PCSK6
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Official Full Name
proprotein convertase subtilisin/kexin type 6
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Overview
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
PCSK6; proprotein convertase subtilisin/kexin type 6; PACE4, paired basic amino acid cleaving system 4; SPC4; subtilisin like proprotein convertase 4; subtilisin like protease; subtilisin/kexin like protease PACE4; subtilisin/kexin-like protease PACE4; s;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- C
- hFc
- His
- Fc
- Avi
- SUMO
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PCSK6-30177TH | Recombinant Human PCSK6 | Wheat Germ | Non | 110 amino acids |
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| Human | PCSK6-3241H | Recombinant Human PCSK6 protein, His-tagged | E.coli | His | Met168~Val487 |
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| Human | PCSK6-3302H | Recombinant Human PCSK6 protein, His-SUMO-tagged | E.coli | His&SUMO | Met168~Val487 |
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| Human | PCSK6-3303H | Recombinant Human PCSK6 protein, His-tagged | E.coli | His | Met168~Val487 |
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| Human | PCSK6-7845H | Recombinant Human PCSK6 protein, hFc-tagged | HEK293 | C-hFc | 860-969aa |
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| Human | PCSK6-6332H | Recombinant Human PCSK6 protein, His-tagged | E.coli | His | 860-969aa |
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| Rat | PCSK6-4309R | Recombinant Rat PCSK6 Protein | Mammalian Cell | His |
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| Rat | PCSK6-3969R | Recombinant Rat PCSK6 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | PCSK6-3969R-B | Recombinant Rat PCSK6 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
PCSK6 involved in several pathways and played different roles in them. We selected most pathways PCSK6 participated on our site, such as Developmental Biology, NGF processing, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | TCF4;HIF3A;EFNA4;KALRNB;COL9A1;TRPC4;DPYSL5B;MED23;KCNQ2 |
| NGF processing | FURINA;PCSK5;NTF7;FURINB;PCSK6 |
| Signal Transduction | TRH;CDC42EP2;DHRS3;DACT1;PNOCB;LRP12;RBBP5;NOXA1;APOC2 |
| Signaling by NODAL | LEFTY1;ACVR1C;FOXH1;CFC1;GDF1;PCSK6;TDGF1;DRAP1 |
| Signalling by NGF | PRDM4;AATF;RIT2;RTN4;KIDINS220B;ARHGEF1B;RIT1;LINGO1B;DNAL4 |
PCSK6 has several biochemical functions, for example, endopeptidase activity, heparin binding, nerve growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK6 itself. We selected most functions PCSK6 had, and list some proteins which have the same functions with PCSK6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase activity | TPP1;MMP12;KLK1B16;KLK1B3;PARL;KLK1B1;APH1B;ADAM10;APH1C |
| heparin binding | FGF2;SMOC2;CCL8;TGFBR3;VTN;WISP1;LPA;CLEC3B;SLIT1B |
| nerve growth factor binding | SORT1;PCSK6;FURIN;NTRK1;NGFR;NGFRB |
| serine-type endopeptidase activity | DPP4;CMA1;GZMK;CTRC;KLK8;F11;PARLA;KLK1B22;GZMM |
PCSK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK6.
RXRB; CACNA1A; treB
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Q&As (7)
Ask a questionIt activates growth factors and hormones, influencing cell growth and differentiation.
Altered PCSK6 activity is associated with cancer progression, impacting cell growth.
PCSK6 is key in development, affecting organ formation and body patterning.
PCSK6 activates precursor proteins into their active forms, essential for protein regulation.
Mutations in PCSK6 can disrupt protein processing, leading to developmental disorders.
PCSK6 cooperates with other proteases, playing a role in various cellular pathways.
Targeting PCSK6 could be therapeutic in conditions involving abnormal protein activation.
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