| Description : |
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
96.7 kDa |
| AA Sequence : |
Tag(s)MESCYNPGLDGIIEYDDFKLNSSIV EPKEPAPETADGPYLVIVEQPKQRG FRFRYGCEGPSHGGLPGASSEKGRK TYPTVKICNYEGPAKIEVDLVTHSD PPRAHAHSLVGKQCSELGICAVSVG PKDMTAQFNNLGVLHVTKKNMMGTM IQKLQRQRLRSRPQGLTEAEQRELE QEAKELKKVMDLSIVRLRFSAFLRA SDGSFSLPLKPVISQPIHDSKSPGA SNLKISRMDKTAGSVRGGDEVYLLC DKVQKDDIEVRFYEDDENGWQAFGD FSPTDVHKQYAIVFRTPPYHKMKIE RPVTVFLQLKRKRGGDVSDSKQFTY YPLVEDKEEVQRKRRKALPTFSQPF GGGSHMGGGSGGAAGGYGGAGGGGS LGFFPSSLAYSPYQSGAGPMGCYPG GGGGAQMAATVPSRDSGEEAAEPSA PSRTPQCEPQAPEMLQRAREYNARL FGLAQRSARALLDYGVTADARALLA GQRHLLTAQDENGDTPLHLAIIHGQ TSVIEQIVYVIHHAQDLGVVNLTNH LHQTPLHLAVITGQTSVVSFLLRVG ADPALLDRHGDSAMHLALRAGAGAP ELLRALLQSGAPAVPQLLHMPDFEG LYPVHLAVRARSPECLDLLVDSGAE VEATERQGGRTALHLATEMEELGLV THLVTKLRANVNARTFAGNTPLHLA AGLGYPTLTRLLLKAGADIHAENEE PLCPLPSPPTSDSDSDSEGPEKDTR SSFRGHTPLDLTCSTKVKTLLLNAA QNTMEPPLTPPSPAGPGLSLGDTAL QNLEQLLDGPEAQGSWAELAERLGL RSLVDTYRQTTSPSGSLLRSYELAG GDLAGLLEALSDMGLEEGVRLLRGP ETRDKLPSTEVKEDSAYGSQSVEQE AEKLGPPPEPPGGLCHGHPQPQVHT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
