• Official Full Name

    proprotein convertase subtilisin/kexin type 6

  • Overview

    The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    PCSK6; proprotein convertase subtilisin/kexin type 6; PACE4, paired basic amino acid cleaving system 4; SPC4; subtilisin like proprotein convertase 4; subtilisin like protease; subtilisin/kexin like protease PACE4; subtilisin/kexin-like protease PACE4; s;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PCSK6-30177TH Recombinant Human PCSK6 Wheat Germ N/A 110 amino acids
Human PCSK6-3241H Recombinant Human PCSK6 protein, His-tagged E.coli His Met168~Val487
Human PCSK6-3302H Recombinant Human PCSK6 protein, His-SUMO-tagged E.coli His-SUMO Met168~Val487
Human PCSK6-3303H Recombinant Human PCSK6 protein, His-tagged E.coli His Met168~Val487
Rat PCSK6-4309R Recombinant Rat PCSK6 Protein Mammalian Cell His
Rat PCSK6-3969R Recombinant Rat PCSK6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PCSK6-3969R-B Recombinant Rat PCSK6 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PCSK6 involved in several pathways and played different roles in them. We selected most pathways PCSK6 participated on our site, such as Developmental Biology, NGF processing, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Developmental BiologyDUSP1;KLB;AP2B1;MED15;FGFR1B;PEBP1;LGI2B;PLXND1;GFRA2

PCSK6 has several biochemical functions, for example, endopeptidase activity, heparin binding, nerve growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK6 itself. We selected most functions PCSK6 had, and list some proteins which have the same functions with PCSK6. You can find most of the proteins on our site.

Function Related Protein
endopeptidase activityPSMA7;ELANE;TMEM59;TPP2;PSMA2;SENP5;KLK1B8;PSMA3;PSMB9A
nerve growth factor bindingNGFRB;NGFR;FURIN;NTRK1;SORT1;PCSK6
serine-type endopeptidase activityKLK15;PCSK9;PARLA;TMPRSS11G;IMMP1L;KLK1B26;FURINA;PREP;PRSS27

PCSK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK6.


  • Q&As
  • Reviews

Q&As (7)

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How does PCSK6 influence the activation of growth factors and hormones? 10/15/2022

It activates growth factors and hormones, influencing cell growth and differentiation.

What is the impact of altered PCSK6 activity in diseases like cancer? 08/28/2022

Altered PCSK6 activity is associated with cancer progression, impacting cell growth.

What role does PCSK6 play in developmental processes and organogenesis? 08/02/2021

PCSK6 is key in development, affecting organ formation and body patterning.

What is the primary function of PCSK6 in protein processing and regulation? 03/15/2021

PCSK6 activates precursor proteins into their active forms, essential for protein regulation.

How do genetic variations in PCSK6 affect its enzymatic activity and contribute to developmental disorders? 10/23/2020

Mutations in PCSK6 can disrupt protein processing, leading to developmental disorders.

How does PCSK6 interact with other proteases and signaling pathways in the cell? 05/07/2018

PCSK6 cooperates with other proteases, playing a role in various cellular pathways.

What potential therapeutic applications could arise from modulating PCSK6 activity in various diseases? 12/29/2017

Targeting PCSK6 could be therapeutic in conditions involving abnormal protein activation.

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