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PCSK6

Official Full Name

proprotein convertase subtilisin/kexin type 6
Background

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms

PCSK6; proprotein convertase subtilisin/kexin type 6; PACE4, paired basic amino acid cleaving system 4; SPC4; subtilisin like proprotein convertase 4; subtilisin like protease; subtilisin/kexin like protease PACE4; subtilisin/kexin-like protease PACE4; s;

Type:
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species :
Human
Rat

Source :
E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag :
His
His (Fc)
Avi
SUMO
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PCSK6-3241H	Recombinant Human PCSK6 protein, His-tagged	E.coli	His	Inquiry
Human	PCSK6-3302H	Recombinant Human PCSK6 protein, His-SUMO-tagged	E.coli	His-SUMO	Inquiry
Human	PCSK6-3303H	Recombinant Human PCSK6 protein, His-tagged	E.coli	His	Inquiry
Human	PCSK6-30177TH	Recombinant Human PCSK6	Wheat Germ	N/A	Inquiry
Rat	PCSK6-4309R	Recombinant Rat PCSK6 Protein	Mammalian Cell	His	Inquiry
Rat	PCSK6-3969R	Recombinant Rat PCSK6 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug
Rat	PCSK6-3969R-B	Recombinant Rat PCSK6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry

Involved Pathway
Protein Function
Interacting Protein

PCSK6 involved in several pathways and played different roles in them. We selected most pathways PCSK6 participated on our site, such as Developmental Biology, NGF processing, Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCSK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Developmental Biology	LGI1A;GPC1B;EFNB3B;EPHB4B;DUSP10;PLXNC1;SMAD3B;FGF18B;RHOAE
NGF processing	FURINA;PCSK5;PCSK6;FURINB;NTF7
Signal Transduction	STARD13;ARHGAP31;CGNB;HHAT;PMEPA1;NOG;BCO2A;SOX4A;S1PR3
Signaling by NODAL	PCSK6;LEFTY1;ACVR1C;DRAP1;FOXH1;CFC1;TDGF1;GDF1
Signalling by NGF	RTN4A;ARHGEF1B;KIDINS220B;DNAL4B;DNAL4;LINGO1;DNAL4A;PCSK6;OMG

PCSK6 has several biochemical functions, for example, endopeptidase activity, heparin binding, nerve growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCSK6 itself. We selected most functions PCSK6 had, and list some proteins which have the same functions with PCSK6. You can find most of the proteins on our site.

Function	Related Protein
endopeptidase activity	PSMA5;AP1S2;CTSH;SENP3B;TPP1;PSMB2;PSMB5;ACE2;ADAM10
heparin binding	NRP2;F11;RSPO1;COL13A1;TGFBR3;RSPO2;REG4;PTPRF;GREM2
nerve growth factor binding	FURIN;NGFRB;PCSK6;SORT1;NGFR;NTRK1
serine-type endopeptidase activity	PCSK2;KLK1B1;KLKB1;PRSS23;FAM108A1;TMPRSS12;PCSK9;KLK8;KLK10

PCSK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCSK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCSK6.

RXRB; CACNA1A; treB