Recombinant Human MMP11 Protein, His-GST-tagged

• Cat.No.: MMP11-001H
• Product Overview: Recombinant Human MMP11 Protein (33-488 aa (full-length)) with 6xHis-GST tags was expressed in E. coli.

Specification

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.
• Source: E. coli
• Species: Human
• Tag: His-GST
• Molecular Mass: 79.8 kDa
• Protein length: 33-488
• Purity: >80% confirmed by 10% SDS-PAGE stained with Coomassie Blue (CB).
• Applications: ELISA, Western Blot, Antibody Production, Protein array
• Quality Control Test: 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-GST monoclonal and peptide fingerprinting by MALDI-TOF mass spectrometry.
• Storage: Store working aliquots at 4 centigrade for up to one week. For extended storage, conserve at −80 centigrade.
• Expiry: 12 months from the date of purchase, if it is properly stored.
• Storage Buffer: 20mM Sodium Phosphate, 0.5M NaCl, 0.15M imidazole, pH 7.4. No preservatives added.
• Shipping: Dry Ice

Gene Information

• Gene Name: MMP11 matrix metallopeptidase 11 [ Homo sapiens (human) ]
• Official Symbol: MMP11
• Synonyms: MMP11; matrix metallopeptidase 11; ST3; SL-3; STMY3; stromelysin-3; matrix metallopeptidase 11 (stromelysin 3); stromelysin III; EC 3.4.24.-
• Gene ID: 4320
• mRNA Refseq: NM_005940
• Protein Refseq: NP_005931
• MIM: 185261
• UniProt ID: P24347