human
Mouse
Zebrafish

Source :
E.coli
HEK293
HEK293T
Human
Mammalian Cell
Sf9 Insect Cell

Tag :
GST
His
Myc/DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	MAPK11-1045H	Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged	E.coli	GST	Inquiry
Human	MAPK11-1134H	Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged	Sf9 Insect Cell	GST	Inquiry
Human	MAPK11-27606TH	Recombinant Human MAPK11, His-tagged	E.coli	His	Inquiry
Human	MAPK11-29H	Recombinant human biotinylated MAPK11, His-tagged	E.coli	His	Inquiry
Human	MAPK11-373H	Recombinant Human MAPK11, GST-tagged, Active	Sf9 Insect Cell	GST	Inquiry
Human	MAPK11-734H	Recombinant Human Mitogen-activated Protein Kinase 11	E.coli	N/A	Inquiry
Human	MAPK11-936H	Recombinant Human Mitogen-Activated Protein Kinase 11, His-tagged	Human	His	Inquiry
Mouse	MAPK11-9527M	Recombinant Mouse MAPK11 Protein	Mammalian Cell	His	Inquiry
Chicken	MAPK11-1375C	Recombinant Chicken MAPK11	Mammalian Cell	His	Inquiry
Zebrafish	MAPK11-327Z	Recombinant Zebrafish MAPK11	Mammalian Cell	His	Inquiry
Human	MAPK11-4496HCL	Recombinant Human MAPK11 293 Cell Lysate	HEK293	N/A	Inquiry
Human	MAPK11-2038HF	Recombinant Full Length Human MAPK11 Protein, GST-tagged	E.coli	GST	Inquiry
Mouse	Mapk11-3939M	Recombinant Mouse Mapk11 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry

