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Official Full Name mitogen-activated protein kinase 11
Background The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for;multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,;differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase,;both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through;its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown;to be a substrate of this kinase.
Synonyms MAPK11; mitogen-activated protein kinase 11; PRKM11; p38 2; p38Beta; SAPK2; MAPK 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase 2; stress-activated protein kinase-2; stress-activated protein kinase 2b; stress-activated protein kin
    • Species :
    • Chicken
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAPK11-1045H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged E.coli GST
    Human MAPK11-1134H Recombinant Human Mitogen-Activated Protein Kinase 11, GST-tagged Sf9 Insect Cell GST
    Human MAPK11-27606TH Recombinant Human MAPK11, His-tagged E.coli His
    Human MAPK11-29H Recombinant human biotinylated MAPK11, His-tagged E.coli His
    Human MAPK11-373H Recombinant Human MAPK11, GST-tagged, Active Sf9 Insect Cell GST
    Human MAPK11-4496HCL Recombinant Human MAPK11 293 Cell Lysate HEK293 N/A
    Human MAPK11-734H Recombinant Human Mitogen-activated Protein Kinase 11 E.coli N/A
    Human MAPK11-936H Recombinant Human Mitogen-Activated Protein Kinase 11, His-tagged Human His
    Mouse Mapk11-3939M Recombinant Mouse Mapk11 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse MAPK11-9527M Recombinant Mouse MAPK11 Protein Mammalian Cell His
    Chicken MAPK11-1375C Recombinant Chicken MAPK11 Mammalian Cell His
    Zebrafish MAPK11-327Z Recombinant Zebrafish MAPK11 Mammalian Cell His

