| Description : |
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. |
| Source : |
Sf9 insect cells |
| Species : |
Human |
| Tag : |
N-GST |
| Protein length : |
Full Length |
| Molecular Mass : |
92 kDa |
| Purity : |
The purity of PPP2R1A was determined to be > 70% by densitometry, approx. MW 92 kDa. |
| Stability : |
One year at -70 centigrade from date of shipment. |
| Storage : |
Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration : |
0.5 μg/μL |
| Storage Buffer : |
50mM Tris-HCl pH 7.5, 150mM NaCl,10mM glutathione, 0.1mM EDTA,0.25mMDTT, 0.1mM PMSF, 25% glycerol. |
| Shipping : |
Dry ice |
| References : |
1. Tang Z, et al: PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Dev Cell. 10(5):575-85, 2006. |