Involved Pathway Protein Function Interacting Protein MAPK11 Related Articles

MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	TRAF2; TAB2; PTPN7; RPS6KA1; PPP3CA; GADD45BA; MAPK12B; HSPB1; MAPK1; SRF
Rap signaling pathway	PIK3R5; PIK3R1; FGF11; INS2; PFN2; PRKCB; GRIN2A; PIK3CB; FGF10; CALM3
FoxO signaling pathway	GABARAP; MAPK10; RAF1; GRB2; INS2; HOMER3; RBL2; SMAD3A; TGFB1A; CDKN2D
Sphingolipid signaling pathway	MAPK13; GNAI2; TRADD; PPP2R2A; PPP2R3A; CERS5; PPP2R2B; MAPK10; NFKB1; BAX
Adrenergic signaling in cardiomyocytes	GNAQ; ADRB2; CACNA1DA; PPP2R1B; MAPK14B; PPP2R5E; PPP2R5A; PIK3CD; CAMK2A; CAMK2B
VEGF signaling pathway	RAF1A; MAPK14B; MAPK12; PTK2AB; RAC3A; CDC42L2; RAF1B; RAC1A; PLA2G4C; AKT3A
Osteoclast differentiation	SIRPA; FCGR2C; TNFRSF1A; MAP2K1; SFPI1; IKBKG; MAPK8; CSF1; PPP3CB; PPP3R1
Signaling pathways regulating pluripotency of stem cells	PCGF3; WNT7A; BMPR2; ZIC3; ESX1; SMARCAD1; FGFR4; WNT9A; MAPK12; ID3
Platelet activation	GP6; COL27A1; GNAQ; AKT1; MAPK13; PIK3R2; PIK3CB; ITGA2B; PTGS1; MYLK2
Toll-like receptor signaling pathway	LY96; IFNPHI3; MAPK12B; IKBKB; PIK3R5; PIK3R3A; MAP3K7; TOLLIP; MAPK8A; IRF7
NOD-like receptor signaling pathway	TNFAIP3; ERBB2IP; BIRC2; TAB2; NFKBIB; CARD18; NLRP1; TNF; IL1B; NLRP3
RIG-I-like receptor signaling pathway	TRADD; TNF; IFNA17; IRF3; IFNA12; MAVS; DAK; TMEM173; RNF207B; OTUD5
T cell receptor signaling pathway	PTPRC; VAV2; CD28; EVLB; PIK3R3; PAK3; AKT1; PIK3CB; PTPN6; TEC
Fc epsilon RI signaling pathway	PIK3CG; AKT1; FCER1G; PIK3R3; RAC3; PLCG1; IL13; IL3; PIK3CD; HRAS
TNF signaling pathway	IL1B; SELE; AKT2; VCAM1; MAPK1; MMP9; TRAF5; BIRC3; PIK3CA; RIPK1
Leukocyte transendothelial migration	GNAI3; PTK2; MYL5; F11R; PRKCG; VCL; ACTB; MSN; CXCL12; CLDN11
Neurotrophin signaling pathway	MAGED1; NTRK2; MAPK13; MAPK10; FOXO3; NTF4; PTPN11; NFKBIE; RAP1B; Fasl
Retrograde endocannabinoid signaling	GNG4; FAAH; GNB2; GNGT1; MAPK13; GNG2; RIMS1; GNG10; GRIA1; GABRB1
Dopaminergic synapse	GNAS; SLC18A1; CREB3L1; CREB5; PPP2CA; MAPK11; PPP1CB; CALM2; GNGT1; PLCB2
Inflammatory mediator regulation of TRP channels	GNAQ; MAP2K3; ITPR3; HRH1; PPP1CB; TRPA1; PLCB1; PLCG1; CAMK2A; MAPK11
GnRH signaling pathway	MAPK8; PRKACA; ATF4; KRAS; GNAQ; CAMK2G1; Adcy4; CALM2B; MAPK10; MAPK1
Progesterone-mediated oocyte maturation	PGR; CCNB2; MAP2K1; RAF1; PIK3CA; CDC25B; KRAS; CCNB1; HSP90AB1; ANAPC7
Prolactin signaling pathway	NFKB1; MAPK12; INS1; FOS; GSK3B; SOCS6; STAT5A; HRAS; PIK3CD; LHB
Amyotrophic lateral sclerosis (ALS)	GRIN2B; NEFH; APAF1; BCL2L1; GRIN2D; TRP53; SOD1; BCL2; GPX1; MAP2K3
Epithelial cell signaling in Helicobacter pylori infection	NFKB1; RAC1; JAM2; GIT1; ATP6V1F; CCL5; ATP6V0D1; SRC; ATP6V1C2; MAP3K14
Shigellosis	VCL; MAPK10; MAPK3; WASL; ROCK2; MAPK13; MAPK11; MAPK9; SRC; HCLS1
Salmonella infection	IFNG; TLR4; DYNC2H1; IFNGR2; ACTB2; PFN3; KLC1B; TLR4BB; CXCL1; NOS2
Pertussis	IL12B; LY96; IRAK1; C4A; MAPK13; CALM2; C4BPB; Il23a; Il12b; MAPK1; IRF8
Leishmaniasis	MAPK1; TGFB3; IFNG; HLA-DRB1; CYBA; FCGR3B; MARCKSL1; IL1B; FCGR4; PTGS2
Chagas disease (American trypanosomiasis)	MAPK12; MYD88; TLR9; ACE; IL12B; CXCL8; C3; PIK3R1; SMAD3; TLR2
Toxoplasmosis	MAP2K6; PIK3R5; HSPA1L; Toxoplasma Gondii Dense Granule Protein 7; HLA-DQA2; MAPK10; IRAK4; HLA-DRB3; IL10RA; PIK3R3
Tuberculosis	CASP8; NFYA; IFNA13; VDR; RFXANK; FADD; CD209; PPP3R1; CALM3; IRAK2
Hepatitis C	IFNA21; CD81; IFNA10; CLDN22; PDPK1; CLDN2; CLDN4; IFNA7; TRAF6; TNF
Influenza A	CASP9; IFNGR2; IFN-a; CXCL10; IFNB; PIK3CA; PRSS3; HLA-DRA; PABPN1L; DDX39B
Epstein-Barr virus infection	PSMD4; PSMD6; HLA-DRB5; PIK3CG; POLR2J3; CD40; ICAM1; POLR2K; TP53; MAPK13
Proteoglycans in cancer	HIF1A; HPSE2; MAPK3; GAB1; ERBB2; TIMP3; GRB2; CD44; PPP1CC; WNT6

MAPK11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	VSIG8B; FICD; NMRK2; TSSK2; MAT2AL; CSNK1G2B; CDK6; NPR1; DAPK1; AK9
MAP kinase activity	MAPK13; MAPK3; MAPK1; NLK1; MAPK14; MAPK12A; NLK2; MAPK6; MAPK15; MAPK8B
protein binding	TMEM106C; PCOLCE; KISS1R; PAIP1; ZHX3; CEBPA; RABGAP1; YWHAZ; LDHB; MPZL1L
protein serine/threonine kinase activity	MAP2K7; RIPK3; DAPK3; ALPK1; PIM2; CAMK2D1; NLK1; KALRN; ALPK2; MELK

MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.

MAPK14; MAPKAPK3; ZNHIT1; TP53; ATF2; ATF2; TAB1; SOCS3; CPNE6; POLR3D; C9orf78; OBSL1; KRT1; SP1; MYB; VARS

Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).

Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).

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