    MAPK11 involved in several pathways and played different roles in them. We selected most pathways MAPK11 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway PPP3CCA; FGF13A; FAS; MAP2K7; TGFBR2; PRKACAB; RAF1B; GADD45B; RRAS2; TGFB1
    Rap signaling pathway PIK3R3; GNAI1; VEGFC; GNAS; ACTG1; RAC2; PARD6A; PDGFA; Fgf15; INS
    FoxO signaling pathway PTENB; USP7; FOXG1A; HOMER2; Fasl; AKT2; PRKAG3B; SMAD3A; MAP2K2; PTEN
    Sphingolipid signaling pathway TRP53; AKT1; SGMS1; SGPP2; SPTLC1; LASS2; NRAS; PPP2CA; MS4A2; GNAQ
    Adrenergic signaling in cardiomyocytes PLCB3; ADCY7; ATP1B1A; CACNG7; ADCY1A; CALM4; ATP1A4; CACNG3; MYL2B; SCN4BA
    VEGF signaling pathway MAPK13; MAP2K2A; PTK2; CDC42; PPP3CCA; PIK3CD; PPP3CCB; MAPKAPK2A; CDC42L2; PTK2AA
    Osteoclast differentiation SIRPB1; GRB2; NFATC2; IKBKB; TYROBP; IFNB1; NCF4; PPP3R2; LCP2; TNFRSF11A
    Signaling pathways regulating pluripotency of stem cells PIK3R3; ID2; WNT11; AXIN1; ID4; LEFTY2; SMAD2; KRAS; PCGF2; AXIN2
    Platelet activation GNAS; ITPR1; ACTB; VAMP8; MAPK3; ARHGEF12; SNAP23; PIK3CB; VWF; P2RY12
    Toll-like receptor signaling pathway TRAF3; FOS; TLR4BB; TLR1LB; IFNB1; MAPK12A; TLR1; MAPK1; MAP2K2B; IFNA13
    NOD-like receptor signaling pathway HSP90AA1.1; IL18; IKBKG; HSP90AA1; CASP5; IL1B; CXCL8B.3; MAPK10; IL8L2; MAPK14A
    RIG-I-like receptor signaling pathway ISG15; NFKBIB; IFNA12; TRAF3; IL8L1; IFNW1; IKBKE; IFNA6; MAPK12; NFKBIAB
    T cell receptor signaling pathway MAPK11; CD247; IFNG; PPP3CB; NFKBIA; PAK7; CD8A; TEC; MAPK12; CBLB
    Fc epsilon RI signaling pathway FCER1A; VAV3; PLCG1; PLA2G4B; PLA2G4F; MAPK13; MAP2K1; MAPK12; MAP2K7; PDPK1
    TNF signaling pathway MAPK10; LIF; CCL20; PIK3CD; MMP14; PIK3CB; CFLAR; CASP10; IL18R1; FOS
    Leukocyte transendothelial migration CLDN22; NCF4; NCF2; ACTN4; PTK2B; CLDN15; RHOA; NOX3; VAV2; ITGB2
    Neurotrophin signaling pathway MAPK12; ARHGDIG; NTRK2; HRAS; SHC1; CALML3; PIK3CG; MAPK13; IRS1; ZFP110
    Retrograde endocannabinoid signaling GNG11; GABRA1; GRIA3; MAPK9; GRM5; DAGLB; GABRQ; GNG3; GNB4; GABRG3
    Dopaminergic synapse GNGT2; DDC; GNG11; ARNTL; DRD5; PPP2CB; PPP2R5E; CREB3; CLOCK; AKT2
    Inflammatory mediator regulation of TRP channels MAPK10; CYP2C37; CYP2C54; ASIC1; CAMK2G; PRKACA; NTRK1; PLA2G4A; PIK3R3; CYP4A10
    GnRH signaling pathway CALM2; MAP2K4A; PLD1; MAPK8; MAP3K2; GNRHR4; PLCB2; PLA2G4D; MMP2; PRKCDA
    Progesterone-mediated oocyte maturation GNAI3; CDH1-A; PIK3CD; AKT2L; MAPK12; HSP90AA1.1; IGF1RA; RPS6KAL; MAPK12A; AKT2
    Prolactin signaling pathway SRC; MAP2K1; PIK3CG; PIK3R3; MAPK1; SOCS1; SOCS3; PRP2; FOXO3; LHB
    Amyotrophic lateral sclerosis (ALS) CCS; BAD; BAX; MAP2K3; PPP3R1; DERL1; MAPK13; PPP3CC; NEFM; BCL2L1
    Epithelial cell signaling in Helicobacter pylori infection MAPK12; CCL5; IL-8; ATP6V1E2; ATP6V1F; TJP1; PLCG2; NFKBIA; CXCL1; ATP6AP1
    Shigellosis HCLS1; ACTB; VCL; RAC1; CD44; IKBKB; IL-8; CTTN; ATG5; RHOG
    Salmonella infection WASF1; IL-8; IFNG1-2; MAPK10; TLR5B; ARPC5L; RAC1B; DYNC2H1; KLC1B; NOS2
    Pertussis FOS; CASP1; IRAK4; GM5077; C4BP; GNAI3; ITGB1; IRF8; CD14; IRAK1
    Leishmaniasis IRAK1; HLA-DRB1; MYD88; CYBA; HLA-DRB4; FCGR4; PTGS2; PRKCB; TLR4; TGFB3
    Chagas disease (American trypanosomiasis) SERPINE1; IRAK1; AKT1; IL-8; LOC100033925; CFLAR; PLCB3; IFNGR2; CD3E; CD3D; GNAS
    Toxoplasmosis PIK3CD; TGFB2; NFKB1; IRGM; TGFB3; MAPK9; LAMA1; IKBKG; GNAI3; IL12B
    Tuberculosis Il23a; HLA-DMB; LBP; STAT1; LAMP1; FCGR1A; CAMK2G; CALM4; ATP6V0B; IFNA10
    Hepatitis C IFNA1; CLDN11; OAS3; IFNA7; EIF3E; IFNAR1; IFNA14; TRP53; IFNAR2; IFNA10
    Influenza A IL1A; CASP1; IFNA6; KPNA2; EP300; HSPA8; BMA1; IKBKB; IFNA3; CXCL10
    Epstein-Barr virus infection CCNA1; HSPA1L; TBK1; TYK2; POLR3K; POLR2B; GTF2E2; PSMC3; STAT3; YWHAZ
    Proteoglycans in cancer HSPB2; IGF1R; CAMK2A; AKT2; IGF2; ARHGEF12; CBLC; DROSHA; ARAF; GPC1

    MAPK11 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK11 itself. We selected most functions MAPK11 had, and list some proteins which have the same functions with MAPK11. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MAPK14B; DHX15; Abca2; OXSR1A; TWF2; FARSA; ATAD1B; MYO1F; HSP90AA1; SUCLA2
    MAP kinase activity MAPK6; MAPK13; MAPK11; MAPK12; MAPK7; MAPK1; MAPK4; MAPK14; MAPK15; MAPK8B
    protein binding FLNA; ITM2B; ATF7IP; UGGT2; ZFHX3; CIDEB; PPP3CC; TRAPPC10; MYH11; CD200R2
    protein serine/threonine kinase activity ULK3; STK30; MAP4K3; CAMK2D1; MYO3B; HIPK2; ULK2; LMTK3; GM7168; HIPK4

    MAPK11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK11.


    Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
    Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).

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