Recombinant Human MMP11 Protein, His tagged

• Cat.No.: MMP11-33H
• Product Overview: A DNA sequence encoding human matrix metallopeptidase 11 corresponding to amino acid (1-488) was expressed with a C-terminal polyhistidine tag.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: 1-488 aa
• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
• Form: Liquid
• AASequence: MAPAAWLRSAAARALLPPMLLLLLQPPPLLARALPPDAHHLHAERRGPQPWHAALPSSPAPAPATQEAPRPASSLRPPRCGVPDPSDGLSARNRQKRFVLSGGRWEKTDLTYRILRFPWQLVQEQVRQTMAEALKVWSDVTPLTFTEVHEGRADIMIDFARYWHGDDLPFDGPGGILAHAFSPKTHREGDVHFDYDETWTIGDDQGTDLLQVAAHEFGHVLGLQHTTAAKALMSAFYTFRYPLSLSPDDCRGVQHLYGQPWPTVTSRTPALGPQAGIDTNEIAPLEPDAPPDACEASFDAVSTIRGELFFFKAGFVWRLRGGQLQPGYPALASRHWQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPLTELGLVRFPVHAALVWGPEKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFLRGRLYWKFDPVKVKALEGFPRLVGPDFFGCAEPANTFL
• Molecular Mass: 44.1 kDa
• Purity: > 95% as determined by SDS-PAGE
• Storage: Store it at +4 centigrade for short term. For long term storage, store it at -20 to -70 centigrade.
• Storage Buffer: PBS, pH7.4
• Concentration: 0.15 mg/mL

Gene Information

• Gene Name: MMP11 matrix metallopeptidase 11 (stromelysin 3) [ Homo sapiens (human) ]
• Official Symbol: MMP11
• Synonyms: MMP11; matrix metallopeptidase 11 (stromelysin 3); matrix metalloproteinase 11 (stromelysin 3), STMY3; stromelysin-3; MMP-11; stromelysin III; ST3; SL-3; STMY3
• Gene ID: 4320
• mRNA Refseq: NM_005940
• Protein Refseq: NP_005931
• MIM: 185261
• UniProt ID: P24347