RIPK2
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Official Full Name
receptor-interacting serine-threonine kinase 2
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Overview
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008] -
Synonyms
RIPK2; receptor-interacting serine-threonine kinase 2; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; receptor-interacting serine/threonine-protein kinase 2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor-interacting protein 2; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Chicken
- Human
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | RIPK2-419H | Active Recombinant Human RIPK2, His-tagged | Insect Cell | His | amino acids 1-299 |
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| Human | RIPK2-1479H | Active Recombinant Human RIPK2, GST-tagged | Sf9 Insect Cell | GST | 1-299 aa |
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| Human | RIPK2-214H | Active Recombinant Human RIPK2(1-299) Protein, N-His-tagged | Sf21 | His | 1-299 aa |
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| Human | RIPK2-532H | Recombinant Human RIPK2, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | RIPK2-29983TH | Recombinant Human RIPK2 | N/A |
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| Human | RIPK2-711H | Recombinant Human RIPK2, GST-His | Sf9 Insect Cell | GST |
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| Human | RIPK2-418H | Recombinant Human RIPK2, GST-tagged, Active | Sf9 Insect Cell | GST |
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| Human | RIPK2-932H | Recombinant Human RIPK2 protein, His-tagged | E.coli | His | Gln432~Met540 | |
| Human | RIPK2-2333HCL | Recombinant Human RIPK2 293 Cell Lysate | HEK293 | N/A |
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| Human | RIPK2-5269HFL | Recombinant Full Length Human RIPK2, Flag-tagged | Mamanlian cells | Flag |
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| Human | RIPK2-5565H | Recombinant Human RIPK2, GST-tagged | Wheat Germ | GST | 1-540 a.a. |
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| Human | RIPK2-6505H | Recombinant Human RIPK2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | RIPK2-5564H | Recombinant Human RIPK2 Protein, His-tagged | E. coli | His | 1-540 aa |
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| Human | RIPK2-6795HF | Recombinant Full Length Human RIPK2 Protein, GST-tagged | In Vitro Cell Free System | GST | 540 amino acids |
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| Human | RIPK2-3761H | Recombinant Human RIPK2 protein, His-tagged | E.coli | His | 221-524 aa | |
| Human | RIPK2-6660H | Recombinant Human RIPK2 Protein (Gln432-Met540), N-GST tagged | E.coli | N-GST | Gln432-Met540 |
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| Mouse | Ripk2-1795M | Recombinant Mouse Ripk2 protein, His & T7-tagged | E.coli | His/T7 | Met1~Leu294 (Accession # P58801) |
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| Mouse | RIPK2-14244M | Recombinant Mouse RIPK2 Protein | Mammalian Cell | His |
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| Mouse | Ripk2-5522M | Recombinant Mouse Ripk2 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Mouse | RIPK2-7616M | Recombinant Mouse RIPK2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | RIPK2-7616M-B | Recombinant Mouse RIPK2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | Ripk2-1796R | Recombinant Rat Ripk2 protein, His & T7-tagged | E.coli | His/T7 | Met1~Leu294 (Accession # G3V783) |
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| Zebrafish | RIPK2-9761Z | Recombinant Zebrafish RIPK2 | Mammalian Cell | His |
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| Chicken | RIPK2-2632C | Recombinant Chicken RIPK2 | Mammalian Cell | His |
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| Kit-1623 | RIPK2 Kinase Binding Assay Kit | N/A |
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- Involved Pathway
- Protein Function
- Interacting Protein
- RIPK2 Related Signal Pathway
RIPK2 involved in several pathways and played different roles in them. We selected most pathways RIPK2 participated on our site, such as NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIPK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NOD-like receptor signaling pathway | ERBB2IP;NLRC4;TRAF6;HSP90AA1.1;MAPK3;MAPK8;IL8L2;PYCARD;MAPK8A |
| Neurotrophin signaling pathway | SHC2;AKT1;NTF4;CDC42;MAP3K3;PLCG2;ATF4;PIK3CA;BAX |
| Shigellosis | MAPK9;RELA;CD44;DIAPH1;NFKBIA;ATG5;CDC42;MAPK8;WASL |
| Tuberculosis | EP300;IRAK1;RHOA;HLA-DRB3;CLEC7A;HLA-DMA;HLA-DPB1;TLR4;FCGR1 |
RIPK2 has several biochemical functions, for example, ATP binding, CARD domain binding, LIM domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIPK2 itself. We selected most functions RIPK2 had, and list some proteins which have the same functions with RIPK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CHORDC1;UBE2Q2;RUNX3;PRKCH;PET112L;TTLL3;UBE1Y1;RNASEL;PRKAG2 |
| CARD domain binding | RIPK2;CARD14;NOD1;CARD11;CARD9;MAVS;C9orf89 |
| LIM domain binding | LDB2B;CSRP2BP;LDB1B;LDB2A;RPH3AL;RIPK2;LDB2;TLN1;ACTN2 |
| non-membrane spanning protein tyrosine kinase activity | BMX;ZAP70;PKDCC;YRK;SRMS;YES1;STK16;FYNA;PTK2 |
| protein binding | CCAR1;TRAF6;CUL2;KIF20B;BLZF1;HNRNPH1;WDR77;LRP6;BIRC5 |
| protein homodimerization activity | TRIM5;TSG101;PSPH;SYT6;CRTAM;BMP2B;SDS;ABP1;NR4A3 |
| protein serine/threonine kinase activity | STK10;SLC14A2;HIPK2;ZAK;BMPR1BB;IRAK1;CASK;SRPK1;PRKACAB |
| receptor binding | SRI;SERPINE2;TNFSF18;SSTR3;POMC;CSNK2B;IL28A;SCYL2;PICK1 |
| signal transducer activity | OPN3;GNA15.1;STAT3;TRIM54;GNAI2;PTGER2A;CELSR3;RGS6;SHC3 |
RIPK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIPK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIPK2.
XIAP; NOD2; TRAF3; BIRC3; BIRC2; TRAF2
- Q&As
- Reviews
Q&As (7)
Ask a questionRIPK2 plays a significant role in driving inflammatory responses, implicated in autoimmune disease mechanisms.
RIPK2 is crucial in NOD1/NOD2 signaling, activating innate immune responses against microbial intrusions.
Changes in RIPK2 signaling can impact cancer development, influencing tumor cell survival and immune interactions.
RIPK2 regulates NF-κB activation and cytokine production, crucial for immune response and inflammation.
RIPK2 modulates defense mechanisms against bacterial pathogens, coordinating immune signaling and responses.
RIPK2 influences cell survival and apoptosis decisions, particularly in response to stress or microbial infection.
Dysregulation of RIPK2 is linked to IBD, affecting intestinal inflammation and immune responses.
Customer Reviews (3)
Write a reviewPrecise mass spectrometry analysis, key for our proteomics investigations.
Dependable protein purification, consistently delivers high yield and purity.
Great antibody validation, enhances our immunoprecipitation success.
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