Recombinant Full Length Human NFKB2 Protein, C-Flag-tagged

• Cat.No.: NFKB2-559HFL
• Product Overview: Recombinant Full Length Human NFKB2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 96.5 kDa
• AA Sequence: MESCYNPGLDGIIEYDDFKLNSSIV EPKEPAPETADGPYLVIVEQPKQRG FRFRYGCEGPSHGGLPGAS SEKGRKTYPTVKICNYEGPAKIEVD LVTHSDPPRAHAHSLVGKQCSELGI CAVSVGPKDMTAQFNNLGV LHVTKKNMMGTMIQKLQRQRLRSRP QGLTEAEQRELEQEAKELKKVMDLS IVRLRFSAFLRASDGSFSL PLKPVISQPIHDSKSPGASNLKISR MDKTAGSVRGGDEVYLLCDKVQKDD IEVRFYEDDENGWQAFGDF SPTDVHKQYAIVFRTPPYHKMKIER PVTVFLQLKRKRGGDVSDSKQFTYY PLVEDKEEVQRKRRKALPT FSQPFGGGSHMGGGSGGAAGGYGGA GGGGSLGFFPSSLAYSPYQSGAGPM GCYPGGGGGAQMAATVPSR DSGEEAAEPSAPSRTPQCEPQAPEM LQRAREYNARLFGLAQRSARALLDY GVTADARALLAGQRHLLTA QDENGDTPLHLAIIHGQTSVIEQIV YVIHHAQDLGVVNLTNHLHQTPLHL AVITGQTSVVSFLLRVGAD PALLDRHGDSAMHLALRAGAGAPEL LRALLQSGAPAVPQLLHMPDFEGLY PVHLAVRARSPECLDLLVD SGAEVEATERQGGRTALHLATEMEE LGLVTHLVTKLRANVNARTFAGNTP LHLAAGLGYPTLTRLLLKA GADIHAENEEPLCPLPSPPTSDSDS DSEGPEKDTRSSFRGHTPLDLTCST KVKTLLLNAAQNTMEPPLT PPSPAGPGLSLGDTALQNLEQLLDG PEAQGSWAELAERLGLRSLVDTYRQ TTSPSGSLLRSYELAGGDL AGLLEALSDMGLEEGVRLLRGPETR DKLPSTEVKEDSAYGSQSVEQEAEK LGPPPEPPGGLCHGHPQPQ
  VHTRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Transcription Factors
• Protein Pathways: MAPK signaling pathway, Pathways in cancer

Gene Information

• Gene Name: NFKB2 nuclear factor kappa B subunit 2 [ Homo sapiens (human) ]
• Official Symbol: NFKB2
• Synonyms: p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100
• Gene ID: 4791
• mRNA Refseq: NM_002502.6
• Protein Refseq: NP_002493.3
• MIM: 164012
• UniProt ID: Q00653