Recombinant Human MMP11 Protein, GST-tagged

• Cat.No.: MMP11-5417H
• Product Overview: Human MMP11 full-length ORF (1 a.a. - 488 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMPs, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 81 kDa
• AA Sequence: MAPAAWLRSAAARALLPPMLLLLLQ PPPLLARALPPDVHHLHAERRGPQP WHAALPSSPAPAPATQEAPRPASSL RPPRCGVPDPSDGLSARNRQKRFVL SGGRWEKTDLTYRILRFPWQLVQEQ VRQTMAEALKVWSDVTPLTFTEVHE GRADIMIDFARYWHGDDLPFDGPGG ILAHAFFPKTHREGDVHFDYDETWT IGDDQGTDLLQVAAHEFGHVLGLQH TTAAKALMSAFYTFRYPLSLSPDDC RGVQHLYGQPWPTVTSRTPALGPQA GIDTNEIAPLEPDAPPDACEASFDA VSTIRGELFFFKAGFVWRLRGGQLQ PGYPALASRHWQGLPSPVDAAFEDA QGHIWFFQGAQYWVYDGEKPVLGPA PLTELGLVRFPVHAALVWGPEKNKI YFFRGRDYWRFHPSTRRVDSPVPRR ATDWRGVPSEIDAAFQDADGYAYFL RGRLYWKFDPVKVKALEGFPRLVGP DFFGCAEPANTFL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MMP11 matrix metallopeptidase 11 (stromelysin 3) [ Homo sapiens ]
• Official Symbol: MMP11
• Synonyms: MMP11; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3) , STMY3; stromelysin-3; MMP-11; stromelysin III; ST3; SL-3; STMY3
• Gene ID: 4320
• mRNA Refseq: NM_005940
• Protein Refseq: NP_005931
• MIM: 185261
• UniProt ID: P24347